{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:18:15Z","timestamp":1783437495080,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1124\/jpet.115.230771","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T03:15:40Z","timestamp":1457147740000},"page":"264-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum"],"prefix":"10.1016","volume":"357","author":[{"given":"Jenni","family":"Kononoff Vanhanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Nuutinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervi","family":"Tuominen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pertti","family":"Panula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.115.230771_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/nn.2862","article-title":"Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors","volume":"14","author":"Bello","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1124\/jpet.115.230771_bib2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00213-008-1345-y","article-title":"Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions","volume":"202","author":"Brabant","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.115.230771_bib3","doi-asserted-by":"crossref","first-page":"8911","DOI":"10.1523\/JNEUROSCI.22-20-08911.2002","article-title":"Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation","volume":"22","author":"Brami-Cherrier","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.115.230771_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbr.2003.11.001","article-title":"Enhancement of prepulse inhibition of startle in mice by the H3 receptor antagonists thioperamide and ciproxifan","volume":"153","author":"Browman","year":"2004","journal-title":"Behav Brain Res"},{"key":"10.1124\/jpet.115.230771_bib5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00213-010-1863-2","article-title":"Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists","volume":"210","author":"Burban","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.115.230771_bib6","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1523\/JNEUROSCI.20-05-01849.2000","article-title":"Activation of extracellular signal-regulated protein kinases is associated with a sensitized locomotor response to D(2) dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats","volume":"20","author":"Cai","year":"2000","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.115.230771_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2013.10.052","article-title":"Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice","volume":"81","author":"Castellan Baldan","year":"2014","journal-title":"Neuron"},{"key":"10.1124\/jpet.115.230771_bib8","doi-asserted-by":"crossref","first-page":"39317","DOI":"10.1074\/jbc.M403891200","article-title":"D1 dopamine receptor mediates dopamine-induced cytotoxicity via the ERK signal cascade","volume":"279","author":"Chen","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.230771_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00213-005-0203-4","article-title":"Blockage of histamine H1 receptor attenuates social isolation-induced disruption of prepulse inhibition: a study in H1 receptor gene knockout mice","volume":"183","author":"Dai","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.115.230771_bib10","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1056\/NEJMoa0907006","article-title":"L-histidine decarboxylase and Tourette\u2019s syndrome","volume":"362","author":"Ercan-Sencicek","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.115.230771_bib11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s002130100794","article-title":"Brain stem circuits mediating prepulse inhibition of the startle reflex","volume":"156","author":"Fendt","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.115.230771_bib12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuropharm.2008.05.008","article-title":"Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function","volume":"55","author":"Ferrada","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.115.230771_bib13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1476-5381.2009.00152.x","article-title":"Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors","volume":"157","author":"Ferrada","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.230771_bib14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1124\/jpet.104.078402","volume":"313","author":"Fox","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.230771_bib15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1460-9568.1999.00453.x","article-title":"Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington\u2019s and Parkinson\u2019s disease cases","volume":"11","author":"Goodchild","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1124\/jpet.115.230771_bib16","doi-asserted-by":"crossref","first-page":"13316","DOI":"10.1073\/pnas.93.23.13316","article-title":"Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors","volume":"93","author":"Inoue","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.230771_bib17","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1517\/13543784.2011.625010","article-title":"Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?","volume":"20","author":"Kuhne","year":"2011","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1124\/jpet.115.230771_bib18","doi-asserted-by":"crossref","first-page":"e24159","DOI":"10.1371\/journal.pone.0024159","article-title":"Removal of GABA(A) receptor \u03b32 subunits from parvalbumin neurons causes wide-ranging behavioral alterations","volume":"6","author":"Lepp\u00e4","year":"2011","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.230771_bib19","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.bcp.2007.01.023","article-title":"Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649","volume":"73","author":"Ligneau","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.230771_bib20","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1046\/j.1460-9568.1998.00240.x","article-title":"Postnatal expression of H1-receptor mRNA in the rat brain: correlation to L-histidine decarboxylase expression and local upregulation in limbic seizures","volume":"10","author":"Lintunen","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1124\/jpet.115.230771_bib21","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/WNR.0b013e3282e9a863","article-title":"Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice","volume":"18","author":"Mohr","year":"2007","journal-title":"Neuroreport"},{"key":"10.1124\/jpet.115.230771_bib22","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1074\/jbc.M110.161489","article-title":"Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway","volume":"286","author":"Moreno","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.230771_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1471-4159.2000.0740339.x","article-title":"Changes in histamine H3 receptor responsiveness in mouse brain","volume":"74","author":"Morisset","year":"2000","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.115.230771_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00213-009-1710-5","article-title":"Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice","volume":"208","author":"Nuutinen","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.115.230771_bib25","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1038\/npp.2011.90","article-title":"Evidence for the role of histamine H3 receptor in alcohol consumption and alcohol reward in mice","volume":"36","author":"Nuutinen","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.115.230771_bib26","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neuropharm.2010.10.027","article-title":"Effects of histamine H3 receptor ligands on the rewarding, stimulant and motor-impairing effects of ethanol in DBA\/2J mice","volume":"60","author":"Nuutinen","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.115.230771_bib27","doi-asserted-by":"crossref","first-page":"28439","DOI":"10.1074\/jbc.271.45.28439","article-title":"Histidine decarboxylase expression in mouse mast cell line P815 is induced by mouse peritoneal cavity incubation","volume":"271","author":"Ohtsu","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.230771_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(01)02663-1","article-title":"Mice lacking histidine decarboxylase exhibit abnormal mast cells","volume":"502","author":"Ohtsu","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.115.230771_bib29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0006-8993(89)90366-1","article-title":"Histamine-immunoreactive nerve fibers in the mammalian spinal cord","volume":"484","author":"Panula","year":"1989","journal-title":"Brain Res"},{"key":"10.1124\/jpet.115.230771_bib30","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrn3526","article-title":"The histaminergic network in the brain: basic organization and role in disease","volume":"14","author":"Panula","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/jpet.115.230771_bib31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0306-4522(02)00135-5","article-title":"A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain","volume":"114","author":"Pillot","year":"2002","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.115.230771_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0920-9964(94)00034-6","article-title":"Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and ratings of symptoms","volume":"14","author":"Prell","year":"1995","journal-title":"Schizophr Res"},{"key":"10.1124\/jpet.115.230771_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1124\/jpet.111.186585","article-title":"CEP-26401 (irdabisant), a potent and selective histamine H\u2083 receptor antagonist\/inverse agonist with cognition-enhancing and wake-promoting activities","volume":"340","author":"Raddatz","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.230771_bib34","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/sj.npp.1300017","article-title":"Dopamine D1 rather than D2 receptor agonists disrupt prepulse inhibition of startle in mice","volume":"28","author":"Ralph-Williams","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.115.230771_bib35","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1523\/JNEUROSCI.22-21-09604.2002","article-title":"Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice","volume":"22","author":"Ralph-Williams","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.115.230771_bib36","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.pbb.2007.02.014","article-title":"Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine","volume":"86","author":"Roegge","year":"2007","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.115.230771_bib37","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.neubiorev.2012.09.002","article-title":"Update: studies of prepulse inhibition of startle, with particular relevance to the pathophysiology or treatment of Tourette Syndrome","volume":"37","author":"Swerdlow","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1124\/jpet.115.230771_bib38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00213-008-1072-4","article-title":"Realistic expectations of prepulse inhibition in translational models for schizophrenia research","volume":"199","author":"Swerdlow","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.115.230771_bib39","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00213-014-3751-7","article-title":"Histamine H3 receptor antagonist JNJ-39220675 modulates locomotor responses but not place conditioning by dopaminergic drugs","volume":"232","author":"Vanhanen","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.115.230771_bib40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bph.12170","article-title":"Histamine is required for H\u2083 receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation","volume":"170","author":"Vanhanen","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.230771_bib41","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1471-4159.2005.03055.x","article-title":"Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases","volume":"93","author":"Wang","year":"2005","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.115.230771_bib42","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S0022-3565(24)29209-0","article-title":"Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists","volume":"299","author":"Wieland","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.230771_bib43","doi-asserted-by":"crossref","first-page":"11607","DOI":"10.1073\/pnas.96.20.11607","article-title":"D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons","volume":"96","author":"Yan","year":"1999","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524193123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524193123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.115.230771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:44:56Z","timestamp":1739994296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524193123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0022356524193123"],"URL":"https:\/\/doi.org\/10.1124\/jpet.115.230771","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.115.230771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}