{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:16:02Z","timestamp":1774124162916,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1124\/jpet.300.3.946","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:32:29Z","timestamp":1042223549000},"page":"946-951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["The Role of ATP-Sensitive Potassium Channels in Neutrophil Migration and Plasma Exudation"],"prefix":"10.1016","volume":"300","author":[{"given":"Jos\u00e9 Eduardo","family":"Da Silva-Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cl\u00e1udia","family":"Santos-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando de Queiroz","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamil","family":"Assreuy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.300.3.946_bib1","first-page":"2572","article-title":"Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide.","volume":"85","author":"Aljad","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1124\/jpet.300.3.946_bib2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s001250051247","article-title":"ATP-sensitive K+ channels and insulin secretion: their role in health and disease.","volume":"42","author":"Ashcroft","year":"1999","journal-title":"Diabetologia"},{"key":"10.1124\/jpet.300.3.946_bib3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0167-4889(98)00081-0","article-title":"Extracellular Ca2+ regulates the respiratory burst of human neutrophils.","volume":"404","author":"Bei","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.300.3.946_bib4","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s002100000218","article-title":"Atypical effect of minoxidil sulphate on guinea pig airways.","volume":"361","author":"Buchheit","year":"2000","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1124\/jpet.300.3.946_bib5","first-page":"R414","article-title":"Vasodilator responses to acetylcholine,bradykinin, and substance P are mediated by a TEA-sensitive mechanism.","volume":"273","author":"Champion","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.300.3.946_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0167-4889(87)90204-7","article-title":"Calcium signals in neutrophils can be divided into three distinct phases.","volume":"931","author":"Chandler","year":"1987","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.300.3.946_bib7","first-page":"284","article-title":"Acute colitis produced by chemotactic peptides in rats and mice.","volume":"121","author":"Chester","year":"1985","journal-title":"Am J Pathol"},{"key":"10.1124\/jpet.300.3.946_bib8","first-page":"68","article-title":"The function and fate of neutrophils at the inflamed site: prospects for therapeutic intervention.","volume":"34","author":"Chilvers","year":"2000","journal-title":"J R Coll Physicians Lond"},{"key":"10.1124\/jpet.300.3.946_bib9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0022-3565(24)34911-0","article-title":"Long-lasting changes of rat blood pressure to vasoconstrictors and vasodilators induced by nitric oxide donor infusion: involvement of potassium channels.","volume":"290","author":"Da Silva-Santos","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.300.3.946_bib10","first-page":"11","article-title":"Chemotaxis and spontaneous migration of neutrophil leukocytes from patients with diabetes.","volume":"49","author":"Debczynski","year":"1994","journal-title":"Pol Tyg Lek"},{"key":"10.1124\/jpet.300.3.946_bib11","doi-asserted-by":"crossref","first-page":"321S","DOI":"10.1378\/chest.112.6_Supplement.321S","article-title":"Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock.","volume":"112","author":"Dinarello","year":"1997","journal-title":"Chest"},{"key":"10.1124\/jpet.300.3.946_bib12","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1016\/S0021-9258(18)61231-1","article-title":"Plasma membrane potential modulates chemotactic peptide-stimulated cytosolic free Ca2+ changes in human neutrophils.","volume":"262","author":"Di Virgilio","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.300.3.946_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0006-2952(99)00342-1","article-title":"Inhibition of interleukin-8-activated human neutrophil chemotaxis by thapsigargin in a calcium- and cyclic AMP-dependent way.","volume":"59","author":"Elferink","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.300.3.946_bib14","doi-asserted-by":"crossref","first-page":"660","DOI":"10.7326\/0003-4819-89-5-660","article-title":"The spectrum of vasculitis: clinical, pathologic, immunology, and therapeutic considerations.","volume":"89","author":"Fauci","year":"1978","journal-title":"Ann Intern Med"},{"key":"10.1124\/jpet.300.3.946_bib15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1476-5381.1996.tb15219.x","article-title":"Effects of glibenclamide on the regional haemodynamic actions of \u03b1-trinositol and its influence on responses to vasodilators in conscious rats.","volume":"117","author":"Gardiner","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.300.3.946_bib16","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/sj.bjp.0702985","article-title":"Regional haemodynamic responses to infusion of lipopolysaccharide in conscious rats: effects of pre- or post-treatment with glibenclamide.","volume":"128","author":"Gardiner","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.300.3.946_bib17","series-title":"Inflammation: Basic Principles and Clinical Correlates","first-page":"921","article-title":"Vasculitis: pathogenic mechanisms of vessel damage","author":"Haynes","year":"1992"},{"key":"10.1124\/jpet.300.3.946_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ki.1984.150","article-title":"Differential effects of steroids on leukocyte-mediated glomerulonephritis in the rabbit.","volume":"26","author":"Holdsworth","year":"1984","journal-title":"Kidney Int"},{"key":"10.1124\/jpet.300.3.946_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0955-0674(95)80112-X","article-title":"Adhesion in cell migration.","volume":"7","author":"Huttenlocher","year":"1995","journal-title":"Curr Opin Cell Biol"},{"key":"10.1124\/jpet.300.3.946_bib20","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1073\/pnas.75.8.3818","article-title":"Changes in membrane potential of human granulocytes antecede the metabolic responses to surface stimulation.","volume":"75","author":"Korchak","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.300.3.946_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0009-9120(90)80030-M","article-title":"The calcium signal and neutrophil activation.","volume":"23","author":"Krause","year":"1990","journal-title":"Clin Biochem"},{"key":"10.1124\/jpet.300.3.946_bib22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1172\/JCI114464","article-title":"Voltage-dependent and Ca2+-activated ion channels in human neutrophils.","volume":"85","author":"Krause","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.300.3.946_bib23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0092-8674(00)81280-5","article-title":"Cell migration: a physically integrated molecular process.","volume":"84","author":"Lauffenburger","year":"1996","journal-title":"Cell"},{"key":"10.1124\/jpet.300.3.946_bib24","doi-asserted-by":"crossref","first-page":"10959","DOI":"10.1016\/S0021-9258(19)38542-4","article-title":"Neutrophil hyperpolarization in response to a chemotactic peptide.","volume":"265","author":"Lazzari","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.300.3.946_bib25","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/01.RES.65.4.1102","article-title":"Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.","volume":"65","author":"Leblanc","year":"1989","journal-title":"Circ Res"},{"key":"10.1124\/jpet.300.3.946_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0005-2736(89)90392-1","article-title":"The plasma membrane potential of human neutrophils. Role of ion channels and the sodium\/potassium pump.","volume":"980","author":"Majander","year":"1989","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.300.3.946_bib27","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.4049\/jimmunol.140.11.3928","article-title":"Depolarization blunts the oxidative burst of human neutrophils. Parallel effects of monoclonal antibodies, depolarizing buffers, and glycolytic inhibitors.","volume":"140","author":"Martin","year":"1988","journal-title":"J Immunol"},{"key":"10.1124\/jpet.300.3.946_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.93.1.129","article-title":"Calcium movement and membrane potential changes in the early phase of neutrophil activation by phorbol myristate acetate: a study with ion-selective electrodes.","volume":"93","author":"Mottola","year":"1982","journal-title":"J Cell Biol"},{"key":"10.1124\/jpet.300.3.946_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00005344-200007000-00014","article-title":"Glibenclamide inhibits accumulation of cholesteryl ester in THP-1 human macrophages.","volume":"36","author":"Nobusawa","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.300.3.946_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0026-2862(89)90016-2","article-title":"The endothelial cell cytoskeleton modulates extravascular polymorphonuclear leukocyte accumulations in vivo.","volume":"38","author":"Paterson","year":"1989","journal-title":"Microvasc Res"},{"key":"10.1124\/jpet.300.3.946_bib31","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.2337\/diab.36.11.1307","article-title":"Inhibition of leukocyte chemotaxis by factor in alloxan-induced diabetic rat plasma.","volume":"36","author":"Pereira","year":"1987","journal-title":"Diabetes"},{"key":"10.1124\/jpet.300.3.946_bib32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/sj.bjp.0703825","article-title":"In vivo evidence for K(Ca) channel opening properties of acetazolamide in the human vasculature.","volume":"132","author":"Pickkers","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.300.3.946_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF03402125","article-title":"Regulation of macrophage migration inhibitory factor (MIF) expression by glucose and insulin in adipocytes in vitro.","volume":"5","author":"Sakaue","year":"1999","journal-title":"Mol Med"},{"key":"10.1124\/jpet.300.3.946_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01966691","article-title":"Blockage by anti-macrophage serum of the migration of PMN neutrophils into the inflamed peritoneal cavity.","volume":"17","author":"Souza","year":"1985","journal-title":"Agents Actions"},{"key":"10.1124\/jpet.300.3.946_bib35","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.2042-7158.1991.tb03540.x","article-title":"Assay of pyrogens by interleukin-6 release from monocytic cell lines.","volume":"43","author":"Taktak","year":"1991","journal-title":"J Pharmacol"},{"key":"10.1124\/jpet.300.3.946_bib36","first-page":"2588","article-title":"Pathway of onset, development, and decay of carrageenan pleurisy in the rat.","volume":"41","author":"Vinegar","year":"1982","journal-title":"Fed Proc"},{"key":"10.1124\/jpet.300.3.946_bib37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1046\/j.1440-1681.1999.03006.x","article-title":"Activation of vascular smooth muscle K+ channels by endothelium-derived relaxing factors.","volume":"26","author":"Waldron","year":"1999","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1124\/jpet.300.3.946_bib38","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3109\/00365528509088887","article-title":"Function of exudative neutrophilic granulocytes in patients with Crohn\u2019s disease or ulcerative colitis.","volume":"20","author":"Wandall","year":"1985","journal-title":"Scand J Gastroenterol"},{"key":"10.1124\/jpet.300.3.946_bib39","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1182\/blood.V97.3.660","article-title":"Changes in the biomechanical properties of neutrophils and endothelial cells during adhesion.","volume":"97","author":"Wang","year":"2001","journal-title":"Blood"},{"key":"10.1124\/jpet.300.3.946_bib40","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/BF00915708","article-title":"Rheumatoid arthritis. The role of neutrophil activation.","volume":"8","author":"Weissmann","year":"1984","journal-title":"Inflammation"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524355417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524355417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.300.3.946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:15:39Z","timestamp":1740006939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524355417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S0022356524355417"],"URL":"https:\/\/doi.org\/10.1124\/jpet.300.3.946","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of ATP-Sensitive Potassium Channels in Neutrophil Migration and Plasma Exudation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.300.3.946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}