{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:33:39Z","timestamp":1788820419886,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1124\/jpet.119.256750","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T18:05:34Z","timestamp":1552586734000},"page":"834-842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Microneedles Coated with Tramadol Exhibit Antinociceptive Effect in a Rat Model of Temporomandibular Hypernociception"],"prefix":"10.1016","volume":"370","author":[{"given":"Henrique Ballassini","family":"Abdalla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit K.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Henrique","family":"Napimoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Trindade","family":"Clemente-Napimoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvinder Singh","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.119.256750_bib1","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.joms.2013.08.009","article-title":"Comparison of local anesthetic efficacy of tramadol hydrochloride (with adrenaline) versus plain tramadol hydrochloride in the extraction of upper molar teeth","volume":"71","author":"Al-Haideri","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1124\/jpet.119.256750_bib2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00405-007-0479-6","article-title":"Peritonsillar infiltration with tramadol improves pediatric tonsillectomy pain","volume":"265","author":"Atef","year":"2008","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1124\/jpet.119.256750_bib3","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3109\/0284186X.2012.737932","article-title":"Inhibitory effect of opiates on LPS mediated release of TNF and IL-8","volume":"52","author":"Bastami","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1124\/jpet.119.256750_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11095-010-0101-2","article-title":"Microneedles in clinical practice--an exploratory study into the opinions of healthcare professionals and the public","volume":"28","author":"Birchall","year":"2011","journal-title":"Pharm Res"},{"issue":"Suppl 2","key":"10.1124\/jpet.119.256750_bib5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2165\/00003495-199700532-00009","article-title":"Effectiveness and tolerance of tramadol in cancer pain. A comparative study with respect to buprenorphine","volume":"53","author":"Bono","year":"1997","journal-title":"Drugs"},{"key":"10.1124\/jpet.119.256750_bib6","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1080\/17460441.2017.1377697","article-title":"Discovery and development of tramadol for the treatment of pain","volume":"12","author":"Bravo","year":"2017","journal-title":"Expert Opin Drug Discov"},{"key":"10.1124\/jpet.119.256750_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2842.2010.02074.x","article-title":"Pathophysiology of TMD pain--basic mechanisms and their implications for pharmacotherapy","volume":"37","author":"Cairns","year":"2010","journal-title":"J Oral Rehabil"},{"key":"10.1124\/jpet.119.256750_bib8","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neulet.2004.09.048","article-title":"Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint","volume":"372","author":"Clemente","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.119.256750_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.bjp.0702266","article-title":"Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4","volume":"126","author":"Cunha","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.119.256750_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12035-014-8790-x","article-title":"IL-10 cytokine released from M2 macrophages is crucial for analgesic and anti-inflammatory effects of acupuncture in a model of inflammatory muscle pain","volume":"51","author":"da Silva","year":"2015","journal-title":"Mol Neurobiol"},{"key":"10.1124\/jpet.119.256750_bib11","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1460-9592.2006.01910.x","article-title":"Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herniotomy?","volume":"16","author":"Demiraran","year":"2006","journal-title":"Paediatr Anaesth"},{"key":"10.1124\/jpet.119.256750_bib12","first-page":"672","article-title":"Effect of intraarticular tramadol administration in the rat model of knee joint inflammation","volume":"58","author":"Garlicki","year":"2006","journal-title":"Pharmacol Rep"},{"key":"10.1124\/jpet.119.256750_bib13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/AJP.0b013e31816778f9","article-title":"Effect of microneedle design on pain in human volunteers","volume":"24","author":"Gill","year":"2008","journal-title":"Clin J Pain"},{"key":"10.1124\/jpet.119.256750_bib14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2147\/JPR.S127950","article-title":"Management of pain in patients with temporomandibular disorder (TMD): challenges and solutions","volume":"11","author":"Gil-Mart\u00ednez","year":"2018","journal-title":"J Pain Res"},{"key":"10.1124\/jpet.119.256750_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/AJP.0b013e318225dbe9","article-title":"Rapid local anesthesia in humans using minimally invasive microneedles","volume":"28","author":"Gupta","year":"2012","journal-title":"Clin J Pain"},{"key":"10.1124\/jpet.119.256750_bib16","first-page":"29","article-title":"Gender difference in symptoms related to temporomandibular disorders in a population of 50-year-old subjects","volume":"17","author":"Johansson","year":"2003","journal-title":"J Orofac Pain"},{"key":"10.1124\/jpet.119.256750_bib17","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s11095-016-1991-4","article-title":"Large size microneedle patch to deliver lidocaine through skin","volume":"33","author":"Kathuria","year":"2016","journal-title":"Pharm Res"},{"key":"10.1124\/jpet.119.256750_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13075-015-0772-5","article-title":"Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats","volume":"17","author":"Knudsen","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1124\/jpet.119.256750_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1590\/S0034-70942009000300004","article-title":"Proinflammatory cytokines in patients with neuropathic pain treated with Tramadol","volume":"59","author":"Kraychete","year":"2009","journal-title":"Rev Bras Anestesiol"},{"key":"10.1124\/jpet.119.256750_bib20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.farmac.2004.12.002","article-title":"Determination of tramadol hydrochloride in ampoule dosage forms by using UV spectrophotometric and HPLC-DAD methods in methanol and water media","volume":"60","author":"K\u00fc\u00e7\u00fck","year":"2005","journal-title":"Farmaco"},{"key":"10.1124\/jpet.119.256750_bib21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2017.04.012","article-title":"The anti-inflammatory effect of tramadol in the temporomandibular joint of rats","volume":"807","author":"Lamana","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.119.256750_bib22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.pain.2010.08.014","article-title":"Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: involvement of the NO\/cGMP\/PKG\/KATP signaling pathway","volume":"151","author":"Lima","year":"2010","journal-title":"Pain"},{"key":"10.1124\/jpet.119.256750_bib23","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1631\/jzus.B0820039","article-title":"Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain","volume":"9","author":"Liu","year":"2008","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1124\/jpet.119.256750_bib24","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1002\/jps.24159","article-title":"Coating solid dispersions on microneedles via a molten dip-coating method: development and in vitro evaluation for transdermal delivery of a water-insoluble drug","volume":"103","author":"Ma","year":"2014","journal-title":"J Pharm Sci"},{"key":"10.1124\/jpet.119.256750_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2017.06.031","article-title":"Microneedles enhance topical delivery of 15-deoxy-Delta(12,14)-prostaglandin J2 and reduce nociception in temporomandibular joint of rats","volume":"265","author":"Macedo","year":"2017","journal-title":"J Control Release"},{"key":"10.1124\/jpet.119.256750_bib26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1034\/j.1600-0528.2002.300108.x","article-title":"Oro-facial pain in the community: prevalence and associated impact","volume":"30","author":"Macfarlane","year":"2002","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1124\/jpet.119.256750_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2006.11.055","article-title":"Local analgesic efficacy of tramadol following intraplantar injection","volume":"558","author":"Mert","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.119.256750_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1213\/ANE.0000000000001683","article-title":"Trends in tramadol: pharmacology, metabolism, and misuse","volume":"124","author":"Miotto","year":"2017","journal-title":"Anesth Analg"},{"key":"10.1124\/jpet.119.256750_bib29","first-page":"CD004715","article-title":"Pharmacological interventions for pain in patients with temporomandibular disorders","volume":"10","author":"Mujakperuo","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1124\/jpet.119.256750_bib30","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/jpet.119.256750_bib32","first-page":"228","article-title":"Prevalence of symptoms associated with temporomandibular disorders in Hong Kong Chinese","volume":"15","author":"Pow","year":"2001","journal-title":"J Orofac Pain"},{"key":"10.1124\/jpet.119.256750_bib33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/bja\/ael155","article-title":"Efficacy of three doses of tramadol with bupivacaine for caudal analgesia in paediatric inguinal herniotomy","volume":"97","author":"Prakash","year":"2006","journal-title":"Br J Anaesth"},{"key":"10.1124\/jpet.119.256750_bib34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2147\/JPR.S37593","article-title":"Orofacial pain management: current perspectives","volume":"7","author":"Romero-Reyes","year":"2014","journal-title":"J Pain Res"},{"key":"10.1124\/jpet.119.256750_bib35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0304-3959(91)90190-9","article-title":"The formalin test in mice: the influence of ambient temperature","volume":"45","author":"Rosland","year":"1991","journal-title":"Pain"},{"key":"10.1124\/jpet.119.256750_bib36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0304-3959(01)00357-8","article-title":"Development of a behavioral model of TMJ pain in rats: the TMJ formalin test","volume":"94","author":"Roveroni","year":"2001","journal-title":"Pain"},{"key":"10.1124\/jpet.119.256750_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.10.031","article-title":"Adenosine receptor targets for pain","volume":"338","author":"Sawynok","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.119.256750_bib38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejphar.2013.07.012","article-title":"Spinal and peripheral adenosine A1 receptors contribute to antinociception by tramadol in the formalin test in mice","volume":"714","author":"Sawynok","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.119.256750_bib39","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1056\/NEJMra0802472","article-title":"Temporomandibular disorders","volume":"359","author":"Scrivani","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.119.256750_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejps.2016.08.023","article-title":"Influence of salivary washout on drug delivery to the oral cavity using coated microneedles: an in vitro evaluation","volume":"93","author":"Serpe","year":"2016","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/jpet.119.256750_bib41","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1016\/j.vaccine.2015.06.042","article-title":"A comparative study of microneedle-based cutaneous immunization with other conventional routes to assess feasibility of microneedles for allergy immunotherapy","volume":"33","author":"Shakya","year":"2015","journal-title":"Vaccine"},{"key":"10.1124\/jpet.119.256750_bib42","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bjoms.2014.12.018","article-title":"Comparative study in patients with symptomatic internal derangements of the temporomandibular joint: analgesic outcomes of arthrocentesis with or without intra-articular morphine and tramadol","volume":"53","author":"Sipahi","year":"2015","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1124\/jpet.119.256750_bib43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bpg.2009.11.005","article-title":"Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract","volume":"24","author":"Sostres","year":"2010","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1124\/jpet.119.256750_bib44","first-page":"371","article-title":"Local effect of tramadol on formalin evoked flinching behavior in rats","volume":"58","author":"Sousa","year":"2008","journal-title":"Rev Bras Anestesiol"},{"key":"10.1124\/jpet.119.256750_bib45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.119.256750_bib46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0304-3959(00)00414-0","article-title":"Treatment of severe pain from osteoarthritis with slow-release tramadol or dihydrocodeine in combination with NSAID\u2019s: a randomised study comparing analgesia, antinociception and gastrointestinal effects","volume":"91","author":"Wilder-Smith","year":"2001","journal-title":"Pain"},{"key":"10.1124\/jpet.119.256750_bib47","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ejps.2018.06.014","article-title":"Application of composite dissolving microneedles with high drug loading ratio for rapid local anesthesia","volume":"121","author":"Zhan","year":"2018","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/jpet.119.256750_bib48","doi-asserted-by":"crossref","DOI":"10.1007\/s10787-017-0338-z","article-title":"Tramadol differentially regulates M1 and M2 macrophages from human umbilical cord blood","author":"Zhang","year":"2017","journal-title":"Inflammopharmacology"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524260559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524260559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.119.256750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T14:54:02Z","timestamp":1739976842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524260559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0022356524260559"],"URL":"https:\/\/doi.org\/10.1124\/jpet.119.256750","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microneedles Coated with Tramadol Exhibit Antinociceptive Effect in a Rat Model of Temporomandibular Hypernociception","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.119.256750","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}