{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:09:07Z","timestamp":1791806947028,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1124\/jpet.119.259846","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T17:15:23Z","timestamp":1567703723000},"page":"290-298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice"],"prefix":"10.1016","volume":"371","author":[{"given":"Shuichi","family":"Takagahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigekazu","family":"Itokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Satomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.119.259846_bib1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/CIRCULATIONAHA.111.047431","article-title":"Acute coronary events","volume":"125","author":"Arbab-Zadeh","year":"2012","journal-title":"Circulation"},{"key":"10.1124\/jpet.119.259846_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0021-9150(93)90043-T","article-title":"Antiatherosclerotic effects of oral cicaprost in experimental hypercholesterolemia in rabbits","volume":"103","author":"Braun","year":"1993","journal-title":"Atherosclerosis"},{"key":"10.1124\/jpet.119.259846_bib3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/med.21251","article-title":"Eicosanoids and their drugs in cardiovascular diseases: focus on atherosclerosis and stroke","volume":"33","author":"Capra","year":"2013","journal-title":"Med Res Rev"},{"key":"10.1124\/jpet.119.259846_bib4","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/01.CIR.0000027816.54430.96","article-title":"Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice","volume":"106","author":"Cyrus","year":"2002","journal-title":"Circulation"},{"key":"10.1124\/jpet.119.259846_bib5","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cjca.2012.05.003","article-title":"Clinical value of drugs targeting inflammation for the management of coronary artery disease","volume":"28","author":"Duchatelle","year":"2012","journal-title":"Can J Cardiol"},{"key":"10.1124\/jpet.119.259846_bib6","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1194\/jlr.M024216","article-title":"Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model","volume":"53","author":"Fan","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.119.259846_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.021908.132620","article-title":"Immune and inflammatory mechanisms of atherosclerosis","volume":"27","author":"Galkina","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1124\/jpet.119.259846_bib8","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1161\/CIRCULATIONAHA.117.030484","article-title":"Inflammation and atherosclerosis: the end of a controversy","volume":"136","author":"Hansson","year":"2017","journal-title":"Circulation"},{"key":"10.1124\/jpet.119.259846_bib9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1172\/JCI200421446","article-title":"Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice","volume":"114","author":"Kobayashi","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.119.259846_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1734-1140(09)70025-8","article-title":"Rimonabant: an antagonist drug of the endocannabinoid system for the treatment of obesity","volume":"61","author":"Leite","year":"2009","journal-title":"Pharmacol Rep"},{"key":"10.1124\/jpet.119.259846_bib11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.atherosclerosis.2007.07.023","article-title":"Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice","volume":"197","author":"Matsumoto","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1124\/jpet.119.259846_bib12","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/01.ATV.17.6.1185","article-title":"Importance of platelets in neutrophil adhesion and vasoconstriction after deep carotid arterial injury by angioplasty in pigs","volume":"17","author":"Merhi","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.119.259846_bib13","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1001\/jama.286.8.954","article-title":"Risk of cardiovascular events associated with selective COX-2 inhibitors","volume":"286","author":"Mukherjee","year":"2001","journal-title":"JAMA"},{"key":"10.1124\/jpet.119.259846_bib14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1001\/jama.2013.282836","article-title":"Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial","volume":"311","author":"Nicholls","year":"2014","journal-title":"JAMA"},{"key":"10.1124\/jpet.119.259846_bib15","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/jama.2014.11061","article-title":"Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial [published correction appears in JAMA (2014) 312:1473]","volume":"312","author":"O\u2019Donoghue","year":"2014","journal-title":"JAMA"},{"key":"10.1124\/jpet.119.259846_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/DMSO.S106653","article-title":"Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque","volume":"9","author":"Powell","year":"2016","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1124\/jpet.119.259846_bib17","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.119.259846_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.119.259846_bib19","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1172\/JCI119029","article-title":"Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development","volume":"98","author":"Shen","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.119.259846_bib20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.ATV.0000110503.16605.15","article-title":"Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms","volume":"24","author":"Subbarao","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.119.259846_bib21","unstructured":"Suzuki H Fujimoto T Yamamoto T (2010) inventors, Takeda Pharmaceutical Co Ltd, assignee. Delta-5-desaturase inhibitors. Patent WO2010087467 A1. PCT application. 5 Aug 2010"},{"key":"10.1124\/jpet.119.259846_bib22","doi-asserted-by":"crossref","first-page":"480","DOI":"10.5551\/jat.No430","article-title":"Anti-atherosclerotic effects of dihomo-\u03b3-linolenic acid in apoE-deficient mice","volume":"16","author":"Takai","year":"2009","journal-title":"J Atheroscler Thromb"},{"key":"10.1124\/jpet.119.259846_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-319-07320-0_7","article-title":"Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease","volume":"824","author":"Tosi","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"10.1124\/jpet.119.259846_bib24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.plefa.2005.02.002","article-title":"15-Lipoxygenase metabolites of \u03b3-linolenic acid\/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids","volume":"72","author":"Vang","year":"2005","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1124\/jpet.119.259846_bib25","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1161\/ATVBAHA.110.210054","article-title":"Endogenously decreasing tissue n-6\/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation","volume":"30","author":"Wan","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.119.259846_bib26","doi-asserted-by":"crossref","first-page":"14507","DOI":"10.1073\/pnas.0606586103","article-title":"Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis","volume":"103","author":"Wang","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.119.259846_bib27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-511X-11-25","article-title":"Multiple roles of dihomo-\u03b3-linolenic acid against proliferation diseases","volume":"11","author":"Wang","year":"2012","journal-title":"Lipids Health Dis"},{"key":"10.1124\/jpet.119.259846_bib28","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1056\/NEJMoa1315878","article-title":"Darapladib for preventing ischemic events in stable coronary heart disease","volume":"370","author":"White","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.119.259846_bib29","doi-asserted-by":"crossref","first-page":"e0166198","DOI":"10.1371\/journal.pone.0166198","article-title":"A novel selective inhibitor of delta-5 desaturase lowers insulin resistance and reduces body weight in diet-induced obese C57BL\/6J mice","volume":"11","author":"Yashiro","year":"2016","journal-title":"PLoS One"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524268920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524268920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.119.259846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T08:58:08Z","timestamp":1739955488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524268920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0022356524268920"],"URL":"https:\/\/doi.org\/10.1124\/jpet.119.259846","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736562997.793566720","asserted-by":"object"}]},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.119.259846","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}