{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:10:40Z","timestamp":1791403840426,"version":"4.3.3"},"reference-count":64,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1124\/jpet.119.260968","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T20:35:13Z","timestamp":1573072513000},"page":"83-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Positive Allosteric Modulator of \u03b12\/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury"],"prefix":"10.1016","volume":"372","author":[{"given":"Jeffrey M.","family":"Witkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanguan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit K.","family":"Golani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjie","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farjana","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajwana","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rok","family":"Cerne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.119.260968_bib1","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.2174\/156802611795371350","article-title":"GABAA receptor subtype-selective modulators. I. \u03b12\/\u03b13-selective agonists as non-sedating anxiolytics","volume":"11","author":"Atack","year":"2011","journal-title":"Curr Top Med Chem"},{"key":"10.1124\/jpet.119.260968_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1124\/jpet.109.158303","article-title":"Reducing abuse liability of GABAA\/benzodiazepine ligands via selective partial agonist efficacy at \u03b11 and \u03b12\/3 subtypes","volume":"332","author":"Ator","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.119.260968_bib4","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.4103\/0972-2327.128688","article-title":"Epileptogenic networks and drug-resistant epilepsy: present and future perspectives of epilepsy research-utility for the epileptologist and the epilepsy surgeon","volume":"17","author":"Banerjee","year":"2014","journal-title":"Ann Indian Acad Neurol"},{"key":"10.1124\/jpet.119.260968_bib5","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1007\/s11064-017-2227-7","article-title":"Validation of a preclinical drug screening platform for pharmacoresistant epilepsy","volume":"42","author":"Barker-Haliski","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1124\/jpet.119.260968_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0920-1211(01)00302-3","article-title":"Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy","volume":"47","author":"Barton","year":"2001","journal-title":"Epilepsy Res"},{"key":"10.1124\/jpet.119.260968_bib7","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1074\/jbc.M311371200","article-title":"On the benzodiazepine binding pocket in GABAA receptors","volume":"279","author":"Berezhnoy","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.119.260968_bib8","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1089\/neu.2011.1954","article-title":"Development of post-traumatic epilepsy after controlled cortical impact and lateral fluid-percussion-induced brain injury in the mouse","volume":"29","author":"Bolkvadze","year":"2012","journal-title":"J Neurotrauma"},{"key":"10.1124\/jpet.119.260968_bib9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0306-4522(98)00401-1","article-title":"Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy","volume":"89","author":"Bouilleret","year":"1999","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.119.260968_bib10","first-page":"220","article-title":"Sudden unexpected death in epilepsy: risk factors, biomarkers, and prevention","volume":"139","author":"DeGiorgio","year":"2019","journal-title":"Acta Neurol Scand"},{"key":"10.1124\/jpet.119.260968_bib12","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1074\/jbc.271.16.9209","article-title":"The major site of photoaffinity labeling of the \u03b3-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the \u03b1 subunit","volume":"271","author":"Duncalfe","year":"1996","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1124\/jpet.119.260968_bib78","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/cns.13046","article-title":"Pronounced antiepileptic activity of the subtype-selective GABAA -positive allosteric modulator PF-06372865 in the GAERS absence epilepsy model","volume":"25","author":"Duveau","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"10.1124\/jpet.119.260968_bib16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s13311-013-0243-0","article-title":"Effects of marketed antiepileptic drugs and placebo in the human photosensitivity screening protocol","volume":"11","author":"French","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1124\/jpet.119.260968_bib80","series-title":"Burger\u2019s Medicinal Chemistry, Drug Discovery, and Development","article-title":"Anticonvulsants","author":"Gitto","year":"2010"},{"key":"10.1124\/jpet.119.260968_bib18","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/epi.14680","article-title":"Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy","volume":"60","author":"Grabenstatter","year":"2019","journal-title":"Epilepsia"},{"issue":"15","key":"10.1124\/jpet.119.260968_bib79","doi-asserted-by":"crossref","first-page":"e1786","DOI":"10.1212\/WNL.0000000000007271","article-title":"Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator","volume":"92","author":"Gurrell","year":"2019","journal-title":"Neurology"},{"key":"10.1124\/jpet.119.260968_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.eplepsyres.2017.05.001","article-title":"Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models","volume":"134","author":"Hammond","year":"2017","journal-title":"Epilepsy Res"},{"key":"10.1124\/jpet.119.260968_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/jm990341r","article-title":"Pharmacophore\/receptor models for GABAA\/BzR subtypes (\u03b11\u03b23\u03b32, \u03b15\u03b23\u03b32, and \u03b16\u03b23\u03b32) via a comprehensive ligand-mapping approach","volume":"43","author":"Huang","year":"2000","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.119.260968_bib24","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1021\/jm980317y","volume":"41","author":"Huang","year":"1998","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.119.260968_bib25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3340\/jkns.2019.0031","article-title":"From resection to disconnection for seizure control in pediatric epilepsy children","volume":"62","author":"Hwang","year":"2019","journal-title":"J Korean Neurosurg Soc"},{"key":"10.1124\/jpet.119.260968_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0920-1211(96)00031-9","article-title":"Photosensitive epilepsy: a model to study the effects of antiepileptic drugs. Evaluation of the piracetam analogue, levetiracetam","volume":"25","author":"Kasteleijn-Nolst Trenit\u00e9","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1124\/jpet.119.260968_bib28","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1016\/j.celrep.2016.12.004","article-title":"Long-term optical access to an estimated one million neurons in the live mouse cortex","volume":"17","author":"Kim","year":"2016","journal-title":"Cell Rep"},{"key":"10.1124\/jpet.119.260968_bib29","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.eplepsyres.2014.02.013","article-title":"Low potency and limited efficacy of antiepileptic drugs in the mouse 6 Hz corneal kindling model","volume":"108","author":"Leclercq","year":"2014","journal-title":"Epilepsy Res"},{"issue":"20","key":"10.1124\/jpet.119.260968_bib81","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1055\/s-0037-1610211","article-title":"Improved Synthesis of Anxiolytic, Anticonvulsant, and Antinociceptive \u03b12\/\u03b13-GABA(A)-ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, and Neuropathic Pain","volume":"50","author":"Li","year":"2018","journal-title":"Synthesis"},{"key":"10.1124\/jpet.119.260968_bib30","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(07)60460-7","article-title":"The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet"},{"key":"10.1124\/jpet.119.260968_bib31","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41586-018-0832-5","article-title":"GABAA receptor signalling mechanisms revealed by structural pharmacology","volume":"565","author":"Masiulis","year":"2019","journal-title":"Nature"},{"key":"10.1124\/jpet.119.260968_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0920-1211(98)00016-3","article-title":"Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man","volume":"31","author":"Matagne","year":"1998","journal-title":"Epilepsy Res"},{"key":"10.1124\/jpet.119.260968_bib33","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/75761","article-title":"Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor \u03b11 subtype","volume":"3","author":"McKernan","year":"2000","journal-title":"Nat Neurosci"},{"key":"10.1124\/jpet.119.260968_bib34","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/epi4.12354","article-title":"Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine-resistant amygdala kindling model","volume":"4","author":"Metcalf","year":"2019","journal-title":"Epilepsia Open"},{"key":"10.1124\/jpet.119.260968_bib35","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/epi.13764","article-title":"Development and pharmacologic characterization of the rat 6 Hz model of partial seizures","volume":"58","author":"Metcalf","year":"2017","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.119.260968_bib37","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1021\/cb500186a","article-title":"Relative positioning of classical benzodiazepines to the \u03b32-subunit of GABAA receptors","volume":"9","author":"Middendorp","year":"2014","journal-title":"ACS Chem Biol"},{"key":"10.1124\/jpet.119.260968_bib38","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/FBP.0000000000000464","article-title":"Effects of the \u03b12\/\u03b13-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam","volume":"30","author":"Moerke","year":"2019","journal-title":"Behav Pharmacol"},{"issue":"4","key":"10.1124\/jpet.119.260968_bib82","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/bph.14119","article-title":"Pharmacology in translation: the preclinical and early clinical profile of the novel \u03b12\/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865","volume":"175","author":"Nickolls","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.119.260968_bib40","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem"},{"key":"10.1124\/jpet.119.260968_bib41","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1089\/neu.2013.3147","article-title":"PEG-PDLLA micelle treatment improves axonal function of the corpus callosum following traumatic brain injury","volume":"31","author":"Ping","year":"2014","journal-title":"J Neurotrauma"},{"key":"10.1124\/jpet.119.260968_bib42","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1089\/neu.2015.3913","article-title":"Transition from initial hypoactivity to hyperactivity in cortical layer V pyramidal neurons after traumatic brain injury in vivo","volume":"33","author":"Ping","year":"2016","journal-title":"J Neurotrauma"},{"key":"10.1124\/jpet.119.260968_bib43","doi-asserted-by":"crossref","first-page":"10800","DOI":"10.1021\/acs.jmedchem.6b01332","article-title":"Synthesis and characterization of a novel \u03b3-aminobutyric acid type A (GABAA) receptor ligand that combines outstanding metabolic stability, pharmacokinetics, and anxiolytic efficacy","volume":"59","author":"Poe","year":"2016","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.119.260968_bib44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1124\/jpet.119.260968_bib45","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1038\/ncomms7803","article-title":"Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype","volume":"6","author":"Ralvenius","year":"2015","journal-title":"Nat Commun"},{"key":"10.1124\/jpet.119.260968_bib47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0306-4522(02)00064-7","article-title":"Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy","volume":"112","author":"Riban","year":"2002","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.119.260968_bib48","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1021\/jm801652d","article-title":"Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models","volume":"52","author":"Rivas","year":"2009","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.119.260968_bib50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.eplepsyres.2010.09.002","article-title":"Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: correlation with other seizure and epilepsy models","volume":"92","author":"Rowley","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1124\/jpet.119.260968_bib51","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/44579","article-title":"Benzodiazepine actions mediated by specific \u03b3-aminobutyric acidA receptor subtypes","volume":"401","author":"Rudolph","year":"1999","journal-title":"Nature"},{"key":"10.1124\/jpet.119.260968_bib52","first-page":"717","article-title":"Descriptive epidemiology: prevalence, incidence, sociodemographic factors, socioeconomic domains, and quality of life of epilepsy: an update and systematic review","volume":"14","author":"Sadr","year":"2018","journal-title":"Arch Med Sci"},{"key":"10.1124\/jpet.119.260968_bib53","first-page":"57","article-title":"Python: a programming language for software integration and development","volume":"17","author":"Sanner","year":"1999","journal-title":"J Mol Graph Model"},{"key":"10.1124\/jpet.119.260968_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nbd.2018.07.018","article-title":"Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy","volume":"123","author":"Semple","year":"2019","journal-title":"Neurobiol Dis"},{"key":"10.1124\/jpet.119.260968_bib55","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(14)70076-6","article-title":"The challenge and promise of anti-epileptic therapy development in animal models","volume":"13","author":"Simonato","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1124\/jpet.119.260968_bib56","first-page":"3","article-title":"Definition of intractable epilepsy","volume":"16","author":"Sinha","year":"2011","journal-title":"Neurosciences (Riyadh)"},{"key":"10.1124\/jpet.119.260968_bib57","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/epi.12234","article-title":"Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy","volume":"54","author":"Srivastava","year":"2013","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.119.260968_bib60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1528-1167.2008.02005.x","article-title":"Preventing and treating posttraumatic seizures: the human experience","volume":"50","author":"Temkin","year":"2009","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.119.260968_bib61","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJM199008233230801","article-title":"A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures","volume":"323","author":"Temkin","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.119.260968_bib62","first-page":"CD009900","article-title":"Pharmacological treatments for preventing epilepsy following traumatic head injury","volume":"8","author":"Thompson","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1124\/jpet.119.260968_bib63","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"key":"10.1124\/jpet.119.260968_bib64","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.wneu.2018.11.076","article-title":"The effectiveness of antiepileptic medications as prophylaxis of early seizure in patients with traumatic brain injury compared with placebo or no treatment: a systematic review and meta-analysis","volume":"122","author":"Wat","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1124\/jpet.119.260968_bib65","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1111\/epi.14563","article-title":"Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs","volume":"59","author":"West","year":"2018","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.119.260968_bib67","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0074-7742(06)81006-8","article-title":"Mechanisms of action of antiepileptic drugs","volume":"81","author":"White","year":"2007","journal-title":"Int Rev Neurobiol"},{"key":"10.1124\/jpet.119.260968_bib68","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0021-9258(18)45961-3","article-title":"A single histidine in GABAA receptors is essential for benzodiazepine agonist binding","volume":"267","author":"Wieland","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.119.260968_bib69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/epi.12296","article-title":"Issues related to development of new antiseizure treatments","volume":"54","author":"Wilcox","year":"2013","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.119.260968_bib70","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pbb.2019.02.013","article-title":"The \u03b12,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats","volume":"180","author":"Witkin","year":"2019","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.119.260968_bib71","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pbb.2017.04.009","article-title":"Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for \u03b12\/3-containing GABAA receptors","volume":"157","author":"Witkin","year":"2017","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.119.260968_bib72","doi-asserted-by":"crossref","first-page":"146356","DOI":"10.1016\/j.brainres.2019.146356","article-title":"The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs: the example of CERC-611 and KRM-II-81","volume":"1722","author":"Witkin","year":"2019","journal-title":"Brain Res"},{"key":"10.1124\/jpet.119.260968_bib73","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuropharm.2018.05.006","article-title":"Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: improved bioavailability enhances anticonvulsant efficacy","volume":"137","author":"Witkin","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.119.260968_bib74","doi-asserted-by":"crossref","first-page":"12743","DOI":"10.1038\/s41598-017-12972-6","article-title":"Enhancing excitatory activity of somatosensory cortex alleviates neuropathic pain through regulating homeostatic plasticity","volume":"7","author":"Xiong","year":"2017","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.119.260968_bib75","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.seizure.2014.03.011","article-title":"How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy?","volume":"23","author":"Yuen","year":"2014","journal-title":"Seizure"},{"key":"10.1124\/jpet.119.260968_bib76","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0269881115620435","article-title":"NS11821, a partial subtype-selective GABAA agonist, elicits selective effects on the central nervous system in randomized controlled trial with healthy subjects","volume":"30","author":"Zuiker","year":"2016","journal-title":"J Psychopharmacol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524269512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524269512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.119.260968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T11:21:40Z","timestamp":1749813700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524269512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0022356524269512"],"URL":"https:\/\/doi.org\/10.1124\/jpet.119.260968","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Positive Allosteric Modulator of \u03b12\/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.119.260968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}