{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:28:44Z","timestamp":1790274524910,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":2041,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1124\/jpet.118.255034","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T20:07:49Z","timestamp":1554926869000},"page":"511-522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["AK106-001616, a Potent and Selective Inhibitor of Cytosolic Phospholipase A2: In Vivo Efficacy for Inflammation, Neuropathic Pain, and Pulmonary Fibrosis"],"prefix":"10.1016","volume":"369","author":[{"given":"Hirotomo","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Sakurada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Kozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoshi","family":"Shoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.118.255034_bib1","doi-asserted-by":"crossref","first-page":"k3015","DOI":"10.1136\/bmj.k3015","article-title":"Diagnosis and management of rheumatoid arthritis in adults: summary of updated NICE guidance","volume":"362","author":"Allen","year":"2018","journal-title":"BMJ"},{"key":"10.1124\/jpet.118.255034_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00011-009-8149-3","article-title":"Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis","volume":"58","author":"Anderson","year":"2009","journal-title":"Inflamm Res"},{"key":"10.1124\/jpet.118.255034_bib3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J Clin Pathol"},{"key":"10.1124\/jpet.118.255034_bib4","first-page":"6","article-title":"[Experimental study on the pathophysiology of endotoxin shock as analysed by alterations in thromboxane B2 and 6-keto-PGF1 alpha levels]","volume":"89","author":"Baba","year":"1988","journal-title":"Nihon Geka Gakkai Zasshi"},{"key":"10.1124\/jpet.118.255034_bib5","first-page":"616","article-title":"The pharmacological therapy of chronic neuropathic pain","volume":"113","author":"Binder","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"10.1124\/jpet.118.255034_bib6","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1056\/NEJMoa050493","article-title":"Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial","volume":"352","author":"Bresalier","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.118.255034_bib7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/gutjnl-2012-303581","article-title":"Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-\u03b1","volume":"63","author":"Brooke","year":"2014","journal-title":"Gut"},{"key":"10.1124\/jpet.118.255034_bib8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/ard.2005.044354","article-title":"EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)","volume":"66","author":"Combe","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1124\/jpet.118.255034_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2009.06.058","article-title":"CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain","volume":"617","author":"Cortes-Burgos","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.118.255034_bib10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1006\/abbi.1993.1549","article-title":"The 85-kDa, arachidonic acid-specific phospholipase A2 is expressed as an activated phosphoprotein in Sf9 cells","volume":"306","author":"de Carvalho","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/jpet.118.255034_bib11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1465-9921-7-137","article-title":"Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury","volume":"7","author":"Failla","year":"2006","journal-title":"Respir Res"},{"key":"10.1124\/jpet.118.255034_bib12","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.amjcard.2009.01.014","article-title":"An evidence-based review of the cardiovascular risks of nonsteroidal anti-inflammatory drugs","volume":"103","author":"Farkouh","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1124\/jpet.118.255034_bib13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1096\/fj.02-0777fje","article-title":"Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin","volume":"17","author":"Fiorucci","year":"2003","journal-title":"FASEB J"},{"key":"10.1124\/jpet.118.255034_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.plipres.2006.05.003","article-title":"Properties of the Group IV phospholipase A2 family","volume":"45","author":"Ghosh","year":"2006","journal-title":"Prog Lipid Res"},{"key":"10.1124\/jpet.118.255034_bib15","doi-asserted-by":"crossref","first-page":"15359","DOI":"10.1074\/jbc.270.25.15359","article-title":"Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE\/antigen","volume":"270","author":"Glover","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.118.255034_bib16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1042\/bj2990467","article-title":"Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line","volume":"299","author":"Hagmann","year":"1994","journal-title":"Biochem J"},{"key":"10.1124\/jpet.118.255034_bib17","doi-asserted-by":"crossref","first-page":"e10467","DOI":"10.1371\/journal.pone.0010467","article-title":"Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain","volume":"5","author":"Hasegawa","year":"2010","journal-title":"PLoS One"},{"key":"10.1124\/jpet.118.255034_bib18","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1084\/jem.20030016","article-title":"Cytosolic phospholipase A2\u03b1-deficient mice are resistant to collagen-induced arthritis","volume":"197","author":"Hegen","year":"2003","journal-title":"J Exp Med"},{"key":"10.1124\/jpet.118.255034_bib19","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/resp.12072","article-title":"Leukotriene C4 aggravates bleomycin-induced pulmonary fibrosis in mice","volume":"18","author":"Hirata","year":"2013","journal-title":"Respirology"},{"key":"10.1124\/jpet.118.255034_bib20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/acr.21596","article-title":"American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee","volume":"64","author":"Hochberg","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1124\/jpet.118.255034_bib21","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/sj.bjp.0704821","article-title":"Cyclo-oxygenase-2 inhibition increases blood pressure in rats","volume":"136","author":"H\u00f6cherl","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.118.255034_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jim.2009.01.009","article-title":"Collagen antibody-induced arthritis in mice: development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies","volume":"343","author":"Hutamekalin","year":"2009","journal-title":"J Immunol Methods"},{"key":"10.1124\/jpet.118.255034_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1744-8069-8-42","article-title":"Anti-hyperalgesic effects of calcitonin on neuropathic pain interacting with its peripheral receptors","volume":"8","author":"Ito","year":"2012","journal-title":"Mol Pain"},{"key":"10.1124\/jpet.118.255034_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-2999(01)01083-4","article-title":"Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals","volume":"423","author":"Jain","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.118.255034_bib25","doi-asserted-by":"crossref","first-page":"32807","DOI":"10.1074\/jbc.M202568200","article-title":"Identification of calcium-independent phospholipase A2 (iPLA2) \u03b2, and not iPLA2\u03b3, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s","volume":"277","author":"Jenkins","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.118.255034_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.jhh.1001777","article-title":"Cardiovascular risk and COX-2 inhibition in rheumatological practice","volume":"19","author":"Justice","year":"2005","journal-title":"J Hum Hypertens"},{"key":"10.1124\/jpet.118.255034_bib27","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/HYPERTENSIONAHA.114.04803","article-title":"Cytosolic phospholipase A2\u03b1 is critical for angiotensin II-induced hypertension and associated cardiovascular pathophysiology","volume":"65","author":"Khan","year":"2015","journal-title":"Hypertension"},{"key":"10.1124\/jpet.118.255034_bib28","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.neuroscience.2008.04.033","article-title":"Inhibition of spinal cytosolic phospholipase A2 expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia","volume":"154","author":"Kim","year":"2008","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.118.255034_bib29","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1177\/0091270005278202","article-title":"The cardiovascular toxicity of selective and nonselective cyclooxygenase inhibitors: comparisons, contrasts, and aspirin confounding","volume":"45","author":"Konstantinopoulos","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/jpet.118.255034_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0090-6980(02)00020-5","article-title":"Phospholipase A2 enzymes","volume":"68\u201369","author":"Kudo","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1124\/jpet.118.255034_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1074\/jbc.273.1.207","article-title":"Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity","volume":"273","author":"Larsson","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.118.255034_bib32","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/00002281-200309000-00017","article-title":"Role of eicosanoids in structural degradation in osteoarthritis","volume":"15","author":"Laufer","year":"2003","journal-title":"Curr Opin Rheumatol"},{"key":"10.1124\/jpet.118.255034_bib33","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1194\/jlr.R057588","article-title":"Cytosolic phospholipase A2: physiological function and role in disease","volume":"56","author":"Leslie","year":"2015","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.118.255034_bib34","first-page":"229","article-title":"Assaying phospholipase A2 activity","volume":"284","author":"Leslie","year":"2004","journal-title":"Methods Mol Biol"},{"key":"10.1124\/jpet.118.255034_bib35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1021\/acs.jmedchem.6b00935","article-title":"Idiopathic pulmonary fibrosis: current status, recent progress, and emerging targets","volume":"60","author":"Liu","year":"2017","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.118.255034_bib36","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/009286150704100410","article-title":"On the efficiency of interim analyses applied to nonclinical studies","volume":"41","author":"Ma\u00efofiss-Dullin","year":"2007","journal-title":"Drug Inf J"},{"key":"10.1124\/jpet.118.255034_bib37","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1124\/jpet.110.166967","article-title":"Pharmacology of PF-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain","volume":"334","author":"Masferrer","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.118.255034_bib38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.autrev.2007.03.005","article-title":"Role of leukotriene B4 receptors in rheumatoid arthritis","volume":"7","author":"Mathis","year":"2007","journal-title":"Autoimmun Rev"},{"key":"10.1124\/jpet.118.255034_bib39","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nm0502-480","article-title":"A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis","volume":"8","author":"Nagase","year":"2002","journal-title":"Nat Med"},{"key":"10.1124\/jpet.118.255034_bib40","series-title":"Osteoarthritis: care and management in adults","year":"2014"},{"key":"10.1124\/jpet.118.255034_bib41","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1248\/bpb.34.1163","article-title":"Leukotrienes in nociceptive pathway and neuropathic\/inflammatory pain","volume":"34","author":"Noguchi","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"10.1124\/jpet.118.255034_bib42","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJMoa050330","article-title":"Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery","volume":"352","author":"Nussmeier","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.118.255034_bib43","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/nm.2066","article-title":"Prostaglandin F2\u03b1 receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-\u03b2","volume":"15","author":"Oga","year":"2009","journal-title":"Nat Med"},{"key":"10.1124\/jpet.118.255034_bib44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1744-8069-8-8","article-title":"Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury","volume":"8","author":"Okubo","year":"2012","journal-title":"Mol Pain"},{"key":"10.1124\/jpet.118.255034_bib45","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0169-328X(94)90174-0","article-title":"Molecular cloning of rat cDNA for cytosolic phospholipase A2 and the increased gene expression in the dentate gyrus following transient forebrain ischemia","volume":"25","author":"Owada","year":"1994","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1124\/jpet.118.255034_bib46","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/sj.bjp.0701073","article-title":"Nitric oxide synthase and cyclo-oxygenase pathways in the inflammatory response induced by zymosan in the rat air pouch","volume":"120","author":"Pay\u00e1","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.118.255034_bib47","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1111\/j.1476-5381.1996.tb15353.x","article-title":"Involvement of secretory phospholipase A2 activity in the zymosan rat air pouch model of inflammation","volume":"117","author":"Pay\u00e1","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.118.255034_bib48","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1164\/ajrccm.165.2.2104050","article-title":"Protection from pulmonary fibrosis in leukotriene-deficient mice","volume":"165","author":"Peters-Golden","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.118.255034_bib49","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0090-6980(97)00147-0","article-title":"The contribution of synovial fluid lipoproteins to the chronic synovitis of rheumatoid arthritis","volume":"54","author":"Prete","year":"1997","journal-title":"Prostaglandins"},{"key":"10.1124\/jpet.118.255034_bib50","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1164\/rccm.201506-1063ST","article-title":"An official ATS\/ERS\/JRS\/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline","volume":"192","author":"Raghu","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.118.255034_bib51","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1002\/eji.200838545","article-title":"Reduction of cPLA2\u03b1 overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis","volume":"38","author":"Raichel","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1124\/jpet.118.255034_bib52","doi-asserted-by":"crossref","first-page":"14850","DOI":"10.1016\/S0021-9258(18)98550-9","article-title":"Molecular cloning and expression of human Ca2+-sensitive cytosolic phospholipase A2","volume":"266","author":"Sharp","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.118.255034_bib53","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1096\/fj.201601183R","article-title":"Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop","volume":"31","author":"Shindou","year":"2017","journal-title":"FASEB J"},{"key":"10.1124\/jpet.118.255034_bib54","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1056\/NEJMoa050405","article-title":"Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention","volume":"352","author":"Solomon","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.118.255034_bib55","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/S0021-9258(18)61336-5","article-title":"Human plasma platelet-activating factor acetylhydrolase. Purification and properties","volume":"262","author":"Stafforini","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.118.255034_bib56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pain.2006.12.020","article-title":"Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats","volume":"131","author":"Sung","year":"2007","journal-title":"Pain"},{"key":"10.1124\/jpet.118.255034_bib57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00011-009-0069-8","article-title":"Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model","volume":"59","author":"Tai","year":"2010","journal-title":"Inflamm Res"},{"key":"10.1124\/jpet.118.255034_bib58","doi-asserted-by":"crossref","first-page":"34013","DOI":"10.1074\/jbc.C000586200","article-title":"Suppression of intestinal polyposis in Apc\u0394716 knockout mice by an additional mutation in the cytosolic phospholipase A2 gene","volume":"275","author":"Takaku","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.118.255034_bib59","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000028204","article-title":"Inhibitory effects of TRK-530 on rat adjuvant arthritis","volume":"56","author":"Tanahashi","year":"1998","journal-title":"Pharmacology"},{"key":"10.1124\/jpet.118.255034_bib60","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0022-2275(20)39704-2","article-title":"Reverse-phase high-performance liquid chromatographic assay of phospholipases: application of spectrophotometric detection to rat phospholipase A2 isozymes","volume":"34","author":"Tojo","year":"1993","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.118.255034_bib61","doi-asserted-by":"crossref","first-page":"c7086","DOI":"10.1136\/bmj.c7086","article-title":"Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis","volume":"342","author":"Trelle","year":"2011","journal-title":"BMJ"},{"key":"10.1124\/jpet.118.255034_bib62","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1471-4159.2007.04861.x","article-title":"P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain","volume":"103","author":"Tsuda","year":"2007","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.118.255034_bib63","first-page":"1119","article-title":"Prostacyclin, thromboxane A2 and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders","volume":"83","author":"Vainio","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1124\/jpet.118.255034_bib64","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1254\/jjp.78.365","article-title":"Profile of JTE-522 as a human cyclooxygenase-2 inhibitor","volume":"78","author":"Wakitani","year":"1998","journal-title":"Jpn J Pharmacol"},{"key":"10.1124\/jpet.118.255034_bib65","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1172\/JCI118612","article-title":"Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis","volume":"97","author":"Wilborn","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.118.255034_bib66","doi-asserted-by":"crossref","first-page":"30879","DOI":"10.1074\/jbc.271.48.30879","article-title":"Expression, purification, and kinetic characterization of a recombinant 80-kDa intracellular calcium-independent phospholipase A2","volume":"271","author":"Wolf","year":"1996","journal-title":"J Biol Chem"},{"issue":"Suppl 3","key":"10.1124\/jpet.118.255034_bib67","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/annrheumdis-2013-eular.751","article-title":"The novel cPLA2 inhibitor AK106-001616 is a new category of antiinflammatory\/analgesic drug demonstrating efficay and favorable tolerability in the treatment of rheumatoid arthritis","volume":"72","author":"Yamanishi","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1124\/jpet.118.255034_bib68","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.bjp.0703044","article-title":"Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells","volume":"129","author":"Yamashita","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.118.255034_bib69","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10059-009-0059-2","article-title":"Lipoxygenase inhibitors suppressed carrageenan-induced Fos-expression and inflammatory pain responses in the rat","volume":"27","author":"Yoo","year":"2009","journal-title":"Mol Cells"},{"key":"10.1124\/jpet.118.255034_bib70","first-page":"394","article-title":"Pharmacological profile of celecoxib, a specific cyclooxygenase-2 inhibitor","volume":"55","author":"Yoshino","year":"2005","journal-title":"Arzneimittelforschung"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524259966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524259966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.118.255034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T16:00:32Z","timestamp":1739980832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524259966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0022356524259966"],"URL":"https:\/\/doi.org\/10.1124\/jpet.118.255034","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AK106-001616, a Potent and Selective Inhibitor of Cytosolic Phospholipase A2: In Vivo Efficacy for Inflammation, Neuropathic Pain, and Pulmonary Fibrosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.118.255034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}