{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:10:49Z","timestamp":1790644249566,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1124\/jpet.116.237156","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T20:14:11Z","timestamp":1476821651000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis"],"prefix":"10.1016","volume":"360","author":[{"given":"Gretchen","family":"Bain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen E.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Darlington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Goulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Prodanovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina L.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina M.","family":"Santini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Lonergan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imelda","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andiliy","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilly F.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.116.237156_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/jb\/mvu077","article-title":"Lysophosphatidic acid as a lipid mediator with multiple biological actions","volume":"157","author":"Aikawa","year":"2015","journal-title":"J Biochem"},{"key":"10.1124\/jpet.116.237156_bib2","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1021\/cr2003213","article-title":"Chemical evolution of autotaxin inhibitors","volume":"112","author":"Albers","year":"2012","journal-title":"Chem Rev"},{"key":"10.1124\/jpet.116.237156_bib3","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.4049\/jimmunol.1202025","article-title":"Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin\/lysophosphatidic acid axis","volume":"190","author":"Bai","year":"2013","journal-title":"J Immunol"},{"key":"10.1124\/jpet.116.237156_bib4","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1096\/fj.201500197R","article-title":"Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis","volume":"30","author":"Black","year":"2016","journal-title":"FASEB J"},{"key":"10.1124\/jpet.116.237156_bib5","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1021\/acs.jmedchem.5b01599","article-title":"Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature","volume":"59","author":"Castagna","year":"2016","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.116.237156_bib6","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/art.30262","article-title":"Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma","volume":"63","author":"Castelino","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1124\/jpet.116.237156_bib7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbagrm.2016.03.002","article-title":"Nuclear receptors and nonalcoholic fatty liver disease","volume":"1859","author":"Cave","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.116.237156_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.237156_bib9","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.ajpath.2012.06.035","article-title":"Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G\u03b1q-mediated Rho and \u03b1v\u03b26 integrin-dependent activation of TGF-\u03b2","volume":"181","author":"Geng","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1124\/jpet.116.237156_bib10","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1124\/jpet.110.165845","article-title":"A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation","volume":"334","author":"Gierse","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.116.237156_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nsmb.1980","article-title":"Structural basis of substrate discrimination and integrin binding by autotaxin","volume":"18","author":"Hausmann","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"10.1124\/jpet.116.237156_bib12","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1165\/rcmb.2013-0070OC","article-title":"Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice","volume":"49","author":"Huang","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/jpet.116.237156_bib13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1006\/bbrc.1998.8983","article-title":"Effects of lysophosphatidic acid on proliferation of stellate cells and hepatocytes in culture","volume":"248","author":"Ikeda","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.116.237156_bib14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.canlet.2009.04.029","article-title":"Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells","volume":"284","author":"Jansen","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1124\/jpet.116.237156_bib15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1124\/jpet.116.237156_bib16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cca.2014.03.006","article-title":"Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma","volume":"433","author":"Kondo","year":"2014","journal-title":"Clin Chim Acta"},{"key":"10.1124\/jpet.116.237156_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.bjp.0707361","article-title":"Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases","volume":"152","author":"L\u00e9vesque","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.116.237156_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iep.12008","article-title":"An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis","volume":"94","author":"Matsumoto","year":"2013","journal-title":"Int J Exp Pathol"},{"key":"10.1124\/jpet.116.237156_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1073\/pnas.0135855100","article-title":"Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist","volume":"100","author":"McIntyre","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.116.237156_bib20","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cca.2011.03.014","article-title":"Autotaxin as a novel serum marker of liver fibrosis","volume":"412","author":"Nakagawa","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1124\/jpet.116.237156_bib21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.clinbiochem.2006.10.009","article-title":"Measurement of lysophospholipase D\/autotaxin activity in human serum samples","volume":"40","author":"Nakamura","year":"2007","journal-title":"Clin Biochem"},{"key":"10.1124\/jpet.116.237156_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nsmb.1998","article-title":"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators","volume":"18","author":"Nishimasu","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"10.1124\/jpet.116.237156_bib23","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1165\/rcmb.2012-0004OC","article-title":"Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis","volume":"47","author":"Oikonomou","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/jpet.116.237156_bib24","doi-asserted-by":"crossref","first-page":"e103532","DOI":"10.1371\/journal.pone.0103532","article-title":"Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis--a prospective cohort study","volume":"9","author":"Pleli","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/jpet.116.237156_bib25","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbalip.2008.04.001","article-title":"Lysophosphatidic acid and renal fibrosis","volume":"1781","author":"Prad\u00e8re","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.116.237156_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbalip.2006.11.010","article-title":"Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase","volume":"1771","author":"Prad\u00e8re","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.116.237156_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.biochi.2013.04.010","article-title":"Involvement of autotaxin\/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis","volume":"96","author":"Rancoule","year":"2014","journal-title":"Biochimie"},{"key":"10.1124\/jpet.116.237156_bib28","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s13105-012-0181-z","article-title":"Depot-specific regulation of autotaxin with obesity in human adipose tissue","volume":"68","author":"Rancoule","year":"2012","journal-title":"J Physiol Biochem"},{"key":"10.1124\/jpet.116.237156_bib29","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1007\/s10620-016-4128-z","article-title":"Novel pharmacotherapy options for NASH","volume":"61","author":"Ratziu","year":"2016","journal-title":"Dig Dis Sci"},{"key":"10.1124\/jpet.116.237156_bib30","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1002\/oby.21232","article-title":"Serum Autotaxin\/ENPP2 correlates with insulin resistance in older humans with obesity","volume":"23","author":"Reeves","year":"2015","journal-title":"Obesity (Silver Spring)"},{"key":"10.1124\/jpet.116.237156_bib31","doi-asserted-by":"crossref","first-page":"23084","DOI":"10.1074\/jbc.M413438200","article-title":"Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase\/phosphodiesterase family","volume":"280","author":"Sakagami","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.237156_bib32","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1096\/fj.12-219378","article-title":"LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation","volume":"27","author":"Sakai","year":"2013","journal-title":"FASEB J"},{"key":"10.1124\/jpet.116.237156_bib33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbalip.2012.07.019","article-title":"Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)\/LPC and ATX\/LPA axes","volume":"1831","author":"Sevastou","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.116.237156_bib34","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1124\/mol.115.100404","article-title":"Structural basis for inhibition of human autotaxin by four potent compounds with distinct modes of binding","volume":"88","author":"Stein","year":"2015","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.116.237156_bib35","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/S0021-9258(18)45911-X","article-title":"Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein","volume":"267","author":"Stracke","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.237156_bib36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12944-015-0081-7","article-title":"Melatonin: a potential intervention for hepatic steatosis","volume":"14","author":"Sun","year":"2015","journal-title":"Lipids Health Dis"},{"key":"10.1124\/jpet.116.237156_bib37","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1124\/jpet.110.175901","article-title":"Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist","volume":"336","author":"Swaney","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.116.237156_bib38","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1111\/j.1476-5381.2010.00828.x","article-title":"A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model","volume":"160","author":"Swaney","year":"2010","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.116.237156_bib39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nm1685","article-title":"The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak","volume":"14","author":"Tager","year":"2008","journal-title":"Nat Med"},{"key":"10.1124\/jpet.116.237156_bib40","doi-asserted-by":"crossref","first-page":"25822","DOI":"10.1074\/jbc.M605142200","article-title":"Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid","volume":"281","author":"Tanaka","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.116.237156_bib41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.200204026","article-title":"Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production","volume":"158","author":"Umezu-Goto","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1124\/jpet.116.237156_bib42","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/MCB.02419-05","article-title":"Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development","volume":"26","author":"van Meeteren","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1124\/jpet.116.237156_bib43","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/01.mcg.0000225642.90898.0e","article-title":"Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C","volume":"41","author":"Watanabe","year":"2007","journal-title":"J Clin Gastroenterol"},{"key":"10.1124\/jpet.116.237156_bib44","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.lfs.2007.08.013","article-title":"Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity","volume":"81","author":"Watanabe","year":"2007","journal-title":"Life Sci"},{"key":"10.1124\/jpet.116.237156_bib45","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/bbrc.2000.3634","article-title":"Lysophosphatidic acid enhances collagen gel contraction by hepatic stellate cells: association with rho-kinase","volume":"277","author":"Yanase","year":"2000","journal-title":"Biochem Biophys Res Commun"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524194724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524194724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.116.237156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:50:33Z","timestamp":1739994633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524194724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0022356524194724"],"URL":"https:\/\/doi.org\/10.1124\/jpet.116.237156","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.116.237156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}