{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:41:00Z","timestamp":1785465660293,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":153,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1124\/jpet.124.002064","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T15:55:11Z","timestamp":1718898911000},"page":"240-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction"],"prefix":"10.1016","volume":"390","author":[{"given":"Jie","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenju","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-6787","authenticated-orcid":false,"given":"Suhua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanglian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.124.002064_bib1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/00016348509156728","article-title":"The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin","volume":"64","author":"Akerlund","year":"1985","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1124\/jpet.124.002064_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.peptides.2013.04.016","article-title":"Is oxytocin a therapeutic factor for ischemic heart disease?","volume":"45","author":"Alizadeh","year":"2013","journal-title":"Peptides"},{"key":"10.1124\/jpet.124.002064_bib3","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1189\/jlb.69.6.1019","article-title":"Nerve growth factor regulates TNF-alpha production in mouse macrophages via MAP kinase activation","volume":"69","author":"Barouch","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1124\/jpet.124.002064_bib4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1634\/stemcells.2005-0610","article-title":"Nitric oxide signaling in oxytocin-mediated cardiomyogenesis","volume":"25","author":"Danalache","year":"2007","journal-title":"Stem Cell"},{"key":"10.1124\/jpet.124.002064_bib5","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.4049\/jimmunol.159.3.1444","article-title":"Nitric oxide inhibits IgE-mediated degranulation of mast cells and is the principal intermediate in IFN-gamma-induced suppression of exocytosis","volume":"159","author":"Eastmond","year":"1997","journal-title":"J Immunol"},{"key":"10.1124\/jpet.124.002064_bib6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/path.1711770414","article-title":"Transmural changes in mast cell density in rat heart after infarct induction in vivo","volume":"177","author":"Engels","year":"1995","journal-title":"J Pathol"},{"key":"10.1124\/jpet.124.002064_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: structure, function, and regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.124.002064_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuroscience.2014.12.058","article-title":"Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca(2+)\/nNOS\/NO\/KATP pathway","volume":"289","author":"Gong","year":"2015","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.124.002064_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.mce.2015.04.028","article-title":"Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia-reperfusion","volume":"412","author":"Gonzalez-Reyes","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.1124\/jpet.124.002064_bib10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2826.2011.02235.x","article-title":"Oxytocin revisited: its role in cardiovascular regulation","volume":"24","author":"Gutkowska","year":"2012","journal-title":"J Neuroendocrinol"},{"key":"10.1124\/jpet.124.002064_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1590\/1414-431X20133309","article-title":"The role of oxytocin in cardiovascular regulation","volume":"47","author":"Gutkowska","year":"2014","journal-title":"Braz J Med Biol Res"},{"key":"10.1124\/jpet.124.002064_bib12","doi-asserted-by":"crossref","first-page":"11704","DOI":"10.1073\/pnas.94.21.11704","article-title":"Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart","volume":"94","author":"Gutkowska","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.124.002064_bib13","doi-asserted-by":"crossref","unstructured":"Hughes MR, McNagny KM (2015) Mast cells: Methods and Protocols, Methods in Molecular Biology. New York.","DOI":"10.1007\/978-1-4939-1568-2"},{"key":"10.1124\/jpet.124.002064_bib14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1358\/mf.2007.29.9.1161005","article-title":"Cardioprotective effects of mast cell modulators in ischemia-reperfusion-induced injury in rats","volume":"29","author":"Jaggi","year":"2007","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1124\/jpet.124.002064_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00395-009-0076-5","article-title":"Anti-inflammatory effect of oxytocin in rat myocardial infarction","volume":"105","author":"Jankowski","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.124.002064_bib16","doi-asserted-by":"crossref","first-page":"13074","DOI":"10.1073\/pnas.0405324101","article-title":"Oxytocin in cardiac ontogeny","volume":"101","author":"Jankowski","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.124.002064_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/1570159X17666190717150501","article-title":"Vasopressin oxytocin in control of the cardiovascular system: an updated review","volume":"18","author":"Japund\u017ei\u0107-\u017digon","year":"2020","journal-title":"Curr Neuropharmacol"},{"key":"10.1124\/jpet.124.002064_bib18","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1093\/europace\/euz254","article-title":"Impact of persistent left superior vena cava on radiofrequency catheter ablation in patients with atrial fibrillation","volume":"21","author":"Kim","year":"2019","journal-title":"Europace"},{"key":"10.1124\/jpet.124.002064_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1046\/j.1365-2249.1998.00518.x","article-title":"A blockade of complement activation prevents rapid intestinal ischaemia-reperfusion injury by modulating mucosal mast cell degranulation in rats","volume":"111","author":"Kimura","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1124\/jpet.124.002064_bib20","first-page":"620","article-title":"Mast cell: a multi-functional master cell","volume":"6","author":"Krystel-Whittemore","year":"2015","journal-title":"Front Immunol"},{"key":"10.1124\/jpet.124.002064_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.imlet.2007.08.007","article-title":"G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation","volume":"113","author":"Kuehn","year":"2007","journal-title":"Immunol Lett"},{"key":"10.1124\/jpet.124.002064_bib22","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1161\/CIRCRESAHA.110.225730","article-title":"Programmed necrosis, not apoptosis, in the heart","volume":"108","author":"Kung","year":"2011","journal-title":"Circ Res"},{"key":"10.1124\/jpet.124.002064_bib23","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1073\/pnas.91.9.3739","article-title":"Mast cells synthesize, store, and release nerve growth factor","volume":"91","author":"Leon","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.124.002064_bib24","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1172\/JCI25713","article-title":"Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia\/reperfusion","volume":"116","author":"Mackins","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.124.002064_bib25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fendo.2020.00299","article-title":"The role of glucocorticoid receptor and oxytocin receptor in the septic heart in a clinically relevant, resuscitated porcine model with underlying atherosclerosis","volume":"11","author":"Merz","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1124\/jpet.124.002064_bib26","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.4049\/jimmunol.169.8.4586","article-title":"Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production","volume":"169","author":"Nguyen","year":"2002","journal-title":"J Immunol"},{"key":"10.1124\/jpet.124.002064_bib27","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1124\/jpet.104.082073","article-title":"5-Hydroxytryptamine 1A receptors in the paraventricular nucleus of the hypothalamus mediate oxytocin and adrenocorticotropin hormone release and some behavioral components of the serotonin syndrome","volume":"313","author":"Osei-Owusu","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"issue":"Suppl 1","key":"10.1124\/jpet.124.002064_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s000110050041","article-title":"Increased cardiac mast cell density and mediator release in patients with dilated cardiomyopathy","volume":"46","author":"Patella","year":"1997","journal-title":"Inflamm Res"},{"key":"10.1124\/jpet.124.002064_bib29","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/01.CIR.97.10.971","article-title":"Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy","volume":"97","author":"Patella","year":"1998","journal-title":"Circulation"},{"key":"10.1124\/jpet.124.002064_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0160-5402(90)90062-P","article-title":"Investigation of rat mast cell degranulation using flow cytometry","volume":"23","author":"Perretti","year":"1990","journal-title":"J Pharmacol Methods"},{"key":"10.1124\/jpet.124.002064_bib31","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/art.34366","article-title":"Nerve growth factor receptor expression in lymphocytes: comment on the article by Raychaudhuri et al","volume":"64","author":"Ralainirina","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1124\/jpet.124.002064_bib33","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0022-3565(24)37801-2","article-title":"Oxytocin inhibits the uptake of serotonin into uterine mast cells","volume":"287","author":"Rudolph","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002064_bib34","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/jpet.124.002064_bib35","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1042\/CS20190756","article-title":"Oxytocin system alleviates intestinal inflammation by regulating macrophages polarization in experimental colitis","volume":"133","author":"Tang","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"10.1124\/jpet.124.002064_bib36","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.it.2020.06.006","article-title":"Cardiac mast cells: underappreciated immune cells in cardiovascular homeostasis and disease","volume":"41","author":"Varricchi","year":"2020","journal-title":"Trends Immunol"},{"key":"10.1124\/jpet.124.002064_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/pace.13856","article-title":"The autonomic nervous system and ventricular arrhythmias in myocardial infarction and heart failure","volume":"43","author":"Wu","year":"2020","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1124\/jpet.124.002064_bib38","doi-asserted-by":"crossref","first-page":"110358","DOI":"10.1016\/j.biopha.2020.110358","article-title":"Oxytocin ameliorates ischemia\/reperfusion-induced injury by inhibiting mast cell degranulation and inflammation in the rat heart","volume":"128","author":"Xiong","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1124\/jpet.124.002064_bib39","doi-asserted-by":"crossref","first-page":"17473","DOI":"10.18632\/aging.203236","article-title":"Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction","volume":"13","author":"Yang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1124\/jpet.124.002064_bib40","doi-asserted-by":"crossref","first-page":"C41","DOI":"10.1152\/ajpcell.00163.2015","article-title":"Inhibition of Notch signaling pathway attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats post-myocardial infarction","volume":"310","author":"Yin","year":"2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/jpet.124.002064_bib41","doi-asserted-by":"crossref","first-page":"108389","DOI":"10.1016\/j.intimp.2021.108389","article-title":"MrgprX2 regulates mast cell degranulation through PI3K\/AKT and PLC\u03b3 signaling in pseudo-allergic reactions","volume":"102","author":"Zhang","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"10.1124\/jpet.124.002064_bib42","doi-asserted-by":"crossref","first-page":"10099","DOI":"10.1038\/s41598-017-10748-6","article-title":"A new chimeric natriuretic peptide, C(N)AA(C), for the treatment of left ventricular dysfunction after myocardial infarction","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652400209X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652400209X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.124.002064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:38:23Z","timestamp":1774960703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235652400209X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S002235652400209X"],"URL":"https:\/\/doi.org\/10.1124\/jpet.124.002064","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.124.002064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The Author(s)","name":"copyright","label":"Copyright"}]}}