{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:17:43Z","timestamp":1790648263503,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":3167,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1124\/jpet.115.231167","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T04:39:01Z","timestamp":1456288741000},"page":"423-431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea"],"prefix":"10.1016","volume":"357","author":[{"given":"David W.","family":"Griggs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Prinsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy D.","family":"Arnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena","family":"Tajfirouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Ruminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Bond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Neckermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.M.","family":"Choy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"de Hostos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin J.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.115.231167_bib1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0021-9150(00)00565-7","article-title":"Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice","volume":"155","author":"Arnal","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1124\/jpet.115.231167_bib2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/gut.33.6.753","article-title":"Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea","volume":"33","author":"Baumer","year":"1992","journal-title":"Gut"},{"key":"10.1124\/jpet.115.231167_bib3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-2036.1992.tb00052.x","article-title":"Effects of acetorphan, an antidiarrhoeal enkephalinase inhibitor, on oro-caecal and colonic transit times in healthy volunteers","volume":"6","author":"Bergmann","year":"1992","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1124\/jpet.115.231167_bib4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejphar.2011.12.003","article-title":"Effect of inhibition of angiotensin converting enzyme and\/or neutral endopeptidase on vascular and neural complications in high fat fed\/low dose streptozotocin-diabetic rats","volume":"677","author":"Davidson","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.115.231167_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fphar.2012.00093","article-title":"A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril","volume":"3","author":"Eberlin","year":"2012","journal-title":"Front Pharmacol"},{"key":"10.1124\/jpet.115.231167_bib6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/1471-2458-12-220","article-title":"Diarrhea incidence in low- and middle-income countries in 1990 and 2010: a systematic review","volume":"12","author":"Fischer Walker","year":"2012","journal-title":"BMC Public Health"},{"key":"10.1124\/jpet.115.231167_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ajgsup.2014.5","article-title":"Molecular physiology of enteric opioid receptors","volume":"2","author":"Galligan","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1124\/jpet.115.231167_bib8","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0022-3565(25)11036-7","article-title":"Enantiomers of thiorphan and acetorphan: correlation between enkephalinase inhibition, protection of endogenous enkephalins and behavioral effects","volume":"243","author":"Giros","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.231167_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/0091270009343932","article-title":"Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)","volume":"50","author":"Gu","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/jpet.115.231167_bib10","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/00004872-200105000-00015","article-title":"In-vitro and in-vivo inhibition of rat neutral endopeptidase and angiotensin converting enzyme with the vasopeptidase inhibitor gemopatrilat","volume":"19","author":"Hubner","year":"2001","journal-title":"J Hypertens"},{"key":"10.1124\/jpet.115.231167_bib11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/138161212799040547","article-title":"Enkephalin degrading enzymes: metalloproteases with high potential for drug development","volume":"18","author":"Khaket","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1124\/jpet.115.231167_bib12","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1021\/jm00010a014","article-title":"Dicarboxylic acid dipeptide neutral endopeptidase inhibitors","volume":"38","author":"Ksander","year":"1995","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.115.231167_bib13","doi-asserted-by":"crossref","first-page":"e2705","DOI":"10.1371\/journal.pntd.0002705","article-title":"Estimating diarrheal illness and deaths attributable to Shigellae and enterotoxigenic Escherichia coli among older children, adolescents, and adults in South Asia and Africa","volume":"8","author":"Lamberti","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1124\/jpet.115.231167_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.dld.2011.03.001","article-title":"Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis","volume":"43","author":"Lehert","year":"2011","journal-title":"Digest Liver Dis"},{"key":"10.1124\/jpet.115.231167_bib15","doi-asserted-by":"crossref","first-page":"L563","DOI":"10.1152\/ajplung.00317.2014","article-title":"Augmentation of the effects of vasoactive intestinal peptide aerosol on pulmonary hypertension via coapplication of a neutral endopeptidase 24.11 inhibitor","volume":"308","author":"Leuchte","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1124\/jpet.115.231167_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-2999(87)90510-3","article-title":"Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors","volume":"144","author":"Mar\u00e7ais-Collado","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.115.231167_bib17","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2165\/00003495-200059040-00010","article-title":"Racecadotril","volume":"59","author":"Matheson","year":"2000","journal-title":"Drugs"},{"key":"10.1124\/jpet.115.231167_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-2125.1997.00545.x","article-title":"The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides","volume":"43","author":"McDowell","year":"1997","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/jpet.115.231167_bib19","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1080\/00365520212495","article-title":"A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults","volume":"37","author":"Prado","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1124\/jpet.115.231167_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1527-3466.2003.tb00105.x","article-title":"Dual ACE and NEP inhibitors: a review of the pharmacological properties of MDL 100240","volume":"21","author":"Rossi","year":"2003","journal-title":"Cardiovasc Drug Rev"},{"key":"10.1124\/jpet.115.231167_bib21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1056\/NEJM200008173430703","article-title":"Racecadotril in the treatment of acute watery diarrhea in children","volume":"343","author":"Salazar-Lindo","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.115.231167_bib22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.peptides.2003.12.010","article-title":"Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies","volume":"25","author":"Skidgel","year":"2004","journal-title":"Peptides"},{"key":"10.1124\/jpet.115.231167_bib23","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/0006-2952(90)90012-A","article-title":"Characterization of endopeptidase 3.4.24.11 (\u201cenkephalinase\u201d) activity in human plasma and cerebrospinal fluid","volume":"39","author":"Spillantini","year":"1990","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.231167_bib24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fphar.2014.00262","article-title":"Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity","volume":"5","author":"Thompson","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1124\/jpet.115.231167_bib25","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1073\/pnas.1201627109","article-title":"Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors","volume":"109","author":"Tunaru","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.231167_bib26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/00042737-199709000-00010","article-title":"Enkephalins and enkephalinase inhibitors in intestinal fluid and electrolyte transport","volume":"9","author":"Turvill","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1124\/jpet.115.231167_bib27","unstructured":"United Nationals International Children\u2019s Emergency Fund (UNICEF). (2013) Committing to Child Survival: A Promise Renewed\u2014Progress Report."},{"key":"10.1124\/jpet.115.231167_bib28","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3748\/wjg.v11.i10.1540","article-title":"A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults","volume":"11","author":"Wang","year":"2005","journal-title":"World J Gastroenterol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524193081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524193081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.115.231167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T17:18:07Z","timestamp":1740763087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524193081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0022356524193081"],"URL":"https:\/\/doi.org\/10.1124\/jpet.115.231167","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.115.231167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Author(s)","name":"copyright","label":"Copyright"}]}}