{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:22:04Z","timestamp":1791638524610,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1124\/jpet.118.250498","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T17:59:58Z","timestamp":1530035998000},"page":"527-540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects"],"prefix":"10.1016","volume":"366","author":[{"given":"Weimin C.","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Wasko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek S.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takato","family":"Hiranita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichiro","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Snell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffry D.","family":"Madura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Surratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.118.250498_bib1","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1021\/jm970525a","article-title":"Novel N-substituted 3 \u03b1-[bis(4\u2032-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter","volume":"40","author":"Agoston","year":"1997","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.118.250498_bib2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0022-3565(25)20689-9","article-title":"Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys","volume":"251","author":"Bergman","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nn.2146","article-title":"The binding sites for cocaine and dopamine in the dopamine transporter overlap","volume":"11","author":"Beuming","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.1124\/jpet.118.250498_bib4","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.str.2015.09.001","article-title":"Molecular mechanism of dopamine transport by human dopamine transporter","volume":"23","author":"Cheng","year":"2015","journal-title":"Structure"},{"key":"10.1124\/jpet.118.250498_bib5","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0022-3565(25)13038-3","article-title":"Effects of cholecystokinin, d-amphetamine and fenfluramine in rats trained to discriminate 3 from 22 hr of food deprivation","volume":"253","author":"Corwin","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib6","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1523\/JNEUROSCI.4778-04.2005","article-title":"Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine","volume":"25","author":"Desai","year":"2005","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.118.250498_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/archinte.1967.00300010021004","article-title":"Heroin addiction--a metabolic disease","volume":"120","author":"Dole","year":"1967","journal-title":"Arch Intern Med"},{"key":"10.1124\/jpet.118.250498_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00213-009-1653-x","article-title":"A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat","volume":"207","author":"Ferragud","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.250498_bib9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/jpet.113.208264","article-title":"Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats","volume":"348","author":"Hiranita","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1124\/jpet.108.145813","article-title":"Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors","volume":"329","author":"Hiranita","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1124\/jpet.113.212738","article-title":"2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter","volume":"349","author":"Hiranita","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib12","doi-asserted-by":"crossref","first-page":"32616","DOI":"10.1074\/jbc.M110.150565","article-title":"Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding","volume":"285","author":"Hong","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.118.250498_bib13","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.115.230722","article-title":"2-Substituted 3\u03b2-aryltropane cocaine analogs produce atypical effects without inducing inward-facing dopamine transporter conformations","volume":"356","author":"Hong","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0022-3565(25)22646-5","article-title":"Behavioral and neurochemical effects of acute and daily cocaine administration in rats","volume":"245","author":"Kalivas","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib15","series-title":"Sigma Proteins - Molecular Pharmacology in Physiology and Pathophysiology","first-page":"177","article-title":"A role for sigma receptors in stimulant self-administration and addiction","author":"Katz","year":"2017"},{"key":"10.1124\/jpet.118.250498_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1124\/jpet.116.232728","article-title":"Blockade of cocaine or \u03c3 receptor agonist self administration by subtype-selective \u03c3 receptor antagonists","volume":"358","author":"Katz","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-3565(24)37956-X","article-title":"Novel 3\u03b1-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine","volume":"288","author":"Katz","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib18","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1124\/jpet.103.060525","article-title":"Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands","volume":"309","author":"Katz","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib19","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.biopsych.2014.03.031","article-title":"Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine","volume":"76","author":"Kohut","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1124\/jpet.118.250498_bib20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1124\/jpet.110.171629","article-title":"Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability","volume":"335","author":"Kopajtic","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature10737","article-title":"X-ray structures of LeuT in substrate-free outward-open and apo inward-open states","volume":"481","author":"Krishnamurthy","year":"2012","journal-title":"Nature"},{"key":"10.1124\/jpet.118.250498_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0166-2236(91)90141-G","article-title":"The dopamine hypothesis of the reinforcing properties of cocaine","volume":"14","author":"Kuhar","year":"1991","journal-title":"Trends Neurosci"},{"key":"10.1124\/jpet.118.250498_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0969-8051(95)02074-8","article-title":"Synthesis and in vivo studies of a selective ligand for the dopamine transporter: 3 beta-(4-[125I]iodophenyl) tropan-2 beta-carboxylic acid isopropyl ester ([125I]RTI-121)","volume":"23","author":"Lever","year":"1996","journal-title":"Nucl Med Biol"},{"key":"10.1124\/jpet.118.250498_bib24","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00213-012-2862-2","article-title":"The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration","volume":"225","author":"Li","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.250498_bib25","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1124\/jpet.110.173260","article-title":"N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects","volume":"336","author":"Li","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib26","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1124\/jpet.105.084541","article-title":"Place conditioning and locomotor effects of N-substituted, 4\u2032,4\u2032'-difluorobenztropine analogs in rats","volume":"313","author":"Li","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib27","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1124\/mol.107.039800","article-title":"Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors","volume":"73","author":"Loland","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.118.250498_bib29","doi-asserted-by":"crossref","first-page":"35003","DOI":"10.1074\/jbc.M114.586982","article-title":"A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter","volume":"289","author":"Pedersen","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.118.250498_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature12533","article-title":"X-ray structure of dopamine transporter elucidates antidepressant mechanism","volume":"503","author":"Penmatsa","year":"2013","journal-title":"Nature"},{"key":"10.1124\/jpet.118.250498_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2014.12.005","article-title":"Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter","volume":"147","author":"Reith","year":"2015","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.118.250498_bib32","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.2820058","article-title":"Cocaine receptors on dopamine transporters are related to self-administration of cocaine","volume":"237","author":"Ritz","year":"1987","journal-title":"Science"},{"key":"10.1124\/jpet.118.250498_bib33","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1021\/jm990265s","article-title":"Highly selective chiral N-substituted 3\u03b1-[bis(4\u2032-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis","volume":"43","author":"Robarge","year":"2000","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.118.250498_bib34","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/syn.890040415","article-title":"Cocaine receptors: in vivo labeling with 3H-(-)cocaine, 3H-WIN 35,065-2, and 3H-WIN 35,428","volume":"4","author":"Scheffel","year":"1989","journal-title":"Synapse"},{"key":"10.1124\/jpet.118.250498_bib35","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1124\/jpet.104.080465","article-title":"Effects of 4\u2032-chloro-3 \u03b1-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine","volume":"313","author":"Tanda","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00213-013-3109-6","article-title":"Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change","volume":"229","author":"Tanda","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.250498_bib37","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1124\/jpet.109.154302","article-title":"Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity","volume":"330","author":"Tanda","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.250498_bib38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1054-3589(08)57007-4","article-title":"Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors","volume":"57","author":"Tanda","year":"2009","journal-title":"Adv Pharmacol"},{"key":"10.1124\/jpet.118.250498_bib39","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1038\/npp.2009.78","article-title":"The dopamine uptake inhibitor 3 \u03b1-[bis(4\u2032-fluorophenyl)metoxy]-tropane reduces cocaine-induced early-gene expression, locomotor activity, and conditioned reward","volume":"34","author":"Vel\u00e1zquez-S\u00e1nchez","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.118.250498_bib40","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1369-1600.2012.00458.x","article-title":"Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking","volume":"18","author":"Vel\u00e1zquez-S\u00e1nchez","year":"2013","journal-title":"Addict Biol"},{"key":"10.1124\/jpet.118.250498_bib41","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nature14431","article-title":"Neurotransmitter and psychostimulant recognition by the dopamine transporter","volume":"521","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"10.1124\/jpet.118.250498_bib42","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s002130050012","article-title":"3\u2032- and 4\u2032-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys","volume":"147","author":"Woolverton","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.250498_bib43","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature03978","article-title":"Crystal structure of a bacterial homologue of Na+\/Cl--dependent neurotransmitter transporters","volume":"437","author":"Yamashita","year":"2005","journal-title":"Nature"},{"key":"10.1124\/jpet.118.250498_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00213-017-4739-x","article-title":"Behavioral economic analysis of the effects of N-substituted benztropine analogs on cocaine self-administration in rats","volume":"235","author":"Zanettini","year":"2018","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.250498_bib45","doi-asserted-by":"crossref","first-page":"10172","DOI":"10.1021\/acs.jmedchem.7b01454","article-title":"Structure-activity relationship studies on a series of 3\u03b1-[bis(4-fluorophenyl)methoxy]tropanes and 3\u03b1-[bis(4-fluorophenyl)methylamino]tropanes as novel atypical dopamine transporter (DAT) inhibitors for the treatment of cocaine use disorders","volume":"60","author":"Zou","year":"2017","journal-title":"J Med Chem"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652426242X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652426242X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.118.250498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:00:42Z","timestamp":1739995242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235652426242X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S002235652426242X"],"URL":"https:\/\/doi.org\/10.1124\/jpet.118.250498","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.118.250498","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government work not protected by U.S. copyright","name":"copyright","label":"Copyright"}]}}