{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T05:23:59Z","timestamp":1740029039895,"version":"3.37.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1124\/jpet.300.3.824","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:32:29Z","timestamp":1042223549000},"page":"824-830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Enhanced Induction of Cytochrome P450 Enzymes and CAR Binding in TNF (p55\u2212\/\u2212\/p75\u2212\/\u2212) Double Receptor Knockout Mice Following Phenobarbital Treatment"],"prefix":"10.1016","volume":"300","author":[{"given":"Peter J.","family":"Van Ess","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark P.","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Blouin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.300.3.824_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0014-5793(95)00513-9","article-title":"Interleukin-1 beta antagonizes phenobarbital induction of several major cytochromes P450 in adult rat hepatocytes in primary culture.","volume":"366","author":"Abdel-Razzak","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.300.3.824_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: new discoveries and insights.","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu Rev Immuno"},{"key":"10.1124\/jpet.300.3.824_bib3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nm0796-788","article-title":"Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors.","volume":"2","author":"Bruce","year":"1996","journal-title":"Nat Med"},{"key":"10.1124\/jpet.300.3.824_bib4","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1016\/0006-2952(85)90355-7","article-title":"Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.","volume":"34","author":"Burke","year":"1985","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.300.3.824_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0006-2952(94)00438-R","article-title":"Differential effect of cytokines on the phenobarbital or 3-methylcholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes.","volume":"49","author":"Clark","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.300.3.824_bib6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0006-2952(95)02391-7","article-title":"Effects of phenobarbital and interleukin-6 on cytochrome P4502B1 and 2B2 in cultured rat hepatocytes.","volume":"51","author":"Clark","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.300.3.824_bib7","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2165\/00003088-200038060-00003","article-title":"Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans.","volume":"38","author":"Fuhr","year":"2000","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/jpet.300.3.824_bib8","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj2650621","article-title":"Interleukin-6 and the acute phase response.","volume":"265","author":"Heinrich","year":"1990","journal-title":"Biochem J"},{"key":"10.1124\/jpet.300.3.824_bib9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1042\/bj2850979","article-title":"Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital.","volume":"285","author":"Honkakoski","year":"1992","journal-title":"Biochem J"},{"key":"10.1124\/jpet.300.3.824_bib10","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1128\/MCB.18.10.5652","article-title":"The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene.","volume":"18","author":"Honkakoski","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1124\/jpet.300.3.824_bib11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/abbi.2000.1772","article-title":"Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site.","volume":"377","author":"Iber","year":"2000","journal-title":"Arch Biochem Biophys"},{"year":"1996","series-title":"Cytochromes P450: Metabolic and Toxicological Aspects.","author":"Ioannides","key":"10.1124\/jpet.300.3.824_bib12"},{"key":"10.1124\/jpet.300.3.824_bib13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1006\/bbrc.1999.1544","article-title":"Phosphorylation\/Dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital.","volume":"264","author":"Kawamura","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.300.3.824_bib14","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/hep.1840080512","article-title":"Accumulaion of liver macrophages following phenobarbital treatment of rats.","volume":"8","author":"Laskin","year":"1988","journal-title":"Hepatology"},{"key":"10.1124\/jpet.300.3.824_bib15","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1093\/nar\/28.10.2091","article-title":"Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa\/CBF1.","volume":"28","author":"Lee","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/jpet.300.3.824_bib16","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1006\/bbrc.1996.1911","article-title":"Activation of hepatic NF-kappaB by phenobarbital in rats.","volume":"229","author":"Li","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.300.3.824_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with folin phenol reagent.","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.300.3.824_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/carcin\/8.1.67","article-title":"Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates.","volume":"8","author":"Nims","year":"1987","journal-title":"Carcinogenesis"},{"key":"10.1124\/jpet.300.3.824_bib19","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide-binding pigment of liver microsomes. I. Evidence in hemoprotein nature.","volume":"239","author":"Omura","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.300.3.824_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF00755608","article-title":"Repression of cytochrome P450 by cytokines: IL-1 beta counteracts clofibric acid induction of CYP4A in cultured fetal rat hepatocytes.","volume":"9","author":"Parmentier","year":"1993","journal-title":"Cell Biol Toxicol"},{"key":"10.1124\/jpet.300.3.824_bib21","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0006-2952(97)00256-6","article-title":"Regulation of CYP4A1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6, and dexamethasone in cultured fetal rat hepatocytes.","volume":"54","author":"Parmentier","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.300.3.824_bib22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1006\/bbrc.2000.3219","article-title":"Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.","volume":"274","author":"Pascussi","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.300.3.824_bib23","first-page":"288","article-title":"Decreased elimination of theophylline after influenza vaccination.","volume":"123","author":"Renton","year":"1980","journal-title":"Can Med Assoc J"},{"key":"10.1124\/jpet.300.3.824_bib24","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1023\/A:1011915402914","article-title":"The effect of high dose endotoxin on CYP3A2 expression in the rat.","volume":"15","author":"Roe","year":"1998","journal-title":"Pharm Res"},{"key":"10.1124\/jpet.300.3.824_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1182\/blood.V75.1.40.40","article-title":"Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF.","volume":"75","author":"Schindler","year":"1990","journal-title":"Blood"},{"key":"10.1124\/jpet.300.3.824_bib26","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0090-9556(25)07366-0","article-title":"Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450.","volume":"24","author":"Sewer","year":"1996","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.300.3.824_bib27","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1172\/JCI117582","article-title":"Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.","volume":"94","author":"Shedlofsky","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.300.3.824_bib28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1046\/j.1365-2125.1997.00603.x","article-title":"Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women.","volume":"43","author":"Shedlofsky","year":"1997","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/jpet.300.3.824_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0003-9861(87)90291-8","article-title":"Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450.","volume":"255","author":"Sonderfan","year":"1987","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/jpet.300.3.824_bib30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/clpt.1985.117","article-title":"Antipyrine clearance in pneumonia.","volume":"37","author":"Sonne","year":"1985","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.300.3.824_bib31","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1128\/MCB.15.8.4158","article-title":"A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp 2d-9) gene in mouse liver.","volume":"15","author":"Sueyoshi","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1124\/jpet.300.3.824_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pharmtox.41.1.123","article-title":"Phenobarbital response elements of cytochrome P450 genes and nuclear receptors.","volume":"41","author":"Sueyoshi","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/jpet.300.3.824_bib33","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood.V76.12.2520.2520","article-title":"Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways.","volume":"76","author":"van Deventer","year":"1990","journal-title":"Blood"},{"key":"10.1124\/jpet.300.3.824_bib34","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-3565(24)38045-0","article-title":"Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55\/p75) knockout mice after endotoxin administration.","volume":"288","author":"Warren","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.300.3.824_bib35","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1089\/107999001753238060","article-title":"Cytochrome P450 and antioxidant activity in interleukin-6 knockout mice after induction of the acute phase response.","volume":"21","author":"Warren","year":"2001","journal-title":"J Interferon Cytokine Res"},{"key":"10.1124\/jpet.300.3.824_bib36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1042\/bj2810577","article-title":"Phenobarbital induction of cytochrome P-450 gene expression.","volume":"281","author":"Waxman","year":"1992","journal-title":"Biochem J"},{"key":"10.1124\/jpet.300.3.824_bib37","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0006-291X(91)90998-M","article-title":"Effect of interleukin 6 on phenobarbital induction of cytochrome P-450IIB in cultured rat hepatocytes.","volume":"178","author":"Williams","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.300.3.824_bib38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0167-4781(92)90447-8","article-title":"Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.","volume":"1130","author":"Yanagimoto","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.300.3.824_bib39","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0026-895X(24)12838-6","article-title":"Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers.","volume":"59","author":"Yoshinari","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.300.3.824_bib40","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/377348a0","article-title":"Induction of apoptosis in mature T cells by tumour necrosis factor.","volume":"377","author":"Zheng","year":"1995","journal-title":"Nature (Lond)"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524355260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524355260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.300.3.824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:15:10Z","timestamp":1740006910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524355260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S0022356524355260"],"URL":"https:\/\/doi.org\/10.1124\/jpet.300.3.824","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2002,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced Induction of Cytochrome P450 Enzymes and CAR Binding in TNF (p55\u2212\/\u2212\/p75\u2212\/\u2212) Double Receptor Knockout Mice Following Phenobarbital Treatment","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.300.3.824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}