{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:28:29Z","timestamp":1781155709722,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":1980,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1124\/jpet.119.256602","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T20:55:16Z","timestamp":1557780916000},"page":"182-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys"],"prefix":"10.1016","volume":"370","author":[{"given":"Wouter","family":"Korver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Carsillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraja","family":"Idamakanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wagoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy Q.","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glennda","family":"Smithson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachy","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Zalevsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-7172","authenticated-orcid":false,"given":"Eric R.","family":"Fedyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.119.256602_bib1","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1136\/annrheumdis-2014-206016","article-title":"The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus","volume":"74","author":"Alexander","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1124\/jpet.119.256602_bib2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.cell.2016.03.008","article-title":"Personalized immunomonitoring uncovers molecular networks that stratify lupus patients","volume":"165","author":"Banchereau","year":"2016","journal-title":"Cell"},{"key":"10.1124\/jpet.119.256602_bib3","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1182\/bloodadvances.2017006866","article-title":"Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory multiple myeloma","volume":"1","author":"Casneuf","year":"2017","journal-title":"Blood Adv"},{"key":"10.1124\/jpet.119.256602_bib4","unstructured":"Center for Drug Evaluation and Research (2015) Application Number: 761036Orig1s000 Pharmacology Review(s)"},{"key":"10.1124\/jpet.119.256602_bib5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s40262-016-0477-1","article-title":"Pharmacokinetics of daratumumab following intravenous infusion in relapsed or refractory multiple myeloma after prior proteasome inhibitor and immunomodulatory drug treatment","volume":"56","author":"Clemens","year":"2017","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/jpet.119.256602_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13075-018-1578-z","article-title":"Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus","volume":"20","author":"Cole","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1124\/jpet.119.256602_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11926-014-0419-6","article-title":"Preclinical rheumatoid arthritis (autoantibodies): an updated review","volume":"16","author":"Deane","year":"2014","journal-title":"Curr Rheumatol Rep"},{"key":"10.1124\/jpet.119.256602_bib8","unstructured":"European Medicines Agency\u2019s Committee for Medicinal Products for Human Use (2016) Assessment report: Darzalex; International non-proprietary name: daratumumab; Procedure No. EMEA\/H\/C\/004077\/II\/0002. 23 February 2017"},{"key":"10.1124\/jpet.119.256602_bib9","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1182\/blood-2018-99-112916","article-title":"A single administration of the cytolytic CD38 antibody TAK-079 to healthy subjects: tolerability, pharmacokinetics and pharmacodynamics","volume":"132","author":"Fedyk","year":"2018","journal-title":"Blood"},{"key":"10.1124\/jpet.119.256602_bib10","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1172\/JCI200319301","article-title":"Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions","volume":"112","author":"Grammer","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.119.256602_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coi.2018.10.008","article-title":"The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy","volume":"55","author":"Hale","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"10.1124\/jpet.119.256602_bib12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.yexmp.2008.03.003","article-title":"Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model","volume":"84","author":"Kato","year":"2008","journal-title":"Exp Mol Pathol"},{"key":"10.1124\/jpet.119.256602_bib13","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/rheumatology\/38.11.1074","article-title":"Immunohistological analysis of synovial tissue for differential diagnosis in early arthritis","volume":"38","author":"Kraan","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"10.1124\/jpet.119.256602_bib14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1182\/blood-2015-12-687749","article-title":"Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma","volume":"128","author":"Krejcik","year":"2016","journal-title":"Blood"},{"key":"10.1124\/jpet.119.256602_bib15","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1002\/art.40180","article-title":"Peripheral immunophenotyping identifies three subgroups based on T cell heterogeneity in lupus patients","volume":"69","author":"Kubo","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1124\/jpet.119.256602_bib16","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3523","article-title":"The immune system and kidney disease: basic concepts and clinical implications","volume":"13","author":"Kurts","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/jpet.119.256602_bib17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.immunol.24.021605.090517","article-title":"B cell immunobiology in disease: evolving concepts from the clinic","volume":"24","author":"Martin","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"10.1124\/jpet.119.256602_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/clim.2000.4989","article-title":"Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys","volume":"98","author":"Mihara","year":"2001","journal-title":"Clin Immunol"},{"key":"10.1124\/jpet.119.256602_bib19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood-2016-03-703439","article-title":"CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma","volume":"128","author":"Nijhof","year":"2016","journal-title":"Blood"},{"key":"10.1124\/jpet.119.256602_bib20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nri3795","article-title":"The generation of antibody-secreting plasma cells","volume":"15","author":"Nutt","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/jpet.119.256602_bib21","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nri1886","article-title":"Competence and competition: the challenge of becoming a long-lived plasma cell","volume":"6","author":"Radbruch","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/jpet.119.256602_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jprot.2015.11.023","article-title":"Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: the role of CD38","volume":"134","author":"Rosal-Vela","year":"2016","journal-title":"J Proteomics"},{"key":"10.1124\/jpet.119.256602_bib23","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1177\/0961203317691371","article-title":"Successful treatment of refractory systemic lupus erythematosus using proteasome inhibitor bortezomib followed by belimumab: description of two cases","volume":"26","author":"Sj\u00f6wall","year":"2017","journal-title":"Lupus"},{"issue":"Supple 1","key":"10.1124\/jpet.119.256602_bib24","doi-asserted-by":"crossref","first-page":"224.20","DOI":"10.4049\/jimmunol.198.Supp.224.20","article-title":"TAK-079 is a high affinity monoclonal antibody that effectively mediates CD38+ cell depletion","volume":"198","author":"Smithson","year":"2017","journal-title":"J Immunol"},{"key":"10.1124\/jpet.119.256602_bib25","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1002\/art.34400","article-title":"Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus","volume":"64","author":"Stohl","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1124\/jpet.119.256602_bib26","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00296-008-0547-2","article-title":"Anemia in monkey collagen-induced arthritis is correlated with serum IL-6, but not TNF\u03b1","volume":"28","author":"Uchiyama","year":"2008","journal-title":"Rheumatol Int"},{"key":"10.1124\/jpet.119.256602_bib27","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1248\/bpb.31.1159","article-title":"Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis","volume":"31","author":"Uchiyama","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"10.1124\/jpet.119.256602_bib28","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1002\/art.30466","article-title":"B cell biomarkers of rituximab responses in systemic lupus erythematosus","volume":"63","author":"Vital","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"Suppl 10","key":"10.1124\/jpet.119.256602_bib29","first-page":"1085","article-title":"The anti-CD38 monoclonal antibody TAK-079 depletes antibody secreting cells from normal and SLE patients (Abstract)","volume":"68","author":"Wang","year":"2016","journal-title":"Arthritis Rheumatol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524259292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524259292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.119.256602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:58:23Z","timestamp":1739980703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524259292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0022356524259292"],"URL":"https:\/\/doi.org\/10.1124\/jpet.119.256602","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.119.256602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}