{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:26:30Z","timestamp":1779207990221,"version":"3.51.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1124\/jpet.122.001233","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T14:30:12Z","timestamp":1653748212000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Daily Methocinnamox Treatment on Fentanyl Self-Administration in Rhesus Monkeys"],"prefix":"10.1016","volume":"382","author":[{"given":"David R.","family":"Maguire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles P.","family":"France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.122.001233_bib1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0022-3565(24)39155-4","article-title":"Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine","volume":"294","author":"Broadbear","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.122.001233_bib2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00213-004-1891-x","article-title":"Self-administration of fentanyl, cocaine and ketamine: effects on the pituitary-adrenal axis in rhesus monkeys","volume":"176","author":"Broadbear","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.122.001233_bib3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fphar.2019.00088","article-title":"Repeated administration of norbinaltorphimine produces cumulative kappa opioid receptor inactivation","volume":"10","author":"Chavkin","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1124\/jpet.122.001233_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/jpet.118.253286","article-title":"Reversal and prevention of the respiratory-depressant effects of heroin by the novel \u03bc-opioid receptor antagonist methocinnamox in rhesus monkeys","volume":"368","author":"Gerak","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.122.001233_bib5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1124\/jpet.119.260331","article-title":"Methocinnamox produces long-lasting antagonism of the behavioral effects of \u03bc-opioid receptor agonists but not prolonged precipitated withdrawal in rats","volume":"371","author":"Gerak","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.122.001233_bib6","first-page":"1","article-title":"Drug overdose deaths in the United States, 1999\u20132018","volume":"356","author":"Hedegaard","year":"2020","journal-title":"NCHS Data Brief"},{"key":"10.1124\/jpet.122.001233_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1124\/jpet.120.000387","article-title":"Methocinnamox reverses and prevents fentanyl-induced ventilatory depression in rats","volume":"377","author":"Jimenez","year":"2021","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.122.001233_bib8","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1038\/s41386-020-0698-8","article-title":"Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys","volume":"45","author":"Maguire","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.122.001233_bib9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/jpet.118.252353","article-title":"Long-lasting effects of methocinnamox on opioid self-administration in rhesus monkeys","volume":"368","author":"Maguire","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.122.001233_bib10","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1007\/s00213-020-05592-y","article-title":"Methocinnamox (MCAM) antagonizes the behavioral suppressant effects of morphine without impairing delayed matching-to-sample accuracy in rhesus monkeys","volume":"237","author":"Minervini","year":"2020","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.122.001233_bib11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1037\/a0013088","article-title":"Micro\/kappa opioid interactions in rhesus monkeys: implications for analgesia and abuse liability","volume":"16","author":"Negus","year":"2008","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1124\/jpet.122.001233_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainres.2005.07.060","article-title":"Comparison of the antinociceptive effect of acute morphine in female and male Sprague-Dawley rats using the long-lasting mu-antagonist methocinnamox","volume":"1058","author":"Peckham","year":"2005","journal-title":"Brain Res"},{"key":"10.1124\/jpet.122.001233_bib13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.15585\/mmwr.mm6911a4","article-title":"Drug and opioid-involved overdose deaths - United States, 2017-2018","volume":"69","author":"Wilson","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1124\/jpet.122.001233_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.887","article-title":"Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox","volume":"9","author":"Zamora","year":"2021","journal-title":"Pharmacol Res Perspect"},{"key":"10.1124\/jpet.122.001233_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s002130050185","article-title":"Clocinnamox inhibits the intravenous self-administration of opioid agonists in rhesus monkeys: comparison with effects on opioid agonist-mediated antinociception","volume":"129","author":"Zernig","year":"1997","journal-title":"Psychopharmacology (Berl)"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524002970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524002970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.122.001233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T23:17:23Z","timestamp":1742944643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524002970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0022356524002970"],"URL":"https:\/\/doi.org\/10.1124\/jpet.122.001233","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Daily Methocinnamox Treatment on Fentanyl Self-Administration in Rhesus Monkeys","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.122.001233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}