{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:08:57Z","timestamp":1772309337877,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1124\/jpet.119.256594","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T23:24:07Z","timestamp":1557357847000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by \u03b2-2 Adrenoceptors in Human Airway Smooth-Muscle Cells"],"prefix":"10.1016","volume":"370","author":[{"given":"Shailesh R.","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chase","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Miyashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rennolds S.","family":"Ostrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.119.256594_bib1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fphar.2018.00332","article-title":"Compartmentalized cAMP signaling associated with lipid raft and non-raft membrane domains in adult ventricular myocytes","volume":"9","author":"Agarwal","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1124\/jpet.119.256594_bib2","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1111\/bph.13904","article-title":"Compartmentalized cAMP responses to prostaglandin EP2 receptor activation in human airway smooth muscle cells","volume":"174","author":"Agarwal","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.119.256594_bib3","doi-asserted-by":"crossref","first-page":"e95835","DOI":"10.1371\/journal.pone.0095835","article-title":"Role of membrane microdomains in compartmentation of cAMP signaling","volume":"9","author":"Agarwal","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/jpet.119.256594_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pupt.2012.05.007","article-title":"cAMP regulation of airway smooth muscle function","volume":"26","author":"Billington","year":"2013","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1124\/jpet.119.256594_bib5","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1124\/jpet.112.193425","article-title":"Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle","volume":"342","author":"Bogard","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.119.256594_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00210-013-0950-4","article-title":"Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms","volume":"387","author":"Bogard","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.119.256594_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1124\/jpet.110.177923","article-title":"Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains","volume":"337","author":"Bogard","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.119.256594_bib8","doi-asserted-by":"crossref","first-page":"13376","DOI":"10.1016\/S0021-9258(18)42221-1","article-title":"Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain","volume":"267","author":"Carr","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.119.256594_bib9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.76.060305.150444","article-title":"Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling","volume":"76","author":"Conti","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/jpet.119.256594_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1039\/C0MB00079E","article-title":"Visualization of PKA activity in plasma membrane microdomains","volume":"7","author":"Depry","year":"2011","journal-title":"Mol Biosyst"},{"key":"10.1124\/jpet.119.256594_bib11","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1124\/mol.109.059345","article-title":"Adenylyl cyclase-A-kinase anchoring protein complexes: the next dimension in cAMP signaling","volume":"76","author":"Dessauer","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.119.256594_bib12","doi-asserted-by":"crossref","first-page":"14450","DOI":"10.1074\/jbc.M110.109769","article-title":"AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors","volume":"285","author":"Efendiev","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.119.256594_bib13","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1096\/fj.11-201020","article-title":"A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle","volume":"26","author":"Horvat","year":"2012","journal-title":"FASEB J"},{"key":"10.1124\/jpet.119.256594_bib14","doi-asserted-by":"crossref","first-page":"C414","DOI":"10.1152\/ajpcell.00038.2008","article-title":"Cytoplasmic cAMP concentrations in intact cardiac myocytes","volume":"295","author":"Iancu","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/jpet.119.256594_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1196\/annals.1341.015","article-title":"Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes","volume":"1047","author":"Insel","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/jpet.119.256594_bib16","doi-asserted-by":"crossref","first-page":"23540","DOI":"10.1074\/jbc.M109.030072","article-title":"An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes","volume":"284","author":"Kapiloff","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.119.256594_bib17","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1096\/fj.03-0274com","article-title":"PDE4D plays a critical role in the control of airway smooth muscle contraction","volume":"17","author":"M\u00e9hats","year":"2003","journal-title":"FASEB J"},{"key":"10.1124\/jpet.119.256594_bib18","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1074\/jbc.274.6.3910","article-title":"Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated","volume":"274","author":"Melkonian","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.119.256594_bib19","doi-asserted-by":"crossref","first-page":"37215","DOI":"10.1074\/jbc.C400302200","article-title":"Novel single chain cAMP sensors for receptor-induced signal propagation","volume":"279","author":"Nikolaev","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.119.256594_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pupt.2014.07.005","article-title":"Airway smooth muscle in asthma: linking contraction and mechanotransduction to disease pathogenesis and remodelling","volume":"29","author":"Noble","year":"2014","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1124\/jpet.119.256594_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00210-011-0696-9","article-title":"Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps","volume":"385","author":"Ostrom","year":"2012","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.119.256594_bib22","doi-asserted-by":"crossref","first-page":"42063","DOI":"10.1074\/jbc.M105348200","article-title":"Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase","volume":"276","author":"Ostrom","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.119.256594_bib23","first-page":"181","article-title":"Methods for the study of signaling molecules in membrane lipid rafts and caveolae","volume":"332","author":"Ostrom","year":"2006","journal-title":"Methods Mol Biol"},{"key":"10.1124\/jpet.119.256594_bib24","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.rmed.2008.02.020","article-title":"Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma","volume":"102","author":"Pelaia","year":"2008","journal-title":"Respir Med"},{"key":"10.1124\/jpet.119.256594_bib25","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1165\/ajrcmb.19.2.3025","article-title":"Mechanisms of acute desensitization of the beta2AR-adenylyl cyclase pathway in human airway smooth muscle","volume":"19","author":"Penn","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/jpet.119.256594_bib26","doi-asserted-by":"crossref","first-page":"13835","DOI":"10.1073\/pnas.0712100105","article-title":"The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain","volume":"105","author":"Piggott","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.119.256594_bib27","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1164\/rccm.200901-0055CC","article-title":"The beta-agonist saga and its clinical relevance: on and on it goes","volume":"179","author":"Taylor","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.119.256594_bib28","doi-asserted-by":"crossref","first-page":"C455","DOI":"10.1152\/ajpcell.00058.2005","article-title":"Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor","volume":"289","author":"Warrier","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/jpet.119.256594_bib29","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1113\/jphysiol.2006.124891","article-title":"cAMP microdomains and L-type Ca2+ channel regulation in Guinea-pig ventricular myocytes","volume":"580","author":"Warrier","year":"2007","journal-title":"J Physiol"},{"key":"10.1124\/jpet.119.256594_bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1096\/fj.10-164798","article-title":"Anti-mitogenic effects of \u03b2-agonists and PGE2 on airway smooth muscle are PKA dependent","volume":"25","author":"Yan","year":"2011","journal-title":"FASEB J"},{"key":"10.1124\/jpet.119.256594_bib31","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1126\/science.1068539","article-title":"Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells","volume":"296","author":"Zacharias","year":"2002","journal-title":"Science"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524259097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524259097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.119.256594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:57:35Z","timestamp":1739980655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524259097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0022356524259097"],"URL":"https:\/\/doi.org\/10.1124\/jpet.119.256594","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by \u03b2-2 Adrenoceptors in Human Airway Smooth-Muscle Cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.119.256594","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}