{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:22:07Z","timestamp":1773282127190,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1124\/jpet.300.1.291","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:30:34Z","timestamp":1042223434000},"page":"291-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Effects of Diadenosine Polyphosphates on Tear Secretion in New Zealand White Rabbits"],"prefix":"10.1016","volume":"300","author":[{"given":"J.","family":"Pintor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Peral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.H.V.","family":"Hoyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Redick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Douglass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Sims","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Yerxa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.300.1.291_bib1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/sj.bjp.0701880","article-title":"Molecular cloning and characterisation of rat P2Y4 nucleotide receptor.","volume":"124","author":"Bogdanov","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.300.1.291_bib2","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1476-5381.1996.tb15457.x","article-title":"PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors.","volume":"118","author":"Charlton","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.300.1.291_bib3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0014-2999(96)00740-6","article-title":"Pharmacological characterization of the human P2Y4 receptor.","volume":"317","author":"Communi","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.300.1.291_bib4","first-page":"S713","article-title":"Phase 2 dose ranging efficacy trial of INS365 ophthalmic solution, a P2Y2 agonist, in patients with dry eye.","volume":"42","author":"Foulks","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.300.1.291_bib5","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1097\/00003226-200011002-00051","article-title":"P2Y2 agonist, INS365 a potential dry eye therapeutic agent.","volume":"19","author":"Fujihara","year":"2000","journal-title":"Cornea"},{"key":"10.1124\/jpet.300.1.291_bib6","first-page":"96","article-title":"Improvement of corneal barrier function by the P2Y2 agonist INS365 in a rat dry eye model.","volume":"42","author":"Fujihara","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.300.1.291_bib7","first-page":"S485","article-title":"UTP activates the extracellular-signal regulated kinase-1\/2 signaling pathway in primary cultured conjunctival cells.","volume":"42","author":"Fujita","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.300.1.291_bib8","doi-asserted-by":"crossref","unstructured":"Gukasyan HJ, Yerxa BR, Pendergast W, and Lee VHL (2002) Metabolism and transport of purinergic receptor agonists in rabbit conjunctival epithelial cells. Adv Exp Med Biol, in press.","DOI":"10.1007\/978-1-4615-0717-8_35"},{"key":"10.1124\/jpet.300.1.291_bib9","first-page":"372","article-title":"Nucleoside transport mechanisms in the pigmented rabbit conjunctiva.","volume":"39","author":"Hosoya","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.300.1.291_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-3565(24)35070-0","article-title":"Nucleotide stimulation of Cl\u2212 secretion in the pigmented rabbit conjunctiva.","volume":"291","author":"Hosoya","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.300.1.291_bib11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ddr.1123","article-title":"Diadenosine polyphosphates as extracellular signal molecules.","volume":"52","author":"Hoyle","year":"2001","journal-title":"Drug Dev Res"},{"key":"10.1124\/jpet.300.1.291_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1006\/bbrc.1997.6895","article-title":"Cloning of a human heptahelical receptor closely related to the P2Y5 receptor.","volume":"236","author":"Janssens","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.300.1.291_bib13","first-page":"S901","article-title":"Rabbit cornea releases ATP following mild mechanical stimulation or exposure to a hypo-osmotic solution.","volume":"41","author":"Jensen","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.300.1.291_bib14","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0026-895X(24)26501-9","article-title":"ATP, an antagonist at the rat P2Y4 receptor, is an antagonist at the human P2Y4 receptor.","volume":"57","author":"Kennedy","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.300.1.291_bib15","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1111\/j.1476-5381.1995.tb16382.x","article-title":"Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate.","volume":"116","author":"Lazarowski","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.300.1.291_bib16","doi-asserted-by":"crossref","first-page":"C595","DOI":"10.1152\/ajpcell.2001.281.2.C595","article-title":"Rabbit conjunctival epithelium transports fluid, and P2Y2 receptor agonists stimulate chloride and fluid secretion.","volume":"281","author":"Li","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.300.1.291_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00003226-199801000-00015","article-title":"Effect of sensory denervation on the structure and physiologic responsiveness of rabbit lacrimal gland.","volume":"17","author":"Meneray","year":"1998","journal-title":"Cornea"},{"key":"10.1124\/jpet.300.1.291_bib18","first-page":"40","article-title":"Activity of diadenosine polyphosphates at purinergic P2Y receptors stably expressed in 1321N cells.","volume":"50","author":"Patel","year":"2000","journal-title":"Drug Dev Res"},{"key":"10.1124\/jpet.300.1.291_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0960-894X(00)00612-0","article-title":"Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5\u2032-polyphosphates.","volume":"11","author":"Pendergast","year":"2001","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1124\/jpet.300.1.291_bib20","first-page":"S255","article-title":"Effects of diadenosine polyphosphates on intraocular pressure and pupil size in New Zealand rabbits.","volume":"41","author":"Peral","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.300.1.291_bib21","series-title":"Nervous Control of the Eye","first-page":"171","article-title":"Purinergic signalling in the eye","author":"Pintor","year":"1999"},{"key":"10.1124\/jpet.300.1.291_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0304-3940(92)90034-5","article-title":"Presence of diadenosine polyphosphates\u2014Ap4A and Ap5A\u2014in rat brain synaptic terminals. Ca2+ dependent release evoked by 4-aminopyridine and veratridine.","volume":"136","author":"Pintor","year":"1992","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.300.1.291_bib23","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1476-5381.1996.tb15771.x","article-title":"Selectivity and activity of adenine dinucleotides at recombinant P2X2 and P2Y1 receptors.","volume":"119","author":"Pintor","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.300.1.291_bib24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines.","volume":"50","author":"Ralevic","year":"1998","journal-title":"Pharmacol Rev"},{"key":"10.1124\/jpet.300.1.291_bib25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1076\/ceyr.18.6.455.5270","article-title":"Denervation of rabbit lacrimal gland increases levels of transferrin and unidentified tear proteins of 44 and 36 kDa.","volume":"18","author":"Salvatore","year":"1999","journal-title":"Curr Eye Res"},{"key":"10.1124\/jpet.300.1.291_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1476-5381.1996.tb15381.x","article-title":"Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.","volume":"118","author":"Schachter","year":"1996","journal-title":"Br J Pharmacol"},{"issue":"Suppl 2","key":"10.1124\/jpet.300.1.291_bib27","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1097\/00003226-200011002-00179","article-title":"Shear stress-induced ATP release by corneal epithelial cells.","volume":"19","author":"Srinivas","year":"2000","journal-title":"Cornea"},{"key":"10.1124\/jpet.300.1.291_bib28","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/sj.bjp.0703228","article-title":"Diadenosine polyphosphates as antagonists of the endogenous P2Y1 receptor in rat brain capillary endothelial cells of the B7 and B10 clones.","volume":"129","author":"Vigne","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.300.1.291_bib29","first-page":"S871","article-title":"Cellular localization of P2Y2 receptor gene expression in primate ocular tissues by nonisotopic in situ hybridization.","volume":"41","author":"Yerxa","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.300.1.291_bib30","first-page":"S540","article-title":"INS365, AP2Y2 receptor agonist, increases Schirmer scores in albino rabbits.","volume":"40","author":"Yerxa","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524354485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524354485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.300.1.291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:12:38Z","timestamp":1740006758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524354485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0022356524354485"],"URL":"https:\/\/doi.org\/10.1124\/jpet.300.1.291","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Diadenosine Polyphosphates on Tear Secretion in New Zealand White Rabbits","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.300.1.291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}