{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:32:22Z","timestamp":1790742742558,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1124\/jpet.123.001634","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T16:51:28Z","timestamp":1687452688000},"page":"323-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model"],"prefix":"10.1016","volume":"386","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8379-2004","authenticated-orcid":false,"given":"Karolina H.","family":"Dziewulska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Reisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel M.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"D\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Zimring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.123.001634_bib1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0891-5849(96)00542-4","article-title":"Formation of free radicals and protein mixed disulfides in rat red cells exposed to dapsone hydroxylamine","volume":"22","author":"Bradshaw","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/jpet.123.001634_bib2","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.3324\/haematol.2020.246603","article-title":"Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity","volume":"106","author":"D\u2019Alessandro","year":"2021","journal-title":"Haematologica"},{"key":"10.1124\/jpet.123.001634_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.147056","article-title":"Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice","volume":"6","author":"D\u2019Alessandro","year":"2021","journal-title":"JCI Insight"},{"key":"10.1124\/jpet.123.001634_bib4","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1182\/blood-2009-04-214387","article-title":"Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model","volume":"114","author":"Desmarets","year":"2009","journal-title":"Blood"},{"key":"10.1124\/jpet.123.001634_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/bs.vh.2022.10.008","article-title":"Ascorbic acid as antioxidant","volume":"121","author":"G\u0119gotek","year":"2023","journal-title":"Vitam Horm"},{"key":"10.1124\/jpet.123.001634_bib6","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.3390\/ijms17122069","article-title":"Glucose-6-Phosphate Dehydrogenase: Update and Analysis of New Mutations around the World","volume":"17","author":"G\u00f3mez-Manzo","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.123.001634_bib7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0022-3565(25)09600-4","article-title":"Dapsone-induced hemolytic anemia: role of glucose-6-phosphate dehydrogenase in the hemolytic response of rat erythrocytes to N-hydroxydapsone","volume":"273","author":"Grossman","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001634_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0022-3565(25)24263-X","article-title":"Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia","volume":"244","author":"Grossman","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001634_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0041-008X(92)90239-O","article-title":"Dapsone-induced hemolytic anemia: effect of N-hydroxy dapsone on the sulfhydryl status and membrane proteins of rat erythrocytes","volume":"117","author":"Grossman","year":"1992","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001634_bib10","first-page":"50","article-title":"Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries","volume":"21","author":"Hay","year":"2023","journal-title":"Blood Transfus"},{"key":"10.1124\/jpet.123.001634_bib11","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1182\/bloodadvances.2019000605","article-title":"Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice","volume":"3","author":"Howie","year":"2019","journal-title":"Blood Adv"},{"key":"10.1124\/jpet.123.001634_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0022-3565(25)29658-6","article-title":"Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites","volume":"187","author":"Israili","year":"1973","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001634_bib13","first-page":"1250","article-title":"Safety and Pharmacokinetics of Once-Daily Dapsone Gel, 7.5% in Patients With Moderate Acne Vulgaris","volume":"15","author":"Jarratt","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"10.1124\/jpet.123.001634_bib14","first-page":"101","article-title":"Molecular mechanism of glucose-6-phosphate dehydrogenase deficiency","volume":"25","author":"Kahn","year":"1974","journal-title":"Humangenetik"},{"key":"10.1124\/jpet.123.001634_bib15","series-title":"Dapsone","author":"Kurien","year":"2023"},{"key":"10.1124\/jpet.123.001634_bib16","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/emboj\/cdf426","article-title":"Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal","volume":"21","author":"Longo","year":"2002","journal-title":"EMBO J"},{"key":"10.1124\/jpet.123.001634_bib17","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0140-6736(10)60396-0","article-title":"The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics","volume":"376","author":"Luzzatto","year":"2010","journal-title":"Lancet"},{"key":"10.1124\/jpet.123.001634_bib18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood.2019000944","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"136","author":"Luzzatto","year":"2020","journal-title":"Blood"},{"key":"10.1124\/jpet.123.001634_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101639","article-title":"Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase","volume":"36","author":"Matt\u00e8","year":"2020","journal-title":"Redox Biol"},{"key":"10.1124\/jpet.123.001634_bib20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/toxsci\/kfi290","article-title":"Lipids versus proteins as major targets of pro-oxidant, direct-acting hemolytic agents","volume":"88","author":"McMillan","year":"2005","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.123.001634_bib21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0022-3565(25)10682-4","article-title":"Dapsone-induced hemolytic anemia: effect of dapsone hydroxylamine on sulfhydryl status, membrane skeletal proteins and morphology of human and rat erythrocytes","volume":"274","author":"McMillan","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001634_bib22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-genet-102108-134201","article-title":"Thioredoxins and glutaredoxins: unifying elements in redox biology","volume":"43","author":"Meyer","year":"2009","journal-title":"Annu Rev Genet"},{"key":"10.1124\/jpet.123.001634_bib23","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0009-9236(95)90176-0","article-title":"Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo","volume":"58","author":"Mitra","year":"1995","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.123.001634_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102706","article-title":"Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors","volume":"298","author":"Moore","year":"2022","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.123.001634_bib25","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.146175","article-title":"Blood donor exposome and impact of common drugs on red blood cell metabolism","volume":"6","author":"Nemkov","year":"2021","journal-title":"JCI Insight"},{"key":"10.1124\/jpet.123.001634_bib26","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1182\/blood-2012-03-416032","article-title":"Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone","volume":"120","author":"Pamba","year":"2012","journal-title":"Blood"},{"key":"10.1124\/jpet.123.001634_bib27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1172\/JCI105786","article-title":"In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and GdMediterranean deficiency","volume":"47","author":"Piomelli","year":"1968","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.123.001634_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1146\/annurev.pa.30.040190.003131","article-title":"Glutathione: toxicological implications","volume":"30","author":"Reed","year":"1990","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/jpet.123.001634_bib29","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev-biochem-060815-014431","article-title":"Multiple Functions and Regulation of Mammalian Peroxiredoxins","volume":"86","author":"Rhee","year":"2017","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/jpet.123.001634_bib30","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1111\/trf.16395","article-title":"Quantifying dynamic range in red blood cell energetics: Evidence of progressive energy failure during storage","volume":"61","author":"Rogers","year":"2021","journal-title":"Transfusion"},{"key":"10.1124\/jpet.123.001634_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/ada.2020.101637","article-title":"Etiopathogenesis of dermatitis herpetiformis","volume":"39","author":"Rybak-d\u2019Obyrn","year":"2022","journal-title":"Postepy Dermatol Alergol"},{"key":"10.1124\/jpet.123.001634_bib32","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1182\/bloodadvances.2018024562","article-title":"Sensing of red blood cells with decreased membrane deformability by the human spleen","volume":"2","author":"Safeukui","year":"2018","journal-title":"Blood Adv"},{"key":"10.1124\/jpet.123.001634_bib33","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1016\/0006-2952(83)90393-3","article-title":"Effects of physiologic concentrations of lactate, pyruvate and ascorbate on glucose metabolism in unstressed and oxidatively stressed human red blood cells","volume":"32","author":"Sullivan","year":"1983","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.123.001634_bib34","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0022-3565(24)37079-X","article-title":"Comparison of the metabolism and toxicity of dapsone in rat, mouse and man","volume":"283","author":"Tingle","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001634_bib35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/taap.1994.1255","article-title":"Dapsone-induced hematologic toxicity: comparison of the methemoglobin-forming ability of hydroxylamine metabolites of dapsone in rat and human blood","volume":"129","author":"Vage","year":"1994","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001634_bib36","first-page":"532","article-title":"Is topical dapsone safe in glucose-6-phosphate dehydrogenase-deficient and sulfonamide-allergic patients?","volume":"9","author":"Webster","year":"2010","journal-title":"J Drugs Dermatol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524170802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524170802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.123.001634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:30:38Z","timestamp":1739971838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524170802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0022356524170802"],"URL":"https:\/\/doi.org\/10.1124\/jpet.123.001634","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.123.001634","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}