{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:37:28Z","timestamp":1790253448585,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1124\/jpet.118.250019","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T18:05:34Z","timestamp":1536948334000},"page":"509-517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats"],"prefix":"10.1016","volume":"367","author":[{"given":"Koji","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Yoshitomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.118.250019_bib1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/sj.bjp.0703165","article-title":"Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11","volume":"129","author":"Ahmad","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.118.250019_bib2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.lfs.2009.04.024","article-title":"A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure","volume":"85","author":"Asakawa","year":"2009","journal-title":"Life Sci"},{"key":"10.1124\/jpet.118.250019_bib3","author":"Barnes","year":"2010"},{"key":"10.1124\/jpet.118.250019_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1055\/s-2006-925126","article-title":"Effects of an olive oil-enriched diet on glucagon-like peptide 1 release and intestinal content, plasma insulin concentration, glucose tolerance and pancreatic insulin content in an animal model of type 2 diabetes","volume":"38","author":"Cancelas","year":"2006","journal-title":"Horm Metab Res"},{"key":"10.1124\/jpet.118.250019_bib5","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/en.2007-0966","article-title":"A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release","volume":"149","author":"Chu","year":"2008","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.118.250019_bib6","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1210\/en.2006-1608","article-title":"A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release","volume":"148","author":"Chu","year":"2007","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.118.250019_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1463-1326.2001.00115.x","article-title":"Early insulin release effectively improves glucose tolerance: studies in two rodent models of type 2 diabetes mellitus","volume":"3","author":"de Souza","year":"2001","journal-title":"Diabetes Obes Metab"},{"key":"10.1124\/jpet.118.250019_bib8","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.2337\/db08-0307","article-title":"Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion","volume":"57","author":"Edfalk","year":"2008","journal-title":"Diabetes"},{"key":"10.1124\/jpet.118.250019_bib9","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1210\/en.2016-1334","article-title":"GPR119, a major enteroendocrine sensor of dietary triglyceride metabolites coacting in synergy with FFA1 (GPR40)","volume":"157","author":"Ekberg","year":"2016","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.118.250019_bib10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0014-5793(03)01196-7","article-title":"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives","volume":"554","author":"Fredriksson","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.118.250019_bib11","doi-asserted-by":"crossref","first-page":"E1409","DOI":"10.1210\/jc.2011-0647","article-title":"2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans","volume":"96","author":"Hansen","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1124\/jpet.118.250019_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature01478","article-title":"Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40","volume":"422","author":"Itoh","year":"2003","journal-title":"Nature"},{"key":"10.1124\/jpet.118.250019_bib13","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1517\/13543770903153878","article-title":"GPR119 agonists for the treatment of type 2 diabetes","volume":"19","author":"Jones","year":"2009","journal-title":"Expert Opin Ther Pat"},{"key":"10.1124\/jpet.118.250019_bib14","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.drudis.2013.09.011","article-title":"GPR119 agonists: a promising approach for T2DM treatment? A SWOT analysis of GPR119","volume":"18","author":"Kang","year":"2013","journal-title":"Drug Discov Today"},{"key":"10.1124\/jpet.118.250019_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-2999(97)01212-0","article-title":"Repaglinide, glibenclamide and glimepiride administration to normal and hereditarily diabetic rats","volume":"335","author":"Ladri\u00e8re","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.118.250019_bib16","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1111\/j.1476-5381.2011.01754.x","article-title":"Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways","volume":"165","author":"Lan","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.118.250019_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1677\/JOE-08-0453","article-title":"GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis","volume":"201","author":"Lan","year":"2009","journal-title":"J Endocrinol"},{"key":"10.1124\/jpet.118.250019_bib18","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1210\/en.2008-0182","article-title":"GPR119: \u201cdouble-dipping\u201d for better glycemic control","volume":"149","author":"Lauffer","year":"2008","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.118.250019_bib19","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/jm200003p","article-title":"Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response","volume":"54","author":"McClure","year":"2011","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.118.250019_bib20","doi-asserted-by":"crossref","first-page":"e92494","DOI":"10.1371\/journal.pone.0092494","article-title":"Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies","volume":"9","author":"Nunez","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/jpet.118.250019_bib21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.metabol.2012.06.010","article-title":"GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function","volume":"62","author":"Odori","year":"2013","journal-title":"Metabolism"},{"key":"10.1124\/jpet.118.250019_bib22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1476-5381.2009.00194.x","article-title":"The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release","volume":"157","author":"Ong","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.118.250019_bib23","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1021\/acs.jmedchem.5b01198","article-title":"G protein-coupled receptor 119 (GPR119) agonists for the treatment of diabetes: recent progress and prevailing challenges","volume":"59","author":"Ritter","year":"2016","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.118.250019_bib24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/cbdd.13131","article-title":"Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40)","volume":"91","author":"Rodrigues","year":"2018","journal-title":"Chem Biol Drug Des"},{"issue":"Suppl 4","key":"10.1124\/jpet.118.250019_bib25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1463-1326.2009.01108.x","article-title":"Roles of cAMP signalling in insulin granule exocytosis","volume":"11","author":"Seino","year":"2009","journal-title":"Diabetes Obes Metab"},{"key":"10.1124\/jpet.118.250019_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2005.07.042","article-title":"Role of GPR40 in fatty acid action on the beta cell line INS-1E","volume":"335","author":"Shapiro","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.118.250019_bib27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.bbrc.2004.11.120","article-title":"Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor","volume":"326","author":"Soga","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.118.250019_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2009.09.024","article-title":"Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure","volume":"622","author":"Someya","year":"2009","journal-title":"Eur J Pharmacol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652426729X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652426729X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.118.250019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:02:57Z","timestamp":1739995377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235652426729X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S002235652426729X"],"URL":"https:\/\/doi.org\/10.1124\/jpet.118.250019","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.118.250019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}