{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:02:00Z","timestamp":1788328920369,"version":"build-2803163510"},"reference-count":137,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1124\/jpet.117.247106","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T18:55:12Z","timestamp":1534445712000},"page":"302-321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents"],"prefix":"10.1016","volume":"367","author":[{"given":"Xin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramkumar","family":"Kuruba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2735-9550","authenticated-orcid":false,"given":"Doodipala Samba","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.117.247106_bib1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/10408444.2016.1220916","article-title":"Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review","volume":"46","author":"Abou-Donia","year":"2016","journal-title":"Crit Rev Toxicol"},{"key":"10.1124\/jpet.117.247106_bib2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJMoa002141","article-title":"A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus","volume":"345","author":"Alldredge","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.117.247106_bib3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/hipo.1060","article-title":"Alterations of hippocampal GAbaergic system contribute to development of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy","volume":"11","author":"Andr\u00e9","year":"2001","journal-title":"Hippocampus"},{"key":"10.1124\/jpet.117.247106_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1124\/jpet.114.217299","article-title":"The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302","volume":"351","author":"Apland","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.247106_bib6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.neuro.2010.05.014","article-title":"Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala to soman-induced neuropathology","volume":"31","author":"Apland","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib7","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.neuro.2009.06.011","article-title":"Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampus","volume":"30","author":"Aroniadou-Anderjaska","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib8","first-page":"365","article-title":"Early regional changes of GFAP mRNA in rat hippocampus and dentate gyrus during soman-induced seizures","volume":"7","author":"Baille-Le Crom","year":"1995","journal-title":"Neuroreport"},{"key":"10.1124\/jpet.117.247106_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.14712\/18059694.2020.51","article-title":"Differential inhibition of the brain acetylcholinesterase molecular forms following sarin, soman and VX intoxication in laboratory rats","volume":"40","author":"Bajgar","year":"1997","journal-title":"Acta Med (Hradec Kralove)"},{"key":"10.1124\/jpet.117.247106_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0065-2423(04)38006-6","article-title":"Organophosphates\/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment","volume":"38","author":"Bajgar","year":"2004","journal-title":"Adv Clin Chem"},{"key":"10.1124\/jpet.117.247106_bib11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cbi.2008.05.015","article-title":"An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents","volume":"175","author":"Bajgar","year":"2008","journal-title":"Chem Biol Interact"},{"key":"10.1124\/jpet.117.247106_bib12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jbt.2570030404","article-title":"Direct actions of organophosphate anticholinesterases on nicotinic and muscarinic acetylcholine receptors","volume":"3","author":"Bakry","year":"1988","journal-title":"J Biochem Toxicol"},{"key":"10.1124\/jpet.117.247106_bib13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuro.2012.02.002","article-title":"A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation","volume":"33","author":"Banks","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3940(03)00493-2","article-title":"Atropine, an anticholinergic drug, impairs memory retrieval of a high consolidated avoidance response in mice","volume":"345","author":"Boccia","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.117.247106_bib15","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1176\/ajp.108.11.847","article-title":"Mechanism of seizures induced by di-isopropyl fluorophosphate","volume":"108","author":"Bouzarth","year":"1952","journal-title":"Am J Psychiatry"},{"key":"10.1124\/jpet.117.247106_bib16","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1177\/0192623310385140","article-title":"Design-based stereology: introduction to basic concepts and practical approaches for estimation of cell number","volume":"38","author":"Boyce","year":"2010","journal-title":"Toxicol Pathol"},{"issue":"Suppl 7","key":"10.1124\/jpet.117.247106_bib17","first-page":"3.055","article-title":"Neuroactive steroid therapy of status epilepticus in epilepsy rats","volume":"49","author":"Briyal","year":"2008","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.117.247106_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1081\/DCT-120030727","article-title":"Pharmacokinetic studies of intramuscular midazolam in guinea pigs challenged with soman","volume":"27","author":"Capacio","year":"2004","journal-title":"Drug Chem Toxicol"},{"issue":"Suppl 1","key":"10.1124\/jpet.117.247106_bib19","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1002\/jat.813","article-title":"Intramuscular diazepam pharmacokinetics in soman-exposed guinea pigs","volume":"21","author":"Capacio","year":"2001","journal-title":"J Appl Toxicol"},{"key":"10.1124\/jpet.117.247106_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1124\/jpet.115.229302","article-title":"Neurosteroid structure-activity relationships for functional activation of extrasynaptic \u03b4GABA(A) receptors","volume":"357","author":"Carver","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.247106_bib21","doi-asserted-by":"crossref","first-page":"14181","DOI":"10.1523\/JNEUROSCI.0596-14.2014","article-title":"Perimenstrual-like hormonal regulation of extrasynaptic \u03b4-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity","volume":"34","author":"Carver","year":"2014","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.117.247106_bib22","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neuro.2015.05.001","article-title":"Sarin-induced brain damage in rats is attenuated by delayed administration of midazolam","volume":"49","author":"Chapman","year":"2015","journal-title":"Neurotoxicology"},{"issue":"6","key":"10.1124\/jpet.117.247106_bib23","doi-asserted-by":"crossref","first-page":"e99818","DOI":"10.1371\/journal.pone.0099818","article-title":"(\u2212)-Phenserine attenuates soman-induced neuropathology","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/jpet.117.247106_bib24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.neuro.2012.03.011","article-title":"Organophosphate-induced brain damage: mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies","volume":"33","author":"Chen","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.tox.2004.11.036","article-title":"Soman poisoning increases neural progenitor proliferation and induces long-term glial activation in mouse brain","volume":"208","author":"Collombet","year":"2005","journal-title":"Toxicology"},{"key":"10.1124\/jpet.117.247106_bib26","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/j.1528-1167.2009.02478.x","article-title":"Spontaneous recurrent seizures after status epilepticus induced by soman in Sprague-Dawley rats","volume":"51","author":"de Araujo Furtado","year":"2010","journal-title":"Epilepsia"},{"issue":"Suppl 9","key":"10.1124\/jpet.117.247106_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/epi.12037","article-title":"Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures","volume":"53","author":"Deeb","year":"2012","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.117.247106_bib28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/toxsci\/kfq157","article-title":"Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate","volume":"116","author":"Deshpande","year":"2010","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.117.247106_bib29","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/nm1013-1194","article-title":"Syrian gas attack reinforces need for better anti-sarin drugs","volume":"19","author":"Dolgin","year":"2013","journal-title":"Nat Med"},{"key":"10.1124\/jpet.117.247106_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.biopsych.2010.04.030","article-title":"Stereological approaches to identifying neuropathology in psychosis","volume":"69","author":"Dorph-Petersen","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1124\/jpet.117.247106_bib31","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0140-6736(07)61202-1","article-title":"Management of acute organophosphorus pesticide poisoning","volume":"371","author":"Eddleston","year":"2008","journal-title":"Lancet"},{"key":"10.1124\/jpet.117.247106_bib32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuro.2014.06.001","article-title":"4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration","volume":"44","author":"Ferchmin","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1212\/WNL.0000000000000054","article-title":"High-dose midazolam infusion for refractory status epilepticus","volume":"82","author":"Fernandez","year":"2014","journal-title":"Neurology"},{"key":"10.1124\/jpet.117.247106_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1124\/jpet.110.171835","article-title":"The GluK1 (GluR5) Kainate\/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology","volume":"336","author":"Figueiredo","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.247106_bib35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s12974-016-0744-y","article-title":"Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication","volume":"13","author":"Flannery","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.1124\/jpet.117.247106_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0006-8993(96)00203-X","article-title":"The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus","volume":"725","author":"Fujikawa","year":"1996","journal-title":"Brain Res"},{"key":"10.1124\/jpet.117.247106_bib37","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1177\/088307389901400909","article-title":"Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis","volume":"14","author":"Gilbert","year":"1999","journal-title":"J Child Neurol"},{"key":"10.1124\/jpet.117.247106_bib38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5698\/1535-7597-16.1.48","article-title":"Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society","volume":"16","author":"Glauser","year":"2016","journal-title":"Epilepsy Curr"},{"key":"10.1124\/jpet.117.247106_bib39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fnagi.2015.00196","article-title":"Neurostereology protocol for unbiased quantification of neuronal injury and neurodegeneration","volume":"7","author":"Golub","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1124\/jpet.117.247106_bib40","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.3426-07.2008","article-title":"Subunit-specific trafficking of GABA(A) receptors during status epilepticus","volume":"28","author":"Goodkin","year":"2008","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.117.247106_bib41","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1111\/j.1528-1167.2009.02257.x","article-title":"The impact of diazepam\u2019s discovery on the treatment and understanding of status epilepticus","volume":"50","author":"Goodkin","year":"2009","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.117.247106_bib42","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1046\/j.1528-1157.2003.62402.x","article-title":"Diazepam terminates brief but not prolonged seizures in young, na\u00efve rats","volume":"44","author":"Goodkin","year":"2003","journal-title":"Epilepsia"},{"issue":"Suppl 5","key":"10.1124\/jpet.117.247106_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1528-1167.2007.01297.x","article-title":"GABA(A) receptor internalization during seizures","volume":"48","author":"Goodkin","year":"2007","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.117.247106_bib44","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1523\/JNEUROSCI.0900-05.2005","article-title":"Status epilepticus increases the intracellular accumulation of GABAA receptors","volume":"25","author":"Goodkin","year":"2005","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.117.247106_bib45","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hipo.450040409","article-title":"Differential NPY mRNA expression in granule cells and interneurons of the rat dentate gyrus after kainic acid injection","volume":"4","author":"Gruber","year":"1994","journal-title":"Hippocampus"},{"key":"10.1124\/jpet.117.247106_bib46","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/ije\/dyg307","article-title":"Suicide by intentional ingestion of pesticides: a continuing tragedy in developing countries","volume":"32","author":"Gunnell","year":"2003","journal-title":"Int J Epidemiol"},{"key":"10.1124\/jpet.117.247106_bib47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.5507\/bp.2004.041","article-title":"Comparison of changes in AChE activity in the brain of the laboratory rat after soman and tabun intoxication","volume":"148","author":"H\u00e1jek","year":"2004","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1124\/jpet.117.247106_bib48","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neuro.2006.01.007","article-title":"Nicotinic mechanisms contribute to soman-induced symptoms and lethality","volume":"27","author":"Hassel","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib49","first-page":"1","article-title":"Acute seizures in old age leads to a greater loss of CA1 pyramidal neurons, an increased propensity for developing chronic TLE and a severe cognitive dysfunction","volume":"2","author":"Hattiangady","year":"2011","journal-title":"Aging Dis"},{"key":"10.1124\/jpet.117.247106_bib50","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0022-510X(90)90185-P","article-title":"Decreased brain pathology in organophosphate-exposed rhesus monkeys following benzodiazepine therapy","volume":"98","author":"Hayward","year":"1990","journal-title":"J Neurol Sci"},{"key":"10.1124\/jpet.117.247106_bib51","doi-asserted-by":"crossref","first-page":"3190891","DOI":"10.1155\/2016\/3190891","article-title":"Synthesis and storage stability of diisopropylfluorophosphate","volume":"2016","author":"Heiss","year":"2016","journal-title":"J Chem"},{"key":"10.1124\/jpet.117.247106_bib52","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuro.2017.11.009","article-title":"A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication","volume":"66","author":"Hobson","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib53","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/toxsci\/kfx049","article-title":"From the cover: magnetic resonance imaging reveals progressive brain injury in rats acutely intoxicated with diisopropylfluorophosphate","volume":"157","author":"Hobson","year":"2017","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.117.247106_bib54","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s40265-017-0859-1","article-title":"Pharmacotherapy for refractory and super-refractory status epilepticus in adults","volume":"78","author":"Holtkamp","year":"2018","journal-title":"Drugs"},{"key":"10.1124\/jpet.117.247106_bib55","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1513\/pats.201001-003SM","article-title":"The CounterACT Research Network: basic mechanisms and practical applications","volume":"7","author":"Jett","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"10.1124\/jpet.117.247106_bib56","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.etap.2010.01.006","article-title":"Neurotoxic effects in patients poisoned with organophosphorus pesticides","volume":"29","author":"Jokanovi\u0107","year":"2010","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1124\/jpet.117.247106_bib57","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.nbd.2017.03.017","article-title":"Enhanced AMPA receptor-mediated neurotransmission on CA1 pyramidal neurons during status epilepticus","volume":"103","author":"Joshi","year":"2017","journal-title":"Neurobiol Dis"},{"key":"10.1124\/jpet.117.247106_bib58","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tox.2008.11.021","article-title":"Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage","volume":"256","author":"Kadriu","year":"2009","journal-title":"Toxicology"},{"key":"10.1124\/jpet.117.247106_bib59","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/toxsci\/kfq356","article-title":"Acute imidazenil treatment after the onset of DFP-induced seizure is more effective and longer lasting than midazolam at preventing seizure activity and brain neuropathology","volume":"120","author":"Kadriu","year":"2011","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.117.247106_bib60","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0091-3057(82)90485-3","article-title":"Effects of PAM, proPAM, and DFP on behavior, thermoregulation, and brain AChE in rats","volume":"17","author":"Kenley","year":"1982","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.117.247106_bib61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1382-6689(99)00006-X","article-title":"Organophosphate-induced brain injuries: delayed apoptosis mediated by nitric oxide","volume":"7","author":"Kim","year":"1999","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1124\/jpet.117.247106_bib62","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1523\/JNEUROSCI.23-06-02440.2003","article-title":"Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy","volume":"23","author":"Kobayashi","year":"2003","journal-title":"J Neurosci"},{"issue":"Suppl 1","key":"10.1124\/jpet.117.247106_bib63","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1002\/jat.811","article-title":"Combination anticonvulsant treatment of soman-induced seizures","volume":"21","author":"Koplovitz","year":"2001","journal-title":"J Appl Toxicol"},{"key":"10.1124\/jpet.117.247106_bib64","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00204-013-1113-6","article-title":"Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing","volume":"87","author":"Krause","year":"2013","journal-title":"Arch Toxicol"},{"key":"10.1124\/jpet.117.247106_bib65","doi-asserted-by":"crossref","first-page":"e24493","DOI":"10.1371\/journal.pone.0024493","article-title":"Differential susceptibility of interneurons expressing neuropeptide Y or parvalbumin in the aged hippocampus to acute seizure activity","volume":"6","author":"Kuruba","year":"2011","journal-title":"PLoS One"},{"key":"10.1124\/jpet.117.247106_bib67","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1016\/j.bbadis.2018.05.016","article-title":"Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication","volume":"1864","author":"Kuruba","year":"2018","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.117.247106_bib68","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00007691-200202000-00022","article-title":"Organophosphate pesticides: biochemistry and clinical toxicology","volume":"24","author":"Kwong","year":"2002","journal-title":"Ther Drug Monit"},{"key":"10.1124\/jpet.117.247106_bib69","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0091-3057(96)00292-4","article-title":"Efficacy of atropine\/pralidoxime\/diazepam or atropine\/HI-6\/prodiazepam in primates intoxicated by soman","volume":"56","author":"Lallement","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.117.247106_bib70","first-page":"279","article-title":"Guideline for the management of convulsive status epilepticus in infants and children","volume":"53","author":"Lee","year":"2011","journal-title":"BC Med J"},{"key":"10.1124\/jpet.117.247106_bib71","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1097\/00003246-200210000-00026","article-title":"A review of nerve agent exposure for the critical care physician","volume":"30","author":"Leikin","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1124\/jpet.117.247106_bib72","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00230647","article-title":"Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats","volume":"102","author":"Lemos","year":"1995","journal-title":"Exp Brain Res"},{"key":"10.1124\/jpet.117.247106_bib73","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/epi.13972","article-title":"Electroencephalography and behavior patterns during experimental status epilepticus","volume":"59","author":"Lewczuk","year":"2018","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.117.247106_bib74","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12974-015-0283-y","article-title":"Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury","volume":"12","author":"Li","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1124\/jpet.117.247106_bib75","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.taap.2011.03.026","article-title":"Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication","volume":"253","author":"Li","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.117.247106_bib76","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/toxsci\/kfx283","article-title":"Neuroprotective effects of AEOL10150 in a rat organophosphate model","volume":"162","author":"Liang","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.117.247106_bib77","first-page":"90","article-title":"Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP)","volume":"3","author":"Liu","year":"2012","journal-title":"Curr Neurobiol"},{"key":"10.1124\/jpet.117.247106_bib78","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0006-8993(98)00606-4","article-title":"Self-sustaining status epilepticus after brief electrical stimulation of the perforant path","volume":"801","author":"Mazarati","year":"1998","journal-title":"Brain Res"},{"key":"10.1124\/jpet.117.247106_bib79","first-page":"123","article-title":"Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment","volume":"16","author":"McDonough","year":"1995","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib80","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s002040050637","article-title":"Comparative evaluation of benzodiazepines for control of soman-induced seizures","volume":"73","author":"McDonough","year":"1999","journal-title":"Arch Toxicol"},{"key":"10.1124\/jpet.117.247106_bib81","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/01480540903483417","article-title":"Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in Guinea pigs","volume":"33","author":"McDonough","year":"2010","journal-title":"Drug Chem Toxicol"},{"key":"10.1124\/jpet.117.247106_bib82","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0149-7634(96)00050-4","article-title":"Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology","volume":"21","author":"McDonough","year":"1997","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1124\/jpet.117.247106_bib83","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1742-7843.2008.00326.x","article-title":"Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for the control of soman-induced seizures","volume":"104","author":"McDonough","year":"2009","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1124\/jpet.117.247106_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-1211(99)00060-1","article-title":"Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated Guinea pigs","volume":"38","author":"McDonough","year":"2000","journal-title":"Epilepsy Res"},{"issue":"Pt A","key":"10.1124\/jpet.117.247106_bib85","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.expneurol.2017.08.009","article-title":"Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation","volume":"298","author":"McElroy","year":"2017","journal-title":"Exp Neurol"},{"key":"10.1124\/jpet.117.247106_bib86","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.116.1.201","article-title":"NeuN, a neuronal specific nuclear protein in vertebrates","volume":"116","author":"Mullen","year":"1992","journal-title":"Development"},{"key":"10.1124\/jpet.117.247106_bib87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuro.2004.07.011","article-title":"Soman-induced convulsions in rats terminated with pharmacological agents after 45 min: neuropathology and cognitive performance","volume":"26","author":"Myhrer","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib88","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1523\/JNEUROSCI.4944-04.2005","article-title":"Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus","volume":"25","author":"Naylor","year":"2005","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.117.247106_bib140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.nbd.2012.12.015","article-title":"Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus","volume":"54","author":"Naylor","year":"2013","journal-title":"Neurobiol Dis"},{"key":"10.1124\/jpet.117.247106_bib89","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"10.1124\/jpet.117.247106_bib90","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1124\/jpet.114.214932","article-title":"Animal models that best reproduce the clinical manifestations of human intoxication with organophosphorus compounds","volume":"350","author":"Pereira","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.247106_bib91","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/nyas.13137","article-title":"Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents","volume":"1378","author":"Pessah","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/jpet.117.247106_bib92","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0006-8993(77)90539-X","article-title":"Ultrastructural characteristics of the brain and blood-brain barrier in experimental seizures","volume":"127","author":"Petito","year":"1977","journal-title":"Brain Res"},{"key":"10.1124\/jpet.117.247106_bib93","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2006.02.070","article-title":"Function-specific blockage of M(1) and M(3) muscarinic acetylcholine receptors by VX and echothiophate","volume":"1085","author":"Pittel","year":"2006","journal-title":"Brain Res"},{"key":"10.1124\/jpet.117.247106_bib94","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neuro.2017.11.002","article-title":"Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects","volume":"65","author":"Pittel","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib95","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuro.2016.08.002","article-title":"A rodent model of human organophosphate exposure producing status epilepticus and neuropathology","volume":"56","author":"Pouliot","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib96","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuro.2013.06.006","article-title":"Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure","volume":"38","author":"Prager","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib97","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuropharm.2014.01.035","article-title":"The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: relation to anxiety-like behavior","volume":"81","author":"Prager","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.117.247106_bib98","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00726-008-0227-2","article-title":"Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis","volume":"38","author":"Qashu","year":"2010","journal-title":"Amino Acids"},{"key":"10.1124\/jpet.117.247106_bib99","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1124\/jpet.117.247106_bib100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2202-15-47","article-title":"Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes","volume":"15","author":"RamaRao","year":"2014","journal-title":"BMC Neurosci"},{"key":"10.1124\/jpet.117.247106_bib101","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/jnr.20802","article-title":"Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy","volume":"83","author":"Rao","year":"2006","journal-title":"J Neurosci Res"},{"key":"10.1124\/jpet.117.247106_bib102","first-page":"2305","article-title":"Clinical pharmacology of current antiepileptic drugs","volume":"7","author":"Reddy","year":"2014","journal-title":"Int J Pharma Sci Nanotech"},{"key":"10.1124\/jpet.117.247106_bib103","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/nyas.13160","article-title":"Neurosteroids for the potential protection of humans against organophosphate toxicity","volume":"1378","author":"Reddy","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/jpet.117.247106_bib104","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/cts.12435","article-title":"A comparative toxidrome analysis of human organophosphate and nerve agent poisonings using social media","volume":"10","author":"Reddy","year":"2017","journal-title":"Clin Transl Sci"},{"key":"10.1124\/jpet.117.247106_bib105","doi-asserted-by":"crossref","first-page":"18284","DOI":"10.3390\/ijms140918284","article-title":"Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions","volume":"14","author":"Reddy","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.117.247106_bib107","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/epi.12989","article-title":"Midazolam as an anticonvulsant antidote for organophosphate intoxication\u2014a pharmacotherapeutic appraisal","volume":"56","author":"Reddy","year":"2015","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.117.247106_bib108","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1124\/jpet.114.222075","article-title":"Antiseizure activity of midazolam in mice lacking \u03b4-subunit extrasynaptic GABA(A) receptors","volume":"353","author":"Reddy","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.247106_bib109","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/1096-9861(20001211)428:2<240::AID-CNE4>3.0.CO;2-Q","article-title":"Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry","volume":"428","author":"Ribak","year":"2000","journal-title":"J Comp Neurol"},{"key":"10.1124\/jpet.117.247106_bib110","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/epi.12685","article-title":"Safety and effectiveness of long-term treatment with diazepam auto-injector administered by caregivers in an outpatient setting for the treatment of acute repetitive seizures","volume":"55","author":"Rogin","year":"2014","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.117.247106_bib111","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuropharm.2015.01.017","article-title":"Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus","volume":"93","author":"Rojas","year":"2015","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1124\/jpet.117.247106_bib112","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0070-18.2018","article-title":"Beneficial outcome of urethane treatment following status epilepticus in a rat organophosphorus toxicity model","volume":"5","author":"Rojas","year":"2018","journal-title":"eNeuro"},{"key":"10.1124\/jpet.117.247106_bib113","doi-asserted-by":"crossref","first-page":"644","DOI":"10.7326\/M13-2799","article-title":"Lessons learned from the Syrian sarin attack: evaluation of a clinical syndrome through social media","volume":"160","author":"Rosman","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1124\/jpet.117.247106_bib114","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1023\/A:1024960819430","article-title":"Pralidoxime iodide (2-pAM) penetrates across the blood-brain barrier","volume":"28","author":"Sakurada","year":"2003","journal-title":"Neurochem Res"},{"key":"10.1124\/jpet.117.247106_bib115","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/00039896.1988.9934372","article-title":"Chronic neurological sequelae of acute organophosphate pesticide poisoning","volume":"43","author":"Savage","year":"1988","journal-title":"Arch Environ Health"},{"key":"10.1124\/jpet.117.247106_bib116","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(96)01387-X","article-title":"Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration","volume":"751","author":"Schmued","year":"1997","journal-title":"Brain Res"},{"key":"10.1124\/jpet.117.247106_bib117","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuro.2018.02.018","article-title":"Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats","volume":"66","author":"Scholl","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib118","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.eplepsyres.2005.12.003","article-title":"Newly born dentate granule neurons after pilocarpine-induced epilepsy have hilar basal dendrites with immature synapses","volume":"69","author":"Shapiro","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1124\/jpet.117.247106_bib119","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/jnr.20302","article-title":"Hippocampal neurotrophin levels after injury: relationship to the age of the hippocampus at the time of injury","volume":"78","author":"Shetty","year":"2004","journal-title":"J Neurosci Res"},{"key":"10.1124\/jpet.117.247106_bib120","first-page":"86","article-title":"Anticonvulsants for soman-induced seizure activity","volume":"6","author":"Shih","year":"1999","journal-title":"J Biomed Sci"},{"key":"10.1124\/jpet.117.247106_bib121","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0041-008X(03)00019-X","article-title":"Control of nerve agent-induced seizures is critical for neuroprotection and survival","volume":"188","author":"Shih","year":"2003","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.117.247106_bib122","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0149-7634(05)80028-4","article-title":"Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms","volume":"15","author":"Shih","year":"1991","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1124\/jpet.117.247106_bib123","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0091-3057(99)00114-8","article-title":"Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment","volume":"64","author":"Shih","year":"1999","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.117.247106_bib124","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00204-009-0465-4","article-title":"Effects of 4-pyridine aldoxime on nerve agent-inhibited acetylcholinesterase activity in Guinea pigs","volume":"83","author":"Shih","year":"2009","journal-title":"Arch Toxicol"},{"key":"10.1124\/jpet.117.247106_bib125","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12031-009-9259-7","article-title":"Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication","volume":"40","author":"Shih","year":"2010","journal-title":"J Mol Neurosci"},{"key":"10.1124\/jpet.117.247106_bib126","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJMoa1107494","article-title":"Intramuscular versus intravenous therapy for prehospital status epilepticus","volume":"366","author":"Silbergleit","year":"2012","journal-title":"N Engl J Med"},{"issue":"Suppl 8","key":"10.1124\/jpet.117.247106_bib127","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1528-1167.2011.03235.x","article-title":"RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics","volume":"52","author":"Silbergleit","year":"2011","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.117.247106_bib128","doi-asserted-by":"crossref","first-page":"12199","DOI":"10.1021\/jp307790v","article-title":"Aging mechanism of soman inhibited acetylcholinesterase","volume":"116","author":"Sirin","year":"2012","journal-title":"J Phys Chem B"},{"key":"10.1124\/jpet.117.247106_bib129","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/toxsci\/kfx048","article-title":"Editor\u2019s highlight: Spatiotemporal progression and remission of lesions in the rat brain following acute intoxication with diisopropylfluorophosphate","volume":"157","author":"Sis\u00f3","year":"2017","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.117.247106_bib130","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12031-009-9253-0","article-title":"Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801","volume":"40","author":"Skovira","year":"2010","journal-title":"J Mol Neurosci"},{"key":"10.1124\/jpet.117.247106_bib131","doi-asserted-by":"crossref","first-page":"23","DOI":"10.18773\/austprescr.2017.005","article-title":"Midazolam for status epilepticus","volume":"40","author":"Smith","year":"2017","journal-title":"Aust Prescr"},{"key":"10.1124\/jpet.117.247106_bib132","series-title":"Generalized Linear Mixed Models: Modern Concepts, Methods and Applications","author":"Stroup","year":"2012"},{"key":"10.1124\/jpet.117.247106_bib133","first-page":"416864","article-title":"Mechanisms underlying tolerance after long-term benzodiazepine use: a future for subtype-selective GABA(A) receptor modulators?","volume":"2012","author":"Vinkers","year":"2012","journal-title":"Adv Pharmacol Sci"},{"key":"10.1124\/jpet.117.247106_bib134","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ntt.2009.12.006","article-title":"Behavioral sequelae following acute diisopropylfluorophosphate intoxication in rats: comparative effects of atropine and cannabinomimetics","volume":"32","author":"Wright","year":"2010","journal-title":"Neurotoxicol Teratol"},{"key":"10.1124\/jpet.117.247106_bib135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1124\/jpet.113.203653","article-title":"Estrous cycle regulation of extrasynaptic \u03b4-containing GABA(A) receptor plasticity and tonic inhibition in the hippocampus subfields","volume":"346","author":"Wu","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.117.247106_bib136","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ana.21024","article-title":"Human brain structural change related to acute single exposure to sarin","volume":"61","author":"Yamasue","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1124\/jpet.117.247106_bib137","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jns.2006.06.007","article-title":"Sarin experiences in Japan: acute toxicity and long-term effects","volume":"249","author":"Yanagisawa","year":"2006","journal-title":"J Neurol Sci"},{"key":"10.1124\/jpet.117.247106_bib138","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuro.2006.04.006","article-title":"Our recent experiences with sarin poisoning cases in Japan and pesticide users with references to some selected chemicals","volume":"28","author":"Yokoyama","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.117.247106_bib139","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/(SICI)1096-9861(19970224)378:4<482::AID-CNE4>3.0.CO;2-Z","article-title":"Soman-induced seizures rapidly activate astrocytes and microglia in discrete brain regions","volume":"378","author":"Zimmer","year":"1997","journal-title":"J Comp Neurol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524267070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524267070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.117.247106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:02:19Z","timestamp":1739995339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524267070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":137,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0022356524267070"],"URL":"https:\/\/doi.org\/10.1124\/jpet.117.247106","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.117.247106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}