{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:10:58Z","timestamp":1769904658635,"version":"3.49.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1124\/jpet.115.229229","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T03:47:41Z","timestamp":1449805661000},"page":"375-386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor\u2013Mediated Signaling in Neuroblastoma"],"prefix":"10.1016","volume":"356","author":[{"given":"Mehrnoosh","family":"Soori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guizhen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.115.229229_bib1","first-page":"3837","article-title":"Autophagy-induced tumor dormancy in ovarian cancer","volume":"118","author":"Amaravadi","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.115.229229_bib2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/tera.1420500307","article-title":"In vitro embryotoxicity of the cysteine proteinase inhibitors benzyloxycarbonyl-phenylalanine-alanine-diazomethane (Z-Phe-Ala-CHN2) and benzyloxycarbonyl-phenylalanine-phenylalanine-diazomethane (Z-Phe-Phe-CHN2)","volume":"50","author":"Ambroso","year":"1994","journal-title":"Teratology"},{"key":"10.1124\/jpet.115.229229_bib3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbrc.2007.11.104","article-title":"Effects of cathepsins B and L inhibition on postischemic protein alterations in the brain","volume":"366","author":"Anagli","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.115.229229_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4939-3170-5_10","article-title":"Isolation and Analysis of Detergent-Resistant Membrane Fractions","volume":"1376","author":"Aureli","year":"2016","journal-title":"Methods Mol Biol"},{"key":"10.1124\/jpet.115.229229_bib5","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1073\/pnas.1018603108","article-title":"Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells","volume":"108","author":"Benitez","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.229229_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1042\/bj2540693","article-title":"A catalytically active high-Mr form of human cathepsin B from sputum","volume":"254","author":"Buttle","year":"1988","journal-title":"Biochem J"},{"key":"10.1124\/jpet.115.229229_bib7","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/jcp.20670","article-title":"Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells","volume":"208","author":"Carelli","year":"2006","journal-title":"J Cell Physiol"},{"key":"10.1124\/jpet.115.229229_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s10637-012-9826-6","article-title":"Inhibitors of cathepsins B and L induce autophagy and cell death in neuroblastoma cells","volume":"31","author":"Cartledge","year":"2013","journal-title":"Invest New Drugs"},{"key":"10.1124\/jpet.115.229229_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.canlet.2010.01.037","article-title":"Induction of cell death in neuroblastoma by inhibition of cathepsins B and L","volume":"294","author":"Colella","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1124\/jpet.115.229229_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1124\/mol.107.039511","article-title":"Effect of cathepsin k inhibitor basicity on in vivo off-target activities","volume":"73","author":"Desmarais","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.229229_bib11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1530\/ERC-11-0136","article-title":"IGF1\/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer","volume":"18","author":"Dool","year":"2011","journal-title":"Endocr Relat Cancer"},{"key":"10.1124\/jpet.115.229229_bib12","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1128\/AAC.00281-10","article-title":"A nonazole CYP51 inhibitor cures Chagas\u2019 disease in a mouse model of acute infection","volume":"54","author":"Doyle","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/jpet.115.229229_bib13","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1073\/pnas.112632299","article-title":"Neuronal loss and brain atrophy in mice lacking cathepsins B and L","volume":"99","author":"Felbor","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.229229_bib14","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1111\/j.1349-7006.2008.00893.x","article-title":"Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome","volume":"99","author":"Fujii","year":"2008","journal-title":"Cancer Sci"},{"key":"10.1124\/jpet.115.229229_bib15","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/hmg\/ddm002","article-title":"Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin\/proteasome ERAD(I) and autophagy\/lysosome ERAD(II)","volume":"16","author":"Fujita","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1124\/jpet.115.229229_bib16","doi-asserted-by":"crossref","first-page":"11175","DOI":"10.18632\/oncotarget.3579","article-title":"Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin","volume":"6","author":"Gangoda","year":"2015","journal-title":"Oncotarget"},{"key":"10.1124\/jpet.115.229229_bib17","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.18632\/oncotarget.1812","article-title":"IGF-1R, a target of let-7b, mediates crosstalk between IRS-2\/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma","volume":"5","author":"Gao","year":"2014","journal-title":"Oncotarget"},{"key":"10.1124\/jpet.115.229229_bib18","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1073\/pnas.1431613100","article-title":"Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor","volume":"100","author":"Girnita","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.229229_bib19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrn2147","article-title":"How widespread is adult neurogenesis in mammals?","volume":"8","author":"Gould","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/jpet.115.229229_bib20","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1038\/onc.2009.172","article-title":"Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions","volume":"28","author":"Gualberto","year":"2009","journal-title":"Oncogene"},{"key":"10.1124\/jpet.115.229229_bib21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/pbc.22367","article-title":"Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program","volume":"54","author":"Houghton","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"10.1124\/jpet.115.229229_bib22","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1210\/en.2008-0920","article-title":"Expanding the mind: insulin-like growth factor I and brain development","volume":"149","author":"Joseph D\u2019Ercole","year":"2008","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.115.229229_bib23","doi-asserted-by":"crossref","first-page":"e0116972","DOI":"10.1371\/journal.pone.0116972","article-title":"Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose","volume":"10","author":"Jung","year":"2015","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.229229_bib24","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1158\/1078-0432.CCR-09-3239","article-title":"Molecular diagnosis of activating EGFR mutations in non-small cell lung cancer using mutation-specific antibodies for immunohistochemical analysis","volume":"16","author":"Kawahara","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1124\/jpet.115.229229_bib25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/bbrc.1997.6313","article-title":"Type II protein kinase A up-regulation is sufficient to induce growth inhibition in SK-N-SH human neuroblastoma cells","volume":"232","author":"Kim","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.115.229229_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/0008-5472.CAN-12-2464","article-title":"Chloroquine in cancer therapy: a double-edged sword of autophagy","volume":"73","author":"Kimura","year":"2013","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.229229_bib27","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/0014-4886(86)90183-4","article-title":"Elevations of cathepsin B and cathepsin L activities in forelimb and hind limb muscles of genetically dystrophic mice","volume":"93","author":"Komatsu","year":"1986","journal-title":"Exp Neurol"},{"key":"10.1124\/jpet.115.229229_bib28","doi-asserted-by":"crossref","first-page":"e15945","DOI":"10.1371\/journal.pone.0015945","article-title":"High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways","volume":"6","author":"Krall","year":"2011","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.229229_bib29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1507\/endocrj.47.739","article-title":"Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway","volume":"47","author":"Kurihara","year":"2000","journal-title":"Endocr J"},{"key":"10.1124\/jpet.115.229229_bib30","first-page":"3917","article-title":"The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells","volume":"118","author":"Lu","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.115.229229_bib31","first-page":"5073","article-title":"An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation","volume":"63","author":"Maloney","year":"2003","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.229229_bib32","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1056\/NEJMra0804577","article-title":"Recent advances in neuroblastoma","volume":"362","author":"Maris","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.115.229229_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0167-0115(93)90351-8","article-title":"IGF receptor function and regulation in autocrine human neuroblastoma cell growth","volume":"48","author":"Martin","year":"1993","journal-title":"Regul Pept"},{"key":"10.1124\/jpet.115.229229_bib34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0169-328X(92)90114-Q","article-title":"Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines","volume":"15","author":"Martin","year":"1992","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1124\/jpet.115.229229_bib35","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1042\/bj2630945","article-title":"The use of benzyloxycarbonyl[125I]iodotyrosylalanyldiazomethane as a probe for active cysteine proteinases in human tissues","volume":"263","author":"Mason","year":"1989","journal-title":"Biochem J"},{"key":"10.1124\/jpet.115.229229_bib36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0167-0115(93)90350-H","article-title":"Effects of serum and insulin-like growth factors on human neuroblastoma cell growth","volume":"48","author":"Meghani","year":"1993","journal-title":"Regul Pept"},{"key":"10.1124\/jpet.115.229229_bib37","doi-asserted-by":"crossref","first-page":"10310","DOI":"10.1074\/jbc.M109.029561","article-title":"Ethanol alters endosomal recycling of human dopamine transporters","volume":"285","author":"Methner","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.229229_bib38","first-page":"257","article-title":"GABARAP is overexpressed in colorectal carcinoma and correlates with shortened patient survival","volume":"57","author":"Miao","year":"2010","journal-title":"Hepatogastroenterology"},{"key":"10.1124\/jpet.115.229229_bib39","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1158\/0008-5472.CAN-12-3023","article-title":"SRC signaling is crucial in the growth of synovial sarcoma cells","volume":"73","author":"Michels","year":"2013","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.229229_bib40","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1038\/sj.onc.1208523","article-title":"Domain-specific function of ShcC docking protein in neuroblastoma cells","volume":"24","author":"Miyake","year":"2005","journal-title":"Oncogene"},{"key":"10.1124\/jpet.115.229229_bib41","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/onc.2008.413","article-title":"Distinct role of ShcC docking protein in the differentiation of neuroblastoma","volume":"28","author":"Miyake","year":"2009","journal-title":"Oncogene"},{"key":"10.1124\/jpet.115.229229_bib42","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1074\/jbc.273.12.6960","article-title":"N-Shc and Sck, two neuronally expressed Shc adapter homologs: their differential regional expression in the brain and roles in neurotrophin and Src signaling","volume":"273","author":"Nakamura","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.229229_bib43","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat Med"},{"key":"10.1124\/jpet.115.229229_bib44","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1073\/pnas.93.7.2729","article-title":"A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain","volume":"93","author":"O\u2019Bryan","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.229229_bib45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.yfrne.2012.06.002","article-title":"Neurodevelopmental effects of insulin-like growth factor signaling","volume":"33","author":"O\u2019Kusky","year":"2012","journal-title":"Front Neuroendocrinol"},{"key":"10.1124\/jpet.115.229229_bib46","doi-asserted-by":"crossref","first-page":"20737","DOI":"10.1074\/jbc.270.35.20737","article-title":"Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors","volume":"270","author":"Okada","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.229229_bib47","first-page":"633","article-title":"A family of Shc related proteins with conserved PTB, CH1 and SH2 regions","volume":"13","author":"Pelicci","year":"1996","journal-title":"Oncogene"},{"key":"10.1124\/jpet.115.229229_bib48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrc3215","article-title":"The insulin and insulin-like growth factor receptor family in neoplasia: an update","volume":"12","author":"Pollak","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/jpet.115.229229_bib49","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1158\/1078-0432.CCR-11-0998","article-title":"The insulin receptor\/insulin-like growth factor receptor family as a therapeutic target in oncology","volume":"18","author":"Pollak","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1124\/jpet.115.229229_bib50","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1126\/science.1193497","article-title":"Autophagy and metabolism","volume":"330","author":"Rabinowitz","year":"2010","journal-title":"Science"},{"key":"10.1124\/jpet.115.229229_bib51","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1038\/sj.onc.1204776","article-title":"Signaling via Shc family adapter proteins","volume":"20","author":"Ravichandran","year":"2001","journal-title":"Oncogene"},{"key":"10.1124\/jpet.115.229229_bib52","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0896-6273(00)00156-2","article-title":"The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons","volume":"28","author":"Sakai","year":"2000","journal-title":"Neuron"},{"key":"10.1124\/jpet.115.229229_bib53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/er.2006-0001","article-title":"The role of the IGF system in cancer growth and metastasis: overview and recent insights","volume":"28","author":"Samani","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1124\/jpet.115.229229_bib54","first-page":"4522","article-title":"Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis","volume":"56","author":"Singleton","year":"1996","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.229229_bib55","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0005-2760(77)90024-8","article-title":"Chloroquine-induced interference with degradation of serum lipoproteins in rat liver, studied in vivo and in vitro","volume":"486","author":"Stein","year":"1977","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.115.229229_bib56","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0169-328X(97)00264-7","article-title":"Alternative expression of Shc family members in nerve-injured motoneurons","volume":"53","author":"Tanabe","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1124\/jpet.115.229229_bib57","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4161\/auto.1.2.1697","article-title":"Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy","volume":"1","author":"Tanida","year":"2005","journal-title":"Autophagy"},{"key":"10.1124\/jpet.115.229229_bib58","doi-asserted-by":"crossref","first-page":"16798","DOI":"10.1074\/jbc.M110286200","article-title":"Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc","volume":"277","author":"Tarr","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.229229_bib59","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1158\/1078-0432.CCR-04-1681","article-title":"Shc family expression in neuroblastoma: high expression of shcC is associated with a poor prognosis in advanced neuroblastoma","volume":"11","author":"Terui","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1124\/jpet.115.229229_bib60","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-7-2","article-title":"Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway","volume":"7","author":"Tong","year":"2012","journal-title":"Mol Neurodegener"},{"key":"10.1124\/jpet.115.229229_bib61","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1523\/JNEUROSCI.05-10-02762.1985","article-title":"Association of nerve growth factor receptors with the triton X-100 cytoskeleton of PC12 cells","volume":"5","author":"Vale","year":"1985","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.115.229229_bib62","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/sj.cdd.4400693","article-title":"IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma","volume":"7","author":"Van Golen","year":"2000","journal-title":"Cell Death Differ"},{"key":"10.1124\/jpet.115.229229_bib63","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6","article-title":"Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis","volume":"182","author":"Van Golen","year":"2000","journal-title":"J Cell Physiol"},{"key":"10.1124\/jpet.115.229229_bib64","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc3262","article-title":"Deconvoluting the context-dependent role for autophagy in cancer","volume":"12","author":"White","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/jpet.115.229229_bib65","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1158\/1535-7163.MCT-08-0013","article-title":"Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling","volume":"7","author":"Wilhelm","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1124\/jpet.115.229229_bib66","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/jnci\/djs258","article-title":"Insulin-like growth factor receptor inhibitors: baby or the bathwater?","volume":"104","author":"Yee","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"10.1124\/jpet.115.229229_bib67","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.2174\/13816128113199990595","article-title":"Advances in targeting insulin-like growth factor signaling pathway in cancer treatment","volume":"20","author":"You","year":"2014","journal-title":"Curr Pharm Des"},{"key":"10.1124\/jpet.115.229229_bib68","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1161\/01.CIR.0000160864.31351.C1","article-title":"Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice","volume":"111","author":"Zhou","year":"2005","journal-title":"Circulation"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524192294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524192294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.115.229229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:41:51Z","timestamp":1739994111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524192294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0022356524192294"],"URL":"https:\/\/doi.org\/10.1124\/jpet.115.229229","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor\u2013Mediated Signaling in Neuroblastoma","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.115.229229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}