{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:58:13Z","timestamp":1756310293124,"version":"3.37.3"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1124\/jpet.121.000524","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T20:21:35Z","timestamp":1624911695000},"page":"287-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice"],"prefix":"10.1016","volume":"378","author":[{"given":"Todd M","family":"Hillhouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith M","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E","family":"Hallahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren G","family":"Rysztak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan F","family":"Sears","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Meurice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrnoosh","family":"Ostovar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyton O","family":"Koppenhaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua L","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily M","family":"Jutkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M","family":"Husbands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R","family":"Traynor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.121.000524_bib1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1177\/0269881115586937","article-title":"Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice","volume":"29","author":"Almatroudi","year":"2018","journal-title":"J Psychopharmacol"},{"key":"10.1124\/jpet.121.000524_bib2","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1111\/bph.14060","article-title":"Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed \u03ba\/\u03bc receptor antagonist properties, in mice","volume":"175","author":"Almatroudi","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.121.000524_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13321-019-0362-7","article-title":"DockRMSD: an open-source tool for atom mapping and RMSD calculation of symmetric molecules through graph isomorphism","volume":"11","author":"Bell","year":"2019","journal-title":"J Cheminform"},{"key":"10.1124\/jpet.121.000524_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00213-004-2138-6","article-title":"Influence of the dose and the number of drug-context pairings on the magnitude and the long-lasting retention of cocaine-induced conditioned place preference in C57BL\/6J mice","volume":"180","author":"Brabant","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.121.000524_bib4a","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0306-4522(02)00927-2","article-title":"Autoradiographic localization of 125i[tyr14] nociceptin\/orphanin fq binding sites in macaque primate cns","volume":"118","author":"Bridge","year":"2003","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.121.000524_bib6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1124\/jpet.102.036525","article-title":"Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice","volume":"303","author":"Broom","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.121.000524_bib7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2007.05.007","article-title":"Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn","volume":"569","author":"Carey","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.000524_bib8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.pharmthera.2009.05.008","article-title":"Kappa-opioid ligands in the study and treatment of mood disorders","volume":"123","author":"Carlezon","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.121.000524_bib9","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/da.22500","article-title":"Kappa-opioid antagonists for psychiatric disorders: from bench to clinical trials","volume":"33","author":"Carlezon","year":"2016","journal-title":"Depress Anxiety"},{"key":"10.1124\/jpet.121.000524_bib10","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1021\/jm301783x","article-title":"Development of \u03ba opioid receptor antagonists","volume":"56","author":"Carroll","year":"2013","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.121.000524_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tips.2004.03.011","article-title":"Sex and estrogen influence drug abuse","volume":"25","author":"Carroll","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.121.000524_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/npp.2010.137","article-title":"The therapeutic potential of \u03ba-opioids for treatment of pain and addiction","volume":"36","author":"Chavkin","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.121.000524_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cell.2017.12.011","article-title":"Structure of the nanobody-stabilized active state of the kappa opioid receptor","volume":"172","author":"Che","year":"2018","journal-title":"Cell"},{"key":"10.1124\/jpet.121.000524_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/164_2019_209","article-title":"NOP-related mechanisms in substance use disorders","volume":"254","author":"Ciccocioppo","year":"2019","journal-title":"Handb Exp Pharmacol"},{"key":"10.1124\/jpet.121.000524_bib15","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/S0022-3565(25)39443-7","article-title":"Effects of buprenorphine and naltrexone on reinstatement of cocaine-reinforced responding in rats","volume":"267","author":"Comer","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.121.000524_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/adb.12020","article-title":"A non-rewarding, non-aversive buprenorphine\/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm","volume":"19","author":"Cordery","year":"2014","journal-title":"Addict Biol"},{"key":"10.1124\/jpet.121.000524_bib17","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1021\/acs.jmedchem.5b00130","article-title":"C7\u03b2-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin\/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors","volume":"58","author":"Cueva","year":"2015","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.121.000524_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00213-016-4432-5","article-title":"The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors","volume":"234","author":"Dripps","year":"2017","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.121.000524_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00213-011-2187-6","article-title":"Enhancement of cue-induced reinstatement of cocaine-seeking in rats by yohimbine: sex differences and the role of the estrous cycle","volume":"216","author":"Feltenstein","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.121.000524_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature12944","article-title":"Molecular control of \u03b4-opioid receptor signalling","volume":"506","author":"Fenalti","year":"2014","journal-title":"Nature"},{"key":"10.1124\/jpet.121.000524_bib23","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1177\/0269881106060835","article-title":"Naltrexone and buprenorphine combination in the treatment of opioid dependence","volume":"20","author":"Gerra","year":"2006","journal-title":"J Psychopharmacol"},{"key":"10.1124\/jpet.121.000524_bib24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature11111","article-title":"Structure of the \u03b4-opioid receptor bound to naltrindole","volume":"485","author":"Granier","year":"2012","journal-title":"Nature"},{"key":"10.1124\/jpet.121.000524_bib26","series-title":"NCHS Data Brief, no 329","article-title":"Drug overdose deaths in the United States, 1999\u20132017","author":"Hedegaard","year":"2018"},{"key":"10.1124\/jpet.121.000524_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/WNR.0000000000000053","article-title":"Sex differences in cocaine conditioned place preference in C57BL\/6J mice","volume":"25","author":"Hilderbrand","year":"2014","journal-title":"Neuroreport"},{"key":"10.1124\/jpet.121.000524_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature14886","article-title":"Structural insights into \u00b5-opioid receptor activation","volume":"524","author":"Huang","year":"2015","journal-title":"Nature"},{"key":"10.1124\/jpet.121.000524_bib29","series-title":"Buprenorphine and related orvinols","first-page":"127","author":"Husbands","year":"2013"},{"key":"10.1124\/jpet.121.000524_bib30","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1038\/npp.2015.148","article-title":"A cannabinoid CB1 receptor-positive allosteric modulator reduces neuropathic pain in the mouse with no psychoactive effects","volume":"40","author":"Ignatowska-Jankowska","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.121.000524_bib31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00213-012-2716-y","article-title":"Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice","volume":"226","author":"Jackson","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.121.000524_bib32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.drugalcdep.2011.07.019","article-title":"Diversion and abuse of buprenorphine: findings from national surveys of treatment patients and physicians","volume":"120","author":"Johanson","year":"2012","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.121.000524_bib34","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/adb.12513","article-title":"Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption","volume":"23","author":"Kallupi","year":"2018","journal-title":"Addict Biol"},{"key":"10.1124\/jpet.121.000524_bib35","series-title":"Techniques for more effective and strategic drug discovery","article-title":"A Pharmacology Primer 5th edition","author":"Kenakin","year":"2018"},{"key":"10.1124\/jpet.121.000524_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00008877-200205000-00006","article-title":"Orphanin FQ\/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference","volume":"13","author":"Kotli\u0144ska","year":"2002","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.121.000524_bib36a","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nrd2572","article-title":"The nociceptin\/orphanin FQ receptor: a target with broad therapeutic potential","volume":"7","author":"Lambert","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/jpet.121.000524_bib38","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1523\/JNEUROSCI.5470-12.2013","article-title":"Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive G\u03b1o protein","volume":"33","author":"Lamberts","year":"2013","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.121.000524_bib39","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/add.13375","article-title":"Buprenorphine + naloxone plus naltrexone for the treatment of cocaine dependence: the Cocaine Use Reduction with Buprenorphine (CURB) study","volume":"111","author":"Ling","year":"2016","journal-title":"Addiction"},{"key":"10.1124\/jpet.121.000524_bib39a","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/1570159043359477","article-title":"Buprenorphine: a unique drug with complex pharmacology","volume":"2","author":"Lutfy","year":"2004","journal-title":"Curr Neuropharmacol"},{"key":"10.1124\/jpet.121.000524_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002130000609","article-title":"Orphanin FQ\/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats","volume":"154","author":"Lutfy","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.121.000524_bib41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1124\/jpet.102.046433","article-title":"Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats","volume":"305","author":"Mague","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.121.000524_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1124\/jpet.119.261511","article-title":"OREX-1019: a novel treatment of opioid use disorder and relapse prevention","volume":"372","author":"Maguire","year":"2020","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.121.000524_bib43","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1021\/acs.biochem.7b00747","article-title":"Structural basis for G protein-coupled receptor activation","volume":"56","author":"Manglik","year":"2017","journal-title":"Biochemistry"},{"key":"10.1124\/jpet.121.000524_bib44","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.neuroscience.2008.06.027","article-title":"The role of the opioid receptor-like (ORL1) receptor in motor stimulatory and rewarding actions of buprenorphine and morphine","volume":"155","author":"Marquez","year":"2008","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.121.000524_bib45","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.neuropharm.2007.11.003","article-title":"The endogenous OFQ\/N\/ORL-1 receptor system regulates the rewarding effects of acute cocaine","volume":"54","author":"Marquez","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.121.000524_bib46","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/sj.clpt.6100503","article-title":"Potential of buprenorphine\/naltrexone in treating polydrug addiction and co-occurring psychiatric disorders","volume":"83","author":"McCann","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.121.000524_bib47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neulet.2005.12.066","article-title":"Nociceptin\/orphanin FQ evokes knee joint pain in rats via a mast cell independent mechanism","volume":"398","author":"McDougall","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.121.000524_bib48","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.npp.1300860","article-title":"Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning","volume":"31","author":"McLaughlin","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.121.000524_bib49","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1523\/JNEUROSCI.23-13-05674.2003","article-title":"Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses","volume":"23","author":"McLaughlin","year":"2003","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.121.000524_bib50","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.str.2015.07.024","article-title":"The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N\/OFQ G protein-coupled receptor","volume":"23","author":"Miller","year":"2015","journal-title":"Structure"},{"year":"2019","key":"10.1124\/jpet.121.000524_bib51"},{"key":"10.1124\/jpet.121.000524_bib51a","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.clpt.2003.09.004","article-title":"Randomized trial of buprenorphine for treatment of concurrent opiate and cocaine dependence","volume":"75","author":"Montoya","year":"2004","journal-title":"Clinical Pharmacology & Therapeutics"},{"key":"10.1124\/jpet.121.000524_bib54","doi-asserted-by":"crossref","first-page":"e0217371","DOI":"10.1371\/journal.pone.0217371","article-title":"Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids","volume":"14","author":"Olson","year":"2019","journal-title":"PLoS One"},{"key":"10.1124\/jpet.121.000524_bib55","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4172\/2155-6148.1000218","article-title":"Human \u03bc opioid receptor models with evaluation of the accuracy using the crystal structure of the murine \u03bc opioid receptor","volume":"3","author":"Perez-Aguilar","year":"2012","journal-title":"J Anesth Clin Res"},{"key":"10.1124\/jpet.121.000524_bib55a","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00213-008-1122-y","article-title":"Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system","volume":"200","author":"Redila","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.121.000524_bib56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00213-003-1643-3","article-title":"Central administration of nociceptin\/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice","volume":"172","author":"Sakoori","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.121.000524_bib57","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/sj.npp.1301459","article-title":"Endogenous nociceptin (orphanin FQ) suppresses basal hedonic state and acute reward responses to methamphetamine and ethanol, but facilitates chronic responses","volume":"33","author":"Sakoori","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.121.000524_bib59","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuropharm.2005.04.008","article-title":"The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference","volume":"49","author":"Shoblock","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.121.000524_bib60","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/sj.npp.1300712","article-title":"Rats maintained chronically on buprenorphine show reduced heroin and cocaine seeking in tests of extinction and drug-induced reinstatement","volume":"30","author":"Sorge","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.121.000524_bib61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00213-010-1844-5","article-title":"Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration","volume":"210","author":"Sperling","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.121.000524_bib62","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejphar.2014.10.029","article-title":"Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats","volume":"745","author":"Sukhtankar","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.000524_bib63","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0166-4328(02)00102-X","article-title":"Unconditioned and conditioned factors contribute to the \u2018reinstatement\u2019 of cocaine place conditioning following extinction in C57BL\/6 mice","volume":"136","author":"Szumlinski","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1124\/jpet.121.000524_bib64","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nature11085","article-title":"Structure of the nociceptin\/orphanin FQ receptor in complex with a peptide mimetic","volume":"485","author":"Thompson","year":"2012","journal-title":"Nature"},{"key":"10.1124\/jpet.121.000524_bib65","doi-asserted-by":"crossref","first-page":"146ra110","DOI":"10.1126\/scitranslmed.3003948","article-title":"A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence","volume":"4","author":"Wee","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1124\/jpet.121.000524_bib66","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2174\/156802611795371341","article-title":"The nociceptin\/orphanin FQ receptor (NOP) as a target for drug abuse medications","volume":"11","author":"Zaveri","year":"2011","journal-title":"Curr Top Med Chem"},{"key":"10.1124\/jpet.121.000524_bib67","first-page":"313","article-title":"Buprenorphine therapy for opioid use disorder","volume":"97","author":"Zoorob","year":"2018","journal-title":"Am Fam Physician"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524257141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524257141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.121.000524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:53:15Z","timestamp":1739973195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524257141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0022356524257141"],"URL":"https:\/\/doi.org\/10.1124\/jpet.121.000524","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.121.000524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}