{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:13:30Z","timestamp":1772003610378,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,7]]},"DOI":"10.1124\/jpet.302.1.304","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:42:35Z","timestamp":1042224155000},"page":"304-313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Skeletal Efficacy with Parathyroid Hormone in Rats Was Not Entirely Beneficial with Long-Term Treatment"],"prefix":"10.1016","volume":"302","author":[{"given":"M.","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.L.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Hock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Westmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vahle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Villanueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.H.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.302.1.304_bib1","series-title":"Pathology of Laboratory Animals.","author":"Benirschke","year":"1978"},{"key":"10.1124\/jpet.302.1.304_bib2","series-title":"Pathology of the Fischer Rat: Reference and Atlas","author":"Boorman","year":"1990"},{"key":"10.1124\/jpet.302.1.304_bib3","series-title":"Evaluation of Altered Morphology","author":"Bucci","year":"1991"},{"key":"10.1124\/jpet.302.1.304_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0169-6009(89)90039-1","article-title":"Structural mechanisms of trabecular bone loss in man.","volume":"6","author":"Compston","year":"1989","journal-title":"Bone Miner"},{"key":"10.1124\/jpet.302.1.304_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/8756-3282(87)90004-4","article-title":"Age-related changes in iliac crest trabecular microanatomic bone structure in man.","volume":"8","author":"Compston","year":"1987","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s002239900464","article-title":"Is parathyroid hormone a therapeutic option for osteoporosis? A review of the clinical evidence.","volume":"62","author":"Cosman","year":"1998","journal-title":"Calcif Tissue Int"},{"key":"10.1124\/jpet.302.1.304_bib7","first-page":"690","article-title":"Anabolic actions of parathyroid hormone on bone [Erratum appears in Endocr Rev (1994) 15: 261].","volume":"14","author":"Dempster","year":"1993","journal-title":"Endocr Rev"},{"key":"10.1124\/jpet.302.1.304_bib8","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1210\/endo.138.11.5505","article-title":"The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats.","volume":"138","author":"Dobnig","year":"1997","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.302.1.304_bib9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/8756-3282(95)00371-1","article-title":"Parathyroid hormone (1-34) increases vertebral bone mass, compressive strength and quality in old rats.","volume":"17","author":"Ejersted","year":"1995","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1530\/eje.0.1300201","article-title":"Human parathyroid hormone (1-34) increases bone formation and strength of cortical bone in aged rats.","volume":"130","author":"Ejersted","year":"1994","journal-title":"Eur J Endocrinol"},{"key":"10.1124\/jpet.302.1.304_bib11","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/jbmr.5650080910","article-title":"Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats.","volume":"8","author":"Ejersted","year":"1993","journal-title":"J Bone Miner Res"},{"key":"10.1124\/jpet.302.1.304_bib12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2818.1986.tb04289.x","article-title":"A new method for the two-dimensional analysis of bone structure in human iliac crest biopsies.","volume":"142","author":"Garrahan","year":"1986","journal-title":"J Microsc"},{"key":"10.1124\/jpet.302.1.304_bib13","first-page":"111","article-title":"Parathyroid hormone: a cure for osteoporosis.","volume":"31","author":"Gasser","year":"1992","journal-title":"Triangle"},{"key":"10.1124\/jpet.302.1.304_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/8756-3282(94)00030-4","article-title":"Anabolic effect of parathyroid hormone is not modified by supplementation with insulinlike growth factor I (IGF-I) or growth hormone in aged female rats fed an energy-restricted or ad libitum diet.","volume":"16","author":"Gunness","year":"1995","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib15","first-page":"1","article-title":"Anabolic actions of PTH in the skeletons of animals.","volume":"2","author":"Hock","year":"2001","journal-title":"J Musculoskel Neuron Interact"},{"key":"10.1124\/jpet.302.1.304_bib16","first-page":"S412","article-title":"Anabolic PTH targets proliferating cells of the primary spongiosa in young rats and increases the number differentiating into osteoblasts.","volume":"9","author":"Hock","year":"1994","journal-title":"J Bone Miner Res"},{"key":"10.1124\/jpet.302.1.304_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0047-6374(95)01662-7","article-title":"Growth hormone does not enhance the anabolic effect of human parathyroid hormone (1-34) on bone in aging multiparous and virgin rats.","volume":"85","author":"Hock","year":"1995","journal-title":"Mech Ageing Dev"},{"key":"10.1124\/jpet.302.1.304_bib18","series-title":"Pathology of Domestic Animals","author":"Jubb","year":"1985"},{"key":"10.1124\/jpet.302.1.304_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0047-6374(84)90169-6","article-title":"Lifelong food restriction prevents senile osteopenia and hyperparathyroidism in F-344 rats.","volume":"26","author":"Kalu","year":"1984","journal-title":"Mech Ageing Dev"},{"key":"10.1124\/jpet.302.1.304_bib20","series-title":"Animal Models for in Vivo Experimentation in Osteoporosis Research","author":"Kimmel","year":"1996"},{"key":"10.1124\/jpet.302.1.304_bib21","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S8756-3282(98)00045-3","article-title":"Bone responses at various skeletal sites to human parathyroid hormone in ovariectomized rats: effects of long-term administration, withdrawal and readministration.","volume":"22","author":"Kishi","year":"1998","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S8756-3282(00)00448-8","article-title":"Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH (1-34).","volume":"28","author":"Kneissel","year":"2001","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S8756-3282(96)00317-1","article-title":"Time course of femoral neck osteopenia in ovariectomized rats.","volume":"20","author":"Li","year":"1997","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/8756-3282(95)00077-Q","article-title":"Response of femoral neck to estrogen depletion and parathyroid hormone in aged rats.","volume":"16","author":"Li","year":"1995","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib25","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1210\/endo.134.5.8156913","article-title":"The effect on vertebral bone mass and strength of long term treatment with antiresorptive agents (estrogen and calcitonin), human parathyroid hormone-(1-38) and combination therapy, assessed in aged ovariectomized rats.","volume":"134","author":"Mosekilde","year":"1994","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.302.1.304_bib26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/endo-129-1-421","article-title":"The anabolic effects of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing: a comparison study between hPTH-(1-34) and hPTH-(1-84).","volume":"129","author":"Mosekilde","year":"1991","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.302.1.304_bib27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/8756-3282(94)90816-8","article-title":"PTH has a more pronounced effect on vertebral bone mass and biomechanical competence than antiresorptive agents (estrogen and bisphosphonate) assessed in sexually mature, ovariectomized rats.","volume":"15","author":"Mosekilde","year":"1994","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib28","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.","volume":"344","author":"Neer","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.302.1.304_bib29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0047-6374(95)01668-6","article-title":"The effect of aging on bone composition of female Fischer-344 rats.","volume":"85","author":"Nnakwe","year":"1995","journal-title":"Mech Ageing Dev"},{"key":"10.1124\/jpet.302.1.304_bib30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/8756-3282(95)00332-2","article-title":"In vivo, human parathyroid hormone fragment (hPTH 1-34) transiently stimulates immediate early response gene expression, but not proliferation, in trabecular bone cells of young rats.","volume":"17","author":"Onyia","year":"1995","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib31","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1210\/jcem.86.3.7366","article-title":"Clinical review 123: anabolic therapy for osteoporosis.","volume":"86","author":"Rosen","year":"2001","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1124\/jpet.302.1.304_bib32","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1210\/endo.138.10.5440","article-title":"Biosynthetic human parathyroid hormone (1-34) effects on bone quality in aged ovariectomized rats.","volume":"138","author":"Sato","year":"1997","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.302.1.304_bib33","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1210\/endo.134.2.8299562","article-title":"The positive effect of parathyroid hormone on femoral neck bone strength in ovariectomized rats is more pronounced than that of estrogen or bisphosphonates.","volume":"134","author":"Sogaard","year":"1994","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.302.1.304_bib34","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1359\/jbmr.2000.15.8.1517","volume":"15","author":"Stewart","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1124\/jpet.302.1.304_bib35","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/8756-3282(93)90081-K","article-title":"Basic biomechanical measurements of bone: a tutorial.","volume":"14","author":"Turner","year":"1993","journal-title":"Bone"},{"key":"10.1124\/jpet.302.1.304_bib36","first-page":"275","article-title":"Skeletal effects of estrogen.","volume":"15","author":"Turner","year":"1994","journal-title":"Endocr Rev"},{"key":"10.1124\/jpet.302.1.304_bib37","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/01926230252929882","article-title":"Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety.","volume":"30","author":"Vahle","year":"2002","journal-title":"Toxicol Pathol"},{"key":"10.1124\/jpet.302.1.304_bib38","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/BF02556007","article-title":"Long-term effects of ovariectomy and aging on the rat skeleton.","volume":"45","author":"Wronski","year":"1989","journal-title":"Calcif Tissue Int"},{"key":"10.1124\/jpet.302.1.304_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/8756-3282(94)90891-5","article-title":"Anabolic effects of parathyroid hormone on cortical bone in ovariectomized rats.","volume":"15","author":"Wronski","year":"1994","journal-title":"Bone"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524357659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524357659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.302.1.304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:22:53Z","timestamp":1740007373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524357659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["S0022356524357659"],"URL":"https:\/\/doi.org\/10.1124\/jpet.302.1.304","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2002,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skeletal Efficacy with Parathyroid Hormone in Rats Was Not Entirely Beneficial with Long-Term Treatment","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.302.1.304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}