{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:19:42Z","timestamp":1774462782002,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1124\/jpet.115.230409","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T05:05:11Z","timestamp":1455253511000},"page":"94-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inhibition of KV7 Channels Protects the Rat Heart against Myocardial Ischemia and Reperfusion Injury"],"prefix":"10.1016","volume":"357","author":[{"given":"Elise R.","family":"Hedegaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Johnsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas A.","family":"Povlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichlas R.","family":"Jespersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Shanmuganathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia R.","family":"Laursen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen B.","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.115.230409_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/384078a0","article-title":"K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current","volume":"384","author":"Barhanin","year":"1996","journal-title":"Nature"},{"key":"10.1124\/jpet.115.230409_bib2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00424-008-0583-5","article-title":"Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury","volume":"457","author":"Bentzen","year":"2009","journal-title":"Pflugers Arch"},{"key":"10.1124\/jpet.115.230409_bib3","doi-asserted-by":"crossref","first-page":"32436","DOI":"10.1074\/jbc.272.51.32436","article-title":"A primary role for K+ and Na+ efflux in the activation of apoptosis","volume":"272","author":"Bortner","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.230409_bib4","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1172\/JCI112160","article-title":"Myocardial reperfusion: a double-edged sword?","volume":"76","author":"Braunwald","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.115.230409_bib5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/j.1476-5381.2009.00111.x","article-title":"Neural KCNQ (Kv7) channels","volume":"156","author":"Brown","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib6","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1074\/jbc.M113.527820","article-title":"Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels","volume":"289","author":"Brueggemann","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.230409_bib7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/ATVBAHA.114.303405","article-title":"Contribution of kv7.4\/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity","volume":"34","author":"Chadha","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.115.230409_bib8","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.230409_bib9","doi-asserted-by":"crossref","unstructured":"Engholm M, Pinilla E, Mogensen S, Matchkov VV, Hedegaard ER, Chen H, Mulvany MJ, Simonsen U (2015) Involvement of transglutaminase 2 and KV channels in cystamine vasodilatation in rat mesenteric small arteries. Br J Pharmacol In press.","DOI":"10.1111\/bph.13393"},{"key":"10.1124\/jpet.115.230409_bib10","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1124\/pr.113.008300","article-title":"Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning","volume":"66","author":"Ferdinandy","year":"2014","journal-title":"Pharmacol Rev"},{"key":"10.1124\/jpet.115.230409_bib11","doi-asserted-by":"crossref","first-page":"H305","DOI":"10.1152\/ajpheart.2000.278.1.H305","article-title":"Ischemic preconditioning in rats: role of mitochondrial K(ATP) channel in preservation of mitochondrial function","volume":"278","author":"Fryer","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/jpet.115.230409_bib12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/pr.57.4.10","article-title":"International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels","volume":"57","author":"Gutman","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1124\/jpet.115.230409_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4103\/0970-9185.94833","article-title":"Flupirtine: clinical pharmacology","volume":"28","author":"Harish","year":"2012","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/2040622311421542","article-title":"Retigabine (ezogabine) as add-on therapy for partial-onset seizures: an update for clinicians","volume":"2","author":"Harris","year":"2011","journal-title":"Ther Adv Chronic Dis"},{"key":"10.1124\/jpet.115.230409_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/jpet.115.227017","article-title":"Involvement of potassium channels and calcium-independent mechanisms in hydrogen sulfide-induced relaxation of rat mesenteric small arteries","volume":"356","author":"Hedegaard","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.230409_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/bph.12424","article-title":"KV 7 channels are involved in hypoxia-induced vasodilatation of porcine coronary arteries","volume":"171","author":"Hedegaard","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1472-6793-11-8","article-title":"Non-endothelial endothelin counteracts hypoxic vasodilation in porcine large coronary arteries","volume":"11","author":"Hedegaard","year":"2011","journal-title":"BMC Physiol"},{"key":"10.1124\/jpet.115.230409_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2014.10.031","article-title":"Remote ischemic conditioning","volume":"65","author":"Heusch","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.115.230409_bib19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molbrainres.2005.05.007","article-title":"The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes","volume":"139","author":"Jensen","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1124\/jpet.115.230409_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1465-9921-7-31","article-title":"Pulmonary vasoconstrictor action of KCNQ potassium channel blockers","volume":"7","author":"Joshi","year":"2006","journal-title":"Respir Res"},{"key":"10.1124\/jpet.115.230409_bib21","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1161\/HYPERTENSIONAHA.113.01244","article-title":"Contribution of Kv7 channels to basal coronary flow and active response to ischemia","volume":"62","author":"Khanamiri","year":"2013","journal-title":"Hypertension"},{"key":"10.1124\/jpet.115.230409_bib22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/01.fjc.0000159045.35241.95","article-title":"Effects of KATP channel modulation on myocardial glycogen content, lactate, and amino acids in nonischemic and ischemic rat hearts","volume":"45","author":"Kristiansen","year":"2005","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib23","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/cvr\/cvu225","article-title":"Position paper: improving the preclinical assessment of novel cardioprotective therapies","volume":"104","author":"Lecour","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.115.230409_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/micc.12183","article-title":"Heterogeneity in Kv7 channel function in the cerebral and coronary circulation","volume":"22","author":"Lee","year":"2015","journal-title":"Microcirculation"},{"key":"10.1124\/jpet.115.230409_bib25","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1161\/01.CIR.97.24.2463","article-title":"Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?","volume":"97","author":"Liu","year":"1998","journal-title":"Circulation"},{"key":"10.1124\/jpet.115.230409_bib26","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.yjmcc.2010.09.012","article-title":"Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials","volume":"49","author":"Mac\u00edas","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.115.230409_bib27","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1124\/mol.108.049825","article-title":"Cardiovascular KCNQ (Kv7) potassium channels: physiological regulators and new targets for therapeutic intervention","volume":"74","author":"Mackie","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib28","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1073\/pnas.140216197","article-title":"Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis","volume":"97","author":"Maeno","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.230409_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/cvr\/cvv020","article-title":"Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia","volume":"106","author":"Morales-Cano","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.115.230409_bib30","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1124\/jpet.115.230409_bib31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1476-5381.2010.01027.x","article-title":"Expression and function of the K+ channel KCNQ genes in human arteries","volume":"162","author":"Ng","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib58","unstructured":"Okamoto F., et al., Reperfusion conditions: importance of ensuring gentle versus sudden reperfusion during relief of coronary occlusion. J Thorac Cardiovasc Surg, 1986. 92(3 Pt 2): p. 613\u201320."},{"key":"10.1124\/jpet.115.230409_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/FJC.0b013e3181b2b72b","article-title":"Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection","volume":"54","author":"Osipov","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/j.1552-4604.1995.tb04741.x","article-title":"Single-dose pharmacokinetics, safety, and tolerance of linopirdine (DuP 996) in healthy young adults and elderly volunteers","volume":"35","author":"Pieniaszek","year":"1995","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijcard.2013.11.035","article-title":"Frequent biomarker analysis in the isolated perfused heart reveals two distinct phases of reperfusion injury","volume":"171","author":"Povlsen","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1124\/jpet.115.230409_bib35","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1111\/j.1528-1167.2007.01193.x","article-title":"K+ M-current regulates the transition to seizures in immature and adult hippocampus","volume":"48","author":"Qiu","year":"2007","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.115.230409_bib36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/sj.bjp.0707540","article-title":"The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart","volume":"153","author":"Rossoni","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0014-2999(97)01249-1","article-title":"The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells","volume":"336","author":"Rundfeldt","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2125.1989.tb03500.x","article-title":"EEG brain mapping in evaluating the time-course of the central action of DUP 996--a new acetylcholine releasing drug","volume":"28","author":"Saletu","year":"1989","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/384080a0","article-title":"Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel","volume":"384","author":"Sanguinetti","year":"1996","journal-title":"Nature"},{"key":"10.1124\/jpet.115.230409_bib40","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1097\/HJH.0b013e32833c20d5","article-title":"Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide","volume":"28","author":"Schleifenbaum","year":"2010","journal-title":"J Hypertens"},{"key":"10.1124\/jpet.115.230409_bib41","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0022-3565(24)37644-X","article-title":"Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons","volume":"286","author":"Schnee","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.230409_bib42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/1074248413499973","article-title":"Pharmacologic therapy that simulates conditioning for cardiac ischemic\/reperfusion injury","volume":"19","author":"Sivaraman","year":"2014","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1124\/jpet.115.230409_bib43","doi-asserted-by":"crossref","first-page":"C859","DOI":"10.1152\/ajpcell.2001.280.4.C859","article-title":"KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology","volume":"280","author":"S\u00f8gaard","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/jpet.115.230409_bib44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s12975-013-0314-x","article-title":"Ionic regulation of cell volume changes and cell death after ischemic stroke","volume":"5","author":"Song","year":"2014","journal-title":"Transl Stroke Res"},{"key":"10.1124\/jpet.115.230409_bib45","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.drudis.2013.12.003","article-title":"K(V)7 potassium channels: a new therapeutic target in smooth muscle disorders","volume":"19","author":"Stott","year":"2014","journal-title":"Drug Discov Today"},{"key":"10.1124\/jpet.115.230409_bib46","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.niox.2010.11.001","article-title":"Cardioprotective effects of hydrogen sulfide","volume":"25","author":"Szab\u00f3","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1124\/jpet.115.230409_bib47","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/aas.12482","article-title":"Impaired NO-mediated vasodilatation in rat coronary arteries after asphyxial cardiac arrest","volume":"59","author":"Troelsen","year":"2015","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1124\/jpet.115.230409_bib48","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1126\/science.282.5395.1890","article-title":"KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel","volume":"282","author":"Wang","year":"1998","journal-title":"Science"},{"key":"10.1124\/jpet.115.230409_bib49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/jphysiol.2006.113308","article-title":"KCNQ\/M-currents contribute to the resting membrane potential in rat visceral sensory neurons","volume":"575","author":"Wladyka","year":"2006","journal-title":"J Physiol"},{"key":"10.1124\/jpet.115.230409_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6793-14-1","article-title":"Kcnq1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish","volume":"14","author":"Wu","year":"2014","journal-title":"BMC Physiol"},{"key":"10.1124\/jpet.115.230409_bib51","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1523\/JNEUROSCI.22-01-00114.2002","article-title":"Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation","volume":"22","author":"Xia","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.115.230409_bib52","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1074360","article-title":"Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane","volume":"298","author":"Xu","year":"2002","journal-title":"Science"},{"key":"10.1124\/jpet.115.230409_bib53","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.bbrc.2008.04.129","article-title":"Expression profile and characterisation of a truncated KCNQ5 splice variant","volume":"371","author":"Yeung","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.115.230409_bib54","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/sj.bjp.0707284","article-title":"Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity","volume":"151","author":"Yeung","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib55","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/bjp.2008.231","article-title":"Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents","volume":"155","author":"Yeung","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.230409_bib59","doi-asserted-by":"crossref","unstructured":"Zhao Z.Q., et al., Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol, 2003. 285(2): p. H579\u201388.","DOI":"10.1152\/ajpheart.01064.2002"},{"key":"10.1124\/jpet.115.230409_bib56","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1113\/jphysiol.2010.192823","article-title":"Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter","volume":"588","author":"Zhong","year":"2010","journal-title":"J Physiol"},{"key":"10.1124\/jpet.115.230409_bib57","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/cdd.2010.120","article-title":"Novel role of KCNQ2\/3 channels in regulating neuronal cell viability","volume":"18","author":"Zhou","year":"2011","journal-title":"Cell Death Differ"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524192749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524192749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.115.230409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:43:30Z","timestamp":1739994210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524192749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0022356524192749"],"URL":"https:\/\/doi.org\/10.1124\/jpet.115.230409","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of KV7 Channels Protects the Rat Heart against Myocardial Ischemia and Reperfusion Injury","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.115.230409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}