{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:55:06Z","timestamp":1779202506793,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":2133,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1124\/jpet.118.252635","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T21:50:22Z","timestamp":1544824222000},"page":"382-390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["In Vivo Preclinical Molecular Imaging of Repeated Exposure to an N-methyl-d-aspartate Antagonist and a Glutaminase Inhibitor as Potential Glutamatergic Modulators"],"prefix":"10.1016","volume":"368","author":[{"given":"Stijn","family":"Servaes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firat","family":"Kara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorien","family":"Glorie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Stroobants","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemie","family":"Van Der Linden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Staelens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.118.252635_bib1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.biopsych.2016.04.023","article-title":"Increased metabotropic glutamate receptor 5 signaling underlies obsessive-compulsive disorder-like behavioral and striatal circuit abnormalities in mice","volume":"80","author":"Ade","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1124\/jpet.118.252635_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00213-010-1808-9","article-title":"The role of NMDA receptors in the signal attenuation rat model of obsessive-compulsive disorder","volume":"210","author":"Albelda","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.252635_bib3","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00213-004-1847-1","article-title":"Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study","volume":"174","author":"Arnold","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.252635_bib4","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1007\/s11033-014-3417-x","article-title":"Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways","volume":"41","author":"Azad","year":"2014","journal-title":"Mol Biol Rep"},{"key":"10.1124\/jpet.118.252635_bib5","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.biopsych.2012.05.028","article-title":"Effects of ketamine in treatment-refractory obsessive-compulsive disorder","volume":"72","author":"Bloch","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1124\/jpet.118.252635_bib6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/sj.npp.1300733","article-title":"Glutamatergic dysfunction in OCD","volume":"30","author":"Chakrabarty","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.118.252635_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbi.2015.05.009","article-title":"Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: pathophysiological and neurobehavioral implications","volume":"49","author":"Chana","year":"2015","journal-title":"Brain Behav Immun"},{"key":"10.1124\/jpet.118.252635_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10571-006-9062-8","article-title":"Glutamate and schizophrenia: beyond the dopamine hypothesis","volume":"26","author":"Coyle","year":"2006","journal-title":"Cell Mol Neurobiol"},{"key":"10.1124\/jpet.118.252635_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2011.10.049","article-title":"The combination of organoselenium compounds and guanosine prevents glutamate-induced oxidative stress in different regions of rat brains","volume":"1430","author":"Dalla Corte","year":"2012","journal-title":"Brain Res"},{"key":"10.1124\/jpet.118.252635_bib10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biopsych.2014.06.024","article-title":"In vivo ketamine-induced changes in [11C]ABP688 binding to metabotropic glutamate receptor subtype 5","volume":"77","author":"DeLorenzo","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1124\/jpet.118.252635_bib11","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archgenpsychiatry.2010.122","article-title":"Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder","volume":"67","author":"Denys","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.1124\/jpet.118.252635_bib12","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.yebeh.2011.07.024","article-title":"The NMDA receptor complex as a therapeutic target in epilepsy: a review","volume":"22","author":"Ghasemi","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1124\/jpet.118.252635_bib13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/mrm.1910030602","article-title":"RARE imaging: a fast imaging method for clinical MR","volume":"3","author":"Hennig","year":"1986","journal-title":"Magn Reson Med"},{"key":"10.1124\/jpet.118.252635_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fendo.2013.00059","article-title":"The glutamate-glutamine (GABA) cycle: importance of late postnatal development and potential reciprocal interactions between biosynthesis and degradation","volume":"4","author":"Hertz","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1124\/jpet.118.252635_bib15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/FBP.0000000000000014","article-title":"Ketamine, but not MK-801, produces antidepressant-like effects in rats responding on a differential-reinforcement-of-low-rate operant schedule","volume":"25","author":"Hillhouse","year":"2014","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.118.252635_bib16","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2174\/1567205012666151027123728","article-title":"In vivo longitudinal monitoring of changes in the corpus callosum integrity during disease progression in a mouse model of Alzheimer\u2019s disease","volume":"12","author":"Kara","year":"2015","journal-title":"Curr Alzheimer Res"},{"key":"10.1124\/jpet.118.252635_bib17","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/npp.2017.295","article-title":"mGluR5 modulation of behavioral and epileptic phenotypes in a mouse model of tuberous sclerosis complex","volume":"43","author":"Kelly","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.118.252635_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2016.01.013","article-title":"Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction","volume":"248","author":"Kosten","year":"2016","journal-title":"Psychiatry Res Neuroimaging"},{"key":"10.1124\/jpet.118.252635_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/nimg.1996.0066","article-title":"Simplified reference tissue model for PET receptor studies","volume":"4","author":"Lammertsma","year":"1996","journal-title":"Neuroimage"},{"key":"10.1124\/jpet.118.252635_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coph.2014.10.007","article-title":"NMDA receptor dysfunction in autism spectrum disorders","volume":"20","author":"Lee","year":"2015","journal-title":"Curr Opin Pharmacol"},{"key":"10.1124\/jpet.118.252635_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0006-8993(00)02646-9","article-title":"Glutamatergic drugs exacerbate symptomatic behavior in a transgenic model of comorbid Tourette\u2019s syndrome and obsessive-compulsive disorder","volume":"877","author":"McGrath","year":"2000","journal-title":"Brain Res"},{"issue":"4S","key":"10.1124\/jpet.118.252635_bib22","doi-asserted-by":"crossref","first-page":"1007S","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J Nutr"},{"key":"10.1124\/jpet.118.252635_bib23","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.3390\/biom5043112","article-title":"Overview of glutamatergic dysregulation in central pathologies","volume":"5","author":"Miladinovic","year":"2015","journal-title":"Biomolecules"},{"key":"10.1124\/jpet.118.252635_bib24","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/0971-6203.62128","article-title":"Quantitation of normal metabolite concentrations in six brain regions by in-vivoH-MR spectroscopy","volume":"35","author":"Minati","year":"2010","journal-title":"J Med Phys"},{"key":"10.1124\/jpet.118.252635_bib25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tiv.2006.12.014","article-title":"Ebselen and diorganylchalcogenides decrease in vitro glutamate uptake by rat brain slices: prevention by DTT and GSH","volume":"21","author":"Moretto","year":"2007","journal-title":"Toxicol In Vitro"},{"key":"10.1124\/jpet.118.252635_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/A:1014903127672","article-title":"Exposure to ebselen changes glutamate uptake and release by rat brain synaptosomes","volume":"27","author":"Nogueira","year":"2002","journal-title":"Neurochem Res"},{"key":"10.1124\/jpet.118.252635_bib27","doi-asserted-by":"crossref","first-page":"20983","DOI":"10.1038\/srep20983","article-title":"Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice","volume":"6","author":"Oostwoud","year":"2016","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.118.252635_bib28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuroimage.2015.04.012","article-title":"Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy","volume":"114","author":"Orije","year":"2015","journal-title":"Neuroimage"},{"key":"10.1124\/jpet.118.252635_bib29","first-page":"36","article-title":"Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats","volume":"15","author":"Ozyigit","year":"2015","journal-title":"Bosn J Basic Med Sci"},{"key":"10.1124\/jpet.118.252635_bib52","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2013"},{"key":"10.1124\/jpet.118.252635_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1006\/jmre.1999.1895","article-title":"Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain","volume":"141","author":"Pfeuffer","year":"1999","journal-title":"J Magn Reson"},{"key":"10.1124\/jpet.118.252635_bib31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.pharmthera.2011.09.006","article-title":"Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment","volume":"132","author":"Pittenger","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.118.252635_bib32","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s00213-013-3330-3","article-title":"Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development","volume":"231","author":"Pop","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.252635_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0304-3940(01)01519-1","article-title":"Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons","volume":"299","author":"Porci\u00fancula","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.118.252635_bib34","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/nbm.698","article-title":"Automatic quantitation of localized in vivo 1H spectra with LCModel","volume":"14","author":"Provencher","year":"2001","journal-title":"NMR Biomed"},{"key":"10.1124\/jpet.118.252635_bib35","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1038\/npp.2013.150","article-title":"Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept","volume":"38","author":"Rodriguez","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.118.252635_bib36","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0306-3623(95)00003-J","article-title":"Molecular actions of Ebselen-an antiinflammatory antioxidant","volume":"26","author":"Schewe","year":"1995","journal-title":"Gen Pharmacol Vasc Syst"},{"key":"10.1124\/jpet.118.252635_bib37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jns.2009.05.029","article-title":"Neuroprotection of ebselen against ischemia\/reperfusion injury involves GABA shunt enzymes","volume":"285","author":"Seo","year":"2009","journal-title":"J Neurol Sci"},{"key":"10.1124\/jpet.118.252635_bib38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pnpbp.2017.02.027","article-title":"Preclinical molecular imaging of glutamatergic and dopaminergic neuroreceptor kinetics in obsessive compulsive disorder","volume":"77","author":"Servaes","year":"2017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1124\/jpet.118.252635_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2004.04.054","article-title":"Within-session repeated acquisition behavior in rats as a potential model of executive function","volume":"498","author":"Shannon","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.118.252635_bib40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tacc.2014.03.002","article-title":"Ketamine - more mechanisms of action than just NMDA blockade","volume":"2014","author":"Sleigh","year":"2014","journal-title":"Trends Anaesth Crit Care"},{"key":"10.1124\/jpet.118.252635_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbrc.2013.06.110","article-title":"Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors","volume":"438","author":"Thomas","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.118.252635_bib42","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/sj.npp.1300732","article-title":"Chronic NMDA antagonism impairs working memory, decreases extracellular dopamine, and increases D1 receptor binding in prefrontal cortex of conscious monkeys","volume":"30","author":"Tsukada","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.118.252635_bib43","article-title":"Rat brain normalization templates for robust regional analysis of [11C]ABP688 positron emission tomography\/computed tomography","volume":"13","author":"Verhaeghe","year":"2014","journal-title":"Mol Imaging"},{"key":"10.1124\/jpet.118.252635_bib44","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1109\/23.873020","article-title":"New, faster, image-based scatter correction for 3D PET","volume":"47","author":"Watson","year":"2000","journal-title":"IEEE Trans Nucl Sci"},{"key":"10.1124\/jpet.118.252635_bib45","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature06104","article-title":"Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice","volume":"448","author":"Welch","year":"2007","journal-title":"Nature"},{"key":"10.1124\/jpet.118.252635_bib46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00213-004-1944-1","article-title":"Bimodal effects of MK-801 on locomotion and stereotypy in C57BL\/6 mice","volume":"177","author":"Wu","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.118.252635_bib47","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.2967\/jnumed.113.121608","article-title":"N-acetylcysteine- and MK-801-induced changes in glutamate levels do not affect in vivo binding of metabotropic glutamate 5 receptor radioligand 11C-ABP688 in rat brain","volume":"54","author":"Wyckhuys","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1124\/jpet.118.252635_bib48","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1017\/S146114570900042X","article-title":"Dizocilpine (MK-801) induces distinct changes of N-methyl-D-aspartic acid receptor subunits in parvalbumin-containing interneurons in young adult rat prefrontal cortex","volume":"12","author":"Xi","year":"2009","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1124\/jpet.118.252635_bib49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1165\/rcmb.2011-0345OC","article-title":"Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation","volume":"48","author":"Yatmaz","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/jpet.118.252635_bib50","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/jcbfm.2015.35","article-title":"Imaging in vivo glutamate fluctuations with [(11)C]ABP688: a GLT-1 challenge with ceftriaxone","volume":"35","author":"Zimmer","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.118.252635_bib51","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.lfs.2005.09.022","article-title":"Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior","volume":"78","author":"Zuo","year":"2006","journal-title":"Life Sci"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524261206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524261206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.118.252635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T16:53:48Z","timestamp":1740675228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524261206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0022356524261206"],"URL":"https:\/\/doi.org\/10.1124\/jpet.118.252635","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In Vivo Preclinical Molecular Imaging of Repeated Exposure to an N-methyl-d-aspartate Antagonist and a Glutaminase Inhibitor as Potential Glutamatergic Modulators","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.118.252635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by The Author(s)","name":"copyright","label":"Copyright"}]}}