{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:20:18Z","timestamp":1765232418596,"version":"3.37.3"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":2832,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1124\/jpet.116.238378","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T02:50:12Z","timestamp":1485226212000},"page":"87-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging"],"prefix":"10.1016","volume":"361","author":[{"given":"Kristine O.","family":"Vasquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.116.238378_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12011-014-0110-9","article-title":"Liver toxicity of thioacetamide is increased by hepatocellular iron overload","volume":"163","author":"Ackerman","year":"2015","journal-title":"Biol Trace Elem Res"},{"key":"10.1124\/jpet.116.238378_bib2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/jat.2935","article-title":"Drug safety testing paradigm, current progress and future challenges: an overview","volume":"34","author":"Ahuja","year":"2014","journal-title":"J Appl Toxicol"},{"key":"10.1124\/jpet.116.238378_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1439-0264.2000.00207.x","article-title":"Thioacetamide toxicity and the spleen: histological and biochemical analysis","volume":"29","author":"al-Bader","year":"2000","journal-title":"Anat Histol Embryol"},{"key":"10.1124\/jpet.116.238378_bib4","doi-asserted-by":"crossref","first-page":"381413","DOI":"10.1155\/2014\/381413","article-title":"The potential protective effect of Physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression","volume":"2014","author":"Al-Olayan","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1124\/jpet.116.238378_bib5","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1373\/clinchem.2005.049908","article-title":"Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy","volume":"51","author":"Amacher","year":"2005","journal-title":"Clin Chem"},{"key":"10.1124\/jpet.116.238378_bib6","doi-asserted-by":"crossref","first-page":"96003","DOI":"10.1117\/1.JBO.17.9.096003","article-title":"Dynamic contrast-enhanced optical imaging of in vivo organ function","volume":"17","author":"Amoozegar","year":"2012","journal-title":"J Biomed Opt"},{"key":"10.1124\/jpet.116.238378_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/cphy.c120016","article-title":"Iron homeostasis in the liver","volume":"3","author":"Anderson","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1124\/jpet.116.238378_bib8","doi-asserted-by":"crossref","first-page":"e50860","DOI":"10.1371\/journal.pone.0050860","article-title":"In vivo imaging and quantification of carbonic anhydrase IX expression as an endogenous biomarker of tumor hypoxia","volume":"7","author":"Bao","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/jpet.116.238378_bib9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3109\/00365517609081938","article-title":"Effects of different doses of chlorpromazine on renal function in the dog","volume":"36","author":"Berg","year":"1976","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1124\/jpet.116.238378_bib10","doi-asserted-by":"crossref","first-page":"e20887","DOI":"10.1371\/journal.pone.0020887","article-title":"Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways","volume":"6","author":"Bhattacharya","year":"2011","journal-title":"PLoS One"},{"key":"10.1124\/jpet.116.238378_bib11","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1053\/jhep.2001.23505","article-title":"Drug-induced liver injury: mechanisms and test systems","volume":"33","author":"Bissell","year":"2001","journal-title":"Hepatology"},{"key":"10.1124\/jpet.116.238378_bib12","first-page":"525","article-title":"[Pharmacology of rifampicin]","volume":"22","author":"Bykova","year":"1977","journal-title":"Antibiotiki"},{"key":"10.1124\/jpet.116.238378_bib13","first-page":"358","article-title":"Nitric-oxide-mediated activation of iron-regulatory protein controls hepatic iron metabolism during acute inflammation","volume":"232","author":"Cairo","year":"1995","journal-title":"Eur J Biochem"},{"key":"10.1124\/jpet.116.238378_bib14","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1161\/01.CIR.0000017860.20619.23","article-title":"In vivo imaging of proteolytic activity in atherosclerosis","volume":"105","author":"Chen","year":"2002","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.238378_bib15","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2169\/internalmedicine.52.0634","article-title":"Rifampicin-induced acute kidney injury during the initial treatment for pulmonary tuberculosis: a case report and literature review","volume":"52","author":"Chiba","year":"2013","journal-title":"Intern Med"},{"key":"10.1124\/jpet.116.238378_bib16","first-page":"111","article-title":"[Renal effects of chlorpromazine in dogs]","volume":"3","author":"Cuche","year":"1982","journal-title":"Nephrologie"},{"key":"10.1124\/jpet.116.238378_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.22203\/eCM.v027a03","article-title":"Real-time quantification of matrix metalloproteinase and integrin alphavbeta3 expression during biomaterial-associated infection in a murine model","volume":"27","author":"Daghighi","year":"2014","journal-title":"Eur Cell Mater."},{"key":"10.1124\/jpet.116.238378_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCULATIONAHA.106.619056","article-title":"Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo","volume":"114","author":"Deguchi","year":"2006","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.238378_bib19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1089\/jmf.2012.0175","article-title":"Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl4-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression","volume":"16","author":"Domitrovi\u0107","year":"2013","journal-title":"J Med Food"},{"issue":"Pt B","key":"10.1124\/jpet.116.238378_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.fct.2016.10.021","article-title":"Differential susceptibility to acetaminophen-induced liver injury in\u00a0sub-strains of C57BL\/6 mice: 6N versus 6J","volume":"98","author":"Duan","year":"2016","journal-title":"Food Chem Toxicol"},{"key":"10.1124\/jpet.116.238378_bib21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1742-2094-10-138","article-title":"Optical tomographic imaging of near infrared imaging agents quantifies disease severity and immunomodulation of experimental autoimmune encephalomyelitis in vivo","volume":"10","author":"Eaton","year":"2013","journal-title":"J Neuroinflammation"},{"key":"10.1124\/jpet.116.238378_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.reprotox.2007.10.013","article-title":"Toxicity testing in the 21st century: a vision and a strategy","volume":"25","author":"Gibb","year":"2008","journal-title":"Reprod Toxicol"},{"key":"10.1124\/jpet.116.238378_bib23","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/ageing\/afw067","article-title":"Unexpected paracetamol (acetaminophen) hepatotoxicity at standard dosage in two older patients: time to rethink 1 g four times daily?","volume":"45","author":"Ging","year":"2016","journal-title":"Age Ageing"},{"key":"10.1124\/jpet.116.238378_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.etp.2013.12.002","article-title":"Inflammatory regulation of iron metabolism during thioacetamide-induced acute liver injury in rats","volume":"66","author":"Izawa","year":"2014","journal-title":"Exp Toxicol Pathol"},{"key":"10.1124\/jpet.116.238378_bib25","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/1472-6882-13-294","article-title":"Effect of oral administration of ethanolic extract of Vitex negundo on thioacetamide-induced nephrotoxicity in rats","volume":"13","author":"Kadir","year":"2013","journal-title":"BMC Complement Altern Med"},{"key":"10.1124\/jpet.116.238378_bib26","first-page":"789","article-title":"Acute interstitial nephritis associated with intermittent rifampin use","volume":"20","author":"Katz","year":"1986","journal-title":"Drug Intell Clin Pharm"},{"key":"10.1124\/jpet.116.238378_bib27","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1182\/blood.V98.6.1949","article-title":"Regulation of expression of murine transferrin receptor 2","volume":"98","author":"Kawabata","year":"2001","journal-title":"Blood"},{"key":"10.1124\/jpet.116.238378_bib28","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1124\/jpet.108.147579","article-title":"Noninvasive quantitative tomography of the therapeutic response to dexamethasone in ovalbumin-induced murine asthma","volume":"329","author":"Korideck","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.116.238378_bib29","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s11307-009-0279-z","article-title":"Dual in vivo quantification of integrin-targeted and protease-activated agents in cancer using fluorescence molecular tomography (FMT)","volume":"12","author":"Kossodo","year":"2010","journal-title":"Mol Imaging Biol"},{"key":"10.1124\/jpet.116.238378_bib30","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1096\/fj.08-127738","article-title":"Imaging schistosomes in vivo","volume":"23","author":"Krautz-Peterson","year":"2009","journal-title":"FASEB J"},{"key":"10.1124\/jpet.116.238378_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev-publhealth-031210-101153","article-title":"New directions in toxicity testing","volume":"32","author":"Krewski","year":"2011","journal-title":"Annu Rev Public Health"},{"key":"10.1124\/jpet.116.238378_bib32","doi-asserted-by":"crossref","first-page":"189254","DOI":"10.1155\/2012\/189254","article-title":"Quantitative longitudinal imaging of vascular inflammation and treatment by ezetimibe in apoE mice by FMT using new optical imaging biomarkers of cathepsin activity and \u03b1(v)\u03b2(3) integrin","volume":"2012","author":"Lin","year":"2012","journal-title":"Int J Mol Imaging"},{"key":"10.1124\/jpet.116.238378_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/15287390903249057","article-title":"Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity","volume":"73","author":"Maddox","year":"2010","journal-title":"J Toxicol Environ Health A"},{"key":"10.1124\/jpet.116.238378_bib34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.taap.2012.08.015","article-title":"Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity","volume":"264","author":"McGill","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.116.238378_bib35","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1158\/0008-5472.CAN-05-0382","article-title":"Tomographic fluorescence mapping of tumor targets","volume":"65","author":"Montet","year":"2005","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.116.238378_bib36","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/0006-2952(83)90084-9","article-title":"Immune responses to chlorpromazine in rats. Detection and relation to hepatotoxicity","volume":"32","author":"Mullock","year":"1983","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.116.238378_bib37","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J Exp Med"},{"key":"10.1124\/jpet.116.238378_bib38","series-title":"Nutraceuticals: Efficacy, Safety and Toxicity","first-page":"305","article-title":"Noninvasive in vivo optical imaging models for safety and toxicity testing","author":"Peterson","year":"2016"},{"key":"10.1124\/jpet.116.238378_bib39","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1186\/ar3038","article-title":"Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis","volume":"12","author":"Peterson","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1124\/jpet.116.238378_bib40","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/pgmj.47.553.742","article-title":"Potentially serious side-effects of high-dose twice-weekly rifampicin","volume":"47","author":"Poole","year":"1971","journal-title":"Postgrad Med J"},{"key":"10.1124\/jpet.116.238378_bib41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02123714","article-title":"Rifampicin-induced suppression of antitumor immunity","volume":"172","author":"Roszkowski","year":"1984","journal-title":"Med Microbiol Immunol (Berl)"},{"key":"10.1124\/jpet.116.238378_bib42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nbt.2838","article-title":"Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing","volume":"32","author":"Shuhendler","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1124\/jpet.116.238378_bib43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/01480549709003881","article-title":"Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats","volume":"20","author":"Sodhi","year":"1997","journal-title":"Drug Chem Toxicol"},{"key":"10.1124\/jpet.116.238378_bib44","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1161\/CIRCULATIONAHA.106.658930","article-title":"Molecular magnetic resonance imaging in cardiovascular medicine","volume":"115","author":"Sosnovik","year":"2007","journal-title":"Circulation"},{"key":"10.1124\/jpet.116.238378_bib45","first-page":"102","article-title":"Protective effect of ascorbic acid on rifampicin induced hepatotoxicity in mice","volume":"15","author":"Tassaduq","year":"2011","journal-title":"J Rawalpiindi Med Coll"},{"key":"10.1124\/jpet.116.238378_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2310\/7290.2014.00001","article-title":"In vivo molecular imaging of cathepsin and matrix metalloproteinase activity discriminates between arthritic and osteoarthritic processes in mice","volume":"13","author":"Vermeij","year":"2014","journal-title":"Mol Imaging"},{"key":"10.1124\/jpet.116.238378_bib47","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/BF02256121","article-title":"Protective effect of MDL28170 against thioacetamide-induced acute liver failure in mice","volume":"11","author":"Wang","year":"2004","journal-title":"J Biomed Sci"},{"key":"10.1124\/jpet.116.238378_bib48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nm0103-123","article-title":"Shedding light onto live molecular targets","volume":"9","author":"Weissleder","year":"2003","journal-title":"Nat Med"},{"key":"10.1124\/jpet.116.238378_bib49","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/art.20379","article-title":"In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response","volume":"50","author":"Wunder","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1124\/jpet.116.238378_bib50","first-page":"131","article-title":"Acetaminophen-induced hepatotoxicity: a comprehensive update","volume":"4","author":"Yoon","year":"2016","journal-title":"J Clin Transl Hepatol"},{"key":"10.1124\/jpet.116.238378_bib51","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/pgmj.66.774.310","article-title":"Rifampicin-induced upper gastrointestinal bleeding","volume":"66","author":"Zargar","year":"1990","journal-title":"Postgrad Med J"},{"key":"10.1124\/jpet.116.238378_bib52","doi-asserted-by":"crossref","first-page":"F593","DOI":"10.1152\/ajprenal.00361.2011","article-title":"A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo","volume":"303","author":"Zhang","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/jpet.116.238378_bib53","doi-asserted-by":"crossref","first-page":"14258","DOI":"10.1038\/srep14258","article-title":"NIR-driven smart theranostic nanomedicine for on-demand drug release and synergistic antitumour therapy","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.116.238378_bib54","first-page":"210","article-title":"Causes for rifampicin toxicity--experimental study","volume":"5","author":"Z\u00edtkov\u00e1","year":"1982","journal-title":"Czech Med"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524195432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524195432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.116.238378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:54:29Z","timestamp":1739980469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524195432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0022356524195432"],"URL":"https:\/\/doi.org\/10.1124\/jpet.116.238378","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.116.238378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by The Author(s)","name":"copyright","label":"Copyright"}]}}