{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:32:49Z","timestamp":1768296769450,"version":"3.49.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1124\/jpet.119.264390","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T20:05:13Z","timestamp":1584043513000},"page":"248-260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of Motion Sickness"],"prefix":"10.1016","volume":"373","author":[{"given":"Li-Hua","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shui-Feng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Xia","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Hong","family":"Gui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Zhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.119.264390_bib1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neulet.2011.06.041","article-title":"Effect of daily linear acceleration training on the hypergravity-induced vomiting response in house musk shrew (Suncus murinus)","volume":"502","author":"Abe","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.119.264390_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0378-5955(01)00258-1","article-title":"Morphological and functional characteristics of cells cultured from the endolymphatic sac","volume":"157","author":"Agrup","year":"2001","journal-title":"Hear Res"},{"key":"10.1124\/jpet.119.264390_bib3","first-page":"127","article-title":"Vestibular projections to hypothalamic supraoptic and paraventricular nuclei","volume":"131","author":"Azzena","year":"1993","journal-title":"Arch Ital Biol"},{"key":"10.1124\/jpet.119.264390_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1023\/A:1023636620721","article-title":"Aquaporin-mediated fluid regulation in the inner ear","volume":"23","author":"Beitz","year":"2003","journal-title":"Cell Mol Neurobiol"},{"key":"10.1124\/jpet.119.264390_bib5","first-page":"2952","article-title":"Behavioral and electrophysiological studies of peptide-induced emesis in dogs","volume":"43","author":"Carpenter","year":"1984","journal-title":"Fed Proc"},{"key":"10.1124\/jpet.119.264390_bib6","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/j.1552-4604.1994.tb02021.x","article-title":"Etiologic significance of arginine vasopressin in motion sickness","volume":"34","author":"Cheung","year":"1994","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/jpet.119.264390_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/j.1552-4604.1992.tb03822.x","article-title":"Investigation of anti-motion sickness drugs in the squirrel monkey","volume":"32","author":"Cheung","year":"1992","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/jpet.119.264390_bib8","first-page":"462","article-title":"A stimulator for laboratory studies of motion sickness in cats","volume":"56","author":"Crampton","year":"1985","journal-title":"Aviat Space Environ Med"},{"key":"10.1124\/jpet.119.264390_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00319118","article-title":"The endolymphatic duct and sac of the rat: a histological, ultrastructural, and immunocytochemical investigation","volume":"282","author":"Dahlmann","year":"1995","journal-title":"Cell Tissue Res"},{"key":"10.1124\/jpet.119.264390_bib10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.mam.2012.06.004","article-title":"Water channel proteins in the inner ear and their link to hearing impairment and deafness","volume":"33","author":"Eckhard","year":"2012","journal-title":"Mol Aspects Med"},{"key":"10.1124\/jpet.119.264390_bib11","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/labinvest.2013.91","article-title":"Morphological and functional changes in a new animal model of M\u00e9ni\u00e8re\u2019s disease","volume":"93","author":"Egami","year":"2013","journal-title":"Lab Invest"},{"key":"10.1124\/jpet.119.264390_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.heares.2015.12.017","article-title":"Dehydration effects of a V2 antagonist on endolymphatic hydrops in Guinea pigs","volume":"332","author":"Egami","year":"2016","journal-title":"Hear Res"},{"key":"10.1124\/jpet.119.264390_bib13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.mehy.2009.04.031","article-title":"Motion sickness may be caused by a neurohumoral action of acetylcholine","volume":"73","author":"Eisenman","year":"2009","journal-title":"Med Hypotheses"},{"key":"10.1124\/jpet.119.264390_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0163-1047(88)90954-5","article-title":"Conditioned taste aversion induced by motion is prevented by selective vagotomy in the rat","volume":"50","author":"Fox","year":"1988","journal-title":"Behav Neural Biol"},{"key":"10.1124\/jpet.119.264390_bib15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3940(99)00209-8","article-title":"Functional blockade of the parabrachial area by tetrodotoxin disrupts the acquisition of conditioned taste aversion induced by motion-sickness in rats","volume":"265","author":"Gallo","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.119.264390_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.heares.2006.08.016","article-title":"Effects of vasopressin on gene expression in rat inner ear","volume":"222","author":"Gu","year":"2006","journal-title":"Hear Res"},{"key":"10.1124\/jpet.119.264390_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.autneu.2006.07.014","article-title":"Space motion sickness: incidence, etiology, and countermeasures","volume":"129","author":"Heer","year":"2006","journal-title":"Auton Neurosci"},{"key":"10.1124\/jpet.119.264390_bib18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/01.NAJ.0000391242.75887.17","article-title":"The ups and downs of motion sickness","volume":"110","author":"Herron","year":"2010","journal-title":"Am J Nurs"},{"key":"10.1124\/jpet.119.264390_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0006-8993(01)02799-8","article-title":"Vestibular modulation of plasma vasopressin levels in rats","volume":"914","author":"Horii","year":"2001","journal-title":"Brain Res"},{"key":"10.1124\/jpet.119.264390_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1037\/0735-7044.101.3.427","article-title":"Intratympanic injection of sodium arsanilate (atoxyl) solution results in postural changes consistent with changes described for labyrinthectomized rats","volume":"101","author":"Hunt","year":"1987","journal-title":"Behav Neurosci"},{"key":"10.1124\/jpet.119.264390_bib21","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1254\/jjp.89.324","article-title":"Vasopressin induces emesis in Suncus murinus","volume":"89","author":"Ikegaya","year":"2002","journal-title":"Jpn J Pharmacol"},{"key":"10.1124\/jpet.119.264390_bib22","doi-asserted-by":"crossref","first-page":"F931","DOI":"10.1152\/ajprenal.00604.2013","article-title":"The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors","volume":"306","author":"Juul","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/jpet.119.264390_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.anl.2008.04.012","article-title":"Expression of aquaporin1, 3, and 4, NKCC1, and NKCC2 in the human endolymphatic sac","volume":"36","author":"Kakigi","year":"2009","journal-title":"Auris Nasus Larynx"},{"key":"10.1124\/jpet.119.264390_bib24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1083\/jcb.151.4.919","article-title":"The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers","volume":"151","author":"Kamsteeg","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1124\/jpet.119.264390_bib25","first-page":"G853","article-title":"Role of plasma vasopressin as a mediator of nausea and gastric slow wave dysrhythmias in motion sickness","volume":"272","author":"Kim","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.119.264390_bib26","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/00001756-199904260-00009","article-title":"Regulation of inner ear fluid in the rat by vasopressin","volume":"10","author":"Kitano","year":"1999","journal-title":"Neuroreport"},{"key":"10.1124\/jpet.119.264390_bib27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0891-5520(05)70007-6","article-title":"Prevention of common travel ailments","volume":"12","author":"Kozarsky","year":"1998","journal-title":"Infect Dis Clin North Am"},{"key":"10.1124\/jpet.119.264390_bib28","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s004240050731","article-title":"The effect of anti-diuretic hormone on the endolymphatic sac of the inner ear","volume":"436","author":"Kumagami","year":"1998","journal-title":"Pflugers Arch"},{"key":"10.1124\/jpet.119.264390_bib29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000180290","article-title":"Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac","volume":"14","author":"Kumagami","year":"2009","journal-title":"Audiol Neurotol"},{"key":"10.1124\/jpet.119.264390_bib30","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000088991","article-title":"Plasma vasopressin, an etiologic factor of motion sickness in rat and human?","volume":"81","author":"Li","year":"2005","journal-title":"Neuroendocrinology"},{"key":"10.1124\/jpet.119.264390_bib31","doi-asserted-by":"crossref","first-page":"G481","DOI":"10.1152\/ajpgi.00164.2002","article-title":"Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection","volume":"284","author":"Lien","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.119.264390_bib32","doi-asserted-by":"crossref","first-page":"e5767","DOI":"10.1097\/MD.0000000000005767","article-title":"Intratympanic steroids injection is effective for the treatment of drop attacks with M\u00e9ni\u00e8re\u2019s disease and delayed endolymphatic hydrops: a retrospective study","volume":"95","author":"Liu","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1124\/jpet.119.264390_bib33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF01526188","article-title":"Neuronal responses to vestibular stimulation in the Guinea pig hypothalamic paraventricular nucleus","volume":"254","author":"Liu","year":"1997","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1124\/jpet.119.264390_bib34","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1023\/B:DDAS.0000030080.60168.01","article-title":"Effects of intestinal electrical stimulation on intestinal dysrhythmia and symptoms in dogs","volume":"49","author":"Liu","year":"2004","journal-title":"Dig Dis Sci"},{"key":"10.1124\/jpet.119.264390_bib35","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1365-2826.2010.02060.x","article-title":"Expression and translocation of aquaporin-2 in the endolymphatic sac in patients with Meniere\u2019s disease","volume":"22","author":"Maekawa","year":"2010","journal-title":"J Neuroendocrinol"},{"key":"10.1124\/jpet.119.264390_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00429-008-0172-6","article-title":"Projections from the vestibular nuclei to the hypothalamic paraventricular nucleus: morphological evidence for the existence of a vestibular stress pathway in the rat brain","volume":"213","author":"Markia","year":"2008","journal-title":"Brain Struct Funct"},{"key":"10.1124\/jpet.119.264390_bib37","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1681\/ASN.V86861","article-title":"Transcriptional regulation of aquaporin-2 water channel gene by cAMP","volume":"8","author":"Matsumura","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.119.264390_bib38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0378-5955(02)00452-5","article-title":"Aquaporin-2 expression in the mammalian cochlea and investigation of its role in Meniere\u2019s disease","volume":"170","author":"Mhatre","year":"2002","journal-title":"Hear Res"},{"key":"10.1124\/jpet.119.264390_bib39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00424-012-1129-4","article-title":"Cell biology of vasopressin-regulated aquaporin-2 trafficking","volume":"464","author":"Moeller","year":"2012","journal-title":"Pflugers Arch"},{"key":"10.1124\/jpet.119.264390_bib40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0378-5955(01)00219-2","article-title":"Endolymphatic hydrops induced by chronic administration of vasopressin","volume":"155","author":"Naftalin","year":"2001","journal-title":"Hear Res"},{"key":"10.1124\/jpet.119.264390_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/physrev.00024.2001","article-title":"Aquaporins in the kidney: from molecules to medicine","volume":"82","author":"Nielsen","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.119.264390_bib42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/00016480802419115","article-title":"Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist","volume":"129","author":"Nishimura","year":"2009","journal-title":"Acta Otolaryngol"},{"key":"10.1124\/jpet.119.264390_bib43","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1080\/00016480802441754","article-title":"Expression of aquaporins, vasopressin type 2 receptor, and Na+\u2212K+\u2212Cl\u2212 cotransporters in the rat endolymphatic sac","volume":"129","author":"Nishimura","year":"2009","journal-title":"Acta Otolaryngol"},{"key":"10.1124\/jpet.119.264390_bib44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.heares.2009.09.011","article-title":"Expression of aquaporins and vasopressin type 2 receptor in the stria vascularis of the cochlea","volume":"260","author":"Nishioka","year":"2010","journal-title":"Hear Res"},{"key":"10.1124\/jpet.119.264390_bib45","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0163-1047(83)90414-4","article-title":"Area postrema lesions in rats enhance the magnitude of body rotation-induced conditioned taste aversions","volume":"38","author":"Ossenkopp","year":"1983","journal-title":"Behav Neural Biol"},{"key":"10.1124\/jpet.119.264390_bib46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2215\/CJN.05760513","article-title":"Collecting duct principal cell transport processes and their regulation","volume":"10","author":"Pearce","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1124\/jpet.119.264390_bib47","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1046\/j.1523-1755.2001.00965.x","article-title":"Role of aquaporin-2 gene expression in hyponatremic rats with chronic vasopressin-induced antidiuresis","volume":"60","author":"Saito","year":"2001","journal-title":"Kidney Int"},{"key":"10.1124\/jpet.119.264390_bib48","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/00001756-200207020-00011","article-title":"Aquaporin-2 regulation by vasopressin in the rat inner ear","volume":"13","author":"Sawada","year":"2002","journal-title":"Neuroreport"},{"key":"10.1124\/jpet.119.264390_bib49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0163-1047(88)90841-2","article-title":"Role of the area postrema in three putative measures of motion sickness in the rat","volume":"50","author":"Sutton","year":"1988","journal-title":"Behav Neural Biol"},{"key":"10.1124\/jpet.119.264390_bib50","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/mlg.0b013e318031c802","article-title":"Expressions of aquaporin-2, vasopressin type 2 receptor, transient receptor potential channel vanilloid (TRPV)1, and TRPV4 in the human endolymphatic sac","volume":"117","author":"Taguchi","year":"2007","journal-title":"Laryngoscope"},{"key":"10.1124\/jpet.119.264390_bib51","first-page":"483","article-title":"Motion sickness","volume":"57","author":"Taillemite","year":"1997","journal-title":"Med Trop (Mars)"},{"key":"10.1124\/jpet.119.264390_bib52","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/00016489509121909","article-title":"Antidiuretic hormone (ADH) and endolymphatic hydrops","volume":"519","author":"Takeda","year":"1995","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1124\/jpet.119.264390_bib53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-5955(03)00135-7","article-title":"The effects of V2 antagonist (OPC-31260) on endolymphatic hydrops","volume":"182","author":"Takeda","year":"2003","journal-title":"Hear Res"},{"key":"10.1124\/jpet.119.264390_bib54","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.heares.2006.05.001","article-title":"A comparison of dehydration effects of V2-antagonist (OPC-31260) on the inner ear between systemic and round window applications","volume":"218","author":"Takeda","year":"2006","journal-title":"Hear Res"},{"key":"10.1124\/jpet.119.264390_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000265113","article-title":"Hormonal aspects of M\u00e9ni\u00e8re\u2019s disease on the basis of clinical and experimental studies","volume":"71","author":"Takeda","year":"2010","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1124\/jpet.119.264390_bib56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/00016480510038563","article-title":"Protective effect of edaravone against the ototoxicity of Pseudomonas aeruginosa exotoxin A","volume":"126","author":"Takumida","year":"2006","journal-title":"Acta Otolaryngol"},{"key":"10.1124\/jpet.119.264390_bib57","first-page":"807","article-title":"Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear","volume":"132","author":"Takumida","year":"2012","journal-title":"Acta Otolaryngol"},{"key":"10.1124\/jpet.119.264390_bib58","doi-asserted-by":"crossref","first-page":"R401","DOI":"10.1152\/ajpregu.00344.2004","article-title":"Effects of acupuncture on vasopressin-induced emesis in conscious dogs","volume":"288","author":"Tatewaki","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1124\/jpet.119.264390_bib59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1677\/jme.0.0200281","article-title":"Influence of acute elevation of plasma AVP level on rat vasopressin V2 receptor and aquaporin-2 mRNA expression","volume":"20","author":"Terashima","year":"1998","journal-title":"J Mol Endocrinol"},{"key":"10.1124\/jpet.119.264390_bib60","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.neuroscience.2009.02.070","article-title":"Stress axis plasticity during vestibular compensation in the adult cat","volume":"160","author":"Tighilet","year":"2009","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.119.264390_bib61","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0361-9230(98)00090-2","article-title":"Evaluating sensory conflict and postural instability. Theories of motion sickness","volume":"47","author":"Warwick-Evans","year":"1998","journal-title":"Brain Res Bull"},{"key":"10.1124\/jpet.119.264390_bib62","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10157-013-0789-5","article-title":"Vasopressin and the regulation of aquaporin-2","volume":"17","author":"Wilson","year":"2013","journal-title":"Clin Exp Nephrol"},{"key":"10.1124\/jpet.119.264390_bib63","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13041-015-0175-1","article-title":"AVP modulation of the vestibular nucleus via V1b receptors potentially contributes to the development of motion sickness in rat","volume":"8","author":"Xu","year":"2015","journal-title":"Mol Brain"},{"key":"10.1124\/jpet.119.264390_bib64","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1073\/pnas.0813002106","article-title":"Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct","volume":"106","author":"Yu","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.119.264390_bib65","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/0003489415597916","article-title":"Calcium metabolism profile in rat inner ear indicated by MRI after tympanic medial wall administration of manganese chloride","volume":"125","author":"Zou","year":"2016","journal-title":"Ann Otol Rhinol Laryngol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524258742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524258742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.119.264390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:56:21Z","timestamp":1739973381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524258742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0022356524258742"],"URL":"https:\/\/doi.org\/10.1124\/jpet.119.264390","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of Motion Sickness","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.119.264390","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}