{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:25:05Z","timestamp":1787016305912,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":427,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1124\/jpet.123.001740","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:50:23Z","timestamp":1693302623000},"page":"214-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema"],"prefix":"10.1016","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0685-5451","authenticated-orcid":false,"given":"Vahe","family":"Bedian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-5521","authenticated-orcid":false,"given":"Nikolaos","family":"Biris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Omer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jou-Ku","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-0923","authenticated-orcid":false,"given":"James","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafif","family":"Dagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Harwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Kiselak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Violin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-4411","authenticated-orcid":false,"given":"Pradeep","family":"Bista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.123.001740_bib1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/acsmedchemlett.2c00526","article-title":"Plasma Kallikrein Inhibitors as Potential Treatment for Diabetic Macular Edema, Retinal Vein Occlusion, Hereditary Angioedema and Other Related Diseases","volume":"14","author":"Abdel-Magid","year":"2023","journal-title":"ACS Med Chem Lett"},{"key":"10.1124\/jpet.123.001740_bib2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1107\/S2059798318006551","article-title":"Real-space refinement in PHENIX for cryo-EM and crystallography","volume":"74","author":"Afonine","year":"2018","journal-title":"Acta Crystallogr D Struct Biol"},{"key":"10.1124\/jpet.123.001740_bib3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1056\/NEJMoa1716995","article-title":"Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema","volume":"379","author":"Ayg\u00f6ren-P\u00fcrs\u00fcn","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.123.001740_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1056\/NEJMoa1605767","article-title":"Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis","volume":"376","author":"Banerji","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.123.001740_bib5","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1001\/jama.2018.16773","article-title":"Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial","volume":"320","author":"Banerji","year":"2018","journal-title":"JAMA"},{"key":"10.1124\/jpet.123.001740_bib6","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/s41592-019-0575-8","article-title":"Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs","volume":"16","author":"Bepler","year":"2019","journal-title":"Nat Methods"},{"key":"10.1124\/jpet.123.001740_bib7","first-page":"1098","article-title":"Extending human IgG half-life using structure-guided design","volume":"10","author":"Booth","year":"2018","journal-title":"MAbs"},{"key":"10.1124\/jpet.123.001740_bib8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaip.2020.08.046","article-title":"US HAEA Medical Advisory Board 2020 Guidelines for the Management of Hereditary Angioedema","volume":"9","author":"Busse","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1124\/jpet.123.001740_bib9","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1016\/j.jaip.2021.04.072","article-title":"Lanadelumab Efficacy, Safety, and Injection Interval Extension in HAE: A Real-Life Study","volume":"9","author":"Buttgereit","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1124\/jpet.123.001740_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10928-013-9332-2","article-title":"Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies","volume":"40","author":"Cao","year":"2013","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"10.1124\/jpet.123.001740_bib13","doi-asserted-by":"crossref","first-page":"23514","DOI":"10.1074\/jbc.M604292200","article-title":"Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)","volume":"281","author":"Dall\u2019Acqua","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.123.001740_bib14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1124\/jpet.123.001740_bib15","unstructured":"European Medicines Agency (2011) Withdrawal of the marketing authorisation application for Kalbitor (ecallantide)."},{"key":"10.1124\/jpet.123.001740_bib16","doi-asserted-by":"crossref","first-page":"8947","DOI":"10.3390\/ijms22168947","article-title":"The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies","volume":"22","author":"Gogesch","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.123.001740_bib17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1021\/ar50123a006","article-title":"Structural basis of the activation and action of trypsin","volume":"11","author":"Huber","year":"1978","journal-title":"Acc Chem Res"},{"key":"10.1124\/jpet.123.001740_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/BJ20121132","article-title":"Rezymogenation of active urokinase induced by an inhibitory antibody","volume":"449","author":"Jiang","year":"2013","journal-title":"Biochem J"},{"key":"10.1124\/jpet.123.001740_bib19","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002139RR","article-title":"A general strategy to inhibit serine protease by targeting its autolysis loop","volume":"35","author":"Jiang","year":"2021","journal-title":"FASEB J"},{"key":"10.1124\/jpet.123.001740_bib20","first-page":"1","article-title":"Boosting therapeutic potency of antibodies by taming Fc domain functions","volume":"51","author":"Kang","year":"2019","journal-title":"Exp Mol Med"},{"key":"10.1124\/jpet.123.001740_bib21","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jaci.2010.08.012","article-title":"Enzymatic pathways in the pathogenesis of hereditary angioedema: the role of C1 inhibitor therapy","volume":"126","author":"Kaplan","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.123.001740_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.anai.2010.01.007","article-title":"The bradykinin-forming cascade and its role in hereditary angioedema","volume":"104","author":"Kaplan","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1124\/jpet.123.001740_bib23","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1182\/blood.V77.12.2660.2660","article-title":"Alpha 2-macroglobulin-kallikrein complexes detect contact system activation in hereditary angioedema and human sepsis","volume":"77","author":"Kaufman","year":"1991","journal-title":"Blood"},{"key":"10.1124\/jpet.123.001740_bib24","doi-asserted-by":"crossref","first-page":"23596","DOI":"10.1074\/jbc.M114.569061","article-title":"Inhibition of plasma kallikrein by a highly specific active site blocking antibody","volume":"289","author":"Kenniston","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.123.001740_bib25","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1042\/BCJ20210708","article-title":"New tools for automated cryo-EM single-particle analysis in RELION-4.0","volume":"478","author":"Kimanius","year":"2021","journal-title":"Biochem J"},{"key":"10.1124\/jpet.123.001740_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s40259-021-00471-0","article-title":"Recent Achievements and Challenges in Prolonging the Serum Half-Lives of Therapeutic IgG Antibodies Through Fc Engineering","volume":"35","author":"Ko","year":"2021","journal-title":"BioDrugs"},{"key":"10.1124\/jpet.123.001740_bib27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1182\/blood-2018-10-880849","article-title":"MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans","volume":"133","author":"Koch","year":"2019","journal-title":"Blood"},{"key":"10.1124\/jpet.123.001740_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068074","article-title":"Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms","volume":"8","author":"Koumandou","year":"2013","journal-title":"PLoS One"},{"key":"10.1124\/jpet.123.001740_bib29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2500\/aap.2018.39.4164","article-title":"Subcutaneous C1-esterase inhibitor to prevent hereditary angioedema attacks: Safety findings from the COMPACT trial","volume":"39","author":"Li","year":"2018","journal-title":"Allergy Asthma Proc"},{"key":"10.1124\/jpet.123.001740_bib30","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/prot.24576","article-title":"Assessment of fully automated antibody homology modeling protocols in molecular operating environment","volume":"82","author":"Maier","year":"2014","journal-title":"Proteins"},{"key":"10.1124\/jpet.123.001740_bib31","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1016\/S0021-9258(17)40034-2","article-title":"Hageman factor substrates. Human plasma prekallikrein: mechanism of activation by Hageman factor and participation in hageman factor-dependent fibrinolysis","volume":"252","author":"Mandle","year":"1977","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.123.001740_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cbi.2008.10.036","article-title":"Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species","volume":"178","author":"Meier","year":"2009","journal-title":"Chem Biol Interact"},{"key":"10.1124\/jpet.123.001740_bib33","doi-asserted-by":"crossref","first-page":"11076","DOI":"10.1073\/pnas.0402970101","article-title":"Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level","volume":"101","author":"Ober","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.123.001740_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40203-016-0018-5","article-title":"Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide","volume":"4","author":"Offman","year":"2016","journal-title":"In Silico Pharmacol"},{"key":"10.1124\/jpet.123.001740_bib35","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1074\/jbc.M113.537563","article-title":"Structural insights into neonatal Fc receptor-based recycling mechanisms","volume":"289","author":"Oganesyan","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.123.001740_bib36","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1172\/JCI40979","article-title":"Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network","volume":"120","author":"Park","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.123.001740_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2147\/DHPS.S345443","article-title":"Safety Aspects and Rational Use of Lanadelumab Injections in the Treatment of Hereditary Angioedema (HAE): Clinical Insights","volume":"14","author":"Petkova","year":"2022","journal-title":"Drug Healthc Patient Saf"},{"key":"10.1124\/jpet.123.001740_bib38","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem"},{"key":"10.1124\/jpet.123.001740_bib39","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1128\/AAC.01285-13","article-title":"A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults","volume":"57","author":"Robbie","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/jpet.123.001740_bib40","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1083\/jcb.71.2.666","article-title":"pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat","volume":"71","author":"Rodewald","year":"1976","journal-title":"J Cell Biol"},{"key":"10.1124\/jpet.123.001740_bib41","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsb.2015.08.008","article-title":"CTFFIND4: Fast and accurate defocus estimation from electron micrographs","volume":"192","author":"Rohou","year":"2015","journal-title":"J Struct Biol"},{"key":"10.1124\/jpet.123.001740_bib42","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nri2155","article-title":"FcRn: the neonatal Fc receptor comes of age","volume":"7","author":"Roopenian","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/jpet.123.001740_bib43","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.3389\/fimmu.2019.01296","article-title":"Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life","volume":"10","author":"Saunders","year":"2019","journal-title":"Front Immunol"},{"key":"10.1124\/jpet.123.001740_bib45","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1042\/BJ20090010","article-title":"Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases","volume":"422","author":"Sexton","year":"2009","journal-title":"Biochem J"},{"key":"10.1124\/jpet.123.001740_bib46","doi-asserted-by":"crossref","first-page":"41077","DOI":"10.1074\/jbc.M506766200","article-title":"Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein","volume":"280","author":"Tang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.123.001740_bib47","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/jcph.1768","article-title":"Population Pharmacokinetics and Exposure-Response Analyses to Guide Dosing of Icatibant in Pediatric Patients With Hereditary Angioedema","volume":"61","author":"Wang","year":"2021","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/jpet.123.001740_bib48","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/cts.12806","article-title":"Pharmacokinetics, Pharmacodynamics, and Exposure-Response of Lanadelumab for Hereditary Angioedema","volume":"13","author":"Wang","year":"2020","journal-title":"Clin Transl Sci"},{"key":"10.1124\/jpet.123.001740_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/bs.acc.2019.07.008","article-title":"Clotting factors: Clinical biochemistry and their roles as plasma enzymes","volume":"94","author":"Winter","year":"2020","journal-title":"Adv Clin Chem"},{"key":"10.1124\/jpet.123.001740_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112137","article-title":"Discovery and development of plasma kallikrein inhibitors for multiple diseases","volume":"190","author":"Xie","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1124\/jpet.123.001740_bib51","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jaci.2013.03.034","article-title":"A focused parameter update: hereditary angioedema, acquired C1 inhibitor deficiency, and angiotensin-converting enzyme inhibitor-associated angioedema","volume":"131","author":"Zuraw","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.123.001740_bib52","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1517\/13543784.17.5.697","article-title":"New promise and hope for treating hereditary angioedema","volume":"17","author":"Zuraw","year":"2008","journal-title":"Expert Opin Investig Drugs"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524171091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524171091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.123.001740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T11:51:45Z","timestamp":1740657105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524171091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0022356524171091"],"URL":"https:\/\/doi.org\/10.1124\/jpet.123.001740","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.123.001740","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by The Author(s)","name":"copyright","label":"Copyright"}]}}