{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:16:52Z","timestamp":1773148612934,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1124\/jpet.303.2.741","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:48:30Z","timestamp":1042224510000},"page":"741-745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Pharmacokinetics and Metabolism of Infused versus Inhaled Iloprost in Isolated Rabbit Lungs"],"prefix":"10.1016","volume":"303","author":[{"given":"Ralph Theo","family":"Schermuly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein Ardeschir","family":"Ghofrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Meidow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Roehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Weissmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Grimminger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Walmrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Seeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.303.2.741_bib1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF03190976","article-title":"Metabolism of (\u2212)-(S)-nicotine in the isolated perfused rabbit lung.","volume":"22","author":"Aislaitner","year":"1997","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1124\/jpet.303.2.741_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1165\/ajrcmb\/8.3.273","article-title":"Human tracheal epithelial cells selectively incorporate 15- hydroxyeicosatetraenoic acid into phosphatidylinositol.","volume":"8","author":"Alpert","year":"1993","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/jpet.303.2.741_bib3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0022-2275(20)32149-0","article-title":"13-(S)-Hydroxyoctadecadienoic acid (13-HODE) incorporation and conversion to novel products by endothelial cells.","volume":"40","author":"Fang","year":"1999","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.303.2.741_bib4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0140-6736(90)90346-7","article-title":"Trial of iloprost versus aspirin treatment for critical limb ischaemia of thromboangiitis obliterans. The TAO Study.","volume":"335","author":"Fiessinger","year":"1990","journal-title":"Lancet"},{"key":"10.1124\/jpet.303.2.741_bib5","first-page":"450","article-title":"Effect of iloprost on in vivo and in vitro platelet function in patients with peripheral vascular disease (PVD).","volume":"17A","author":"Fitscha","year":"1987","journal-title":"Adv Prostaglandin Thromboxane Leukot Res"},{"key":"10.1124\/jpet.303.2.741_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1183\/09031936.01.17100140","article-title":"Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension.","volume":"17","author":"Gessler","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1124\/jpet.303.2.741_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0090-6980(92)90138-J","article-title":"Pharmacokinetics of iloprost and cicaprost in mice.","volume":"44","author":"Hildebrand","year":"1992","journal-title":"Prostaglandins"},{"key":"10.1124\/jpet.303.2.741_bib8","first-page":"165","article-title":"Development, validation and practical use of a sensitive and specific radioimmunoassay for the determination of iloprost.","volume":"3","author":"Hildebrand","year":"1990","journal-title":"Eicosanoids"},{"key":"10.1124\/jpet.303.2.741_bib9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0735-1097(99)00494-5","article-title":"A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group.","volume":"35","author":"Hoeper","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.303.2.741_bib10","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJM200006223422503","article-title":"Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue.","volume":"342","author":"Hoeper","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.303.2.741_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00614197","article-title":"Pharmacokinetics and pharmacodynamics of the prostacyclin analogue iloprost in man.","volume":"30","author":"Krause","year":"1986","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/jpet.303.2.741_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0090-6980(92)90011-H","article-title":"Dual metabolic pathways of 12-HETE in rat aortic smooth muscle cells.","volume":"44","author":"Lacape","year":"1992","journal-title":"Prostaglandins"},{"key":"10.1124\/jpet.303.2.741_bib13","doi-asserted-by":"crossref","first-page":"21048","DOI":"10.1016\/S0021-9258(17)45325-7","article-title":"12-Hydroxyeicosatetraenoic acid is metabolized by beta-oxidation in mouse peritoneal macrophages. Identification of products and proposed pathway.","volume":"265","author":"Mathur","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.303.2.741_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/ard.47.1.43","article-title":"Infusion of iloprost, a prostacyclin analogue, for treatment of Raynaud\u2019s phenomenon in systemic sclerosis.","volume":"47","author":"McHugh","year":"1988","journal-title":"Ann Rheum Dis"},{"key":"10.1124\/jpet.303.2.741_bib15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.7326\/0003-4819-132-6-200003210-00003","article-title":"Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group.","volume":"132","author":"Olschewski","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1124\/jpet.303.2.741_bib16","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1164\/ajrccm.160.2.9810008","article-title":"Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.","volume":"160","author":"Olschewski","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.303.2.741_bib17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa020204","article-title":"Inhaled iloprost for severe pulmonary hypertension.","volume":"347","author":"Olschewski","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.303.2.741_bib18","doi-asserted-by":"crossref","first-page":"820","DOI":"10.7326\/0003-4819-124-9-199605010-00006","article-title":"Aerosolized prostacyclin and iloprost in severe pulmonary hypertension.","volume":"124","author":"Olschewski","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1124\/jpet.303.2.741_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1164\/ajrccm.156.2.9609092","article-title":"Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury. Impact on gas exchange.","volume":"156","author":"Schermuly","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.303.2.741_bib20","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0022-3565(24)35320-0","article-title":"Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.","volume":"292","author":"Schermuly","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.303.2.741_bib21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1152\/jappl.1996.80.1.351","article-title":"On-line laser-photometric monitoring of aerosol deposition in ventilated rabbit lungs.","volume":"80","author":"Schmehl","year":"1996","journal-title":"J Appl Physiol"},{"key":"10.1124\/jpet.303.2.741_bib22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0076-6879(94)33060-3","article-title":"Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs.","volume":"233","author":"Seeger","year":"1994","journal-title":"Methods Enzymol"},{"key":"10.1124\/jpet.303.2.741_bib23","first-page":"550","article-title":"Pharmacokinetic-pharmacodynamic and metabolite modeling with TopFit.","volume":"33","author":"Tanswell","year":"1995","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1124\/jpet.303.2.741_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1211\/0022357001773689","article-title":"The effect of fenfluramine on the pulmonary disposition of 5-hydroxytryptamine in the isolated perfused rat lung: a comparison with chlorphentermine.","volume":"52","author":"Valodia","year":"2000","journal-title":"J Pharm Pharmacol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652435997X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652435997X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.303.2.741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:30:40Z","timestamp":1740007840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235652435997X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S002235652435997X"],"URL":"https:\/\/doi.org\/10.1124\/jpet.303.2.741","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics and Metabolism of Infused versus Inhaled Iloprost in Isolated Rabbit Lungs","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.303.2.741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}