{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:47:55Z","timestamp":1788184075500,"version":"build-2803163510"},"reference-count":66,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1124\/jpet.116.235119","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T02:09:32Z","timestamp":1466820572000},"page":"431-440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Cardioprotection by H2S Donors: Nitric Oxide-Dependent and \u2011Independent Mechanisms"],"prefix":"10.1016","volume":"358","author":[{"given":"Athanasia","family":"Chatzianastasiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia-Iris","family":"Bibli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Andreadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Efentakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kaludercic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Whiteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Di Lisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Daiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vangelis G.","family":"Manolopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Papapetropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.116.235119_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/SHK.0000000000000478","article-title":"AP39, a mitochondrially targeted hydrogen sulfide donor, exerts protective effects in renal epithelial cells subjected to oxidative stress in vitro and in acute renal injury in vivo","volume":"45","author":"Ahmad","year":"2016","journal-title":"Shock"},{"key":"10.1124\/jpet.116.235119_bib2","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1039\/C5MD00170F","article-title":"Investigating the generation of hydrogen sulfide from the phosphinodithioate slow-release donor GYY4137","volume":"6","author":"Alexander","year":"2015","journal-title":"MedChemComm"},{"key":"10.1124\/jpet.116.235119_bib3","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1124\/jpet.116.235119_bib4","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.235119_bib5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.yjmcc.2014.09.023","article-title":"The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection","volume":"78","author":"Bernardi","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.116.235119_bib6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvv129","article-title":"Cardioprotection by H2S engages a cGMP-dependent protein kinase G\/phospholamban pathway","volume":"106","author":"Bibli","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.116.235119_bib7","doi-asserted-by":"crossref","first-page":"e53319","DOI":"10.1371\/journal.pone.0053319","article-title":"cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation","volume":"7","author":"Bucci","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/jpet.116.235119_bib8","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1021\/jm901638j","article-title":"Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals","volume":"53","author":"Caliendo","year":"2010","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.116.235119_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.235119_bib10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ Res"},{"key":"10.1124\/jpet.116.235119_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1089\/ars.2010.3318","article-title":"Ischemic postconditioning: from receptor to end-effector","volume":"14","author":"Cohen","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.116.235119_bib12","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.235119_bib13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ab.2011.10.016","article-title":"Passive loss of hydrogen sulfide in biological experiments","volume":"421","author":"DeLeon","year":"2012","journal-title":"Anal Biochem"},{"key":"10.1124\/jpet.116.235119_bib14","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbabio.2009.12.006","article-title":"Cyclophilin D in mitochondrial pathophysiology","volume":"1797","author":"Giorgio","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.116.235119_bib15","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1073\/pnas.1217823110","article-title":"Dimers of mitochondrial ATP synthase form the permeability transition pore","volume":"110","author":"Giorgio","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.235119_bib16","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1159\/000356602","article-title":"Exogenous hydrogen sulfide protects against doxorubicin-induced inflammation and cytotoxicity by inhibiting p38MAPK\/NF\u03baB pathway in H9c2 cardiac cells","volume":"32","author":"Guo","year":"2013","journal-title":"Cell Physiol Biochem"},{"key":"10.1124\/jpet.116.235119_bib17","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1476-5381.2011.01700.x","article-title":"Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent","volume":"165","author":"Hausenloy","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.116.235119_bib18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/ars.2014.5933","article-title":"The therapeutic potential of cystathionine \u03b2-synthetase\/hydrogen sulfide inhibition in cancer","volume":"22","author":"Hellmich","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.116.235119_bib19","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.116.305348","article-title":"Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning","volume":"116","author":"Heusch","year":"2015","journal-title":"Circ Res"},{"key":"10.1124\/jpet.116.235119_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00395-005-0569-9","article-title":"Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury\u2014evidence for a role of K ATP channels","volume":"101","author":"Johansen","year":"2006","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.116.235119_bib21","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H2S biogenesis, decay and signaling","volume":"20","author":"Kabil","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.116.235119_bib22","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.bbapap.2014.01.002","article-title":"H2S and its role in redox signaling","volume":"1844","author":"Kabil","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.116.235119_bib23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","article-title":"Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras","volume":"85","author":"Kashfi","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.116.235119_bib24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2009.2919","article-title":"Hydrogen sulfide: from brain to gut","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.116.235119_bib25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/ars.2013.5309","article-title":"Production and physiological effects of hydrogen sulfide","volume":"20","author":"Kimura","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.116.235119_bib26","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.235119_bib27","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/CIRCULATIONAHA.112.000855","article-title":"H\u2082S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase","volume":"127","author":"Kondo","year":"2013","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.235119_bib28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cmet.2014.12.001","article-title":"Physiological and pathological roles of the mitochondrial permeability transition pore in the heart","volume":"21","author":"Kwong","year":"2015","journal-title":"Cell Metab"},{"key":"10.1124\/jpet.116.235119_bib29","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1039\/C3MD00323J","article-title":"The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)","volume":"5","author":"Le Trionnaire","year":"2014","journal-title":"MedChemComm"},{"key":"10.1124\/jpet.116.235119_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13578-015-0035-9","article-title":"Exogenous hydrogen sulfide restores cardioprotection of ischemic post-conditioning via inhibition of mPTP opening in the aging cardiomyocytes","volume":"5","author":"Li","year":"2015","journal-title":"Cell Biosci"},{"key":"10.1124\/jpet.116.235119_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010510-100505","article-title":"Hydrogen sulfide and cell signaling","volume":"51","author":"Li","year":"2011","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/jpet.116.235119_bib32","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.235119_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2015.07.028","article-title":"GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia","volume":"87","author":"Lilyanna","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.116.235119_bib34","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1021\/acs.jmedchem.5b01223","article-title":"Synthesis and pharmacological evaluation of novel adenine-hydrogen sulfide slow release hybrids designed as multitarget cardioprotective agents","volume":"59","author":"Lougiakis","year":"2016","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.116.235119_bib35","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.235119_bib36","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1021\/ml400239a","article-title":"Arylthioamides as H2S donors: l-cysteine-activated releasing properties and vascular effects in vitro and in vivo","volume":"4","author":"Martelli","year":"2013","journal-title":"ACS Med Chem Lett"},{"key":"10.1124\/jpet.116.235119_bib37","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/CIRCULATIONAHA.108.833491","article-title":"Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice","volume":"120","author":"Minamishima","year":"2009","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.235119_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/pcmr.12312","article-title":"Role of the cystathionine \u03b3 lyase\/hydrogen sulfide pathway in human melanoma progression","volume":"28","author":"Panza","year":"2015","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1124\/jpet.116.235119_bib39","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.235119_bib40","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/bph.12806","article-title":"Pharmacological tools for hydrogen sulfide research: a brief, introductory guide for beginners","volume":"172","author":"Papapetropoulos","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.116.235119_bib41","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H\u2082S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/jpet.116.235119_bib42","first-page":"768607","article-title":"The cardioprotective actions of hydrogen sulfide in acute myocardial infarction and heart failure","volume":"2014","author":"Polhemus","year":"2014","journal-title":"Scientifica (Cairo)"},{"key":"10.1124\/jpet.116.235119_bib43","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ Res"},{"key":"10.1124\/jpet.116.235119_bib44","doi-asserted-by":"crossref","first-page":"H2410","DOI":"10.1152\/ajpheart.00044.2012","article-title":"The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability","volume":"302","author":"Predmore","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/jpet.116.235119_bib45","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/cbic.201300552","article-title":"New biologically active hydrogen sulfide donors","volume":"14","author":"Roger","year":"2013","journal-title":"ChemBioChem"},{"key":"10.1124\/jpet.116.235119_bib46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pharmthera.2015.04.004","article-title":"Hydrogen sulfide and cardioprotection\u2014mechanistic insights and clinical translatability","volume":"152","author":"Salloum","year":"2015","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.116.235119_bib47","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1517\/14656566.2012.685163","article-title":"Targeting reperfusion injury in acute myocardial infarction: a review of reperfusion injury pharmacotherapy","volume":"13","author":"Sharma","year":"2012","journal-title":"Expert Opin Pharmacother"},{"key":"10.1124\/jpet.116.235119_bib48","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/cvr\/cvw037","article-title":"Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation","volume":"110","author":"Sun","year":"2016","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.116.235119_bib49","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szab\u00f3","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/jpet.116.235119_bib50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.niox.2010.11.001","article-title":"Cardioprotective effects of hydrogen sulfide","volume":"25","author":"Szab\u00f3","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1124\/jpet.116.235119_bib51","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.niox.2014.04.008","article-title":"AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro","volume":"41","author":"Szczesny","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1124\/jpet.116.235119_bib52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.niox.2014.12.012","article-title":"Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels","volume":"46","author":"Tomasova","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1124\/jpet.116.235119_bib53","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrd4433","article-title":"Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/jpet.116.235119_bib54","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.116.235119_bib55","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.tips.2015.05.007","article-title":"The role of H2S bioavailability in endothelial dysfunction","volume":"36","author":"Wang","year":"2015","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.116.235119_bib56","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11010-013-1946-6","article-title":"GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK\/mTOR signal pathway in H9c2 cells","volume":"389","author":"Wei","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"10.1124\/jpet.116.235119_bib57","series-title":"Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide","first-page":"337","article-title":"Phosphinodithioate and phosphoramidodithioate hydrogen sulfide donors","author":"Whiteman","year":"2015"},{"key":"10.1124\/jpet.116.235119_bib58","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.niox.2014.11.006","article-title":"Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes","volume":"46","author":"Wu","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1124\/jpet.116.235119_bib59","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine \u03b3-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1124\/jpet.116.235119_bib60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2015.05.001","article-title":"The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: a novel mechanism mediated by the activation of Nrf2","volume":"761","author":"Yang","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.116.235119_bib61","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1038\/srep04774","article-title":"Hydrogen sulfide attenuates the recruitment of CD11b\u207aGr-1\u207a myeloid cells and regulates Bax\/Bcl-2 signaling in myocardial ischemia injury","volume":"4","author":"Zhang","year":"2014","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.116.235119_bib62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1021\/ja1085723","article-title":"Cysteine-activated hydrogen sulfide (H2S) donors","volume":"133","author":"Zhao","year":"2011","journal-title":"J Am Chem Soc"},{"key":"10.1124\/jpet.116.235119_bib63","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.1021\/acs.jmedchem.5b01033","article-title":"Design, synthesis, and cardioprotective effects of N-mercapto-based hydrogen sulfide donors","volume":"58","author":"Zhao","year":"2015","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.116.235119_bib64","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.apsb.2015.06.004","article-title":"Hydrogen sulfide prodrugs\u2014a review","volume":"5","author":"Zheng","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"10.1124\/jpet.116.235119_bib65","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1002\/anie.201511244","article-title":"Esterase-sensitive prodrugs with tunable release rates and direct generation of hydrogen sulfide","volume":"55","author":"Zheng","year":"2016","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1124\/jpet.116.235119_bib66","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1016\/j.bmc.2012.02.028","article-title":"Thioglycine and l-thiovaline: biologically active H\u2082S-donors","volume":"20","author":"Zhou","year":"2012","journal-title":"Bioorg Med Chem"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524193858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524193858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.116.235119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:47:32Z","timestamp":1739994452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524193858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0022356524193858"],"URL":"https:\/\/doi.org\/10.1124\/jpet.116.235119","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotection by H2S Donors: Nitric Oxide-Dependent and \u2011Independent Mechanisms","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.116.235119","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}