{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:19:16Z","timestamp":1740136756456,"version":"3.37.3"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1124\/jpet.124.002226","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T19:40:43Z","timestamp":1722022843000},"page":"64-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Genomic Activity of an EP4-Receptor and \u03b22-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression"],"prefix":"10.1016","volume":"391","author":[{"given":"Radhika","family":"Joshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamkeen U.","family":"Paracha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-911X","authenticated-orcid":false,"given":"Mahmoud M.","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varuna","family":"Jayasinghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9893-704X","authenticated-orcid":false,"given":"Omar","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4919-8498","authenticated-orcid":false,"given":"Robert","family":"Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Giembycz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.124.002226_bib1","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1111\/bph.13904","article-title":"Compartmentalized cAMP responses to prostaglandin EP2 receptor activation in human airway smooth muscle cells","volume":"174","author":"Agarwal","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pupt.2011.12.012","article-title":"PGE2 receptor (EP4) agonists: potent dilators of human bronchi and future asthma therapy?","volume":"25","author":"Benyahia","year":"2012","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1124\/jpet.124.002226_bib3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1098\/rspb.1983.0093","article-title":"Operational models of pharmacological agonism","volume":"220","author":"Black","year":"1983","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"10.1124\/jpet.124.002226_bib4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1124\/jpet.112.193425","article-title":"Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle","volume":"342","author":"Bogard","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002226_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00210-013-0950-4","article-title":"Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms","volume":"387","author":"Bogard","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/280078a0","article-title":"Hormonally specific phosphorylation of cardiac troponin I and activation of glycogen phosphorylase","volume":"280","author":"Brunton","year":"1979","journal-title":"Nature"},{"key":"10.1124\/jpet.124.002226_bib7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1136\/thx.2010.158568","article-title":"EP4 receptor as a new target for bronchodilator therapy","volume":"66","author":"Buckley","year":"2011","journal-title":"Thorax"},{"key":"10.1124\/jpet.124.002226_bib8","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1124\/mol.106.028035","article-title":"Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function","volume":"70","author":"Bundey","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib9","article-title":"Safety of regular formoterol or salmeterol in adults with asthma: an overview of Cochrane reviews","volume":"2014","author":"Cates","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1124\/jpet.124.002226_bib10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/00005344-200406000-00009","article-title":"Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse","volume":"43","author":"Chan","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s11658-020-00241-w","article-title":"The nuclear receptor 4A family members: mediators in human disease and autophagy","volume":"25","author":"Chen","year":"2020","journal-title":"Cell Mol Biol Lett"},{"key":"10.1124\/jpet.124.002226_bib12","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1111\/j.1432-1033.2004.04342.x","article-title":"Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release","volume":"271","author":"Chivers","year":"2004","journal-title":"Eur J Biochem"},{"key":"10.1124\/jpet.124.002226_bib13","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00313.2004","article-title":"Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor","volume":"288","author":"Clarke","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1124\/jpet.124.002226_bib14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/clinchem\/25.3.432","article-title":"Incorrect least-squares regression coefficients in method-comparison analysis","volume":"25","author":"Cornbleet","year":"1979","journal-title":"Clin Chem"},{"key":"10.1124\/jpet.124.002226_bib15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.nutr.18.1.353","article-title":"Cyclic AMP signaling and gene regulation","volume":"18","author":"Daniel","year":"1998","journal-title":"Annu Rev Nutr"},{"key":"10.1124\/jpet.124.002226_bib16","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1161\/CIRCULATIONAHA.106.669697","article-title":"Cardioprotection by ecto-5\u2032-nucleotidase (CD73) and A2B adenosine receptors","volume":"115","author":"Eckle","year":"2007","journal-title":"Circulation"},{"key":"10.1124\/jpet.124.002226_bib17","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1124\/mol.63.6.1256","article-title":"The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints","volume":"63","author":"Fredriksson","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1248\/bpb.b15-00840","article-title":"The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling","volume":"39","author":"Fujino","year":"2016","journal-title":"Biol Pharm Bull"},{"key":"10.1124\/jpet.124.002226_bib19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1124\/mol.105.017749","article-title":"EP4 prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein","volume":"69","author":"Fujino","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib20","series-title":"Advances in Drug Research","first-page":"21","article-title":"The use of \u03b2-haloalkylamines in the determination of dissociation constants of receptor-agonist complexes","author":"Furchgott","year":"1966"},{"key":"10.1124\/jpet.124.002226_bib21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41467-017-00357-2","article-title":"Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription","volume":"8","author":"Godbole","year":"2017","journal-title":"Nat Commun"},{"key":"10.1124\/jpet.124.002226_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/jpet.113.206284","article-title":"Concurrent agonism of adenosine A2B and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: a novel approach to treat chronic obstructive pulmonary disease","volume":"346","author":"Greer","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002226_bib23","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1124\/jpet.123.001920","article-title":"The \u03b2-Blocker Carvedilol and Related Aryloxypropanolamines Promote ERK1\/2 Phosphorylation in HEK293 Cells with KA Values Distinct from Their Equilibrium Dissociation Constants as \u03b22-Adrenoceptor Antagonists: Evidence for Functional Affinity","volume":"388","author":"Hamed","year":"2024","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002226_bib24","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1111\/bph.15901","article-title":"\u03b1 and \u03b2 catalytic subunits of cAMP-dependent protein kinase regulate formoterol-induced inflammatory gene expression changes in human bronchial epithelial cells","volume":"179","author":"Hamed","year":"2022","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib25","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1093\/nar\/gku480","article-title":"siPools: highly complex but accurately defined siRNA pools eliminate off-target effects","volume":"42","author":"Hannus","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/jpet.124.002226_bib26","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1073\/pnas.76.4.1570","article-title":"Hormonally specific expression of cardiac protein kinase activity","volume":"76","author":"Hayes","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.124.002226_bib27","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1016\/S0021-9258(19)70757-1","article-title":"Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin E1","volume":"255","author":"Hayes","year":"1980","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.124.002226_bib28","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1021\/jm025600i","article-title":"Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties","volume":"46","author":"Herpin","year":"2003","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.124.002226_bib29","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1016\/j.bbadis.2017.02.027","article-title":"MC1R signaling. Intracellular partners and pathophysiological implications","volume":"1863","author":"Herraiz","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1124\/jpet.124.002226_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2003-4-10-r70","article-title":"Identifying biological themes within lists of genes with EASE","volume":"4","author":"Hosack","year":"2003","journal-title":"Genome Biol"},{"key":"10.1124\/jpet.124.002226_bib31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1124\/jpet.124.002226_bib32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1124\/mol.115.098129","article-title":"G Protein-Coupled Receptor (GPCR) Expression in Native Cells: \u201cNovel\u201d EndoGPCRs as Physiologic Regulators and Therapeutic Targets","volume":"88","author":"Insel","year":"2015","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib33","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1124\/mol.117.110825","article-title":"cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes","volume":"93","author":"Johnstone","year":"2018","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib34","article-title":"The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans","volume":"376","author":"Jones","year":"2022","journal-title":"Science"},{"key":"10.1124\/jpet.124.002226_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/jpet.120.000196","article-title":"Prostanoid Receptors of the EP4-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity","volume":"376","author":"Joshi","year":"2021","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002226_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1124\/mol.118.115311","article-title":"Impact of Phosphodiesterase 4 Inhibition on the Operational Efficacy, Response Maxima, and Kinetics of Indacaterol-Induced Gene Expression Changes in BEAS-2B Airway Epithelial Cells: a Global Transcriptomic Analysis","volume":"96","author":"Joshi","year":"2019","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2020.153247","article-title":"EP4 receptor as a novel promising therapeutic target in colon cancer","volume":"216","author":"Karpisheh","year":"2020","journal-title":"Pathol Res Pract"},{"key":"10.1124\/jpet.124.002226_bib38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.tips.2014.06.003","article-title":"What is pharmacological \u2018affinity\u2019? Relevance to biased agonism and antagonism","volume":"35","author":"Kenakin","year":"2014","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.124.002226_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/bcp.12810","article-title":"The mass action equation in pharmacology","volume":"81","author":"Kenakin","year":"2016","journal-title":"Br J Clin Pharmacol"},{"year":"2019","series-title":"A Pharmacology Primer. Techniques for more effective and strategic drug discovery","author":"Kenakin","key":"10.1124\/jpet.124.002226_bib40"},{"key":"10.1124\/jpet.124.002226_bib41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1937-6448(10)82003-9","article-title":"Lipid rafts, caveolae, and their endocytosis","volume":"282","author":"Lajoie","year":"2010","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1124\/jpet.124.002226_bib42","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1124\/jpet.109.156398","article-title":"Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands","volume":"331","author":"Leduc","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002226_bib43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0160-5402(90)90066-T","article-title":"Estimation of agonist affinity and efficacy by direct, operational model-fitting","volume":"23","author":"Leff","year":"1990","journal-title":"J Pharmacol Methods"},{"key":"10.1124\/jpet.124.002226_bib44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.bjp.0707372","article-title":"Good statistical practice in pharmacology. Problem 2","volume":"152","author":"Lew","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib45","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00210-007-0196-0","article-title":"Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts","volume":"377","author":"Liu","year":"2008","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib46","doi-asserted-by":"crossref","DOI":"10.15252\/embj.20105114","article-title":"SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells","volume":"39","author":"Lukassen","year":"2020","journal-title":"EMBO J"},{"key":"10.1124\/jpet.124.002226_bib47","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/ijms19041019","article-title":"EP4 as a Therapeutic Target for Aggressive Human Breast Cancer","volume":"19","author":"Majumder","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1124\/jpet.124.002226_bib48","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/S0960-894X(01)00364-X","article-title":"Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity","volume":"11","author":"Maruyama","year":"2001","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1124\/jpet.124.002226_bib49","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1124\/jpet.103.060020","article-title":"Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89","volume":"309","author":"Meja","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002226_bib50","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1124\/mol.112.083493","volume":"83","author":"Moodley","year":"2013","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib51","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/molpharm.120.000146","article-title":"Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid\/Long-Acting \u03b22-Adrenoceptor Agonist Combination Therapy in Asthma","volume":"99","author":"Mostafa","year":"2021","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib52","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1084648","article-title":"Comprehensive identification of human bZIP interactions with coiled-coil arrays","volume":"300","author":"Newman","year":"2003","journal-title":"Science"},{"key":"10.1124\/jpet.124.002226_bib53","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1111\/bph.13628","article-title":"Understanding how long-acting \u03b22-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update","volume":"173","author":"Newton","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib54","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/178697b0","article-title":"Receptor occupancy and tissue response","volume":"178","author":"Nickerson","year":"1956","journal-title":"Nature"},{"key":"10.1124\/jpet.124.002226_bib55","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1111\/bph.13331","article-title":"Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?","volume":"172","author":"O\u2019Callaghan","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib56","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1152\/physrev.00013.2021","article-title":"Physiological roles of mammalian transmembrane adenylyl cyclase isoforms","volume":"102","author":"Ostrom","year":"2022","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.124.002226_bib57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/sj.bjp.0705930","article-title":"The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology","volume":"143","author":"Ostrom","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.124.002226_bib58","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nmeth.4324","article-title":"Differential analysis of RNA-seq incorporating quantification uncertainty","volume":"14","author":"Pimentel","year":"2017","journal-title":"Nat Methods"},{"key":"10.1124\/jpet.124.002226_bib59","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-065X.2011.01033.x","article-title":"Epithelial cells and airway diseases","volume":"242","author":"Proud","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1124\/jpet.124.002226_bib60","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01046-2019","article-title":"GINA 2019: a fundamental change in asthma management: Treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and adolescents","volume":"53","author":"Reddel","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1124\/jpet.124.002226_bib61","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1165\/rcmb.2017-0315LE","article-title":"\u03b22-Agonists Enhance Asthma-Relevant Inflammatory Mediators in Human Airway Epithelial Cells","volume":"58","author":"Ritchie","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/jpet.124.002226_bib62","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1136\/thx.2010.155648","article-title":"Safety of long-acting \u03b2 agonists for the treatment of asthma: clearing the air","volume":"67","author":"Rodrigo","year":"2012","journal-title":"Thorax"},{"key":"10.1124\/jpet.124.002226_bib63","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/14728222.2017.1279146","article-title":"The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases","volume":"21","author":"Rodr\u00edguez-Calvo","year":"2017","journal-title":"Expert Opin Ther Targets"},{"key":"10.1124\/jpet.124.002226_bib64","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1358\/dnp.2001.14.9.858410","article-title":"Epinephrine analogues","volume":"14","author":"Sneader","year":"2001","journal-title":"Drug News Perspect"},{"key":"10.1124\/jpet.124.002226_bib65","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM199202203260801","article-title":"The use of beta-agonists and the risk of death and near death from asthma","volume":"326","author":"Spitzer","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.124.002226_bib66","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1210\/endo.141.4.7405","article-title":"The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs","volume":"141","author":"Suzawa","year":"2000","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.124.002226_bib67","unstructured":"Taylor BM. (2020) A multi-way correlation coefficient. arXiv e-prints 2003: 02561. https:\/\/ui.adsabs.harvard.edu\/abs\/2020arXiv200302561T."},{"key":"10.1124\/jpet.124.002226_bib68","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nchembio.1665","article-title":"Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis","volume":"10","author":"Tsvetanova","year":"2014","journal-title":"Nat Chem Biol"},{"key":"10.1124\/jpet.124.002226_bib69","doi-asserted-by":"crossref","first-page":"6788","DOI":"10.4049\/jimmunol.0902738","article-title":"Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells","volume":"183","author":"Wilson","year":"2009","journal-title":"J Immunol"},{"key":"10.1124\/jpet.124.002226_bib70","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1124\/jpet.118.249292","article-title":"Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of \u03b22-Adrenoceptor Agonists","volume":"366","author":"Yan","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002226_bib71","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1124\/pr.112.007195","article-title":"The prostanoid EP4 receptor and its signaling pathway","volume":"65","author":"Yokoyama","year":"2013","journal-title":"Pharmacol Rev"},{"key":"10.1124\/jpet.124.002226_bib72","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1124\/pharmrev.120.000086","article-title":"Subcellular Organization of the cAMP Signaling Pathway","volume":"73","author":"Zaccolo","year":"2021","journal-title":"Pharmacol Rev"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524177877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524177877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.124.002226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:36:38Z","timestamp":1739979398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524177877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0022356524177877"],"URL":"https:\/\/doi.org\/10.1124\/jpet.124.002226","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the Genomic Activity of an EP4-Receptor and \u03b22-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.124.002226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}