{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:13:54Z","timestamp":1765484034840,"version":"3.37.3"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1124\/jpet.116.233932","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T02:29:06Z","timestamp":1470277746000},"page":"457-463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model"],"prefix":"10.1016","volume":"358","author":[{"given":"Tatsuhiko","family":"Harada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ishimatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Towako","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Kakugawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriho","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Kosai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Izumikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.116.233932_bib1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMoa1104623","article-title":"Azithromycin for prevention of exacerbations of COPD","volume":"365","author":"Albert","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.116.233932_bib2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMra1000449","article-title":"Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection","volume":"362","author":"Bautista","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.116.233932_bib3","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3201\/eid1408.071313","article-title":"Deaths from bacterial pneumonia during 1918\u201349 influenza pandemic","volume":"14","author":"Brundage","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1124\/jpet.116.233932_bib4","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1128\/JVI.06156-11","article-title":"Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival","volume":"86","author":"Cilloniz","year":"2012","journal-title":"J Virol"},{"key":"10.1124\/jpet.116.233932_bib5","first-page":"2257","article-title":"Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD Assessment Test","volume":"10","author":"Dai","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1124\/jpet.116.233932_bib6","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.rmed.2013.05.004","article-title":"A meta-analysis on the prophylactic use of macrolide antibiotics for the prevention of disease exacerbations in patients with chronic obstructive pulmonary disease","volume":"107","author":"Donath","year":"2013","journal-title":"Respir Med"},{"key":"10.1124\/jpet.116.233932_bib7","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1183\/09031936.06.00116805","article-title":"Effects of macrolides on pneumolysin of macrolide-resistant Streptococcus pneumoniae","volume":"27","author":"Fukuda","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1124\/jpet.116.233932_bib8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1189\/jlb.4VMR1114-555R","article-title":"Neutrophils in viral infections: current concepts and caveats","volume":"98","author":"Galani","year":"2015","journal-title":"J Leukoc Biol"},{"key":"10.1124\/jpet.116.233932_bib9","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1183\/09031936.00186214","article-title":"Influenza virus-induced lung injury: pathogenesis and implications for treatment","volume":"45","author":"Herold","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1124\/jpet.116.233932_bib10","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1128\/CMR.00078-09","article-title":"Mechanisms of action and clinical application of macrolides as immunomodulatory medications","volume":"23","author":"Kanoh","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1124\/jpet.116.233932_bib11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1440-1843.2007.01208.x","article-title":"Pharmacokinetics of clarithromycin in bronchial epithelial lining fluid","volume":"13","author":"Kikuchi","year":"2008","journal-title":"Respirology"},{"key":"10.1124\/jpet.116.233932_bib12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fmicb.2013.00293","article-title":"Virus-induced exacerbations in asthma and COPD","volume":"4","author":"Kurai","year":"2013","journal-title":"Front Microbiol"},{"key":"10.1124\/jpet.116.233932_bib13","doi-asserted-by":"crossref","first-page":"L158","DOI":"10.1152\/ajplung.00338.2014","article-title":"Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice","volume":"309","author":"Lee","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1124\/jpet.116.233932_bib14","doi-asserted-by":"crossref","first-page":"e1003727","DOI":"10.1371\/journal.ppat.1003727","article-title":"Type I interferon protects against pneumococcal invasive disease by inhibiting bacterial transmigration across the lung","volume":"9","author":"LeMessurier","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1124\/jpet.116.233932_bib15","doi-asserted-by":"crossref","first-page":"12304","DOI":"10.1128\/JVI.01269-12","article-title":"Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of \u03b3\u03b4 T cells","volume":"86","author":"Li","year":"2012","journal-title":"J Virol"},{"key":"10.1124\/jpet.116.233932_bib16","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med"},{"key":"10.1124\/jpet.116.233932_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0149-2918(00)80033-8","article-title":"Clarithromycin in the management of community-acquired pneumonia","volume":"22","author":"McCarty","year":"2000","journal-title":"Clin Ther"},{"key":"10.1124\/jpet.116.233932_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1248\/bpb.31.217","article-title":"Clarithromycin inhibits progeny virus production from human influenza virus-infected host cells","volume":"31","author":"Miyamoto","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"10.1124\/jpet.116.233932_bib19","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1086\/591708","article-title":"Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness","volume":"198","author":"Morens","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1124\/jpet.116.233932_bib20","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"M\u00fcller","year":"1994","journal-title":"Science"},{"key":"10.1124\/jpet.116.233932_bib21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1086\/512160","article-title":"Pulmonary complications of interpandemic influenza A in hospitalized adults","volume":"195","author":"Murata","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1124\/jpet.116.233932_bib22","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1172\/JCI57762","article-title":"Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice","volume":"121","author":"Nakamura","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.116.233932_bib23","doi-asserted-by":"crossref","first-page":"e0121257","DOI":"10.1371\/journal.pone.0121257","article-title":"Prophylactic use of macrolide antibiotics for the prevention of chronic obstructive pulmonary disease exacerbation: a meta-analysis","volume":"10","author":"Ni","year":"2015","journal-title":"PLoS One"},{"key":"10.1124\/jpet.116.233932_bib24","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1128\/AAC.47.12.3699-3703.2003","article-title":"In vivo efficacy of a new quinolone, DQ-113, against Streptococcus pneumoniae in a mouse model","volume":"47","author":"Otsu","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/jpet.116.233932_bib25","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.vaccine.2012.10.111","article-title":"Global production capacity of seasonal influenza vaccine in 2011","volume":"31","author":"Partridge","year":"2013","journal-title":"Vaccine"},{"key":"10.1124\/jpet.116.233932_bib26","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Hyg"},{"key":"10.1124\/jpet.116.233932_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/thorax.58.1.37","article-title":"Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study","volume":"58","author":"Rohde","year":"2003","journal-title":"Thorax"},{"key":"10.1124\/jpet.116.233932_bib28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/thx.2005.041822","article-title":"COPD exacerbations. 2: aetiology","volume":"61","author":"Sapey","year":"2006","journal-title":"Thorax"},{"key":"10.1124\/jpet.116.233932_bib29","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1164\/ajrccm.157.3.9703098","article-title":"Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice","volume":"157","author":"Sato","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.116.233932_bib30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1124\/jpet.116.233932_bib31","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.4049\/jimmunol.0901709","article-title":"Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia","volume":"184","author":"Seki","year":"2010","journal-title":"J Immunol"},{"key":"10.1124\/jpet.116.233932_bib32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1056\/NEJMoa012561","article-title":"New strains of bacteria and exacerbations of chronic obstructive pulmonary disease","volume":"347","author":"Sethi","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.116.233932_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1183\/09031936.00136712","article-title":"Long-term macrolide treatment for chronic respiratory disease","volume":"42","author":"Spagnolo","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1124\/jpet.116.233932_bib34","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nm1765","article-title":"Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection","volume":"14","author":"Sun","year":"2008","journal-title":"Nat Med"},{"key":"10.1124\/jpet.116.233932_bib35","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.4049\/jimmunol.0902497","article-title":"Neutrophils ameliorate lung injury and the development of severe disease during influenza infection","volume":"183","author":"Tate","year":"2009","journal-title":"J Immunol"},{"key":"10.1124\/jpet.116.233932_bib36","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1084\/jem.20101664","article-title":"Type I interferon: friend or foe?","volume":"207","author":"Trinchieri","year":"2010","journal-title":"J Exp Med"},{"key":"10.1124\/jpet.116.233932_bib37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/cc8893","article-title":"Bench-to-bedside review: bacterial pneumonia with influenza\u2014pathogenesis and clinical implications","volume":"14","author":"van der Sluijs","year":"2010","journal-title":"Crit Care"},{"key":"10.1124\/jpet.116.233932_bib38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1128\/AAC.47.1.48-53.2003","article-title":"Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages","volume":"47","author":"Yamaryo","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/jpet.116.233932_bib39","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1183\/09031936.00208011","article-title":"Macrolide effects on the prevention of COPD exacerbations","volume":"40","author":"Yamaya","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1124\/jpet.116.233932_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1124\/jpet.109.162149","article-title":"Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cells","volume":"333","author":"Yamaya","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.116.233932_bib41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00228-011-1161-x","article-title":"Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases","volume":"68","author":"Zarogoulidis","year":"2012","journal-title":"Eur J Clin Pharmacol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524193913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524193913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.116.233932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:47:43Z","timestamp":1739994463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524193913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0022356524193913"],"URL":"https:\/\/doi.org\/10.1124\/jpet.116.233932","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.116.233932","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}