{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:19:43Z","timestamp":1792030783288,"version":"4.4.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1124\/jpet.123.001557","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T19:35:10Z","timestamp":1684179310000},"page":"586-595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Suppression of Lung Oxidative Stress, Inflammation, and Fibrosis following Nitrogen Mustard Exposure by the Selective Farnesoid X Receptor Agonist Obeticholic Acid"],"prefix":"10.1016","volume":"388","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-3594","authenticated-orcid":false,"given":"Jaclynn A.","family":"Meshanni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinal N.","family":"Vayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2666-0635","authenticated-orcid":false,"given":"Grace L.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Gow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1832-7311","authenticated-orcid":false,"given":"Debra L.","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.123.001557_bib1","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.1128\/IAI.72.10.6002-6011.2004","article-title":"Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species","volume":"72","author":"Atochina","year":"2004","journal-title":"Infect Immun"},{"key":"10.1124\/jpet.123.001557_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1472-8206.2005.00325.x","article-title":"The pharmacology, toxicology, and medical treatment of sulphur mustard poisoning","volume":"19","author":"Balali-Mood","year":"2005","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1124\/jpet.123.001557_bib3","series-title":"Wiley Encyclopedia of Biomedical Engineering","first-page":"62","article-title":"Pulmonary mechanics","author":"Bates","year":"2006"},{"key":"10.1124\/jpet.123.001557_bib4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.prp.2006.04.008","article-title":"Mustard lung secrets: long term clinicopathological study following mustard gas exposure","volume":"202","author":"Beheshti","year":"2006","journal-title":"Pathol Res Pract"},{"key":"10.1124\/jpet.123.001557_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/109374099281232","article-title":"Ozone-induced lung inflammation and mucosal barrier disruption: toxicology, mechanisms, and implications","volume":"2","author":"Bhalla","year":"1999","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"10.1124\/jpet.123.001557_bib6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10495-015-1098-0","article-title":"Lactosylceramide-accumulation in lipid-rafts mediate aberrant-autophagy, inflammation and apoptosis in cigarette smoke induced emphysema","volume":"20","author":"Bodas","year":"2015","journal-title":"Apoptosis"},{"key":"10.1124\/jpet.123.001557_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2144\/01301bm06","article-title":"Microplate assay for the measurement of hydroxyproline in acid-hydrolyzed tissue samples","volume":"30","author":"Brown","year":"2001","journal-title":"Biotechniques"},{"key":"10.1124\/jpet.123.001557_bib8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-020-00491-x","article-title":"Regulation of inflammation by the antioxidant haem oxygenase 1","volume":"21","author":"Campbell","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/jpet.123.001557_bib9","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.bbalip.2019.07.006","article-title":"Ursodeoxycholic acid is a GPBAR1 agonist and resets liver\/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH","volume":"1864","author":"Carino","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1124\/jpet.123.001557_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/bmb\/ldaa006","article-title":"Obeticholic acid-a new therapy in PBC and NASH","volume":"133","author":"Chapman","year":"2020","journal-title":"Br Med Bull"},{"key":"10.1124\/jpet.123.001557_bib11","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/resp.12815","article-title":"Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways","volume":"21","author":"Chen","year":"2016","journal-title":"Respirology"},{"key":"10.1124\/jpet.123.001557_bib12","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/nm1010-1078","article-title":"Good and bad lipids in the lung","volume":"16","author":"Chen","year":"2010","journal-title":"Nat Med"},{"key":"10.1124\/jpet.123.001557_bib13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jsbmb.2017.01.010","article-title":"Anti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis","volume":"168","author":"Comeglio","year":"2017","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1124\/jpet.123.001557_bib14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s40618-018-0913-1","article-title":"Therapeutic effects of obeticholic acid (OCA) treatment in a bleomycin-induced pulmonary fibrosis rat model","volume":"42","author":"Comeglio","year":"2019","journal-title":"J Endocrinol Invest"},{"key":"10.1124\/jpet.123.001557_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/toxsci\/kfab107","article-title":"Mast cells promote nitrogen mustard-mediated toxicity in the lung associated with proinflammatory cytokine and bioactive lipid mediator production","volume":"184","author":"Cruz-Hernandez","year":"2021","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.123.001557_bib16","doi-asserted-by":"crossref","first-page":"G979","DOI":"10.1152\/ajpgi.00370.2011","article-title":"Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice","volume":"302","author":"Cui","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.123.001557_bib17","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2174\/1568026619666190401100519","article-title":"Nitrogen mustards as anticancer chemotherapies: Historic perspective, current developments and future trends","volume":"19","author":"Diethelm-Varela","year":"2019","journal-title":"Curr Top Med Chem"},{"key":"10.1124\/jpet.123.001557_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174321","article-title":"Dioscin alleviates lung ischemia\/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation","volume":"908","author":"Dong","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.123.001557_bib19","doi-asserted-by":"crossref","first-page":"12727","DOI":"10.1074\/jbc.RA120.013699","article-title":"Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors","volume":"295","author":"Duffney","year":"2020","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.123.001557_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.intimp.2018.11.005","article-title":"Obeticholic acid alleviate lipopolysaccharide-induced acute lung injury via its anti-inflammatory effects in mice","volume":"66","author":"Fei","year":"2019","journal-title":"Int Immunopharmacol"},{"issue":"Supplement_5","key":"10.1124\/jpet.123.001557_bib21","doi-asserted-by":"crossref","first-page":"S399","DOI":"10.1513\/AnnalsATS.201702-136AW","article-title":"A new frontier in immunometabolism. Cholesterol in lung health and disease","volume":"14","author":"Fessler","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"10.1124\/jpet.123.001557_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/toxsci\/kfaa111","article-title":"Regulation of lung macrophage activation and oxidative stress following ozone exposure by farnesoid x receptor","volume":"177","author":"Francis","year":"2020","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.123.001557_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2021.107270","article-title":"Comprehensive dataset to assess morphological changes subsequent to bleomycin exposure","volume":"37","author":"Golden","year":"2021","journal-title":"Data Brief"},{"key":"10.1124\/jpet.123.001557_bib24","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1038\/s41598-018-26383-8","article-title":"Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis","volume":"8","author":"Goto","year":"2018","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.123.001557_bib25","doi-asserted-by":"crossref","first-page":"L555","DOI":"10.1152\/ajplung.00027.2013","article-title":"Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation","volume":"305","author":"Groves","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1124\/jpet.123.001557_bib25a","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1165\/rcmb.2011-0433OC","article-title":"Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflammation","volume":"47","author":"Groves","year":"2012","journal-title":"American journal of respiratory cell and molecular biology"},{"key":"10.1124\/jpet.123.001557_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154797","article-title":"A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage","volume":"120","author":"Huang","year":"2021","journal-title":"Metabolism"},{"key":"10.1124\/jpet.123.001557_bib27","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2337\/db06-1642","article-title":"Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy","volume":"56","author":"Jiang","year":"2007","journal-title":"Diabetes"},{"key":"10.1124\/jpet.123.001557_bib28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12989-015-0103-7","article-title":"Nitrative stress, oxidative stress and plasma endothelin levels after inhalation of particulate matter and ozone","volume":"12","author":"Kumarathasan","year":"2015","journal-title":"Part Fibre Toxicol"},{"key":"10.1124\/jpet.123.001557_bib29","first-page":"13371","article-title":"RAGE\/NF-\u03baB signaling mediates lipopolysaccharide induced acute lung injury in neonate rat model","volume":"8","author":"Li","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1124\/jpet.123.001557_bib30","first-page":"A3202","article-title":"Role of Oxidative Stress in Pulmonary Injury Induced by Nitrogen Mustard","volume":"205","author":"Malaviya","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.123.001557_bib32","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/toxsci\/kfaa150","article-title":"Progressive lung injury, inflammation, and fibrosis in rats following inhalation of sulfur mustard","volume":"178","author":"Malaviya","year":"2020","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.123.001557_bib33","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pharmthera.2017.06.008","article-title":"Anti-TNF\u03b1 therapy in inflammatory lung diseases","volume":"180","author":"Malaviya","year":"2017","journal-title":"Pharmacol Ther"},{"key":"10.1124\/jpet.123.001557_bib34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/nyas.13123","article-title":"Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants","volume":"1374","author":"Malaviya","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/jpet.123.001557_bib35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/toxsci\/kfv161","article-title":"Attenuation of nitrogen mustard-induced pulmonary injury and fibrosis by anti-tumor necrosis factor-\u03b1 antibody","volume":"148","author":"Malaviya","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.123.001557_bib36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.taap.2012.08.027","article-title":"Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor","volume":"265","author":"Malaviya","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001557_bib36a","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.taap.2014.02.006","article-title":"Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction","volume":"278","author":"Massa","year":"2014","journal-title":"Toxicology and applied pharmacology"},{"key":"10.1124\/jpet.123.001557_bib37","doi-asserted-by":"crossref","first-page":"H272","DOI":"10.1152\/ajpheart.01075.2008","article-title":"Antiatherosclerotic effect of farnesoid X receptor","volume":"296","author":"Mencarelli","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/jpet.123.001557_bib38","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1183\/09031936.00216914","article-title":"Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice","volume":"46","author":"Morissette","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1124\/jpet.123.001557_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116208","article-title":"Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard exposure","volume":"454","author":"Murray","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001557_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1165\/rcmb.2010-0214OC","article-title":"Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide","volume":"45","author":"O\u2019Neill","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/jpet.123.001557_bib41","first-page":"40","article-title":"All the \u201cRAGE\u201d in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses","volume":"23","author":"Oczypok","year":"2017","journal-title":"Paediatr Respir Rev"},{"key":"10.1124\/jpet.123.001557_bib42","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1194\/jlr.M081935","article-title":"FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver","volume":"59","author":"Papazyan","year":"2018","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.123.001557_bib43","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.3390\/molecules27165252","article-title":"Glutathione-mediated conjugation of anticancer drugs: An overview of reaction mechanisms and biological significance for drug detoxification and bioactivation","volume":"27","author":"Pot\u0119ga","year":"2022","journal-title":"Molecules"},{"key":"10.1124\/jpet.123.001557_bib44","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3390\/biomedicines9091221","article-title":"Macrophages and foam cells: Brief overview of their role, linkage, and targeting potential in atherosclerosis","volume":"9","author":"Poznyak","year":"2021","journal-title":"Biomedicines"},{"key":"10.1124\/jpet.123.001557_bib45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3390\/biomedicines9030306","article-title":"Deciphering the role of heme oxygenase-1 (HO-1) expressing macrophages in renal ischemia-reperfusion injury","volume":"9","author":"Rossi","year":"2021","journal-title":"Biomedicines"},{"key":"10.1124\/jpet.123.001557_bib46","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41598-018-36163-z","article-title":"Rage is a critical mediator of pulmonary oxidative stress, alveolar macrophage activation and emphysema in response to cigarette smoke","volume":"9","author":"Sanders","year":"2019","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.123.001557_bib47","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3181\/0712-RM-337","article-title":"Role of oxidative stress and NFkB in hypoxia-induced pulmonary edema","volume":"233","author":"Sarada","year":"2008","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1124\/jpet.123.001557_bib48","first-page":"93","article-title":"Lipid homeostasis in macrophages\u2013implications for atherosclerosis","volume":"160","author":"Schmitz","year":"2008","journal-title":"Rev Physiol Biochem"},{"key":"10.1124\/jpet.123.001557_bib49","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122163","article-title":"Transcriptome network analysis identifies protective role of the LXR\/SREBP-1c axis in murine pulmonary fibrosis","volume":"4","author":"Shichino","year":"2019","journal-title":"JCI Insight"},{"key":"10.1124\/jpet.123.001557_bib50","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3746\/pnf.2020.25.2.166","article-title":"Kmeria duperreana (pierre) dandy extract suppresses IPS-induced INOS and no via regulation of NF-\u03baB pathways and p38 in murin macrophage raw 264.7 cells","volume":"25","author":"So","year":"2020","journal-title":"Prev Nutr Food Sci"},{"key":"10.1124\/jpet.123.001557_bib51","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201701381","article-title":"A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure","volume":"32","author":"Sonett","year":"2018","journal-title":"FASEB J"},{"key":"10.1124\/jpet.123.001557_bib52","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.toxlet.2009.04.012","article-title":"Sulphur mustard induces time- and concentration-dependent regulation of NO-synthesizing enzymes","volume":"188","author":"Steinritz","year":"2009","journal-title":"Toxicol Lett"},{"key":"10.1124\/jpet.123.001557_bib53","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3389\/fmed.2020.00544","article-title":"Bile acids and fxr: Novel targets for liver diseases","volume":"7","author":"Stofan","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"10.1124\/jpet.123.001557_bib54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2010.09.016","article-title":"Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard","volume":"250","author":"Sunil","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001557_bib54a","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.taap.2012.06.009","article-title":"Classical and alternative macrophage activation in the lung following ozoneinduced oxidative stress","volume":"263","author":"Sunil","year":"2012","journal-title":"Toxicology and applied pharmacology"},{"key":"10.1124\/jpet.123.001557_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114798","article-title":"Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard","volume":"387","author":"Sunil","year":"2020","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001557_bib56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.yexmp.2014.05.009","article-title":"Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation","volume":"97","author":"Sunil","year":"2014","journal-title":"Exp Mol Pathol"},{"key":"10.1124\/jpet.123.001557_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116257","article-title":"Impaired energy metabolism and altered functional activity of alveolar type II epithelial cells following exposure of rats to nitrogen mustard","volume":"456","author":"Sunil","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001557_bib58","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.3390\/ijms21124257","article-title":"Lipid mediators regulate pulmonary fibrosis: Potential mechanisms and signaling pathways","volume":"21","author":"Suryadevara","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.123.001557_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116281","article-title":"Regulation of macrophage activation by S-Nitrosothiols following ozone-induced lung injury","volume":"457","author":"Taylor","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001557_bib60","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jdermsci.2012.10.009","article-title":"Propionibacterium acnes-induced iNOS and COX-2 protein expression via ROS-dependent NF-\u03baB and AP-1 activation in macrophages","volume":"69","author":"Tsai","year":"2013","journal-title":"J Dermatol Sci"},{"key":"10.1124\/jpet.123.001557_bib61","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.4049\/jimmunol.0803978","article-title":"The bile acid receptor FXR is a modulator of intestinal innate immunity","volume":"183","author":"Vavassori","year":"2009","journal-title":"J Immunol"},{"key":"10.1124\/jpet.123.001557_bib62","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/toxsci\/kfx032","article-title":"Regulation of nitrogen mustard-induced lung macrophage activation by valproic acid, a histone deacetylase inhibitor","volume":"157","author":"Venosa","year":"2017","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.123.001557_bib63","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1165\/rcmb.2015-0120OC","article-title":"Characterization of distinct macrophage subpopulations during nitrogen mustard\u2013induced lung injury and fibrosis","volume":"54","author":"Venosa","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/jpet.123.001557_bib64","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/toxsci\/kfz187","article-title":"Regulation of macrophage foam cell formation during nitrogen mustard (NM)-induced pulmonary fibrosis by lung lipids","volume":"172","author":"Venosa","year":"2019","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.123.001557_bib65","doi-asserted-by":"crossref","first-page":"33453","DOI":"10.1038\/srep33453","article-title":"FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis","volume":"6","author":"Verbeke","year":"2016","journal-title":"Sci Rep"},{"key":"10.1124\/jpet.123.001557_bib66","doi-asserted-by":"crossref","first-page":"G117","DOI":"10.1152\/ajpgi.00274.2021","article-title":"Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs","volume":"322","author":"Vonderohe","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.123.001557_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.111949","article-title":"Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver","volume":"390","author":"Wang","year":"2020","journal-title":"Exp Cell Res"},{"key":"10.1124\/jpet.123.001557_bib68","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1136\/gut.2010.233304","article-title":"FXR activation inhibits inflammation and preserves the intestinal barrier in IBD","volume":"60","author":"Wildenberg","year":"2011","journal-title":"Gut"},{"key":"10.1124\/jpet.123.001557_bib69","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbrc.2013.11.057","article-title":"Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease","volume":"443","author":"Wu","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.123.001557_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109609","article-title":"Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease","volume":"121","author":"Xi","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1124\/jpet.123.001557_bib71","doi-asserted-by":"crossref","first-page":"14430","DOI":"10.3748\/wjg.v20.i39.14430","article-title":"FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation","volume":"20","author":"Yao","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1124\/jpet.123.001557_bib72","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tox.2017.01.007","article-title":"Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation","volume":"378","author":"Zhang","year":"2017","journal-title":"Toxicology"},{"key":"10.1124\/jpet.123.001557_bib73","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.apsb.2016.07.008","article-title":"Fatty liver diseases, bile acids, and FXR","volume":"6","author":"Zhu","year":"2016","journal-title":"Acta Pharm Sin B"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524171893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524171893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.123.001557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T22:21:38Z","timestamp":1743200498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524171893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0022356524171893"],"URL":"https:\/\/doi.org\/10.1124\/jpet.123.001557","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of Lung Oxidative Stress, Inflammation, and Fibrosis following Nitrogen Mustard Exposure by the Selective Farnesoid X Receptor Agonist Obeticholic Acid","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.123.001557","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}