{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:44:56Z","timestamp":1776786296981,"version":"3.51.2"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1124\/jpet.123.001837","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T23:40:13Z","timestamp":1706226013000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine"],"prefix":"10.1016","volume":"391","author":[{"given":"Candace B.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Walther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Baggott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa E.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.123.001837_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00008877-199504000-00007","article-title":"Assessment of the discriminative stimulus effects of the optical isomers of Ecstasy (3,4-methylenedioxymethamphetamine; MDMA)","volume":"6","author":"Baker","year":"1995","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.123.001837_bib2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0091-3057(96)00334-6","article-title":"Assessment of the MDA and MDMA optical isomers in a stimulant-hallucinogen discrimination","volume":"57","author":"Baker","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.123.001837_bib3","series-title":"New Psychoactive Substances: Pharmacology, Clinical, Forensic and Analytical Toxicology","first-page":"113","article-title":"Neuropharmacology of synthetic cathinones","author":"Baumann","year":"2018"},{"key":"10.1124\/jpet.123.001837_bib5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1177\/0886260515587667","article-title":"The effects of intimate partner violence exposure on the maternal bond and PTSD symptoms of children","volume":"32","author":"Boeckel","year":"2017","journal-title":"J Interpers Violence"},{"key":"10.1124\/jpet.123.001837_bib6","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1007\/s00213-020-05648-z","article-title":"The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats","volume":"237","author":"Brandt","year":"2020","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.123.001837_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1017\/S1461145713001405","article-title":"The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories","volume":"17","author":"Carhart-Harris","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1124\/jpet.123.001837_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pbb.2016.08.002","article-title":"5-(2-Aminopropyl)benzofuran and phenazepam demonstrate the possibility of dependence by increasing dopamine levels in the brain","volume":"149","author":"Cha","year":"2016","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.123.001837_bib9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1365-2125.2000.00121.x","article-title":"Non-linear pharmacokinetics of MDMA (\u2018Ecstasy\u2019) in humans","volume":"49","author":"de la Torre","year":"2000","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/jpet.123.001837_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.drugalcdep.2017.07.041","article-title":"Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine","volume":"180","author":"Dolan","year":"2017","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.123.001837_bib11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00213-018-5059-5","article-title":"Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters","volume":"236","author":"Eshleman","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.123.001837_bib12","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1124\/jpet.107.129056","article-title":"Pharmacological interaction between 3,4-methylenedioxymethamphetamine (Ecstasy) and paroxetine: pharmacological effects and pharmacokinetics","volume":"323","author":"Farr\u00e9","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001837_bib13","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/jts.22344","article-title":"Trauma memory processing in posttraumatic stress disorder psychotherapy: a unifying framework","volume":"31","author":"Ford","year":"2018","journal-title":"J Trauma Stress"},{"key":"10.1124\/jpet.123.001837_bib14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2131\/jts.41.329","article-title":"Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum","volume":"41","author":"Fuwa","year":"2016","journal-title":"J Toxicol Sci"},{"key":"10.1124\/jpet.123.001837_bib17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/pr.55.3.3","article-title":"The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, \u201cEcstasy\u201d)","volume":"55","author":"Green","year":"2003","journal-title":"Pharmacol Rev"},{"key":"10.1124\/jpet.123.001837_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109375","article-title":"Experimental strategies to discover and develop the next generation of psychedelics and entactogens as medicines","volume":"225","author":"Heal","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.123.001837_bib20","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.1126\/scitranslmed.aaw6435","article-title":"Distinct neural mechanisms for the prosocial and rewarding properties of MDMA","volume":"11","author":"Heifets","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1124\/jpet.123.001837_bib22","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1007\/s00213-020-05548-2","article-title":"Long-term follow-up outcomes of MDMA-assisted psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials","volume":"237","author":"Jerome","year":"2020","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.123.001837_bib24","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/JCP.0b013e31817ef470","article-title":"Physiological and subjective responses to controlled oral 3,4-methylenedioxymethamphetamine administration","volume":"28","author":"Kolbrich","year":"2008","journal-title":"J Clin Psychopharmacol"},{"key":"10.1124\/jpet.123.001837_bib25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0893-133X(99)00148-7","article-title":"Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, \u201cEcstasy\u201d) are attenuated by the serotonin uptake inhibitor citalopram","volume":"22","author":"Liechti","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.123.001837_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.990405","article-title":"3,4-Methylenedioxy methamphetamine, synthetic cathinones and psychedelics: From recreational to novel psychotherapeutic drugs","volume":"13","author":"L\u00f3pez-Arnau","year":"2022","journal-title":"Front Psychiatry"},{"key":"10.1124\/jpet.123.001837_bib27","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/ijnp\/pyy047","article-title":"Monoamine transporter and receptor interaction profiles in vitro predict reported human doses of novel psychoactive stimulants and psychedelics","volume":"21","author":"Luethi","year":"2018","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1124\/jpet.123.001837_bib28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0022-3565(24)34877-3","article-title":"Cardiovascular and neuroendocrine effects and pharmacokinetics of 3, 4-methylenedioxymethamphetamine in humans","volume":"290","author":"Mas","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001837_bib29","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/s41380-022-01843-w","article-title":"Serotonin-releasing agents with reduced off-target effects","volume":"28","author":"Mayer","year":"2023","journal-title":"Mol Psychiatry"},{"key":"10.1124\/jpet.123.001837_bib30","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/s41591-021-01336-3","article-title":"MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study","volume":"27","author":"Mitchell","year":"2021","journal-title":"Nat Med"},{"key":"10.1124\/jpet.123.001837_bib31","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S2215-0366(18)30135-4","article-title":"3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial","volume":"5","author":"Mithoefer","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"10.1124\/jpet.123.001837_bib500","series-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1124\/jpet.123.001837_bib32","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1177\/0269881120920420","article-title":"Beyond Ecstasy: alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy","volume":"35","author":"Oeri","year":"2021","journal-title":"J Psychopharmacol"},{"key":"10.1124\/jpet.123.001837_bib33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/JCP.0b013e318184ff6e","article-title":"The consequences of 3,4-methylenedioxymethamphetamine induced CYP2D6 inhibition in humans","volume":"28","author":"O\u2019Math\u00fana","year":"2008","journal-title":"J Clin Psychopharmacol"},{"key":"10.1124\/jpet.123.001837_bib34","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.neubiorev.2013.04.016","article-title":"MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational \u2018Ecstasy\u2019 users","volume":"37","author":"Parrott","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1124\/jpet.123.001837_bib36","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/0269881106061515","article-title":"Neuroimaging findings with MDMA\/Ecstasy: technical aspects, conceptual issues and future prospects","volume":"20","author":"Reneman","year":"2006","journal-title":"J Psychopharmacol"},{"key":"10.1124\/jpet.123.001837_bib37","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1111\/bph.13128","article-title":"Pharmacological profile of novel psychoactive benzofurans","volume":"172","author":"Rickli","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.123.001837_bib38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neubiorev.2016.02.003","article-title":"Meta-analysis of molecular imaging of serotonin transporters in Ecstasy\/polydrug users","volume":"63","author":"Roberts","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1124\/jpet.123.001837_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1098-2396(20010101)39:1<32::AID-SYN5>3.0.CO;2-3","article-title":"Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin","volume":"39","author":"Rothman","year":"2001","journal-title":"Synapse"},{"key":"10.1124\/jpet.123.001837_bib40","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00213-018-5075-5","article-title":"The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates","volume":"236","author":"Saha","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.123.001837_bib41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1124\/mol.115.101394","article-title":"Binding mode selection determines the action of Ecstasy homologs at monoamine transporters","volume":"89","author":"Sandtner","year":"2016","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.123.001837_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0091-3057(87)90474-6","article-title":"MDMA as a discriminative stimulus: isomeric comparisons","volume":"27","author":"Schechter","year":"1987","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.123.001837_bib44","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1111\/jnc.15348","article-title":"Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse","volume":"157","author":"Schenk","year":"2021","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.123.001837_bib45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/bph.12423","article-title":"Effects of 3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites on cardiovascular function in conscious rats","volume":"171","author":"Schindler","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.123.001837_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00210-016-1297-4","article-title":"Neurochemical binding profiles of novel indole and benzofuran MDMA analogues","volume":"390","author":"Shimshoni","year":"2017","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.001837_bib47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/164_2018_113","article-title":"Pharmacology of MDMA- and amphetamine-like new psychoactive substances","volume":"252","author":"Simmler","year":"2018","journal-title":"Handb Exp Pharmacol"},{"key":"10.1124\/jpet.123.001837_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tips.2014.11.006","article-title":"Amphetamines, new psychoactive drugs and the monoamine transporter cycle","volume":"36","author":"Sitte","year":"2015","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.123.001837_bib49","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00213-006-0576-z","article-title":"The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans","volume":"189","author":"Tancer","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.123.001837_bib50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1124\/jpet.123.001650","article-title":"Bath salts to therapies: can separation of adverse and therapeutic effects of substituted cathinones lead to a medication for psychostimulant use disorder?","volume":"385","author":"Unterwald","year":"2023","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001837_bib51","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00213-005-0174-5","article-title":"MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment","volume":"189","author":"Verrico","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.123.001837_bib52","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1007\/s00216-015-8552-2","article-title":"Metabolic fate, mass spectral fragmentation, detectability, and differentiation in urine of the benzofuran designer drugs 6-APB and 6-MAPB in comparison to their 5-isomers using GC-MS and LC-(HR)-MS(n) techniques","volume":"407","author":"Welter","year":"2015","journal-title":"Anal Bioanal Chem"},{"key":"10.1124\/jpet.123.001837_bib53","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00216-014-8360-0","article-title":"Benzofuran analogues of amphetamine and methamphetamine: studies on the metabolism and toxicological analysis of 5-APB and 5-MAPB in urine and plasma using GC-MS and LC-(HR)-MS(n) techniques","volume":"407","author":"Welter","year":"2015","journal-title":"Anal Bioanal Chem"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524177786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524177786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.123.001837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:36:08Z","timestamp":1739979368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524177786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0022356524177786"],"URL":"https:\/\/doi.org\/10.1124\/jpet.123.001837","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.123.001837","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government work not protected by U.S. copyright","name":"copyright","label":"Copyright"}]}}