{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:10:00Z","timestamp":1785150600184,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":1218,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1124\/jpet.121.000491","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T16:00:38Z","timestamp":1625241638000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Small-Molecule Integrated Stress Response Inhibitor Reduces Susceptibility to Postinfarct Atrial Fibrillation in Rats via the Inhibition of Integrated Stress Responses"],"prefix":"10.1016","volume":"378","author":[{"given":"Ting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LV","family":"Kun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengwei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.121.000491_bib1","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1161\/CIRCRESAHA.114.303211","article-title":"The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms","volume":"114","author":"Andrade","year":"2014","journal-title":"Circ Res"},{"key":"10.1124\/jpet.121.000491_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2174\/0929867324666170718130408","article-title":"Redox state in atrial fibrillation pathogenesis and relevant therapeutic approaches","volume":"26","author":"Antonopoulos","year":"2019","journal-title":"Curr Med Chem"},{"key":"10.1124\/jpet.121.000491_bib3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/j.pain.0000000000001387","article-title":"Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain","volume":"160","author":"Barrag\u00e1n-Iglesias","year":"2019","journal-title":"Pain"},{"key":"10.1124\/jpet.121.000491_bib4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0735-1097(02)02922-4","article-title":"Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces I(Ca,L) and I(to) in rapid atrial pacing in rabbits","volume":"41","author":"Bosch","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.121.000491_bib5","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/01.CIR.103.5.684","article-title":"Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation","volume":"103","author":"Brundel","year":"2001","journal-title":"Circulation"},{"key":"10.1124\/jpet.121.000491_bib6","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0735-1097(00)01195-5","article-title":"Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels","volume":"37","author":"Brundel","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.121.000491_bib7","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.amjcard.2008.05.038","article-title":"Increased inflammatory cell infiltration in the atrial myocardium of patients with atrial fibrillation","volume":"102","author":"Chen","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1124\/jpet.121.000491_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2362.2010.02410.x","article-title":"Autophagy as a mechanism for myolysis of cardiomyocytes in mitral regurgitation","volume":"41","author":"Chen","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"10.1124\/jpet.121.000491_bib9","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1096\/fj.201802455RRR","article-title":"Mutation in NPPA causes atrial fibrillation by activating inflammation and cardiac fibrosis in a knock-in rat model","volume":"33","author":"Cheng","year":"2019","journal-title":"FASEB J"},{"key":"10.1124\/jpet.121.000491_bib10","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.hrthm.2015.01.044","article-title":"Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K\/AKT\/eNOS signaling pathway activation","volume":"12","author":"Chong","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1124\/jpet.121.000491_bib11","doi-asserted-by":"crossref","first-page":"E6420","DOI":"10.1073\/pnas.1707661114","article-title":"Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury","volume":"114","author":"Chou","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.121.000491_bib12","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.jacc.2012.07.031","article-title":"Colchicine for prevention of early atrial fibrillation recurrence after pulmonary vein isolation: a randomized controlled study","volume":"60","author":"Deftereos","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.121.000491_bib13","doi-asserted-by":"crossref","first-page":"3694362","DOI":"10.1155\/2018\/3694362","article-title":"The transcription factor ATF4 promotes expression of cell stress genes and cardiomyocyte death in a cellular model of atrial fibrillation","volume":"2018","author":"Freundt","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1124\/jpet.121.000491_bib15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1378\/chest.14-0321","article-title":"Prevalence, incidence, and lifetime risk of atrial fibrillation in China: new insights into the global burden of atrial fibrillation","volume":"147","author":"Guo","year":"2015","journal-title":"Chest"},{"key":"10.1124\/jpet.121.000491_bib16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/cvr\/cvv275","article-title":"The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis","volume":"109","author":"Heijman","year":"2016","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.121.000491_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/JAHA.117.006717","article-title":"Concomitant obesity and metabolic syndrome add to the atrial arrhythmogenic phenotype in male hypertensive rats","volume":"6","author":"Hohl","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1124\/jpet.121.000491_bib18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrcardio.2015.2","article-title":"Inflammation and the pathogenesis of atrial fibrillation","volume":"12","author":"Hu","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1124\/jpet.121.000491_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.aaw2922","article-title":"eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response","volume":"364","author":"Kenner","year":"2019","journal-title":"Science"},{"key":"10.1124\/jpet.121.000491_bib20","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1093\/eurheartj\/eht280","article-title":"Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060","volume":"34","author":"Krijthe","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1124\/jpet.121.000491_bib21","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol Cell"},{"key":"10.1124\/jpet.121.000491_bib22","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/CIRCEP.114.001752","article-title":"Atrial fibrosis and conduction slowing in the left atrial appendage of patients undergoing thoracoscopic surgical pulmonary vein isolation for atrial fibrillation","volume":"8","author":"Krul","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1124\/jpet.121.000491_bib23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yjmcc.2019.01.012","article-title":"Inhibition of soluble TNF\u03b1 prevents adverse atrial remodeling and atrial arrhythmia susceptibility induced in mice by endurance exercise","volume":"129","author":"Lakin","year":"2019","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.121.000491_bib24","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/hc4601.099402","article-title":"Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure","volume":"104","author":"Li","year":"2001","journal-title":"Circulation"},{"key":"10.1124\/jpet.121.000491_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/1747493019897870","article-title":"Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge","volume":"16","author":"Lippi","year":"2020","journal-title":"Int J Stroke"},{"key":"10.1124\/jpet.121.000491_bib26","doi-asserted-by":"crossref","first-page":"e013133","DOI":"10.1161\/JAHA.119.013133","article-title":"CTRP9 ameliorates atrial inflammation, fibrosis, and vulnerability to atrial fibrillation in post-myocardial infarction rats","volume":"8","author":"Liu","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1124\/jpet.121.000491_bib27","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/s41467-020-15067-5","article-title":"Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy","volume":"11","author":"Mahameed","year":"2020","journal-title":"Nat Commun"},{"key":"10.1124\/jpet.121.000491_bib28","doi-asserted-by":"crossref","first-page":"18545","DOI":"10.1038\/s41598-019-53867-y","article-title":"Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling","volume":"9","author":"Martin","year":"2019","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.121.000491_bib29","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1161\/CIRCULATIONAHA.113.004742","article-title":"Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation","volume":"129","author":"Martins","year":"2014","journal-title":"Circulation"},{"key":"10.1124\/jpet.121.000491_bib30","doi-asserted-by":"crossref","first-page":"e008296","DOI":"10.1161\/CIRCEP.120.008296","article-title":"Ion channel and structural remodeling in obesity-mediated atrial fibrillation","volume":"13","author":"McCauley","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1124\/jpet.121.000491_bib31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00395-017-0635-0","article-title":"Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation","volume":"112","author":"Meyer-Roxlau","year":"2017","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.121.000491_bib32","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jacc.2012.11.014","article-title":"Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction","volume":"61","author":"Nakatani","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.121.000491_bib33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jacep.2017.03.002","article-title":"Molecular and cellular mechanisms of atrial fibrosis in atrial fibrillation","volume":"3","author":"Nattel","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1124\/jpet.121.000491_bib34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/CIRCRESAHA.120.316363","article-title":"Molecular basis of atrial fibrillation pathophysiology and therapy: A translational perspective","volume":"127","author":"Nattel","year":"2020","journal-title":"Circ Res"},{"key":"10.1124\/jpet.121.000491_bib35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/physrev.00014.2006","article-title":"Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation","volume":"87","author":"Nattel","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.121.000491_bib36","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jacc.2018.12.055","article-title":"Intercepting the lipid-induced integrated stress response reduces atherosclerosis","volume":"73","author":"Onat","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.121.000491_bib37","doi-asserted-by":"crossref","first-page":"e015343","DOI":"10.1161\/JAHA.119.015343","article-title":"Characterization, pathogenesis, and clinical implications of inflammation-related atrial myopathy as an important cause of atrial fibrillation","volume":"9","author":"Packer","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1124\/jpet.121.000491_bib38","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response","volume":"17","author":"Pakos-Zebrucka","year":"2016","journal-title":"EMBO Rep"},{"key":"10.1124\/jpet.121.000491_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cellsig.2019.03.008","article-title":"Activation of PERK-eIF2\u03b1-ATF4 pathway contributes to diabetic hepatotoxicity: attenuation of ER stress by morin","volume":"59","author":"Pandey","year":"2019","journal-title":"Cell Signal"},{"key":"10.1124\/jpet.121.000491_bib40","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/CIRCRESAHA.113.301646","article-title":"Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts","volume":"113","author":"Parikh","year":"2013","journal-title":"Circ Res"},{"key":"10.1124\/jpet.121.000491_bib41","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1073\/pnas.1815767116","article-title":"Small molecule ISRIB suppresses the integrated stress response within a defined window of activation","volume":"116","author":"Rabouw","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.121.000491_bib42","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.drudis.2018.02.008","article-title":"The integrated stress response system in cardiovascular disease","volume":"23","author":"Santos-Ribeiro","year":"2018","journal-title":"Drug Discov Today"},{"key":"10.1124\/jpet.121.000491_bib43","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1126\/science.aaa6986","article-title":"Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound","volume":"348","author":"Sekine","year":"2015","journal-title":"Science"},{"key":"10.1124\/jpet.121.000491_bib44","doi-asserted-by":"crossref","first-page":"e0224713","DOI":"10.1371\/journal.pone.0224713","article-title":"Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation","volume":"15","author":"Shingu","year":"2020","journal-title":"PLoS One"},{"key":"10.1124\/jpet.121.000491_bib45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.7554\/eLife.05033","article-title":"The small molecule ISRIB reverses the effects of eIF2\u03b1 phosphorylation on translation and stress granule assembly","volume":"4","author":"Sidrauski","year":"2015","journal-title":"eLife"},{"key":"10.1124\/jpet.121.000491_bib46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0002-9343(02)01236-6","article-title":"A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew\/Paisley study","volume":"113","author":"Stewart","year":"2002","journal-title":"Am J Med"},{"key":"10.1124\/jpet.121.000491_bib47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00395-016-0584-z","article-title":"Cross-talk between macrophages and atrial myocytes in atrial fibrillation","volume":"111","author":"Sun","year":"2016","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.121.000491_bib48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.aaq0939","article-title":"Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule","volume":"359","author":"Tsai","year":"2018","journal-title":"Science"},{"key":"10.1124\/jpet.121.000491_bib49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.biopha.2018.10.156","article-title":"Focal selective chemo-ablation of spinal cardiac afferent nerve by resiniferatoxin protects the heart from pressure overload-induced hypertrophy","volume":"109","author":"Wang","year":"2019","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1124\/jpet.121.000491_bib50","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ijcard.2010.07.025","article-title":"Mesenchymal stem cell injection ameliorates the inducibility of ventricular arrhythmias after myocardial infarction in rats","volume":"152","author":"Wang","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1124\/jpet.121.000491_bib51","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.biopha.2016.09.054","article-title":"Effects of relaxin on cardiac fibrosis, apoptosis, and tachyarrhythmia in rats with myocardial infarction","volume":"84","author":"Wang","year":"2016","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1124\/jpet.121.000491_bib52","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1113\/JP273764","article-title":"Cardiac sympathetic afferent reflex control of cardiac function in normal and chronic heart failure states","volume":"595","author":"Wang","year":"2017","journal-title":"J Physiol"},{"key":"10.1124\/jpet.121.000491_bib53","doi-asserted-by":"crossref","first-page":"e013416","DOI":"10.1161\/JAHA.119.013416","article-title":"Atrial tissue pro-fibrotic M2 macrophage marker CD163+, gene expression of procollagen and B-type natriuretic peptide","volume":"9","author":"Watson","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1124\/jpet.121.000491_bib54","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/JAHA.117.006458","article-title":"Endoplasmic reticulum stress is associated with autophagy and cardiomyocyte remodeling in experimental and human atrial fibrillation","volume":"6","author":"Wiersma","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1124\/jpet.121.000491_bib55","doi-asserted-by":"crossref","first-page":"172836","DOI":"10.1016\/j.ejphar.2019.172836","article-title":"Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats","volume":"867","author":"Wu","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.000491_bib56","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/s41419-018-0860-y","article-title":"Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel","volume":"9","author":"Yuan","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1124\/jpet.121.000491_bib57","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/CIRCULATIONAHA.113.005300","article-title":"Activation of histone deacetylase-6 induces contractile dysfunction through derailment of \u03b1-tubulin proteostasis in experimental and human atrial fibrillation","volume":"129","author":"Zhang","year":"2014","journal-title":"Circulation"},{"key":"10.1124\/jpet.121.000491_bib58","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fcvm.2020.00062","article-title":"Evidence for inflammation as a driver of atrial fibrillation","volume":"7","author":"Zhou","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"10.1124\/jpet.121.000491_bib59","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2015.02.026","article-title":"Doxycycline ameliorates aggregation of collagen and atrial natriuretic peptide in murine post-infarction heart","volume":"754","author":"Zhu","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.000491_bib61","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1126\/science.aar5129","article-title":"Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B","volume":"359","author":"Zyryanova","year":"2018","journal-title":"Science"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524257050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524257050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.121.000491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:53:05Z","timestamp":1739973185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524257050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0022356524257050"],"URL":"https:\/\/doi.org\/10.1124\/jpet.121.000491","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small-Molecule Integrated Stress Response Inhibitor Reduces Susceptibility to Postinfarct Atrial Fibrillation in Rats via the Inhibition of Integrated Stress Responses","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.121.000491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The Author(s)","name":"copyright","label":"Copyright"}]}}