{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:29:29Z","timestamp":1792132169902,"version":"4.4.0"},"reference-count":133,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1124\/jpet.121.001051","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T09:55:18Z","timestamp":1646387718000},"page":"106-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model"],"prefix":"10.1016","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3264-8808","authenticated-orcid":false,"given":"Yukinori","family":"Nagakura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.121.001051_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.phrs.2013.10.006","article-title":"Depressive behavior in the forced swim test can be induced by TRPV1 receptor activity and is dependent on NMDA receptors","volume":"79","author":"Abdelhamid","year":"2014","journal-title":"Pharmacol Res"},{"key":"10.1124\/jpet.121.001051_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.berh.2015.04.018","article-title":"Update on the genetics of the fibromyalgia syndrome","volume":"29","author":"Ablin","year":"2015","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1124\/jpet.121.001051_bib3","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.jad.2013.08.032","article-title":"Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model","volume":"151","author":"Arora","year":"2013","journal-title":"J Affect Disord"},{"key":"10.1124\/jpet.121.001051_bib4","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.psyneuen.2011.04.012","article-title":"Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences","volume":"36","author":"Arora","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1124\/jpet.121.001051_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.rbr.2015.03.012","article-title":"Food intake assessment and quality of life in women with fibromyalgia","volume":"56","author":"Batista","year":"2016","journal-title":"Rev Bras Reumatol Engl Ed"},{"key":"10.1124\/jpet.121.001051_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.biopha.2018.04.056","article-title":"Fibromyalgia and nutrition: Therapeutic possibilities?","volume":"103","author":"Bj\u00f8rklund","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1124\/jpet.121.001051_bib7","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/cne.24829","article-title":"Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers","volume":"528","author":"Blasco-Serra","year":"2020","journal-title":"J Comp Neurol"},{"key":"10.1124\/jpet.121.001051_bib8","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1007\/s12035-020-01996-1","article-title":"Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model","volume":"57","author":"Brum","year":"2020","journal-title":"Mol Neurobiol"},{"key":"10.1124\/jpet.121.001051_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107959","article-title":"Animal models of fibromyalgia: What is the best choice?","volume":"230","author":"Brum","year":"2022","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.121.001051_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bcp.2019.06.023","article-title":"Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice","volume":"168","author":"Brusco","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain","volume":"14","author":"Bushnell","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/jpet.121.001051_bib12","doi-asserted-by":"crossref","first-page":"18732","DOI":"10.1073\/pnas.1900872116","article-title":"Endogenous fluctuations in the dopaminergic midbrain drive behavioral choice variability","volume":"116","author":"Chew","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.121.001051_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11916-016-0556-x","article-title":"Fibromyalgia Pathogenesis and Treatment Options Update","volume":"20","author":"Chinn","year":"2016","journal-title":"Curr Pain Headache Rep"},{"key":"10.1124\/jpet.121.001051_bib14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrrheum.2015.56","article-title":"The role of sleep in pain and fibromyalgia","volume":"11","author":"Choy","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"10.1124\/jpet.121.001051_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029831","article-title":"Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model","volume":"7","author":"Corey","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/jpet.121.001051_bib16","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.3390\/ijms22126471","article-title":"Inhibition of P2X7 Purinergic Receptor Ameliorates Fibromyalgia Syndrome by Suppressing NLRP3 Pathway","volume":"22","author":"D\u2019Amico","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.121.001051_bib17","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1097\/j.pain.0000000000001513","article-title":"Nociceptin\/orphanin FQ receptor modulates painful and fatigue symptoms in a mouse model of fibromyalgia","volume":"160","author":"Dagnino","year":"2019","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib18","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.pain.2011.04.015","article-title":"Antinociceptive effect of Brazilian armed spider venom toxin Tx3-3 in animal models of neuropathic pain","volume":"152","author":"Dalmolin","year":"2011","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172443","article-title":"Blockade of spinal \u03b15-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats","volume":"858","author":"De la Luz-Cuellar","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.toxicon.2014.01.015","article-title":"The effects of Ph\u03b11\u03b2, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model","volume":"81","author":"de Souza","year":"2014","journal-title":"Toxicon"},{"key":"10.1124\/jpet.121.001051_bib21","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14984","article-title":"The role of spinal cord extrasynaptic \u03b15 GABAA receptors in chronic pain","volume":"9","author":"Delgado-Lezama","year":"2021","journal-title":"Physiol Rep"},{"key":"10.1124\/jpet.121.001051_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/19336950.2020.1852831","article-title":"Acid-sensing ion channel 3: An analgesic target","volume":"15","author":"Dulai","year":"2021","journal-title":"Channels (Austin)"},{"key":"10.1124\/jpet.121.001051_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166150","article-title":"Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model","volume":"1867","author":"Elkholy","year":"2021","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1124\/jpet.121.001051_bib24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/ijms20030765","article-title":"Mitochondrial Dysfunction in Skeletal Muscle of a Fibromyalgia Model: The Potential Benefits of Melatonin","volume":"20","author":"Favero","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.121.001051_bib25","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3390\/ijms18071389","article-title":"Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats","volume":"18","author":"Favero","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.121.001051_bib26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroscience.2021.04.017","article-title":"Exercise Reduces Pain and Deleterious Histological Effects in Fibromyalgia-like Model","volume":"465","author":"Ferrarini","year":"2021","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.121.001051_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104673","article-title":"Involvement of TRPV1 and the efficacy of \u03b1-spinasterol on experimental fibromyalgia symptoms in mice","volume":"134","author":"Fischer","year":"2020","journal-title":"Neurochem Int"},{"key":"10.1124\/jpet.121.001051_bib28","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","article-title":"Nociplastic pain: towards an understanding of prevalent pain conditions","volume":"397","author":"Fitzcharles","year":"2021","journal-title":"Lancet"},{"key":"10.1124\/jpet.121.001051_bib29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neures.2020.02.010","article-title":"Chloride homeodynamics underlying modal shifts in cellular and network oscillations","volume":"156","author":"Fukuda","year":"2020","journal-title":"Neurosci Res"},{"key":"10.1124\/jpet.121.001051_bib30","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3390\/antiox8120628","article-title":"Melatonin Plus Folic Acid Treatment Ameliorates Reserpine-Induced Fibromyalgia: An Evaluation of Pain, Oxidative Stress, and Inflammation","volume":"8","author":"Fusco","year":"2019","journal-title":"Antioxidants"},{"key":"10.1124\/jpet.121.001051_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxicon.2021.03.012","article-title":"Effects of intravenous administration of recombinant Ph\u03b11\u03b2 toxin in a mouse model of fibromyalgia","volume":"195","author":"Garcia Mendes","year":"2021","journal-title":"Toxicon"},{"key":"10.1124\/jpet.121.001051_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105424","article-title":"An insight into the therapeutic applications of coumarin compounds and their mechanisms of action","volume":"152","author":"Garg","year":"2020","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/jpet.121.001051_bib33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1023\/A:1021836403433","article-title":"Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels","volume":"22","author":"Gomez","year":"2002","journal-title":"Cell Mol Neurobiol"},{"key":"10.1124\/jpet.121.001051_bib34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neubiorev.2020.03.004","article-title":"The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?","volume":"113","author":"Gonz\u00e1lez-Cano","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1124\/jpet.121.001051_bib35","first-page":"E581","article-title":"Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats","volume":"23","author":"Gonzalez-Soler","year":"2020","journal-title":"Pain Physician"},{"key":"10.1124\/jpet.121.001051_bib36","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1523\/JNEUROSCI.1650-20.2020","article-title":"The Neuroimmunology of Chronic Pain: From Rodents to Humans","volume":"41","author":"Grace","year":"2021","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.121.001051_bib37","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1080\/07853890.2021.1916069","article-title":"Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model","volume":"53","author":"Hassan","year":"2021","journal-title":"Ann Med"},{"key":"10.1124\/jpet.121.001051_bib38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/ar4441","article-title":"Review of pharmacological therapies in fibromyalgia syndrome","volume":"16","author":"H\u00e4user","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1124\/jpet.121.001051_bib39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fphys.2018.00044","article-title":"Coenzyme Q10 Supplementation in Aging and Disease","volume":"9","author":"Hern\u00e1ndez-Camacho","year":"2018","journal-title":"Front Physiol"},{"key":"10.1124\/jpet.121.001051_bib40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bbr.2018.01.005","article-title":"Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats","volume":"364","author":"Hernandez-Leon","year":"2019","journal-title":"Behav Brain Res"},{"issue":"Suppl 6","key":"10.1124\/jpet.121.001051_bib41","first-page":"4","article-title":"History and evolution of the monoamine hypothesis of depression","volume":"61","author":"Hirschfeld","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"10.1124\/jpet.121.001051_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40265-020-01429-2","article-title":"TRPV1-Targeted Drugs in Development for Human Pain Conditions","volume":"81","author":"Iftinca","year":"2021","journal-title":"Drugs"},{"key":"10.1124\/jpet.121.001051_bib43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and Central Sensitization in Chronic and Widespread Pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.121.001051_bib44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pain.2004.12.032","article-title":"Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition","volume":"114","author":"Julien","year":"2005","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib45","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2014.01.007","article-title":"The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia","volume":"562","author":"Kaneko","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.121.001051_bib46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0928-4680(00)00053-5","article-title":"Oxidative stress and apoptosis","volume":"7","author":"Kannan","year":"2000","journal-title":"Pathophysiology"},{"key":"10.1124\/jpet.121.001051_bib47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12031-020-01656-y","article-title":"Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin","volume":"71","author":"Kaur","year":"2021","journal-title":"J Mol Neurosci"},{"key":"10.1124\/jpet.121.001051_bib48","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bcp.2019.05.012","article-title":"Ameliorative effect of imperatorin in chemically induced fibromyalgia: Role of NMDA\/NFkB mediated downstream signaling","volume":"166","author":"Kaur","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib49","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1111\/1750-3841.15476","article-title":"Optimization of extraction conditions of Angelica archangelica extract and activity evaluation in experimental fibromyalgia","volume":"85","author":"Kaur","year":"2020","journal-title":"J Food Sci"},{"key":"10.1124\/jpet.121.001051_bib50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/biomedicines5020020","article-title":"Update on Treatment Guideline in Fibromyalgia Syndrome with Focus on Pharmacology","volume":"5","author":"Kia","year":"2017","journal-title":"Biomedicines"},{"key":"10.1124\/jpet.121.001051_bib51","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejphar.2018.03.011","article-title":"Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia","volume":"827","author":"Kiso","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib52","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1111\/bph.14448","article-title":"Analgesic effects of ASP3662, a novel 11\u03b2-hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain","volume":"175","author":"Kiso","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173194","article-title":"ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain","volume":"881","author":"Kiso","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuropharm.2014.05.043","article-title":"Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice","volume":"86","author":"Klein","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.121.001051_bib55","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1038\/cddis.2013.54","article-title":"Minocycline selectively inhibits M1 polarization of microglia","volume":"4","author":"Kobayashi","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1124\/jpet.121.001051_bib56","article-title":"Efficacy of nonpharmacological interventions for individual features of fibromyalgia: a systematic review and meta-analysis of randomised controlled trials","author":"Kundakci","year":"2021","journal-title":"Pain."},{"key":"10.1124\/jpet.121.001051_bib57","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nmeth.1455","article-title":"Coding of facial expressions of pain in the laboratory mouse","volume":"7","author":"Langford","year":"2010","journal-title":"Nat Methods"},{"key":"10.1124\/jpet.121.001051_bib58","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11011-015-9786-6","article-title":"Echinocystic acid reduces reserpine-induced pain\/depression dyad in mice","volume":"31","author":"Li","year":"2016","journal-title":"Metab Brain Dis"},{"key":"10.1124\/jpet.121.001051_bib59","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12017-013-8280-8","article-title":"Attenuation of reserpine-induced pain\/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice","volume":"16","author":"Liu","year":"2014","journal-title":"Neuromolecular Med"},{"key":"10.1124\/jpet.121.001051_bib60","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.neuropharm.2017.08.021","article-title":"KCa3.1 channels modulate the processing of noxious chemical stimuli in mice","volume":"125","author":"Lu","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.121.001051_bib61","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/annrheumdis-2016-209724","article-title":"EULAR revised recommendations for the management of fibromyalgia","volume":"76","author":"Macfarlane","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1124\/jpet.121.001051_bib62","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13063-015-0659-4","article-title":"Fibromyalgia, milnacipran and experimental pain modulation: study protocol for a double blind randomized controlled trial","volume":"16","author":"Macian","year":"2015","journal-title":"Trials"},{"key":"10.1124\/jpet.121.001051_bib63","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.autneu.2006.04.004","article-title":"Depletion and recovery of catecholamines in several organs of rats treated with reserpine","volume":"128","author":"Mart\u00ednez-Olivares","year":"2006","journal-title":"Auton Neurosci"},{"key":"10.1124\/jpet.121.001051_bib64","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4103\/1673-5374.317984","article-title":"Pramipexole, a dopamine D3\/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice","volume":"17","author":"Martins","year":"2022","journal-title":"Neural Regen Res"},{"key":"10.1124\/jpet.121.001051_bib65","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.neubiorev.2020.07.013","article-title":"The development and use of facial grimace scales for pain measurement in animals","volume":"116","author":"Mogil","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1124\/jpet.121.001051_bib66","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1210\/endo-127-3-1450","article-title":"11 beta-hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus, and cortex","volume":"127","author":"Moisan","year":"1990","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.121.001051_bib67","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00002508-199812000-00007","article-title":"Self-reported sleep and mood disturbance in chronic pain patients","volume":"14","author":"Morin","year":"1998","journal-title":"Clin J Pain"},{"key":"10.1124\/jpet.121.001051_bib68","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.neuroscience.2014.12.065","article-title":"Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats","volume":"289","author":"Murai","year":"2015","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.121.001051_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172750","article-title":"A novel GABAB receptor positive allosteric modulator, ASP8062, exerts analgesic effects in a rat model of fibromyalgia","volume":"865","author":"Murai","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib70","doi-asserted-by":"crossref","first-page":"G260","DOI":"10.1152\/ajpgi.00353.2011","article-title":"Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress","volume":"302","author":"Myers","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.121.001051_bib71","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1517\/17460441.2015.1066776","article-title":"Challenges in drug discovery for overcoming \u2018dysfunctional pain\u2019: an emerging category of chronic pain","volume":"10","author":"Nagakura","year":"2015","journal-title":"Expert Opin Drug Discov"},{"key":"10.1124\/jpet.121.001051_bib72","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/17460441.2017.1261108","article-title":"The need for fundamental reforms in the pain research field to develop innovative drugs","volume":"12","author":"Nagakura","year":"2017","journal-title":"Expert Opin Drug Discov"},{"key":"10.1124\/jpet.121.001051_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172716","article-title":"Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia","volume":"864","author":"Nagakura","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib74","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pain.2009.05.024","article-title":"Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia","volume":"146","author":"Nagakura","year":"2009","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib75","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.physbeh.2018.07.007","article-title":"Monoamine system disruption induces functional somatic syndromes associated symptomatology in mice","volume":"194","author":"Nagakura","year":"2018","journal-title":"Physiol Behav"},{"key":"10.1124\/jpet.121.001051_bib76","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bbr.2011.09.023","article-title":"Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats","volume":"226","author":"Nagakura","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1124\/jpet.121.001051_bib77","doi-asserted-by":"crossref","first-page":"398","DOI":"10.12965\/jer.2040672.336","article-title":"Free gait in a shallow pool accelerates recovery after exercise in model mice with fibromyalgia","volume":"16","author":"Nakata","year":"2020","journal-title":"J Exerc Rehabil"},{"key":"10.1124\/jpet.121.001051_bib78","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1744-8069-4-52","article-title":"Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia","volume":"4","author":"Nishiyori","year":"2008","journal-title":"Mol Pain"},{"key":"10.1124\/jpet.121.001051_bib79","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.neuroscience.2010.06.061","article-title":"Reserpine causes biphasic nociceptive sensitivity alteration in conjunction with brain biogenic amine tones in rats","volume":"169","author":"Oe","year":"2010","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.121.001051_bib80","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pbb.2013.04.007","article-title":"Systemic administration of 5-HT(2C) receptor agonists attenuates muscular hyperalgesia in reserpine-induced myalgia model","volume":"108","author":"Ogino","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.121.001051_bib81","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ejphar.2016.10.021","article-title":"Pain-depression dyad induced by reserpine is relieved by p,p\u2032-methoxyl-diphenyl diselenide in rats","volume":"791","author":"Oliveira","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2020.102094","article-title":"Phoneutria nigriventer Tx3-3 peptide toxin reduces fibromyalgia symptoms in mice","volume":"85","author":"Pedron","year":"2021","journal-title":"Neuropeptides"},{"key":"10.1124\/jpet.121.001051_bib83","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1111\/bph.12645","article-title":"Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain","volume":"171","author":"Percie du Sert","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib84","article-title":"Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model","volume":"2016","author":"Peres Klein","year":"2016","journal-title":"Pain Res Treat"},{"key":"10.1124\/jpet.121.001051_bib85","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1152\/physrev.00048.2010","article-title":"Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors","volume":"92","author":"Petho","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.121.001051_bib86","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0304-3959(03)00204-5","article-title":"Increased pain sensitivity in fibromyalgia: effects of stimulus type and mode of presentation","volume":"105","author":"Petzke","year":"2003","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib87","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1478-811X-11-70","article-title":"Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation","volume":"11","author":"Pinheiro","year":"2013","journal-title":"Cell Commun Signal"},{"key":"10.1124\/jpet.121.001051_bib88","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1007\/s13197-014-1278-x","article-title":"Efficacy of Angelica archangelica essential oil, phenyl ethyl alcohol and \u03b1- terpineol against isolated molds from walnut and their antiaflatoxigenic and antioxidant activity","volume":"52","author":"Prakash","year":"2015","journal-title":"J Food Sci Technol"},{"key":"10.1124\/jpet.121.001051_bib89","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"key":"10.1124\/jpet.121.001051_bib90","doi-asserted-by":"crossref","first-page":"e901","DOI":"10.1097\/PR9.0000000000000901","article-title":"Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome","volume":"6","author":"Rehm","year":"2021","journal-title":"Pain Rep"},{"key":"10.1124\/jpet.121.001051_bib91","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pbb.2013.10.014","article-title":"Effect of \u03c9-conotoxin MVIIA and Ph\u03b11\u03b2 on paclitaxel-induced acute and chronic pain","volume":"114-115","author":"Rigo","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.121.001051_bib92","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/art.1780350509","article-title":"Cerebrospinal fluid biogenic amine metabolites in fibromyalgia\/fibrositis syndrome and rheumatoid arthritis","volume":"35","author":"Russell","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1124\/jpet.121.001051_bib93","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.pain.2010.12.022","article-title":"Sodium oxybate reduces pain, fatigue, and sleep disturbance and improves functionality in fibromyalgia: results from a 14-week, randomized, double-blind, placebo-controlled study","volume":"152","author":"Russell","year":"2011","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib94","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.3390\/molecules26082398","article-title":"Serotonergic Neurotransmission System Modulator, Vortioxetine, and Dopaminergic D(2)\/D(3) Receptor Agonist, Ropinirole, Attenuate Fibromyalgia-Like Symptoms in Mice","volume":"26","author":"Sa\u0142at","year":"2021","journal-title":"Molecules"},{"issue":"6, Suppl 74","key":"10.1124\/jpet.121.001051_bib95","first-page":"143","article-title":"Dysfunctional syndromes and fibromyalgia: a 2012 critical digest","volume":"30","author":"Sarzi-Puttini","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"10.1124\/jpet.121.001051_bib96","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41584-020-00506-w","article-title":"Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment","volume":"16","author":"Sarzi-Puttini","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1124\/jpet.121.001051_bib97","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2017.01.014","article-title":"Neural Circuitry of Wakefulness and Sleep","volume":"93","author":"Scammell","year":"2017","journal-title":"Neuron"},{"key":"10.1124\/jpet.121.001051_bib98","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1007\/s12035-021-02483-x","article-title":"Effect of m-Trifluoromethyl-diphenyl diselenide on the Pain-Depression Dyad Induced by Reserpine: Insights on Oxidative Stress, Apoptotic, and Glucocorticoid Receptor Modulation","volume":"58","author":"Schossler Garcia","year":"2021","journal-title":"Mol Neurobiol"},{"key":"10.1124\/jpet.121.001051_bib99","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.1111\/jcmm.15436","article-title":"Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization","volume":"24","author":"Shan","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1124\/jpet.121.001051_bib100","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/FBP.0000000000000454","article-title":"Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats","volume":"30","author":"Siemian","year":"2019","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib101","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/bph.14161","article-title":"Mechanisms of imidazoline I2 receptor agonist-induced antinociception in rats: involvement of monoaminergic neurotransmission","volume":"175","author":"Siemian","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib102","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1021\/acsomega.0c04739","article-title":"Biological Evaluation of Aegle marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain - Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS","volume":"6","author":"Singh","year":"2021","journal-title":"ACS Omega"},{"key":"10.1124\/jpet.121.001051_bib103","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11011-020-00604-4","article-title":"Skimmetin\/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation","volume":"36","author":"Singh","year":"2021","journal-title":"Metab Brain Dis"},{"key":"10.1124\/jpet.121.001051_bib104","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1007\/s11064-020-03095-y","article-title":"Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A","volume":"45","author":"Singh","year":"2020","journal-title":"Neurochem Res"},{"key":"10.1124\/jpet.121.001051_bib105","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00221-021-06064-1","article-title":"Daphnetin, a natural coumarin averts reserpine-induced fibromyalgia in mice: modulation of MAO-A","volume":"239","author":"Singh","year":"2021","journal-title":"Exp Brain Res"},{"key":"10.1124\/jpet.121.001051_bib106","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.3390\/ijms22083891","article-title":"Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update","volume":"22","author":"Siracusa","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.121.001051_bib107","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuroscience.2016.06.006","article-title":"Neurobiology of fibromyalgia and chronic widespread pain","volume":"338","author":"Sluka","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.121.001051_bib108","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0304-3959(03)00269-0","article-title":"Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1","volume":"106","author":"Sluka","year":"2003","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1005444719169","article-title":"Sleep quality and presleep arousal in chronic pain","volume":"23","author":"Smith","year":"2000","journal-title":"J Behav Med"},{"key":"10.1124\/jpet.121.001051_bib110","first-page":"55","article-title":"The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions","volume":"7","author":"Sotocinal","year":"2011","journal-title":"Mol Pain"},{"key":"10.1124\/jpet.121.001051_bib111","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainresbull.2018.07.007","article-title":"\u03b1- (phenylselanyl) acetophenone mitigates reserpine-induced pain-depression dyad: Behavioral, biochemical and molecular docking evidences","volume":"142","author":"Sousa","year":"2018","journal-title":"Brain Res Bull"},{"key":"10.1124\/jpet.121.001051_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119571","article-title":"Detection of blood flow perfusion and post - occlusive reactive hyperemia in the skeletal muscle of rats","volume":"278","author":"Souza-Silva","year":"2021","journal-title":"Life Sci"},{"key":"10.1124\/jpet.121.001051_bib113","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/nutrit\/nuw053","article-title":"Role of folic acid in nitric oxide bioavailability and vascular endothelial function","volume":"75","author":"Stanhewicz","year":"2017","journal-title":"Nutr Rev"},{"key":"10.1124\/jpet.121.001051_bib114","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0304-3959(02)00325-1","article-title":"Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients","volume":"101","author":"Staud","year":"2003","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrd2280","article-title":"The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept","volume":"6","author":"Szallasi","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/jpet.121.001051_bib116","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/01.j.pain.0000460334.49525.5e","article-title":"Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model","volume":"156","author":"Taguchi","year":"2015","journal-title":"Pain"},{"key":"10.1124\/jpet.121.001051_bib117","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2147\/JPR.S274563","article-title":"A KCa3.1 Channel Opener, ASP0819, Modulates Nociceptive Signal Processing from Peripheral Nerves in Fibromyalgia-Like Pain in Rats","volume":"14","author":"Takeshita","year":"2021","journal-title":"J Pain Res"},{"key":"10.1124\/jpet.121.001051_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2020.100826","article-title":"The method simulating spontaneous pain in patients with nociplastic pain using rats with fibromyalgia-like condition","volume":"7","author":"Tanei","year":"2020","journal-title":"MethodsX"},{"key":"10.1124\/jpet.121.001051_bib119","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/ejn.12643","article-title":"Studying ongoing and spontaneous pain in rodents--challenges and opportunities","volume":"39","author":"Tappe-Theodor","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1124\/jpet.121.001051_bib120","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fncel.2019.00345","article-title":"Mast Cells in Gut and Brain and Their Potential Role as an Emerging Therapeutic Target for Neural Diseases","volume":"13","author":"Traina","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1124\/jpet.121.001051_bib121","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2021.10.010","article-title":"Neuronal Sensitization and Synaptic Facilitation in the Superficial Dorsal Horn of a Rat Reserpine-induced Pain Model","volume":"479","author":"Uta","year":"2021","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.121.001051_bib122","doi-asserted-by":"crossref","first-page":"8595","DOI":"10.1523\/JNEUROSCI.3058-04.2004","article-title":"Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats","volume":"24","author":"Wang","year":"2004","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.121.001051_bib123","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejphar.2017.10.007","article-title":"In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor","volume":"815","author":"Watabiki","year":"2017","journal-title":"Eur J Pharmacol"},{"issue":"Suppl 3","key":"10.1124\/jpet.121.001051_bib124","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/00005344-199627003-00007","article-title":"Aspects of tolerability of centrally acting antihypertensive drugs","volume":"27","author":"Webster","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.121.001051_bib125","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"Wolfe","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1124\/jpet.121.001051_bib126","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jpain.2008.12.008","article-title":"Changes in gray matter density in fibromyalgia: correlation with dopamine metabolism","volume":"10","author":"Wood","year":"2009","journal-title":"J Pain"},{"key":"10.1124\/jpet.121.001051_bib127","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1172\/JCI45178","article-title":"What is this thing called pain?","volume":"120","author":"Woolf","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.121.001051_bib128","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pharmthera.2011.12.009","article-title":"Targeting ASIC3 for pain, anxiety, and insulin resistance","volume":"134","author":"Wu","year":"2012","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.121.001051_bib129","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/732845","article-title":"Effects of Electroacupuncture with Dominant Frequency at SP 6 and ST 36 Based on Meridian Theory on Pain-Depression Dyad in Rats","volume":"2015","author":"Wu","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1124\/jpet.121.001051_bib130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3892\/etm.2017.4479","article-title":"5-HT in the dorsal raphe nucleus is involved in the effects of 100-Hz electro-acupuncture on the pain-depression dyad in rats","volume":"14","author":"Wu","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1124\/jpet.121.001051_bib131","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11011-013-9404-4","article-title":"Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses","volume":"28","author":"Xu","year":"2013","journal-title":"Metab Brain Dis"},{"key":"10.1124\/jpet.121.001051_bib132","first-page":"1343","article-title":"Attenuation of reserpine-induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol","volume":"19","author":"Yao","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1124\/jpet.121.001051_bib133","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/aps.2016.45","article-title":"Evaluation of the analgesic effects of ammoxetine, a novel potent serotonin and norepinephrine reuptake inhibitor","volume":"37","author":"Zhang","year":"2016","journal-title":"Acta Pharmacol Sin"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524002611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524002611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.121.001051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:18:24Z","timestamp":1739971104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524002611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":133,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0022356524002611"],"URL":"https:\/\/doi.org\/10.1124\/jpet.121.001051","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.121.001051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}