{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:11:19Z","timestamp":1791216679513,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1124\/jpet.116.234591","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T16:29:16Z","timestamp":1467217756000},"page":"441-449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation"],"prefix":"10.1016","volume":"358","author":[{"given":"Mitsuru","family":"Seki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"LaCanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery C.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Vrakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remus","family":"Berretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geena","family":"Chacko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Holten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Jadiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery S.","family":"Arkles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Copper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Houser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickas V.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio A.","family":"Recchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.116.234591_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5935\/1678-9741.20120005","article-title":"Perioperative intravenous corticosteroids reduce incidence of atrial fibrillation following cardiac surgery: a randomized study","volume":"27","author":"Abbaszadeh","year":"2012","journal-title":"Rev Bras Cir Cardiovasc"},{"key":"10.1124\/jpet.116.234591_bib2","doi-asserted-by":"crossref","first-page":"12617","DOI":"10.1073\/pnas.1006774107","article-title":"Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease","volume":"107","author":"Bradner","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.234591_bib3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCEP.109.859116","article-title":"Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation","volume":"3","author":"Cappato","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1124\/jpet.116.234591_bib4","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1073\/pnas.1215840110","article-title":"B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile","volume":"110","author":"DeFuria","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.234591_bib5","doi-asserted-by":"crossref","first-page":"21896","DOI":"10.1074\/jbc.M114.549642","article-title":"Interleukin-1\u03b2 reduces L-type Ca2+ current through protein kinase C\u03f5 activation in mouse heart","volume":"289","author":"El Khoury","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.234591_bib6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.molmed.2011.05.007","article-title":"Inflammatory pathways underlying atrial fibrillation","volume":"17","author":"Friedrichs","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1124\/jpet.116.234591_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCEP.108.774885","article-title":"Long-term clinical results of 2 different ablation strategies in patients with paroxysmal and persistent atrial fibrillation","volume":"1","author":"Gaita","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1124\/jpet.116.234591_bib8","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1540-8167.2009.01713.x","article-title":"Reduction of ventricular sodium current in a mouse model of HIV","volume":"21","author":"Grandy","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1124\/jpet.116.234591_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.yjmcc.2009.02.025","article-title":"Ventricular K+ currents are reduced in mice with elevated levels of serum TNFalpha","volume":"47","author":"Grandy","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.116.234591_bib10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1023\/A:1005937502511","article-title":"Preclinical toxicity of a new oral anticancer drug, CI-994 (acetyldinaline), in rats and dogs","volume":"15","author":"Graziano","year":"1997","journal-title":"Invest New Drugs"},{"key":"10.1124\/jpet.116.234591_bib11","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jacc.2012.04.063","article-title":"Inflammation in atrial fibrillation","volume":"60","author":"Guo","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.116.234591_bib12","doi-asserted-by":"crossref","first-page":"14663","DOI":"10.1074\/jbc.M109.081679","article-title":"Redundant control of adipogenesis by histone deacetylases 1 and 2","volume":"285","author":"Haberland","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.234591_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jacc.2015.04.056","article-title":"Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression","volume":"66","author":"Harada","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.116.234591_bib14","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/01.RES.0000163108.47258.f3","article-title":"Homeobox protein Hop functions in the adult cardiac conduction system","volume":"96","author":"Ismat","year":"2005","journal-title":"Circ Res"},{"key":"10.1124\/jpet.116.234591_bib15","doi-asserted-by":"crossref","first-page":"e33402","DOI":"10.1371\/journal.pone.0033402","article-title":"The action of D-dopachrome tautomerase as an adipokine in adipocyte lipid metabolism","volume":"7","author":"Iwata","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/jpet.116.234591_bib16","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/hc4601.099402","article-title":"Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure","volume":"104","author":"Li","year":"2001","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.234591_bib17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/01.RES.0000181132.11393.18","article-title":"Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis","volume":"97","author":"Li","year":"2005","journal-title":"Circ Res"},{"key":"10.1124\/jpet.116.234591_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00395-012-0293-1","article-title":"Adipocytes modulate the electrophysiology of atrial myocytes: implications in obesity-induced atrial fibrillation","volume":"107","author":"Lin","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.116.234591_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.yjmcc.2008.08.015","article-title":"Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin","volume":"45","author":"Liu","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.116.234591_bib20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1161\/CIRCGENETICS.113.000587","article-title":"GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function","volume":"8","author":"Liu","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1124\/jpet.116.234591_bib21","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/jcb.22091","article-title":"Trafficking and differentiation of mesenchymal stem cells","volume":"106","author":"Liu","year":"2009","journal-title":"J Cell Biochem"},{"key":"10.1124\/jpet.116.234591_bib22","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/europace\/eun111","article-title":"Source of inflammatory markers in patients with atrial fibrillation","volume":"10","author":"Liuba","year":"2008","journal-title":"Europace"},{"key":"10.1124\/jpet.116.234591_bib23","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.ijcard.2014.09.175","article-title":"Histone deacetylase inhibition reduces pulmonary vein arrhythmogenesis through calcium regulation","volume":"177","author":"Lkhagva","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1124\/jpet.116.234591_bib24","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1634\/theoncologist.12-10-1247","article-title":"FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma","volume":"12","author":"Mann","year":"2007","journal-title":"Oncologist"},{"key":"10.1124\/jpet.116.234591_bib25","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/jama.2014.3","article-title":"Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study","volume":"311","author":"Marrouche","year":"2014","journal-title":"JAMA"},{"key":"10.1124\/jpet.116.234591_bib26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature06504","article-title":"Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart","volume":"451","author":"Miller","year":"2008","journal-title":"Nature"},{"key":"10.1124\/jpet.116.234591_bib27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/CIRCHEARTFAILURE.114.001167","article-title":"The gut hormone ghrelin partially reverses energy substrate metabolic alterations in the failing heart","volume":"7","author":"Mitacchione","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1124\/jpet.116.234591_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2004.10.001","article-title":"Histone deacetylase inhibitors","volume":"40","author":"Monneret","year":"2005","journal-title":"Eur J Med Chem"},{"key":"10.1124\/jpet.116.234591_bib29","doi-asserted-by":"crossref","first-page":"e86443","DOI":"10.1371\/journal.pone.0086443","article-title":"Clinical characteristics, management, and control of permanent vs. nonpermanent atrial fibrillation: insights from the RealiseAF survey","volume":"9","author":"Murin","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/jpet.116.234591_bib30","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.amjcard.2009.07.022","article-title":"Increasing prevalence of atrial fibrillation and flutter in the United States","volume":"104","author":"Naccarelli","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1124\/jpet.116.234591_bib31","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jjcc.2013.10.008","article-title":"Increased level of resistin predicts development of atrial fibrillation","volume":"63","author":"\u00d6zcan","year":"2014","journal-title":"J Cardiol"},{"key":"10.1124\/jpet.116.234591_bib32","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1081\/CNV-200039852","article-title":"Phase I study of oral CI-994 in combination with carboplatin and paclitaxel in the treatment of patients with advanced solid tumors","volume":"22","author":"Pauer","year":"2004","journal-title":"Cancer Invest"},{"key":"10.1124\/jpet.116.234591_bib33","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1172\/JCI73061","article-title":"The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury","volume":"124","author":"Qi","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.116.234591_bib34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fphys.2012.00296","article-title":"An introduction to murine models of atrial fibrillation","volume":"3","author":"Riley","year":"2012","journal-title":"Front Physiol"},{"key":"10.1124\/jpet.116.234591_bib35","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1253\/circj.72.1120","article-title":"Circulating adiponectin levels in patients with atrial fibrillation","volume":"72","author":"Shimano","year":"2008","journal-title":"Circ J"},{"key":"10.1124\/jpet.116.234591_bib36","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/01.RES.86.12.1259","article-title":"Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro","volume":"86","author":"Siwik","year":"2000","journal-title":"Circ Res"},{"key":"10.1124\/jpet.116.234591_bib37","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1172\/JCI60806","article-title":"HDAC3 is essential for DNA replication in hematopoietic progenitor cells","volume":"123","author":"Summers","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.116.234591_bib38","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/annonc\/mdh438","article-title":"A phase I study of the oral combination of CI-994, a putative histone deacetylase inhibitor, and capecitabine","volume":"15","author":"Undevia","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1124\/jpet.116.234591_bib39","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/eurheartj\/eht099","article-title":"Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines","volume":"36","author":"Venteclef","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1124\/jpet.116.234591_bib40","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/cmi.12336","article-title":"Inflammation and macrophage modulation in adipose tissues","volume":"16","author":"Vieira-Potter","year":"2014","journal-title":"Cell Microbiol"},{"key":"10.1124\/jpet.116.234591_bib41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jacc.2015.04.071","article-title":"Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy","volume":"66","author":"Woitek","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.116.234591_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2567.1999.00652.x","article-title":"Human B cells secrete migration inhibition factor (MIF) and present a naturally processed MIF peptide on HLA-DRB1*0405 by a FXXL motif","volume":"96","author":"Wymann","year":"1999","journal-title":"Immunology"},{"key":"10.1124\/jpet.116.234591_bib43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1101\/gad.552310","article-title":"Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression","volume":"24","author":"Yamaguchi","year":"2010","journal-title":"Genes Dev"},{"key":"10.1124\/jpet.116.234591_bib44","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1253\/circj.CJ-09-0644","article-title":"Recruitment of immune cells across atrial endocardium in human atrial fibrillation","volume":"74","author":"Yamashita","year":"2010","journal-title":"Circ J"},{"key":"10.1124\/jpet.116.234591_bib45","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1152\/japplphysiol.00451.2012","article-title":"Simvastatin attenuates sympathetic hyperinnervation to prevent atrial fibrillation during the postmyocardial infarction remodeling process","volume":"113","author":"Yu","year":"2012","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/jpet.116.234591_bib46","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.echo.2010.05.017","article-title":"An evaluation of transmitral and pulmonary venous Doppler indices for assessing murine left ventricular diastolic function","volume":"23","author":"Yuan","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1124\/jpet.116.234591_bib47","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/CIRCULATIONAHA.113.005300","article-title":"Activation of histone deacetylase-6 induces contractile dysfunction through derailment of \u03b1-tubulin proteostasis in experimental and human atrial fibrillation","volume":"129","author":"Zhang","year":"2014","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.234591_bib48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2147\/CLEP.S47385","article-title":"Epidemiology of atrial fibrillation: European perspective","volume":"6","author":"Zoni-Berisso","year":"2014","journal-title":"Clin Epidemiol"},{"key":"10.1124\/jpet.116.234591_bib49","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/nm.3284","article-title":"B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction","volume":"19","author":"Zouggari","year":"2013","journal-title":"Nat Med"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652419386X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652419386X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.116.234591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:47:28Z","timestamp":1739994448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235652419386X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S002235652419386X"],"URL":"https:\/\/doi.org\/10.1124\/jpet.116.234591","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.116.234591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}