{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:54:09Z","timestamp":1793073249602,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1124\/jpet.116.235127","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T02:48:43Z","timestamp":1471920523000},"page":"262-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Myeloperoxidase Inhibition Increases Neurogenesis after Ischemic Stroke"],"prefix":"10.1016","volume":"359","author":[{"given":"HyeonJu","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Moskowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.116.235127_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002","article-title":"Neurogenesis in adult subventricular zone","volume":"22","author":"Alvarez-Buylla","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.116.235127_bib2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat Med"},{"key":"10.1124\/jpet.116.235127_bib3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/dneu.20781","article-title":"Neurotrophic factor control of adult SVZ neurogenesis","volume":"70","author":"Bath","year":"2010","journal-title":"Dev Neurobiol"},{"key":"10.1124\/jpet.116.235127_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.116.235127_bib5","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1523\/JNEUROSCI.21-17-06718.2001","article-title":"Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain","volume":"21","author":"Benraiss","year":"2001","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.116.235127_bib6","doi-asserted-by":"crossref","first-page":"18584","DOI":"10.1073\/pnas.0803945105","article-title":"Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase","volume":"105","author":"Breckwoldt","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.235127_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-5728(00)00392-1","article-title":"Mice lacking myeloperoxidase are more susceptible to experimental autoimmune encephalomyelitis","volume":"112","author":"Brennan","year":"2001","journal-title":"J Neuroimmunol"},{"key":"10.1124\/jpet.116.235127_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10874","article-title":"Transient expression of doublecortin during adult neurogenesis","volume":"467","author":"Brown","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.1124\/jpet.116.235127_bib9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/glia.20616","article-title":"In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia","volume":"56","author":"Cacci","year":"2008","journal-title":"Glia"},{"key":"10.1124\/jpet.116.235127_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1161\/01.STR.0000200561.69611.f8","article-title":"The harms and benefits of inflammatory and immune responses in vascular disease","volume":"37","author":"Chamorro","year":"2006","journal-title":"Stroke"},{"key":"10.1124\/jpet.116.235127_bib11","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/jcbfm.2009.47","article-title":"Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion","volume":"29","author":"Chen","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.116.235127_bib12","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/brain\/awn004","article-title":"Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis","volume":"131","author":"Chen","year":"2008","journal-title":"Brain"},{"key":"10.1124\/jpet.116.235127_bib13","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1111\/j.1460-9568.2007.05818.x","article-title":"BDNF\/TrkB interaction regulates migration of SVZ precursor cells via PI3-K and MAP-K signalling pathways","volume":"26","author":"Chiaramello","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1124\/jpet.116.235127_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1164\/rccm.201103-0468OC","article-title":"Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease","volume":"185","author":"Churg","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.116.235127_bib15","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1136281","article-title":"Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension","volume":"315","author":"Curtis","year":"2007","journal-title":"Science"},{"key":"10.1124\/jpet.116.235127_bib16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nchembio.497","article-title":"Nox2 redox signaling maintains essential cell populations in the brain","volume":"7","author":"Dickinson","year":"2011","journal-title":"Nat Chem Biol"},{"key":"10.1124\/jpet.116.235127_bib17","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.2234031100","article-title":"Inflammation is detrimental for neurogenesis in adult brain","volume":"100","author":"Ekdahl","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.235127_bib18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fimmu.2013.00060","article-title":"Modulation of neutrophil apoptosis and the resolution of Inflammation through \u03b22 Integrins","volume":"4","author":"El Kebir","year":"2013","journal-title":"Front Immunol"},{"key":"10.1124\/jpet.116.235127_bib19","doi-asserted-by":"crossref","first-page":"36636","DOI":"10.1074\/jbc.M113.507756","article-title":"Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates","volume":"288","author":"Forbes","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.235127_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1148\/radiol.12111593","article-title":"Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target","volume":"263","author":"Forghani","year":"2012","journal-title":"Radiology"},{"key":"10.1124\/jpet.116.235127_bib21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/jcbfm.2014.222","article-title":"Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke","volume":"35","author":"Forghani","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.116.235127_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fneur.2015.00081","article-title":"The ischemic environment drives microglia and macrophage function","volume":"6","author":"Fumagalli","year":"2015","journal-title":"Front Neurol"},{"key":"10.1124\/jpet.116.235127_bib23","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/nn1340","article-title":"GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain","volume":"7","author":"Garcia","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1124\/jpet.116.235127_bib24","doi-asserted-by":"crossref","first-page":"10105","DOI":"10.1523\/JNEUROSCI.3512-05.2005","article-title":"cAMP response element-binding protein regulates differentiation and survival of newborn neurons in the olfactory bulb","volume":"25","author":"Giachino","year":"2005","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.116.235127_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0300-483X(02)00192-0","article-title":"Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins","volume":"177","author":"Heinecke","year":"2002","journal-title":"Toxicology"},{"key":"10.1124\/jpet.116.235127_bib26","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/jcbfm.2008.47","article-title":"Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1","volume":"28","author":"Iosif","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.116.235127_bib27","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s10753-013-9686-z","article-title":"Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice","volume":"36","author":"Ji","year":"2013","journal-title":"Inflammation"},{"key":"10.1124\/jpet.116.235127_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1044-7431(03)00159-3","article-title":"Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum","volume":"24","author":"Jin","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"10.1124\/jpet.116.235127_bib29","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1097\/01.WCB.0000090680.07515.C8","article-title":"Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion\/reperfusion of the middle cerebral artery in rats","volume":"23","author":"Justicia","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.116.235127_bib30","first-page":"206","article-title":"HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation","volume":"6","author":"Kim","year":"2014","journal-title":"Am J Transl Res"},{"key":"10.1124\/jpet.116.235127_bib31","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1124\/jpet.107.120188","article-title":"Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action","volume":"321","author":"Kim","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.116.235127_bib32","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1471-4159.2009.06212.x","article-title":"The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain","volume":"110","author":"Kim","year":"2009","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.116.235127_bib33","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1182\/blood-2010-05-284513","article-title":"Myeloperoxidase attracts neutrophils by physical forces","volume":"117","author":"Klinke","year":"2011","journal-title":"Blood"},{"key":"10.1124\/jpet.116.235127_bib34","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbi.2012.09.003","article-title":"Neurogenesis, inflammation and behavior","volume":"27","author":"Kohman","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1124\/jpet.116.235127_bib35","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.niox.2005.04.002","article-title":"Inducible nitric oxide synthase expression is inhibited by myeloperoxidase","volume":"13","author":"Kumar","year":"2005","journal-title":"Nitric Oxide"},{"key":"10.1124\/jpet.116.235127_bib36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s001090050266","article-title":"Prevalence of myeloperoxidase deficiency: population studies using Bayer-Technicon automated hematology","volume":"76","author":"Kutter","year":"1998","journal-title":"J Mol Med (Berl)"},{"key":"10.1124\/jpet.116.235127_bib37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000041062","article-title":"Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit?","volume":"104","author":"Kutter","year":"2000","journal-title":"Acta Haematol"},{"key":"10.1124\/jpet.116.235127_bib38","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s001090050267","article-title":"Clinical manifestation of myeloperoxidase deficiency","volume":"76","author":"Lanza","year":"1998","journal-title":"J Mol Med (Berl)"},{"key":"10.1124\/jpet.116.235127_bib39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pharmthera.2005.06.023","article-title":"Myeloperoxidase and its contributory role in inflammatory vascular disease","volume":"111","author":"Lau","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.116.235127_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","article-title":"Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner","volume":"8","author":"Le Belle","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1124\/jpet.116.235127_bib41","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrn1106","article-title":"Mechanisms, challenges and opportunities in stroke","volume":"4","author":"Lo","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/jpet.116.235127_bib42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","article-title":"The science of stroke: mechanisms in search of treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"10.1124\/jpet.116.235127_bib43","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1074\/jbc.M807731200","article-title":"Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease","volume":"284","author":"Maki","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.235127_bib44","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1124\/jpet.116.235127_bib45","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory blockade restores adult hippocampal neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"10.1124\/jpet.116.235127_bib46","first-page":"1176","article-title":"Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice","volume":"118","author":"Nakano","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.116.235127_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1465-9921-11-33","article-title":"Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice","volume":"11","author":"Ni","year":"2010","journal-title":"Respir Res"},{"key":"10.1124\/jpet.116.235127_bib48","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1089\/ars.2012.4783","article-title":"Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease","volume":"18","author":"Nussbaum","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.116.235127_bib49","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1523\/JNEUROSCI.4323-06.2006","article-title":"A neurovascular niche for neurogenesis after stroke","volume":"26","author":"Ohab","year":"2006","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.116.235127_bib50","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1161\/STROKEAHA.109.554824","article-title":"Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats","volume":"40","author":"Park","year":"2009","journal-title":"Stroke"},{"key":"10.1124\/jpet.116.235127_bib51","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1523\/JNEUROSCI.21-17-06706.2001","article-title":"Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus","volume":"21","author":"Pencea","year":"2001","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.116.235127_bib52","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1161\/STROKEAHA.108.531806","article-title":"Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats","volume":"40","author":"Ploughman","year":"2009","journal-title":"Stroke"},{"key":"10.1124\/jpet.116.235127_bib53","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1089\/ars.2009.2578","article-title":"NOX enzymes in the central nervous system: from signaling to disease","volume":"11","author":"Sorce","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.116.235127_bib54","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/147323000703500411","article-title":"Apocynin attenuates cerebral infarction after transient focal ischaemia in rats","volume":"35","author":"Tang","year":"2007","journal-title":"J Int Med Res"},{"key":"10.1124\/jpet.116.235127_bib55","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.brainresrev.2006.08.002","article-title":"BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation","volume":"53","author":"Taupin","year":"2007","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1124\/jpet.116.235127_bib56","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1634\/stemcells.2005-0281","article-title":"Persistent production of neurons from adult brain stem cells during recovery after stroke","volume":"24","author":"Thored","year":"2006","journal-title":"Stem Cells"},{"key":"10.1124\/jpet.116.235127_bib57","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/jcbfm.2014.130","article-title":"Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here","volume":"34","author":"Tobin","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.116.235127_bib58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jneuroim.2006.11.014","article-title":"The inflammatory response in stroke","volume":"184","author":"Wang","year":"2007","journal-title":"J Neuroimmunol"},{"key":"10.1124\/jpet.116.235127_bib59","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.freeradbiomed.2013.08.166","article-title":"NOX2 deficiency ameliorates cerebral injury through reduction of complexin II-mediated glutamate excitotoxicity in experimental stroke","volume":"65","author":"Wang","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/jpet.116.235127_bib60","doi-asserted-by":"crossref","first-page":"9187","DOI":"10.1021\/bi401354d","article-title":"Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry\u2014activity-based protein profiling","volume":"52","author":"Ward","year":"2013","journal-title":"Biochemistry"},{"key":"10.1124\/jpet.116.235127_bib61","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1523\/JNEUROSCI.0149-06.2006","article-title":"Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum","volume":"26","author":"Yamashita","year":"2006","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.116.235127_bib62","doi-asserted-by":"crossref","first-page":"46116","DOI":"10.1074\/jbc.M209124200","article-title":"Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation","volume":"277","author":"Zhang","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.235127_bib63","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00004647-200404000-00009","article-title":"Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats","volume":"24","author":"Zhang","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.116.235127_bib64","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1523\/JNEUROSCI.4969-06.2007","article-title":"Neuroblast division during migration toward the ischemic striatum: a study of dynamic migratory and proliferative characteristics of neuroblasts from the subventricular zone","volume":"27","author":"Zhang","year":"2007","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.116.235127_bib65","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"10.1124\/jpet.116.235127_bib66","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1073\/pnas.0401063101","article-title":"Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus","volume":"101","author":"Zhu","year":"2004","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524194438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524194438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.116.235127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:49:49Z","timestamp":1739994589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524194438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0022356524194438"],"URL":"https:\/\/doi.org\/10.1124\/jpet.116.235127","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myeloperoxidase Inhibition Increases Neurogenesis after Ischemic Stroke","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.116.235127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}