{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:08:44Z","timestamp":1785150524162,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1124\/jpet.123.002060","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T20:35:14Z","timestamp":1711485314000},"page":"174-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Initial Characterization of a Transgenic Mouse with Overexpression of the Human H1-Histamine Receptor on the Heart"],"prefix":"10.1016","volume":"389","author":[{"given":"Lina Maria","family":"Rayo Abella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Schindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Pockes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Pitzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Klimas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7055-9561","authenticated-orcid":false,"given":"Katar\u00edna","family":"Hadova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor B.","family":"Buchwalow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CongYu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pertti","family":"Panula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Kirchhefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5018-3851","authenticated-orcid":false,"given":"Joachim","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-485X","authenticated-orcid":false,"given":"Ulrich","family":"Gergs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.123.002060_bib1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1476-5381.1963.tb02013.x","article-title":"The action of histamine in the isolated heart","volume":"21","author":"Bartlet","year":"1963","journal-title":"Br J Pharmacol Chemother"},{"key":"10.1124\/jpet.123.002060_bib5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s00210-003-0702-y","article-title":"Molecular characterization of specific H1-receptor agonists histaprodifen and its Nalpha-substituted analogues on bovine aortic H1-receptors","volume":"367","author":"Carman-Krzan","year":"2003","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1620\/tjem.120.299","article-title":"Blocking effect of tripelennamine on histamine-induced positive chronotropic and inotropic responses of the dog atrium","volume":"120","author":"Chiba","year":"1976","journal-title":"Tohoku J Exp Med"},{"key":"10.1124\/jpet.123.002060_bib7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1254\/jjp.27.267","article-title":"Absence of blocking effect of burimamide and metiamide on positive chronotropic and inotropic responses to histamine in isolated dog atrium","volume":"27","author":"Chiba","year":"1977","journal-title":"Jpn J Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1440-1681.1976.tb00612.x","article-title":"A study of the actions of histamine on the isolated rat heart","volume":"3","author":"Dai","year":"1976","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1124\/jpet.123.002060_bib10","first-page":"416","article-title":"Effect of H1-antagonism on cardiovascular, pulmonary, and immunological dysfunction in porcine endotoxic shock","volume":"3","author":"Dimmeler","year":"1995","journal-title":"Shock"},{"key":"10.1124\/jpet.123.002060_bib11","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.3390\/ijms22179448","article-title":"Mechanisms of systolic cardiac dysfunction in PP2A, PP5 and PP2AxPP5 double transgenic mice","volume":"22","author":"D\u00f6rner","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.123.002060_bib12","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1021\/jm991056a","article-title":"Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists","volume":"43","author":"Elz","year":"2000","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.123.002060_bib13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-3565(25)27551-6","article-title":"The actions of histamine on the mammalian heart","volume":"155","author":"Flacke","year":"1967","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.002060_bib14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/BF01966761","article-title":"Histamine modification of spontaneous rate and rhythm in infarcted canine ventricle","volume":"15","author":"Gaide","year":"1984","journal-title":"Agents Actions"},{"key":"10.1124\/jpet.123.002060_bib15","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0022-3565(25)13290-4","article-title":"Adenosine promotes histamine H1-mediated negative chronotropic and inotropic effects on human atrial myocardium","volume":"247","author":"Genovese","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.002060_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1124\/jpet.118.255711","article-title":"Initial characterization of transgenic mice overexpressing human histamine H2 receptors","volume":"369","author":"Gergs","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.002060_bib18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1124\/jpet.120.000063","article-title":"Characterization of stressed transgenic mice overexpressing H2-histamine receptors in the heart","volume":"374","author":"Gergs","year":"2020","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.002060_bib19","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s00210-021-02098-y","article-title":"Human histamine H2 receptors can initiate cardiac arrhythmias in a transgenic mouse","volume":"394","author":"Gergs","year":"2021","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib20","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/00005344-198411000-00031","article-title":"Inotropic effects of histamine in human myocardium: differentiation between positive and negative components","volume":"6","author":"Guo","year":"1984","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1254\/jjp.65.327","article-title":"Histamine receptors mediating a positive inotropic effect in guinea pig and rabbit ventricular myocardium: distribution of the receptors and their possible intracellular coupling processes","volume":"65","author":"Hattori","year":"1994","journal-title":"Jpn J Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib200","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00168846","article-title":"Effects of Ca2+ channel antagonists and ryanodine on H1-receptor mediated electromechanical response to histamine in guinea-pig left atria","volume":"337","author":"Hattori","year":"1988","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00213-011-2471-5","article-title":"Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo","volume":"220","author":"Humbert-Claude","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.123.002060_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0091-6749(81)90134-2","article-title":"Effects of infused histamine: analysis of the effects of H-1 and H-2 histamine receptor antagonists on cardiovascular and pulmonary responses","volume":"68","author":"Kaliner","year":"1981","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.123.002060_bib35","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1139\/y80-192","article-title":"Effects of histamine in the isolated kitten heart","volume":"58","author":"Laher","year":"1980","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib36","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1139\/y80-166","article-title":"Effects of histamine on rat isolated atria","volume":"58","author":"Laher","year":"1980","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0014-2999(75)90117-X","article-title":"Pharmacological characterization of cardiac histamine receptors: sensitivity to H1-and H2-receptor agonists and antagonists","volume":"30","author":"Levi","year":"1975","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib38","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1161\/01.RES.49.2.545","article-title":"The arrhythmogenic actions of histamine on human atrial fibers","volume":"49","author":"Levi","year":"1981","journal-title":"Circ Res"},{"key":"10.1124\/jpet.123.002060_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.phrs.2016.10.010","article-title":"Label-free versus conventional cellular assays: functional investigations on the human histamine H1 receptor","volume":"114","author":"Lieb","year":"2016","journal-title":"Pharmacol Res"},{"key":"10.1124\/jpet.123.002060_bib46","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1124\/mol.104.005926","article-title":"Nuclear factor-kappaB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis","volume":"67","author":"Matsuda","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib47","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00210-002-0651-x","article-title":"Hemodynamic significance of histamine synthesis and histamine H1- and H2-receptor gene expression during endotoxemia","volume":"366","author":"Matsuda","year":"2002","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib48","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1124\/jpet.103.063065","article-title":"Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans","volume":"309","author":"Matsuda","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.002060_bib49","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1139\/y84-119","article-title":"Histamine and the heart","volume":"62","author":"McNeill","year":"1984","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib50","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1021\/jm0309147","article-title":"N(\u03b1)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists","volume":"46","author":"Menghin","year":"2003","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.123.002060_bib52","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0924-977X(94)90293-3","article-title":"The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat","volume":"4","author":"Monti","year":"1994","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1124\/jpet.123.002060_bib53","series-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1124\/jpet.123.002060_bib54","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00210-021-02065-7","article-title":"Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria","volume":"394","author":"Neumann","year":"2021","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib55","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1006\/jmcc.1998.0760","article-title":"Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility","volume":"30","author":"Neumann","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.123.002060_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.582916","article-title":"Histamine can be formed and degraded in the human and mouse heart","volume":"12","author":"Neumann","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib58","article-title":"Contractile effects of amphetamine, pseudoephedrine, nor-pseudoephedrine (cathine) and cathinone on atrial preparations of mice and humans","author":"Neumann","year":"2023","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib59","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3390\/ph16050734","article-title":"Function and role of histamine H1 receptors in the mammalian heart","volume":"16","author":"Neumann","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1124\/jpet.123.002060_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.732842","article-title":"Role of cardiovascular H2-histamine-receptors under normal and pathophysiological conditions","volume":"12","author":"Neumann","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib62","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1007\/s00210-021-02145-8","article-title":"Functional interaction of H2-receptors and 5HT4-receptors in atrial tissues isolated from double transgenic mice and from human patients","volume":"394","author":"Neumann","year":"2021","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib63","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s00210-021-02052-y","article-title":"Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H2-histamine-receptor activation in isolated atria of transgenic mice","volume":"394","author":"Neumann","year":"2021","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib68","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01965222","article-title":"Differentiation of H1- and H2-receptors mediating positive chrono- and inotropic responses to histamine on atrial preparations of the guinea-pig","volume":"4","author":"Reinhardt","year":"1974","journal-title":"Agents Actions"},{"key":"10.1124\/jpet.123.002060_bib70","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/BF00167185","article-title":"Chronic beta 1-adrenoceptor blockade sensitises the H1 and H2 receptor systems in human atrium: role of cyclic nucleotides","volume":"353","author":"Sanders","year":"1996","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib71","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s002100100414","article-title":"Novel histaprodifen analogues as potent histamine H1-receptor agonists in the pithed and in the anaesthetized rat","volume":"364","author":"Schlicker","year":"2001","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib72","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1526-4610.2003.03034.x","article-title":"Ergotamine and dihydroergotamine: history, pharmacology, and efficacy","volume":"43","author":"Silberstein","year":"2003","journal-title":"Headache"},{"key":"10.1124\/jpet.123.002060_bib75","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.3390\/ijms22189739","article-title":"Label-free investigations on the G protein dependent signaling pathways of histamine receptors","volume":"22","author":"Seibel-Ehlert","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.123.002060_bib77","article-title":"Experimental autoimmune myocarditis in rats and therapeutic histamine H1-H4 receptor inhibition","volume":"69","author":"Stasiak","year":"2018","journal-title":"J Physiol Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib81","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0022-3565(25)33406-3","article-title":"Reduction of ventricular fibrillation threshold by histamine: resolution into separate H1- and H2-mediated components","volume":"223","author":"Trzeciakowski","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.002060_bib82","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0022-3565(25)30779-2","article-title":"Cardiac histamine receptors: differences between left and right atria and right ventricle","volume":"200","author":"Verma","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.123.002060_bib84","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0167-4889(03)00101-0","article-title":"Coupling to Gs and G(q\/11) of histamine H2 receptors heterologously expressed in adult rat atrial myocytes","volume":"1642","author":"Wellner-Kienitz","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.123.002060_bib85","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1124\/jpet.123.002060_bib86","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/sj.bjp.0702008","article-title":"Histamine H1-receptor-mediated increase in the Ca2+ transient without a change in the Ca2+ current in electrically stimulated guinea-pig atrial myocytes","volume":"124","author":"Yoshimoto","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.123.002060_bib88","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF00165383","article-title":"Comparison of the positive inotropic effects of serotonin, histamine, angiotensin II, endothelin and isoprenaline in the isolated human right atrium","volume":"347","author":"Zerkowski","year":"1993","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524172412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524172412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.123.002060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:18:38Z","timestamp":1739978318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524172412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0022356524172412"],"URL":"https:\/\/doi.org\/10.1124\/jpet.123.002060","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Initial Characterization of a Transgenic Mouse with Overexpression of the Human H1-Histamine Receptor on the Heart","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.123.002060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}