{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T16:10:04Z","timestamp":1739981404252,"version":"3.37.3"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1124\/jpet.117.240788","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T01:00:21Z","timestamp":1492045221000},"page":"492-500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Brain Disposition of cis-para-Methyl-4-Methylaminorex (cis-4,4\u2032-DMAR) and Its Potential Metabolites after Acute and Chronic Treatment in Rats: Correlation with Central Behavioral Effects"],"prefix":"10.1016","volume":"361","author":[{"given":"Jacopo","family":"Lucchetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio M.","family":"Marzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Passoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Di Clemente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo","family":"Bagnati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gobbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Cervo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.117.240788_bib1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuropharm.2013.04.003","article-title":"The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: self-administration and locomotor activity in rats","volume":"71","author":"Aarde","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.117.240788_bib2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/jm00342a001","article-title":"Metabolism of tranyleypromine-C14 and Dl amphetamine-C14 in the rat","volume":"6","author":"Alleva","year":"1963","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.117.240788_bib3","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/dta.1668","article-title":"Characterization of a novel and potentially lethal designer drug (\u00b1)-cis-para-methyl-4-methylaminorex (4,4\u2032-DMAR, or \u2018Serotoni\u2019)","volume":"6","author":"Brandt","year":"2014","journal-title":"Drug Test Anal"},{"key":"10.1124\/jpet.117.240788_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0014-2999(90)90597-Y","article-title":"Neurochemical effects of an acute treatment with 4-methylaminorex: a new stimulant of abuse","volume":"180","author":"Bunker","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.117.240788_bib5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.pbb.2005.11.015","article-title":"Selective antagonist at D3 receptors, but not non-selective partial agonists, influences the expression of cocaine-induced conditioned place preference in free-feeding rats","volume":"82","author":"Cervo","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.117.240788_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00213-002-1145-8","article-title":"Stimulation of serotonin1B receptors induces conditioned place aversion and facilitates cocaine place conditioning in rats","volume":"163","author":"Cervo","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.117.240788_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuroscience.2011.03.037","article-title":"Importance of D1 and D2 receptors in the dorsal caudate-putamen for the locomotor activity and stereotyped behaviors of preweanling rats","volume":"183","author":"Charntikov","year":"2011","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.117.240788_bib8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.npp.1300789","article-title":"Characterization of the rapid-onset type of behavioral sensitization to amphetamine in mice: role of drug-environment conditioning","volume":"31","author":"Chinen","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.117.240788_bib9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/jat\/bku031","article-title":"Multiple fatalities involving a new designer drug: para-methyl-4-methylaminorex","volume":"38","author":"Cosbey","year":"2014","journal-title":"J Anal Toxicol"},{"key":"10.1124\/jpet.117.240788_bib10","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1476-5381.1971.tb07187.x","article-title":"Effect of phenmetrazine, aminorex and (.) p-chloramphetamine on the motor activity and turnover rate of brain catecholamines","volume":"43","author":"Costa","year":"1971","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.117.240788_bib11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1520\/JFS11971J","article-title":"A fatality involving U4Euh, a cyclic derivative of phenylpropanolamine","volume":"33","author":"Davis","year":"1988","journal-title":"J Forensic Sci"},{"key":"10.1124\/jpet.117.240788_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00210-002-0642-y","article-title":"Guaifenesin enhances the analgesic potency of paracetamol in mice","volume":"366","author":"Dolezal","year":"2002","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.117.240788_bib13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.2042-7158.1966.tb07896.x","article-title":"The fate of amphetamine in man and other mammals","volume":"18","author":"Dring","year":"1966","journal-title":"J Pharm Pharmacol"},{"key":"10.1124\/jpet.117.240788_bib14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-3565(25)27336-0","article-title":"The comparative metabolism of d-amphetamine-C14 in the rat, dog and monkey","volume":"152","author":"Ellison","year":"1966","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.240788_bib15","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1124\/jpet.104.076653","article-title":"Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors","volume":"313","author":"Flavahan","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.240788_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00213-007-0749-4","article-title":"Methamphetamine-induced locomotor activity and sensitization in dopamine transporter and vesicular monoamine transporter 2 double mutant mice","volume":"193","author":"Fukushima","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.117.240788_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hup.2472","article-title":"4-methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4\u2032-DMAR, 4,4\u2032-dimethylaminorex): availability, prevalence of use, desired effects and acute toxicity","volume":"30","author":"Glanville","year":"2015","journal-title":"Hum Psychopharmacol"},{"key":"10.1124\/jpet.117.240788_bib18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/jat\/19.7.563","article-title":"Metabolism of 4-methylaminorex (\u201cEU4EA\u201d) in the rat","volume":"19","author":"Henderson","year":"1995","journal-title":"J Anal Toxicol"},{"key":"10.1124\/jpet.117.240788_bib19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuint.2013.11.010","article-title":"Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters","volume":"73","author":"Hofmaier","year":"2014","journal-title":"Neurochem Int"},{"key":"10.1124\/jpet.117.240788_bib20","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pbb.2011.01.013","article-title":"Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine","volume":"98","author":"Kameda","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.117.240788_bib21","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1124\/jpet.300.2.450","article-title":"Acute neurochemical and behavioral effects of stereoisomers of 4-methylaminorex in relation to brain drug concentrations","volume":"300","author":"Kankaanp\u00e4\u00e4","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.240788_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0379-0738(01)00453-4","article-title":"Detection and assay of cis- and trans-isomers of 4-methylaminorex in urine, plasma and tissue samples","volume":"121","author":"Kankaanp\u00e4\u00e4","year":"2001","journal-title":"Forensic Sci Int"},{"key":"10.1124\/jpet.117.240788_bib23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/thx.26.3.262","article-title":"Aminorex and the pulmonary circulation","volume":"26","author":"Kay","year":"1971","journal-title":"Thorax"},{"key":"10.1124\/jpet.117.240788_bib24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1476-5381.2012.01998.x","article-title":"Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone","volume":"167","author":"L\u00f3pez-Arnau","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.117.240788_bib25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.18433\/J3GP53","article-title":"Understanding the hysteresis loop conundrum in pharmacokinetic\/pharmacodynamic relationships","volume":"17","author":"Louizos","year":"2014","journal-title":"J Pharm Pharm Sci"},{"key":"10.1124\/jpet.117.240788_bib26","doi-asserted-by":"crossref","unstructured":"Lucchetti J, Marzo CM, Di Clemente A, Cervo L, Gobbi M (2016) A validated, sensitive HPLC-MS\/MS method for quantification of cis-para-methyl-4-methylaminorex (cis-4,4\u2032-DMAR) in rat and human plasma: application to pharmacokinetic studies in rats. Drug Test Anal DOI: [published ahead of print].","DOI":"10.1002\/dta.2052"},{"key":"10.1124\/jpet.117.240788_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pnpbp.2014.11.010","article-title":"Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice","volume":"58","author":"Marinho","year":"2015","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1124\/jpet.117.240788_bib28","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/FTD.0b013e3181eea318","article-title":"Chemistry, pharmacology, and metabolism of emerging drugs of abuse","volume":"32","author":"Maurer","year":"2010","journal-title":"Ther Drug Monit"},{"key":"10.1124\/jpet.117.240788_bib29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/dta.1732","article-title":"Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3\u2032,4\u2032-methylenedioxy-4-methylaminorex (MDMAR)","volume":"7","author":"McLaughlin","year":"2015","journal-title":"Drug Test Anal"},{"key":"10.1124\/jpet.117.240788_bib30","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1124\/jpet.103.060053","article-title":"Pharmacokinetics and tissue distribution of the stereoisomers of 4-methylaminorex in the rat","volume":"309","author":"Meririnne","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.240788_bib31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fnins.2016.00153","article-title":"Neuropharmacology of new psychoactive substances (NPS): focus on the rewarding and reinforcing properties of cannabimimetics and amphetamine-like stimulants","volume":"10","author":"Miliano","year":"2016","journal-title":"Front Neurosci"},{"key":"10.1124\/jpet.117.240788_bib32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-8993(82)91123-4","article-title":"Drug reinforcement studied by the use of place conditioning in rat","volume":"243","author":"Mucha","year":"1982","journal-title":"Brain Res"},{"key":"10.1124\/jpet.117.240788_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0014-2999(83)90006-7","article-title":"Behavioral sensitization and relative hyperresponsiveness of striatal and limbic dopaminergic neurons after repeated methamphetamine treatment","volume":"88","author":"Nishikawa","year":"1983","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.117.240788_bib34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pbb.2010.12.011","article-title":"Behavioral, hyperthermic and pharmacokinetic profile of para-methoxymethamphetamine (PMMA) in rats","volume":"98","author":"P\u00e1len\u00ed\u010dek","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.117.240788_bib35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1021\/jm00339a011","article-title":"2-amino-5-aryl-2-oxazolines. Potent new anorectic agents","volume":"6","author":"Poos","year":"1963","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.117.240788_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tox.2009.02.003","article-title":"Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) in rats after subcutaneous administration","volume":"259","author":"Rohanova","year":"2009","journal-title":"Toxicology"},{"key":"10.1124\/jpet.117.240788_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bcp.2006.09.022","article-title":"Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series)","volume":"73","author":"Theobald","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.117.240788_bib38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1369-1600.2007.00070.x","article-title":"Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade","volume":"12","author":"Tzschentke","year":"2007","journal-title":"Addict Biol"},{"key":"10.1124\/jpet.117.240788_bib39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0166-4328(98)00034-5","article-title":"Discrete quinolinic acid lesions of the rat prelimbic medial prefrontal cortex affect cocaine- and MK-801-, but not morphine- and amphetamine-induced reward and psychomotor activation as measured with the place preference conditioning paradigm","volume":"97","author":"Tzschentke","year":"1998","journal-title":"Behav Brain Res"},{"key":"10.1124\/jpet.117.240788_bib40","doi-asserted-by":"crossref","first-page":"9579","DOI":"10.1523\/JNEUROSCI.19-21-09579.1999","article-title":"A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats","volume":"19","author":"Vanderschuren","year":"1999","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.117.240788_bib41","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.drugalcdep.2008.10.005","article-title":"Changes in feeding and locomotion induced by amphetamine analogs in rats","volume":"100","author":"Wellman","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.117.240788_bib42","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00216-013-7595-5","article-title":"Studies on the metabolism and the detectability of 4-methyl-amphetamine and its isomers 2-methyl-amphetamine and 3-methyl-amphetamine in rat urine using GC-MS and LC-(high-resolution)-MSn","volume":"406","author":"Welter","year":"2014","journal-title":"Anal Bioanal Chem"},{"key":"10.1124\/jpet.117.240788_bib43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cmpb.2010.01.007","article-title":"PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel","volume":"99","author":"Zhang","year":"2010","journal-title":"Comput Methods Programs Biomed"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524195778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524195778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.117.240788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:55:28Z","timestamp":1739980528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524195778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0022356524195778"],"URL":"https:\/\/doi.org\/10.1124\/jpet.117.240788","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain Disposition of cis-para-Methyl-4-Methylaminorex (cis-4,4\u2032-DMAR) and Its Potential Metabolites after Acute and Chronic Treatment in Rats: Correlation with Central Behavioral Effects","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.117.240788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}