{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:26:51Z","timestamp":1787016411647,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1124\/jpet.121.000875","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T13:15:17Z","timestamp":1641215717000},"page":"220-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Potent Inhibitor of Aminopeptidase P2 Reduces Reperfusion Injury in Models of Myocardial Infarction and Stroke"],"prefix":"10.1016","volume":"380","author":[{"given":"Morgan R.","family":"Lenz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Yen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Roessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periannan","family":"Sethupathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Keith","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn L.","family":"Kartje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.121.000875_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jss.2010.11.879","article-title":"The MPTP status during early reoxygenation is critical for cardioprotection","volume":"174","author":"Husainy","year":"2012","journal-title":"J Surg Res"},{"key":"10.1124\/jpet.121.000875_bib2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/sj.bjp.0704548","article-title":"Role of bradykinin in preconditioning and protection of the ischaemic myocardium","volume":"135","author":"Baxter","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib3","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.3390\/ijms21082965","article-title":"Autocrine bradykinin release promotes ischemic preconditioning-induced cytoprotection in bovine aortic endothelial cells","volume":"21","author":"Bellis","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.121.000875_bib4","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1007\/s12325-020-01455-2","article-title":"Angiotensin-converting enzyme inhibition: beyond blood pressure control\u2013the role of zofenopril","volume":"37","author":"Borghi","year":"2020","journal-title":"Adv Ther"},{"key":"10.1124\/jpet.121.000875_bib5","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1161\/01.CIR.102.18.2190","article-title":"Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B(2) receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway","volume":"102","author":"Brown","year":"2000","journal-title":"Circulation"},{"key":"10.1124\/jpet.121.000875_bib6","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","article-title":"Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00395-017-0653-y","article-title":"The impact of irreproducibility and competing protection from P2Y12 antagonists on the discovery of cardioprotective interventions","volume":"112","author":"Cohen","year":"2017","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.121.000875_bib8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s00395-008-0737-9","article-title":"Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning\u2019s success","volume":"103","author":"Cohen","year":"2008","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.121.000875_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.vph.2005.02.007","article-title":"Mechanisms of acetylcholine- and bradykinin-induced preconditioning","volume":"42","author":"Critz","year":"2005","journal-title":"Vascul Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1254\/jjp.79.403","article-title":"Pharmacology and cardiovascular implications of the kinin-kallikrein system","volume":"79","author":"Dendorfer","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib11","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1253\/circj.CJ-09-0338","article-title":"Why do we still not have cardioprotective drugs?","volume":"73","author":"Downey","year":"2009","journal-title":"Circ J"},{"key":"10.1124\/jpet.121.000875_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/00005344-199707000-00014","article-title":"Inhibition of both aminopeptidase P and angiotensin-converting enzyme prevents bradykinin degradation in the rat coronary circulation","volume":"30","author":"Er\u015fahin","year":"1997","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib13","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/00005344-199910000-00019","article-title":"Cardioprotective effects of the aminopeptidase P inhibitor apstatin: studies on ischemia\/reperfusion injury in the isolated rat heart","volume":"34","author":"Er\u015fahin","year":"1999","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0002-8703(81)90226-X","article-title":"Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique","volume":"101","author":"Fishbein","year":"1981","journal-title":"Am Heart J"},{"key":"10.1124\/jpet.121.000875_bib15","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1161\/01.CIR.97.22.2202","article-title":"Indications for ACE inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials","volume":"97","year":"1998","journal-title":"Circulation"},{"key":"10.1124\/jpet.121.000875_bib16","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1136\/bmj.292.6522.746","article-title":"Confidence intervals rather than P values: estimation rather than hypothesis testing","volume":"292","author":"Gardner","year":"1986","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1124\/jpet.121.000875_bib17","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1107\/S0907444904018724","article-title":"Structure of Escherichia coli aminopeptidase P in complex with the inhibitor apstatin","volume":"60","author":"Graham","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1124\/jpet.121.000875_bib18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cardiores.2005.06.007","article-title":"Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia\/reperfusion injury revisited","volume":"68","author":"Gross","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.121.000875_bib19","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/0003-4975(95)00192-N","article-title":"The role of bradykinin and nitric oxide in the cardioprotective action of ACE inhibitors","volume":"60","author":"Hartman","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1124\/jpet.121.000875_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.121.000875_bib21","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41592-019-0470-3","article-title":"Moving beyond P values: data analysis with estimation graphics","volume":"16","author":"Ho","year":"2019","journal-title":"Nat Methods"},{"key":"10.1124\/jpet.121.000875_bib22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cphy.c160006","article-title":"Ischemia\/reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr Physiol"},{"key":"10.1124\/jpet.121.000875_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1476-5381.1995.tb14897.x","article-title":"Potentiation by aminopeptidase P of blood pressure response to bradykinin","volume":"114","author":"Kitamura","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib24","first-page":"H1664","article-title":"Effects of aminopeptidase P inhibition on kinin-mediated vasodepressor responses","volume":"276","author":"Kitamura","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.121.000875_bib25","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3389\/fnins.2019.01105","article-title":"A novel method for assessing cerebral edema, infarcted zone and blood-brain barrier breakdown in a single post-stroke rodent brain","volume":"13","author":"Kuts","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1124\/jpet.121.000875_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.yjmcc.2018.04.012","article-title":"Exosomal miR-21a-5p mediates cardioprotection by mesenchymal stem cells","volume":"119","author":"Luther","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.121.000875_bib27","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1021\/jm9805642","article-title":"Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme","volume":"42","author":"Maggiora","year":"1999","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.121.000875_bib28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-0270(02)00012-2","article-title":"Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination","volume":"115","author":"Metz","year":"2002","journal-title":"J Neurosci Methods"},{"key":"10.1124\/jpet.121.000875_bib29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1124\/jpet.119.264143","article-title":"New author guidelines for displaying data and reporting data analysis and statistical methods in experimental biology","volume":"372","author":"Michel","year":"2020","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.121.000875_bib30","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1124\/jpet.121.000875_bib31","doi-asserted-by":"crossref","first-page":"11227","DOI":"10.1021\/bi00035a032","article-title":"Purification and properties of membrane-bound aminopeptidase P from rat lung","volume":"34","author":"Orawski","year":"1995","journal-title":"Biochemistry"},{"key":"10.1124\/jpet.121.000875_bib32","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.jacc.2019.10.034","article-title":"Management of acute ischemic stroke due to large-vessel occlusion: JACC Focus Seminar","volume":"75","author":"Ospel","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.121.000875_bib33","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00395-007-0695-7","article-title":"Postconditioning and intermittent bradykinin induced cardioprotection require cyclooxygenase activation and prostacyclin release during reperfusion","volume":"103","author":"Penna","year":"2008","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.121.000875_bib34","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1177\/0271678X17730994","article-title":"Improved functional outcome after chronic stroke with delayed anti-Nogo-A therapy: A clinically relevant intention-to-treat analysis","volume":"38","author":"Podraza","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.121.000875_bib35","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S0022-3565(25)12164-2","article-title":"Effect of a new aminopeptidase P inhibitor, apstatin, on bradykinin degradation in the rat lung","volume":"275","author":"Prechel","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.121.000875_bib36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jss.2004.03.010","article-title":"TNF-alpha is required for late ischemic preconditioning but not for remote preconditioning of trauma","volume":"121","author":"Ren","year":"2004","journal-title":"J Surg Res"},{"key":"10.1124\/jpet.121.000875_bib37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0076-6879(83)91010-8","article-title":"Reassessment of Ellman\u2019s reagent","volume":"91","author":"Riddles","year":"1983","journal-title":"Methods Enzymol"},{"key":"10.1124\/jpet.121.000875_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/ejn.13133","article-title":"Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats","volume":"43","author":"Sang","year":"2016","journal-title":"Eur J Neurosci"},{"key":"10.1124\/jpet.121.000875_bib39","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1161\/STROKEAHA.118.023927","article-title":"Stroke Treatment Academic Industry Roundtable X: brain cytoprotection therapies in the reperfusion era","volume":"50","author":"Savitz","year":"2019","journal-title":"Stroke"},{"key":"10.1124\/jpet.121.000875_bib40","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1042\/BST0341271","article-title":"Perspectives on neuroprotective stroke therapy","volume":"34","author":"Sch\u00e4bitz","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"10.1124\/jpet.121.000875_bib41","unstructured":"Simmons WH (2008) inventor and assignee. Thio-containing inhibitors of aminopeptidase P and compositions thereof. U.S. patent 7,190,789 B2."},{"key":"10.1124\/jpet.121.000875_bib42","series-title":"Handbook of Proteolytic Enzymes","first-page":"2","article-title":"Aminopeptidase","author":"Simmons","year":"2013"},{"key":"10.1124\/jpet.121.000875_bib43","unstructured":"Simmons WH (2015) inventor and assignee. 4-Fluoro-thio-containing Inhibitors of APP2, compositions thereof and method of use. U.S. patent 9,212,206 B1."},{"key":"10.1124\/jpet.121.000875_bib44","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1016\/S0021-9258(18)42915-8","article-title":"Membrane-bound aminopeptidase P from bovine lung. Its purification, properties, and degradation of bradykinin","volume":"267","author":"Simmons","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.121.000875_bib45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-017-1667-0","article-title":"Ischemic stroke: experimental models and reality","volume":"133","author":"Sommer","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1124\/jpet.121.000875_bib46","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0003-2697(03)00464-0","article-title":"A continuous fluorimetric assay for aminopeptidase P detailed analysis of product inhibition","volume":"322","author":"St\u00f6ckel-Maschek","year":"2003","journal-title":"Anal Biochem"},{"key":"10.1124\/jpet.121.000875_bib47","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.iac.2017.04.006","article-title":"Angiotensin-converting enzyme inhibitor and other drug-associated angioedema","volume":"37","author":"Stone","year":"2017","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1124\/jpet.121.000875_bib48","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1124\/jpet.103.064105","article-title":"The effect of acute angiotensin-converting enzyme and neutral endopeptidase 24.11 inhibition on plasma extravasation in the rat","volume":"309","author":"Sulpizio","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.121.000875_bib49","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1124\/jpet.105.084749","article-title":"Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11\/angiotensin-converting enzyme inhibitor GW796406","volume":"315","author":"Sulpizio","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.121.000875_bib50","series-title":"Sulfhydryl and Disulfide Groups of Proteins","author":"Torchinskii","year":"1974"},{"key":"10.1124\/jpet.121.000875_bib51","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1038\/s41598-018-23504-1","article-title":"Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia","volume":"8","author":"Tu","year":"2018","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.121.000875_bib52","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1043-6618(03)00222-6","article-title":"Infarct size limiting effect of apstatin alone and in combination with enalapril, lisinopril and ramipril in rats with experimental myocardial infarction","volume":"48","author":"Veeravalli","year":"2003","journal-title":"Pharmacol Res"},{"key":"10.1124\/jpet.121.000875_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phrs.2003.07.010","article-title":"Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction","volume":"49","author":"Veeravalli","year":"2004","journal-title":"Pharmacol Res"},{"key":"10.1124\/jpet.121.000875_bib54","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bjp.0706256","article-title":"Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids","volume":"145","author":"Weston","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib55","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/sj.bjp.0704236","article-title":"Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway","volume":"134","author":"Wolfrum","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.121.000875_bib56","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/abbi.1994.1204","article-title":"Substrate specificity of aminopeptidase P from Escherichia coli: comparison with membrane-bound forms from rat and bovine lung","volume":"311","author":"Yoshimoto","year":"1994","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/jpet.121.000875_bib57","doi-asserted-by":"crossref","first-page":"H579","DOI":"10.1152\/ajpheart.01064.2002","article-title":"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning","volume":"285","author":"Zhao","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524002453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524002453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.121.000875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T08:26:01Z","timestamp":1739953561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524002453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0022356524002453"],"URL":"https:\/\/doi.org\/10.1124\/jpet.121.000875","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Potent Inhibitor of Aminopeptidase P2 Reduces Reperfusion Injury in Models of Myocardial Infarction and Stroke","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.121.000875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government work not protected by U.S. copyright.","name":"copyright","label":"Copyright"}]}}