{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:26:51Z","timestamp":1787016411184,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1124\/jpet.123.001952","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T15:35:13Z","timestamp":1703259313000},"page":"4-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy"],"prefix":"10.1016","volume":"390","author":[{"given":"Maria","family":"Lembo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Trimarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Izzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Virginia","family":"Manzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Morisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imma","family":"Forzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-375X","authenticated-orcid":false,"given":"Gaetano","family":"Santulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Trimarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.123.001952_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jelectrocard.2009.06.007","article-title":"Electrocardiography-left ventricular mass discrepancies in left ventricular hypertrophy: electrocardiography imperfection or beyond perfection?","volume":"42","author":"Bacharova","year":"2009","journal-title":"J Electrocardiol"},{"key":"10.1124\/jpet.123.001952_bib2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/HJH.0000000000002323","article-title":"Identification of cardiac organ damage in arterial hypertension: insights by echocardiography for a comprehensive assessment","volume":"38","author":"Cameli","year":"2020","journal-title":"J Hypertens"},{"key":"10.1124\/jpet.123.001952_bib3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/ajh.2012.38","article-title":"Arterial stiffness is associated with carotid atherosclerosis in hypertensive patients (the Campania Salute Network)","volume":"25","author":"Casalnuovo","year":"2012","journal-title":"Am J Hypertens"},{"key":"10.1124\/jpet.123.001952_bib4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/CIRCULATIONAHA.110.937821","article-title":"Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study","volume":"122","author":"Cheng","year":"2010","journal-title":"Circulation"},{"key":"10.1124\/jpet.123.001952_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/jhh.2016.9","article-title":"The possible role of chromosome X variability in hypertensive familiarity","volume":"31","author":"Ciccarelli","year":"2017","journal-title":"J Hum Hypertens"},{"key":"10.1124\/jpet.123.001952_bib6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","article-title":"Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol","volume":"359","author":"Dahl\u00f6f","year":"2002","journal-title":"Lancet"},{"key":"10.1124\/jpet.123.001952_bib7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.2337\/dci17-0026","article-title":"Diabetes and hypertension: a position statement by the American Diabetes Association","volume":"40","author":"de Boer","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1124\/jpet.123.001952_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40292-018-0259-y","article-title":"Echocardiography in arterial hypertension","volume":"25","author":"de Simone","year":"2018","journal-title":"High Blood Press Cardiovasc Prev"},{"key":"10.1124\/jpet.123.001952_bib9","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/ehjci\/jex244","volume":"18","author":"Galderisi","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1124\/jpet.123.001952_bib10","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.healun.2021.12.008","article-title":"Glycation of ryanodine receptor in circulating lymphocytes predicts the response to cardiac resynchronization therapy","volume":"41","author":"Gambardella","year":"2022","journal-title":"J Heart Lung Transplant"},{"key":"10.1124\/jpet.123.001952_bib11","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1161\/HYPERTENSIONAHA.123.21454","article-title":"Middle-aged and older patients with left ventricular hypertrophy: higher mortality with drug treated systolic blood pressure below 130 mm Hg","volume":"80","author":"Heimark","year":"2023","journal-title":"Hypertension"},{"key":"10.1124\/jpet.123.001952_bib12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/HJH.0b013e328343ce32","article-title":"Initial left-ventricular mass predicts probability of uncontrolled blood pressure in arterial hypertension","volume":"29","author":"Izzo","year":"2011","journal-title":"J Hypertens"},{"key":"10.1124\/jpet.123.001952_bib13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ijcard.2015.03.022","article-title":"Prevalence and characteristics of true and apparent treatment resistant hypertension in the Campania Salute Network","volume":"184","author":"Izzo","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1124\/jpet.123.001952_bib14","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1097\/HJH.0000000000000740","article-title":"Development of new atherosclerotic plaque in hypertensive patients: an observational registry study from the Campania-Salute network","volume":"33","author":"Izzo","year":"2015","journal-title":"J Hypertens"},{"key":"10.1124\/jpet.123.001952_bib15","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1161\/HYPERTENSIONAHA.123.21071","article-title":"Left ventricular mechano-energetic efficiency identifies an early impairment of myocardial blood flow in arterial hypertension","volume":"80","author":"Lembo","year":"2023","journal-title":"Hypertension"},{"key":"10.1124\/jpet.123.001952_bib16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/HJH.0000000000002257","article-title":"Interrelation between midwall mechanics and longitudinal strain in newly diagnosed and never-treated hypertensive patients without clinically defined hypertrophy","volume":"38","author":"Lembo","year":"2020","journal-title":"J Hypertens"},{"key":"10.1124\/jpet.123.001952_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijcard.2020.01.038","article-title":"Prominent basal and middle strain longitudinal involvement in newly diagnosed and never treated hypertensive patients without clear-cut hypertrophy","volume":"304","author":"Lembo","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1124\/jpet.123.001952_bib18","doi-asserted-by":"crossref","first-page":"977657","DOI":"10.3389\/fcvm.2022.977657","article-title":"Determinants of improvement of left ventricular mechano-energetic efficiency in hypertensive patients","volume":"9","author":"Lembo","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1124\/jpet.123.001952_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/anec.12880","article-title":"The association between ECG criteria and Echo criteria for left ventricular hypertrophy in a general Chinese population","volume":"26","author":"Lv","year":"2021","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1124\/jpet.123.001952_bib20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1161\/HYPERTENSIONAHA.121.18792","article-title":"White-coat hypertension without organ damage: impact on long-term mortality, new hypertension, and new organ damage","volume":"79","author":"Mancia","year":"2022","journal-title":"Hypertension"},{"key":"10.1124\/jpet.123.001952_bib21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ndt\/gfx062","article-title":"Determinants of decline of renal function in treated hypertensive patients: the Campania Salute Network","volume":"33","author":"Mancusi","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"10.1124\/jpet.123.001952_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022345","article-title":"Carotid atherosclerosis predicts blood pressure control in patients with hypertension: the Campania Salute Network Registry","volume":"11","author":"Mancusi","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1124\/jpet.123.001952_bib23","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/ehf2.13908","article-title":"Low mechano-energetic efficiency is associated with future left ventricular systolic dysfunction in hypertensives","volume":"9","author":"Manzi","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1124\/jpet.123.001952_bib24","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.jacc.2016.07.754","article-title":"Diastolic blood pressure, subclinical myocardial damage, and cardiac events: implications for blood pressure control","volume":"68","author":"McEvoy","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.123.001952_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCULATIONAHA.114.009625","article-title":"Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction","volume":"131","author":"Mohammed","year":"2015","journal-title":"Circulation"},{"key":"10.1124\/jpet.123.001952_bib26","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/eurjpc\/zwad173","article-title":"Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study","volume":"30","author":"Mone","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"10.1124\/jpet.123.001952_bib27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1124\/jpet.121.001251","article-title":"Empagliflozin improves the microRNA signature of endothelial dysfunction in patients with heart failure with preserved ejection fraction and diabetes","volume":"384","author":"Mone","year":"2023","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001952_bib28","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2337\/dc22-0783","article-title":"Stress hyperglycemia drives the risk of hospitalization for chest pain in patients with ischemia and nonobstructive coronary arteries (INOCA)","volume":"46","author":"Mone","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1124\/jpet.123.001952_bib29","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1161\/HYPERTENSIONAHA.122.19586","article-title":"SGLT2 inhibition via empagliflozin improves endothelial function and reduces mitochondrial oxidative stress: insights from frail hypertensive and diabetic patients","volume":"79","author":"Mone","year":"2022","journal-title":"Hypertension"},{"key":"10.1124\/jpet.123.001952_bib30","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.hrthm.2014.03.023","article-title":"Electrocardiographic versus echocardiographic left ventricular hypertrophy and sudden cardiac arrest in the community","volume":"11","author":"Narayanan","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1124\/jpet.123.001952_bib31","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/HJH.0b013e3283516499","article-title":"Impact of lower achieved blood pressure on outcomes in hypertensive patients","volume":"30","author":"Okin","year":"2012","journal-title":"J Hypertens"},{"key":"10.1124\/jpet.123.001952_bib32","doi-asserted-by":"crossref","first-page":"831556","DOI":"10.3389\/fendo.2022.831556","article-title":"Hyperglycemia and physical impairment in frail hypertensive older adults","volume":"13","author":"Pansini","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1124\/jpet.123.001952_bib33","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1124\/jpet.123.001878","article-title":"Long-lasting control of LDL-cholesterol induces a forty percent reduction in the incidence of cardiovascular events: new insights from a 7-year study","volume":"388","author":"Trimarco","year":"2024","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.001952_bib34","doi-asserted-by":"crossref","first-page":"106557","DOI":"10.1016\/j.phrs.2022.106557","article-title":"Therapeutic concordance improves blood pressure control in patients with resistant hypertension","volume":"187","author":"Trimarco","year":"2023","journal-title":"Pharmacol Res"},{"key":"10.1124\/jpet.123.001952_bib35","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/HYPERTENSIONAHA.122.19912","article-title":"High HDL (high-density lipoprotein) cholesterol increases cardiovascular risk in hypertensive patients","volume":"79","author":"Trimarco","year":"2022","journal-title":"Hypertension"},{"key":"10.1124\/jpet.123.001952_bib36","doi-asserted-by":"crossref","first-page":"1137706","DOI":"10.3389\/fcvm.2023.1137706","article-title":"The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension","volume":"10","author":"Trimarco","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1124\/jpet.123.001952_bib37","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"10.1124\/jpet.123.001952_bib38","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1124\/jpet.123.001952_bib39","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Wright","year":"2015","journal-title":"N Engl J Med"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524001848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524001848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.123.001952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:04:26Z","timestamp":1739959466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524001848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0022356524001848"],"URL":"https:\/\/doi.org\/10.1124\/jpet.123.001952","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.123.001952","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}