{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:37:14Z","timestamp":1780519034603,"version":"3.54.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1124\/jpet.123.001686","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:15:21Z","timestamp":1700244921000},"page":"526-535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach"],"prefix":"10.1016","volume":"388","author":[{"given":"Robert","family":"Shalwitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tovah","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-1384","authenticated-orcid":false,"given":"Anna Kotsakis","family":"Ruehlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Julio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shellaina","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Vandeuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Lyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Altvater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celinia","family":"Ondeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan L.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Wayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandrea","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaiah","family":"Shalwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Batchelor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-4565","authenticated-orcid":false,"given":"Patrick","family":"McNutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.123.001686_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/156800909787314011","article-title":"Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy","volume":"9","author":"Andreassen","year":"2009","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1124\/jpet.123.001686_bib2","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1128\/MCB.20.20.7450-7459.2000","article-title":"Tumor suppressor p53 is required to modulate BRCA1 expression","volume":"20","author":"Arizti","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1124\/jpet.123.001686_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1742-7843.2006.pto_429.x","article-title":"Comparison of early and late toxic effects of sulfur mustard in Iranian veterans","volume":"99","author":"Balali-Mood","year":"2006","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1124\/jpet.123.001686_bib4","first-page":"383","article-title":"Mustard gas induced ocular surface disorders","volume":"8","author":"Baradaran-Rafii","year":"2013","journal-title":"J Ophthalmic Vis Res"},{"key":"10.1124\/jpet.123.001686_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2015.01.001","article-title":"A guanine-ethylthioethyl-glutathione adduct as a major DNA lesion in the skin and in organs of mice exposed to sulfur mustard","volume":"233","author":"Batal","year":"2015","journal-title":"Toxicol Lett"},{"key":"10.1124\/jpet.123.001686_bib6","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/msb.2011.20","article-title":"Stimulus-dependent dynamics of p53 in single cells","volume":"7","author":"Batchelor","year":"2011","journal-title":"Mol Syst Biol"},{"key":"10.1124\/jpet.123.001686_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molcel.2008.03.016","article-title":"Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage","volume":"30","author":"Batchelor","year":"2008","journal-title":"Mol Cell"},{"key":"10.1124\/jpet.123.001686_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.molcel.2018.08.016","article-title":"The BRCT domains of the BRCA1 and BARD1 tumor suppressors differentially regulate homology-directed repair and stalled fork protection","volume":"72","author":"Billing","year":"2018","journal-title":"Mol Cell"},{"key":"10.1124\/jpet.123.001686_bib9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/004982597240460","article-title":"Biological fate of sulphur mustard: identification of valine and histidine adducts in haemoglobin from casualties of sulphur mustard poisoning","volume":"27","author":"Black","year":"1997","journal-title":"Xenobiotica"},{"key":"10.1124\/jpet.123.001686_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejca.2006.09.002","article-title":"Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours","volume":"43","author":"Butcher","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1124\/jpet.123.001686_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/cdd.2016.117","article-title":"p53 on the crossroad between regeneration and cancer","volume":"24","author":"Charni","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1124\/jpet.123.001686_bib12","first-page":"342","article-title":"Protective role of ADP-ribose against ionizing radiation induced oral mucositis and UV-mediated skin damage","volume":"65","author":"Das","year":"2005","journal-title":"Proc Am Assoc Cancer Res"},{"key":"10.1124\/jpet.123.001686_bib13","doi-asserted-by":"crossref","first-page":"15110","DOI":"10.1038\/ncomms15110","article-title":"PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA","volume":"8","author":"Day","year":"2017","journal-title":"Nat Commun"},{"key":"10.1124\/jpet.123.001686_bib14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrc3088","article-title":"DNA interstrand crosslink repair and cancer","volume":"11","author":"Deans","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/jpet.123.001686_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0921-8777(01)00092-1","article-title":"Repair of DNA interstrand cross-links","volume":"486","author":"Dronkert","year":"2001","journal-title":"Mutat Res"},{"key":"10.1124\/jpet.123.001686_bib16","unstructured":"Fabbro M, Henderson BR (2008) BARD1 regulates BRCA1-mediated transactivation."},{"key":"10.1124\/jpet.123.001686_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/tx00038a013","article-title":"Synthesis, characterization, and quantitation of the major adducts formed between sulfur mustard and DNA of calf thymus and human blood","volume":"7","author":"Fidder","year":"1994","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/jpet.123.001686_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/msb4100068","article-title":"Oscillations and variability in the p53 system","volume":"2","author":"Geva-Zatorsky","year":"2006","journal-title":"Mol Syst Biol"},{"key":"10.1124\/jpet.123.001686_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF03167075","article-title":"p53: twenty five years understanding the mechanism of genome protection","volume":"60","author":"Gomez-Lazaro","year":"2004","journal-title":"J Physiol Biochem"},{"key":"10.1124\/jpet.123.001686_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7205\/MILMED.169.1.7","article-title":"Morphological and immunohistochemical changes on rat skin exposed to nitrogen mustard","volume":"169","author":"G\u00fcnhan","year":"2004","journal-title":"Mil Med"},{"key":"10.1124\/jpet.123.001686_bib21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.biopha.2018.10.155","article-title":"Reactivation of p53 gene by MDM2 inhibitors: a novel therapy for cancer treatment","volume":"109","author":"Gupta","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1124\/jpet.123.001686_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.abb.2011.04.006","article-title":"The activity of an ancient atypical protein kinase is stimulated by ADP-ribose in vitro","volume":"511","author":"Haile","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/jpet.123.001686_bib24","doi-asserted-by":"crossref","first-page":"e8685","DOI":"10.15252\/msb.20188685","article-title":"p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions","volume":"15","author":"Harton","year":"2019","journal-title":"Mol Syst Biol"},{"key":"10.1124\/jpet.123.001686_bib25","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbrc.2007.05.141","article-title":"Treatment of keratin intermediate filaments with sulfur mustard analogs","volume":"359","author":"Hess","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.123.001686_bib26","first-page":"436","article-title":"Incidence of spontaneous ocular lesions in laboratory rabbits","volume":"61","author":"Holve","year":"2011","journal-title":"Comp Med"},{"key":"10.1124\/jpet.123.001686_bib27","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.18632\/aging.101513","article-title":"Sirt6 deficiency impairs corneal epithelial wound healing","volume":"10","author":"Hu","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1124\/jpet.123.001686_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2011.11.009","article-title":"DNA damage responses in cells exposed to sulphur mustard","volume":"209","author":"Jowsey","year":"2012","journal-title":"Toxicol Lett"},{"key":"10.1124\/jpet.123.001686_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.toxlet.2010.04.020","article-title":"The role of homologous recombination in the cellular response to sulphur mustard","volume":"197","author":"Jowsey","year":"2010","journal-title":"Toxicol Lett"},{"key":"10.1124\/jpet.123.001686_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0167-4889(93)90001-6","article-title":"Function of NAD glycohydrolase in ADP-ribose uptake from NAD by human erythrocytes","volume":"1178","author":"Kim","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.123.001686_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0009-2797(83)90127-8","article-title":"DNA alkylation by mustard gas in yeast strains of different repair capacity","volume":"44","author":"Kircher","year":"1983","journal-title":"Chem Biol Interact"},{"key":"10.1124\/jpet.123.001686_bib34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exer.2016.11.005","article-title":"PAX6 regulates human corneal epithelium cell identity","volume":"154","author":"Kitazawa","year":"2017","journal-title":"Exp Eye Res"},{"key":"10.1124\/jpet.123.001686_bib35","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.tcb.2021.06.009","article-title":"Sirtuin 6: linking longevity with genome and epigenome stability","volume":"31","author":"Korotkov","year":"2021","journal-title":"Trends Cell Biol"},{"key":"10.1124\/jpet.123.001686_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/stke.2642004pe55","article-title":"The strength of indecisiveness: oscillatory behavior for better cell fate determination","volume":"2004","author":"Lahav","year":"2004","journal-title":"Sci STKE"},{"key":"10.1124\/jpet.123.001686_bib37","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/path.2256","article-title":"Down-regulation of Pax6 is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseases","volume":"214","author":"Li","year":"2008","journal-title":"J Pathol"},{"key":"10.1124\/jpet.123.001686_bib38","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/carcin\/7.7.1203","article-title":"Formation of O6-ethylthioethylguanine in DNA by reaction with the sulfur mustard, chloroethyl sulfide, and its apparent lack of repair by O6-alkylguanine-DNA alkyltransferase","volume":"7","author":"Ludlum","year":"1986","journal-title":"Carcinogenesis"},{"key":"10.1124\/jpet.123.001686_bib40","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/genes8020066","article-title":"Dynamics of p53: a master decider of cell fate","volume":"8","author":"Luo","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1124\/jpet.123.001686_bib41","first-page":"229","article-title":"A study of mustard gas lesions of the eyes of rabbits and men (Section of Ophthalmology)","volume":"35","author":"Mann","year":"1942","journal-title":"Proc R Soc Med"},{"key":"10.1124\/jpet.123.001686_bib42","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/carcin\/22.4.661","article-title":"Repair of sulfur mustard-induced DNA damage in mammalian cells measured by a host cell reactivation assay","volume":"22","author":"Matijasevic","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1124\/jpet.123.001686_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109395","article-title":"Progress towards a standardized model of ocular sulfur mustard injury for therapeutic testing","volume":"228","author":"McNutt","year":"2023","journal-title":"Exp Eye Res"},{"key":"10.1124\/jpet.123.001686_bib44","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/ICO.0B013E31823D02CD","article-title":"Pathogenesis of acute and delayed corneal lesions after ocular exposure to sulfur mustard vapor","volume":"31","author":"McNutt","year":"2012","journal-title":"Cornea"},{"key":"10.1124\/jpet.123.001686_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042837","article-title":"Architectural and biochemical expressions of mustard gas keratopathy: preclinical indicators and pathogenic mechanisms","volume":"7","author":"McNutt","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/jpet.123.001686_bib46","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1167\/iovs.13-12402","article-title":"Structural, morphological, and functional correlates of corneal endothelial toxicity following corneal exposure to sulfur mustard vapor","volume":"54","author":"McNutt","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.123.001686_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.toxlet.2021.01.016","article-title":"Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes","volume":"341","author":"McNutt","year":"2021","journal-title":"Toxicol Lett"},{"key":"10.1124\/jpet.123.001686_bib48","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/ICO.0000000000002278","article-title":"Corneal endothelial cell toxicity determines long-term outcome after ocular exposure to sulfur mustard vapor","volume":"39","author":"McNutt","year":"2020","journal-title":"Cornea"},{"key":"10.1124\/jpet.123.001686_bib49","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/nyas.13105","article-title":"Contributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor","volume":"1374","author":"McNutt","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/jpet.123.001686_bib50","first-page":"220","article-title":"Long story short: p53 mediates innate immunity","volume":"1865","author":"Miciak","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.123.001686_bib51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.taap.2008.02.006","article-title":"Proteomic assessment of sulfur mustard-induced protein adducts and other protein modifications in human epidermal keratinocytes","volume":"230","author":"Mol","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.123.001686_bib52","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1021\/tx9900369","article-title":"Alkylation of human serum albumin by sulfur mustard in vitro and in vivo: mass spectrometric analysis of a cysteine adduct as a sensitive biomarker of exposure","volume":"12","author":"Noort","year":"1999","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/jpet.123.001686_bib53","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1101\/gad.13.20.2633","article-title":"XRCC3 promotes homology-directed repair of DNA damage in mammalian cells","volume":"13","author":"Pierce","year":"1999","journal-title":"Genes Dev"},{"key":"10.1124\/jpet.123.001686_bib54","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cels.2016.03.006","article-title":"p53 pulses diversify target gene expression dynamics in an mRNA half-life-dependent manner and delineate co-regulated target gene subnetworks","volume":"2","author":"Porter","year":"2016","journal-title":"Cell Syst"},{"key":"10.1124\/jpet.123.001686_bib55","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1097-2765(03)00400-3","article-title":"Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization","volume":"12","author":"Poyurovsky","year":"2003","journal-title":"Mol Cell"},{"key":"10.1124\/jpet.123.001686_bib56","doi-asserted-by":"crossref","first-page":"7587","DOI":"10.1093\/nar\/gkq669","article-title":"Deconstructing nucleotide binding activity of the Mdm2 RING domain","volume":"38","author":"Priest","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/jpet.123.001686_bib57","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.1218351","article-title":"p53 dynamics control cell fate","volume":"336","author":"Purvis","year":"2012","journal-title":"Science"},{"key":"10.1124\/jpet.123.001686_bib57A","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111866","article-title":"The ADP-ribose hydrolase NUDT5 is important for DNA repair.","volume":"41","author":"Qi","year":"2022","journal-title":"Cell Rep"},{"key":"10.1124\/jpet.123.001686_bib58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mrgentox.2018.06.014","article-title":"Inter strand crosslinks in DNA induced in vivo by percutaneous application of sulphur mustard to rats and mice","volume":"832\u2013833","author":"Richterova","year":"2018","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"},{"key":"10.1124\/jpet.123.001686_bib59","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jbt.20321","article-title":"Sulfur mustard induced cytokine production and cell death: investigating the potential roles of the p38, p53, and NF-kappaB signaling pathways with RNA interference","volume":"24","author":"Ruff","year":"2010","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/jpet.123.001686_bib60","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/milmed\/166.1.67","article-title":"Ocular injuries caused by mustard gas: diagnosis, treatment, and medical defense","volume":"166","author":"Safarinejad","year":"2001","journal-title":"Mil Med"},{"key":"10.1124\/jpet.123.001686_bib61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfp253","article-title":"Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure","volume":"114","author":"Shakarjian","year":"2010","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.123.001686_bib62","series-title":"Medical Aspects of Chemical and Biological Warfare","author":"Sidell","year":"1997"},{"key":"10.1124\/jpet.123.001686_bib63","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0039-6257(97)00021-0","article-title":"Ocular injury by mustard gas","volume":"41","author":"Solberg","year":"1997","journal-title":"Surv Ophthalmol"},{"key":"10.1124\/jpet.123.001686_bib65","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00204-015-1459-z","article-title":"The role of DNA damage responses in p53 biology","volume":"89","author":"Speidel","year":"2015","journal-title":"Arch Toxicol"},{"key":"10.1124\/jpet.123.001686_bib66","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41580-020-0218-z","article-title":"The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication","volume":"21","author":"Tarsounas","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/jpet.123.001686_bib68","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1071\/CH9930293","article-title":"The hydrolysis of bis(2-chloroethyl) sulfide (sulfur mustard) in aqueous mixtures of ethanol, acetone, and dimethyl sulfoxide","volume":"46","author":"Tilley","year":"1993","journal-title":"Aust J Chem"},{"key":"10.1124\/jpet.123.001686_bib70","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/s41556-019-0425-z","article-title":"Advances in genome editing through control of DNA repair pathways","volume":"21","author":"Yeh","year":"2019","journal-title":"Nat Cell Biol"},{"key":"10.1124\/jpet.123.001686_bib71","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1021\/tx5004886","article-title":"Distribution of DNA adducts and corresponding tissue damage of Sprague-Dawley rats with percutaneous exposure to sulfur mustard","volume":"28","author":"Yue","year":"2015","journal-title":"Chem Res Toxicol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524171832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524171832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.123.001686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T22:16:54Z","timestamp":1743200214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524171832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0022356524171832"],"URL":"https:\/\/doi.org\/10.1124\/jpet.123.001686","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.123.001686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government work not protected by U.S. copyright","name":"copyright","label":"Copyright"}]}}