{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:59:00Z","timestamp":1776409140034,"version":"3.51.2"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1124\/jpet.122.001265","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:35:14Z","timestamp":1656812114000},"page":"246-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice"],"prefix":"10.1016","volume":"382","author":[{"given":"Bruce S.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Peiser-Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Alamein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon N.","family":"Mostyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Shimmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Rawling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MacDonald J.","family":"Christie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1523-4814","authenticated-orcid":false,"given":"Robert J.","family":"Vandenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-8635","authenticated-orcid":false,"given":"Sarasa A.","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.122.001265_bib1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00429-013-0537-3","article-title":"GlyT1 and GlyT2 in brain astrocytes: expression, distribution and function","volume":"219","author":"Aroeira","year":"2014","journal-title":"Brain Struct Funct"},{"key":"10.1124\/jpet.122.001265_bib2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/ALN.0000000000000203","article-title":"Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats","volume":"121","author":"Barthel","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.122.001265_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/bja\/aet127","article-title":"Sex differences in pain: a brief review of clinical and experimental findings","volume":"111","author":"Bartley","year":"2013","journal-title":"Br J Anaesth"},{"key":"10.1124\/jpet.122.001265_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ejpain.2007.10.002","article-title":"Sciatic nerve cuffing in mice: a model of sustained neuropathic pain","volume":"12","author":"Benbouzid","year":"2008","journal-title":"Eur J Pain"},{"key":"10.1124\/jpet.122.001265_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/BST0340055","article-title":"Glycine transporters: essential regulators of synaptic transmission","volume":"34","author":"Betz","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"10.1124\/jpet.122.001265_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-4886(03)00086-4","article-title":"Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model","volume":"182","author":"Borges","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1124\/jpet.122.001265_bib7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur J Pain"},{"key":"10.1124\/jpet.122.001265_bib8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jpain.2007.10.011","article-title":"Modulation of mechanical and thermal nociceptive sensitivity in the laboratory mouse by behavioral state","volume":"9","author":"Callahan","year":"2008","journal-title":"J Pain"},{"key":"10.1124\/jpet.122.001265_bib9","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1021\/jm0011272","article-title":"The first potent and selective inhibitors of the glycine transporter type 2. 1","volume":"44","author":"Caulfield","year":"2001","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.122.001265_bib10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejphar.2009.04.052","article-title":"Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors","volume":"614","author":"Cheng","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.122.001265_bib11","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1021\/acs.jmedchem.7b00956","article-title":"Modulation of glycine-mediated spinal neurotransmission for the treatment of chronic pain","volume":"61","author":"Cioffi","year":"2018","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.122.001265_bib12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2009.03.018","article-title":"Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain","volume":"123","author":"Dohi","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.122.001265_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0896-6273(03)00673-1","article-title":"Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality","volume":"40","author":"Gomeza","year":"2003","journal-title":"Neuron"},{"key":"10.1124\/jpet.122.001265_bib14","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1213\/ANE.0b013e3181c7ebbb","article-title":"The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model","volume":"110","author":"Haranishi","year":"2010","journal-title":"Anesth Analg"},{"key":"10.1124\/jpet.122.001265_bib15","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nrd3893","article-title":"Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain","volume":"12","author":"Harvey","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/jpet.122.001265_bib16","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype to reveal neural mechanisms","volume":"73","author":"von Hehn","year":"2012","journal-title":"Neuron"},{"key":"10.1124\/jpet.122.001265_bib17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neulet.2008.09.012","article-title":"Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain","volume":"445","author":"Hermanns","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.122.001265_bib18","doi-asserted-by":"crossref","first-page":"37104","DOI":"10.1038\/srep37104","article-title":"Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain","volume":"6","author":"Imlach","year":"2016","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.122.001265_bib19","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1046\/j.1471-4159.1995.64031026.x","article-title":"Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor","volume":"64","author":"Jursky","year":"1995","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.122.001265_bib20","first-page":"1","article-title":"Deaths: Final Data for 2017","volume":"68","author":"Kochanek","year":"2019","journal-title":"Natl Vital Stat Rep"},{"key":"10.1124\/jpet.122.001265_bib21","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1002\/j.1460-2075.1991.tb07779.x","article-title":"Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain","volume":"10","author":"Malosio","year":"1991","journal-title":"EMBO J"},{"key":"10.1124\/jpet.122.001265_bib22","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1097\/j.pain.0000000000001265","article-title":"Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats","volume":"159","author":"Mapplebeck","year":"2018","journal-title":"Pain"},{"key":"10.1124\/jpet.122.001265_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1124\/mol.119.118927","article-title":"New author guidelines for displaying data and reporting data analysis and statistical methods in experimental biology","volume":"97","author":"Michel","year":"2020","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.122.001265_bib24","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/bph.12343","article-title":"Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain","volume":"170","author":"Mingorance-Le Meur","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.122.001265_bib25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrn3360","article-title":"Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon","volume":"13","author":"Mogil","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/jpet.122.001265_bib26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1744-8069-10-64","article-title":"\u03b19-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia","volume":"10","author":"Mohammadi","year":"2014","journal-title":"Mol Pain"},{"key":"10.1124\/jpet.122.001265_bib27","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1124\/jpet.108.136267","article-title":"Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice","volume":"326","author":"Morita","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.122.001265_bib28","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1021\/acs.jmedchem.8b01775","article-title":"Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain","volume":"62","author":"Mostyn","year":"2019","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.122.001265_bib29","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1213\/ANE.0000000000000388","article-title":"Relief of cancer pain by glycine transporter inhibitors","volume":"119","author":"Motoyama","year":"2014","journal-title":"Anesth Analg"},{"key":"10.1124\/jpet.122.001265_bib30","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1254\/jphs.09351FP","article-title":"Blockade of glycine transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain","volume":"112","author":"Nishikawa","year":"2010","journal-title":"J Pharmacol Sci"},{"key":"10.1124\/jpet.122.001265_bib31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jphs.2015.02.010","article-title":"Analgesic effect of GT-0198, a structurally novel glycine transporter 2 inhibitor, in a mouse model of neuropathic pain","volume":"127","author":"Omori","year":"2015","journal-title":"J Pharmacol Sci"},{"key":"10.1124\/jpet.122.001265_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.drudis.2012.01.003","article-title":"A series of case studies: practical methodology for identifying antinociceptive multi-target drugs","volume":"17","author":"Pang","year":"2012","journal-title":"Drug Discov Today"},{"key":"10.1124\/jpet.122.001265_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1744806916656635","article-title":"EXPRESS: Voluntary and evoked behavioral correlates in neuropathic pain states under different social housing conditions","volume":"12","author":"Pitzer","year":"2016","journal-title":"Mol Pain"},{"key":"10.1124\/jpet.122.001265_bib34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuint.2007.04.027","article-title":"Functional expression of release-regulating glycine transporters GLYT1 on GABAergic neurons and GLYT2 on astrocytes in mouse spinal cord","volume":"52","author":"Raiteri","year":"2008","journal-title":"Neurochem Int"},{"key":"10.1124\/jpet.122.001265_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neulet.2015.06.026","article-title":"Glycine transporter GlyT1, but not GlyT2, is expressed in rat dorsal root ganglion--Possible implications for neuropathic pain","volume":"600","author":"Schl\u00f6sser","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.122.001265_bib36","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.15585\/mmwr.mm675152e1","article-title":"Drug and Opioid-Involved Overdose Deaths - United States, 2013-2017","volume":"67","author":"Scholl","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1124\/jpet.122.001265_bib37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2105\/AJPH.2017.304265","article-title":"Quantifying the epidemic of prescription opioid overdose deaths","volume":"108","author":"Seth","year":"2018","journal-title":"Am J Public Health"},{"key":"10.1124\/jpet.122.001265_bib38","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nn.4053","article-title":"Different immune cells mediate mechanical pain hypersensitivity in male and female mice","volume":"18","author":"Sorge","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1124\/jpet.122.001265_bib39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pbb.2015.01.001","article-title":"Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain","volume":"130","author":"Takahashi","year":"2015","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.122.001265_bib40","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/ALN.0b013e31816c9044","article-title":"Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment","volume":"108","author":"Tanabe","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.122.001265_bib41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fnagi.2016.00012","article-title":"Motor performance is impaired following vestibular stimulation in ageing mice","volume":"8","author":"Tung","year":"2016","journal-title":"Front Aging Neurosci"},{"key":"10.1124\/jpet.122.001265_bib42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tips.2014.05.006","article-title":"Glycine transport inhibitors for the treatment of pain","volume":"35","author":"Vandenberg","year":"2014","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.122.001265_bib43","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/mds.21720","article-title":"The role of executive function and attention in gait","volume":"23","author":"Yogev-Seligmann","year":"2008","journal-title":"Mov Disord"},{"key":"10.1124\/jpet.122.001265_bib44","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1523\/JNEUROSCI.15-05-03952.1995","article-title":"Glycine transporters are differentially expressed among CNS cells","volume":"15","author":"Zafra","year":"1995","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.122.001265_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cne.20349","article-title":"Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice","volume":"482","author":"Zeilhofer","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1124\/jpet.122.001265_bib46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5173(94)90103-1","article-title":"Release and absorption rates of intramuscularly and subcutaneously injected pharmaceuticals (II)","volume":"105","author":"Zuidema","year":"1994","journal-title":"Int J Pharm"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524003240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524003240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.122.001265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:16:41Z","timestamp":1739971001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524003240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0022356524003240"],"URL":"https:\/\/doi.org\/10.1124\/jpet.122.001265","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.122.001265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}