{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:24:11Z","timestamp":1787725451787,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"am","delay-in-days":360,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA017763"],"award-info":[{"award-number":["R01 DA017763"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F31 DA060614"],"award-info":[{"award-number":["F31 DA060614"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F31 DA053776"],"award-info":[{"award-number":["F31 DA053776"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50 DA006634"],"award-info":[{"award-number":["P50 DA006634"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA041349-06"],"award-info":[{"award-number":["T32 DA041349-06"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA 000389"],"award-info":[{"award-number":["DA 000389"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1124\/jpet.124.002356","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:45:12Z","timestamp":1726850712000},"page":"100033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Contrasting the reinforcing effects of the novel dopamine transport inhibitors JJC8-088 and JJC8-091 in monkeys: Potential translation to medication assisted treatment"],"prefix":"10.1016","volume":"392","author":[{"given":"Mia I.","family":"Allen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omeed","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard N.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-4072","authenticated-orcid":false,"given":"Amy Hauck","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.124.002356_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.addicn.2024.100151","article-title":"Behavioral and neuronal extracellular vesicle biomarkers associated with nicotine\u2019s enhancement of the reinforcing strength of cocaine in female and male monkeys","volume":"11","author":"Allen","year":"2024","journal-title":"Addict Neurosci"},{"key":"10.1124\/jpet.124.002356_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2023.110952","article-title":"A\u00a0comparison of the reinforcing strength of cocaethylene and cocaine in monkeys responding under progressive-ratio and concurrent choice schedules of reinforcement","volume":"251","author":"Allen","year":"2023","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.124.002356_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.drugalcdep.2009.04.015","article-title":"Modafinil for the treatment of cocaine dependence","volume":"104","author":"Anderson","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.124.002356_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tips.2016.11.002","article-title":"Insights from preclinical choice models on treating drug addiction","volume":"38","author":"Banks","year":"2017","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.124.002356_bib5","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0022-3565(25)24543-8","article-title":"Novel 2-substituted cocaine analogs: uptake and ligand binding studies at dopamine, serotonin and norepinephrine transport sites in the rat brain","volume":"272","author":"Bennett","year":"1995","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002356_bib6","doi-asserted-by":"crossref","first-page":"10676","DOI":"10.1021\/acs.jmedchem.6b01373","article-title":"Novel and high affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (modafinil) analogues as atypical dopamine transporter inhibitors","volume":"59","author":"Cao","year":"2016","journal-title":"J\u00a0Med Chem"},{"key":"10.1124\/jpet.124.002356_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00213-008-1222-8","article-title":"Cocaine self-administration reinforced on a progressive ratio schedule decreases with continuous D-amphetamine treatment in rats","volume":"200","author":"Chiodo","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.124.002356_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00213-009-1622-4","article-title":"Decreased reinforcing effects of cocaine following 2 weeks of continuous D-amphetamine treatment in rats","volume":"206","author":"Chiodo","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.124.002356_bib9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/jat\/19.6.459","article-title":"Pharmacokinetics and pharmacodynamics of cocaine","volume":"19","author":"Cone","year":"1995","journal-title":"J\u00a0Anal Toxicol"},{"key":"10.1124\/jpet.124.002356_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/npp.2010.185","article-title":"Prolonged attenuation of the reinforcing strength of cocaine by chronic d-amphetamine in rhesus monkeys","volume":"36","author":"Czoty","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.124.002356_bib11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00213-010-1807-x","article-title":"Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys","volume":"209","author":"Czoty","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.124.002356_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/sj.npp.1300600","article-title":"A\u00a0double-blind, placebo-controlled trial of modafinil for cocaine dependence","volume":"30","author":"Dackis","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.124.002356_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jsat.2011.12.014","article-title":"A\u00a0double-blind, placebo-controlled trial of modafinil for cocaine dependence","volume":"43","author":"Dackis","year":"2012","journal-title":"J\u00a0Subst Abuse Treat"},{"key":"10.1124\/jpet.124.002356_bib14","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1021\/jm00035a005","article-title":"Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex","volume":"37","author":"Davies","year":"1994","journal-title":"J\u00a0Med Chem"},{"key":"10.1124\/jpet.124.002356_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0922-4106(93)90063-F","article-title":"Novel 2-substituted cocaine analogs: binding properties at dopamine transport sites in rat striatum","volume":"244","author":"Davies","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.124.002356_bib16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/00004714-200110000-00010","article-title":"Dextroamphetamine for cocaine-dependence treatment: a double-blind randomized clinical trial","volume":"21","author":"Grabowski","year":"2001","journal-title":"J\u00a0Clin Psychopharmacol"},{"key":"10.1124\/jpet.124.002356_bib17","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.addbeh.2004.06.018","article-title":"Agonist-like, replacement pharmacotherapy for stimulant abuse and dependence","volume":"29","author":"Grabowski","year":"2004","journal-title":"Addict Behav"},{"key":"10.1124\/jpet.124.002356_bib18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/sj.npp.1301472","article-title":"Smoked cocaine self-administration is decreased by modafinil","volume":"33","author":"Hart","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.124.002356_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.656475","article-title":"Psychostimulant use disorder, an unmet therapeutic goal: can modafinil narrow the gap?","volume":"15","author":"Hersey","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1124\/jpet.124.002356_bib20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-12-420118-7.00004-4","article-title":"Monoamine transporter inhibitors and substrates as treatments for stimulant abuse","volume":"69","author":"Howell","year":"2014","journal-title":"Adv Pharmacol"},{"key":"10.1124\/jpet.124.002356_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/026988110001400107","article-title":"An evaluation of the abuse potential of modafinil using methylphenidate as a reference","volume":"14","author":"Jasinski","year":"2000","journal-title":"J\u00a0Psychopharmacol"},{"key":"10.1124\/jpet.124.002356_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.drugalcdep.2015.08.005","article-title":"A\u00a0double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence","volume":"155","author":"Kampman","year":"2015","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.124.002356_bib23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1037\/pha0000302","article-title":"Pharmacological validation of a translational model of cocaine use disorder: effects of d-amphetamine maintenance on choice between intravenous cocaine and a nondrug alternative in humans and rhesus monkeys","volume":"28","author":"Lile","year":"2020","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1124\/jpet.124.002356_bib24","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1124\/jpet.102.039180","article-title":"The reinforcing efficacy of the dopamine reuptake inhibitor 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys","volume":"303","author":"Lile","year":"2002","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002356_bib25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s002130000554","article-title":"Self-administration of two long-acting monoamine transport blockers in rhesus monkeys","volume":"152","author":"Lile","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.124.002356_bib26","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1037\/1064-1297.8.3.424","article-title":"First- versus last-session substitution: an evaluation of the reinforcing effects of cocaine and the cocaine analogue 2beta-propanoyl-3beta-(4-tolyl)-tropane","volume":"8","author":"Lile","year":"2000","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1124\/jpet.124.002356_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.biopsych.2012.03.022","article-title":"R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse","volume":"72","author":"Loland","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1124\/jpet.124.002356_bib28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00213-013-3232-4","article-title":"The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders","volume":"229","author":"Mereu","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.124.002356_bib29","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/s41386-020-0680-5","article-title":"Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions","volume":"45","author":"Mereu","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.124.002356_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.120.264952","article-title":"Evaluation of the reinforcing strength of phendimetrazine using a progressive-ratio schedule of reinforcement in rhesus monkeys","volume":"374","author":"Minkiewicz","year":"2020","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002356_bib31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0022-3565(24)36440-7","article-title":"The reinforcing and discriminative stimulus effects of the novel cocaine analog 2beta-propanoyl-3beta-(4-tolyl)-tropane in rhesus monkeys","volume":"280","author":"Nader","year":"1997","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002356_bib32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.biopsych.2012.03.002","article-title":"Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement","volume":"72","author":"Nader","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1124\/jpet.124.002356_bib33","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/sj.npp.1300096","article-title":"Rapid assessment of choice between cocaine and food in rhesus monkeys: effects of environmental manipulations and treatment with d-amphetamine and flupenthixol","volume":"28","author":"Negus","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.124.002356_bib34","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/s41386-019-0366-z","article-title":"Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders","volume":"44","author":"Newman","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.124.002356_bib35","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev-pharmtox-030220-124205","article-title":"New drugs, old targets: tweaking the dopamine system to treat psychostimulant use disorders","volume":"61","author":"Newman","year":"2021","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/jpet.124.002356_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1124\/jpet.122.001363","article-title":"The effects of the dopamine transporter ligands JJC8-088 and JJC8-091 on cocaine versus food choice in rhesus monkeys","volume":"384","author":"Rahimi","year":"2023","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1124\/jpet.124.002356_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0270(95)00153-0","article-title":"Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy","volume":"66","author":"Richardson","year":"1996","journal-title":"J Neurosci Methods"},{"key":"10.1124\/jpet.124.002356_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s002130051022","article-title":"Self-administration of cocaine analogs by rats","volume":"144","author":"Roberts","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.124.002356_bib38","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1037\/pha0000655","article-title":"Effects of naltrexone on amphetamine choice in rhesus monkeys and rats","volume":"31","author":"Robinson","year":"2023","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1124\/jpet.124.002356_bib39","series-title":"Key Substance Use and Mental Health Indicators in the United States: Results from the 2022 National Survey on Drug Use and Health","year":"2023"},{"key":"10.1124\/jpet.124.002356_bib40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJMra1604339","article-title":"Treatment of opioid-use disorders","volume":"375","author":"Schuckit","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1124\/jpet.124.002356_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.coph.2020.07.007","article-title":"Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder","volume":"56","author":"Tanda","year":"2021","journal-title":"Curr Opin Pharmacol"},{"key":"10.1124\/jpet.124.002356_bib42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1054-3589(08)57007-4","article-title":"Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors","volume":"57","author":"Tanda","year":"2009","journal-title":"Adv Pharmacol"},{"key":"10.1124\/jpet.124.002356_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2021.109110","article-title":"A\u00a0drug-vs-food \u201cchoice\u201d self-administration procedure in rats to investigate pharmacological and environmental mechanisms of substance use disorders","volume":"354","author":"Townsend","year":"2021","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1124\/jpet.124.002356_bib44","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neuropharm.2017.12.006","article-title":"Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats","volume":"131","author":"Tunstall","year":"2018","journal-title":"Neuropharmacology"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524000910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524000910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.124.002356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:27:50Z","timestamp":1778646470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524000910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0022356524000910"],"URL":"https:\/\/doi.org\/10.1124\/jpet.124.002356","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contrasting the reinforcing effects of the novel dopamine transport inhibitors JJC8-088 and JJC8-091 in monkeys: Potential translation to medication assisted treatment","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.124.002356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100033"}}