{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:17:22Z","timestamp":1780985842392,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1124\/mol.105.017210","type":"journal-article","created":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T03:48:17Z","timestamp":1129693697000},"page":"354-362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pharmacological Profiling of Orthochirus scrobiculosus Toxin 1 Analogs with a Trimmed N-Terminal Domain"],"prefix":"10.1016","volume":"69","author":[{"given":"St\u00e9phanie","family":"Mouhat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgeta","family":"Teodorescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Homerick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Visan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Wulff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grissmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Darbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Waard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Sabatier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.105.017210_bib1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0896-6273(95)90104-3","article-title":"Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins","volume":"15","author":"Aiyar","year":"1995","journal-title":"Neuron"},{"key":"10.1124\/mol.105.017210_bib2","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1124\/mol.104.008193","article-title":"Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases","volume":"67","author":"Beeton","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.105.017210_bib3","doi-asserted-by":"crossref","first-page":"9928","DOI":"10.1074\/jbc.M212868200","article-title":"A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes","volume":"278","author":"Beeton","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.105.017210_bib4","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1126\/science.1720574","article-title":"Refined structure of charybdotoxin: common motifs in scorpion toxins and insect defensins","volume":"254","author":"Bontems","year":"1991","journal-title":"Science (Wash DC)"},{"key":"10.1124\/mol.105.017210_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1124\/mol.63.2.409","article-title":"Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels","volume":"63","author":"Castle","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.105.017210_bib6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tips.2004.03.010","article-title":"K+ channels as targets for specific immunomodulation","volume":"25","author":"Chandy","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.105.017210_bib7","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.1021\/bi00188a012","article-title":"Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom","volume":"33","author":"Garcia","year":"1994","journal-title":"Biochemistry"},{"key":"10.1124\/mol.105.017210_bib8","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0026-895X(25)10594-4","article-title":"Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5 and 3.1, stably expressed in mammalian cell lines","volume":"45","author":"Grissmer","year":"1994","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.105.017210_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pflueg Arch Eur J Physiol"},{"key":"10.1124\/mol.105.017210_bib10","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1021\/bi9614390","article-title":"Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom","volume":"36","author":"Jaravine","year":"1997","journal-title":"Biochemistry"},{"key":"10.1124\/mol.105.017210_bib11","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.toxicon.2004.03.024","article-title":"Toxin determinants required for interaction with voltage-gated K+ channels","volume":"43","author":"Jouirou","year":"2004","journal-title":"Toxicon"},{"key":"10.1124\/mol.105.017210_bib12","doi-asserted-by":"crossref","first-page":"32697","DOI":"10.1074\/jbc.273.49.32697","article-title":"ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide","volume":"273","author":"Kalman","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.105.017210_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1126\/science.3961484","article-title":"Solid phase synthesis","volume":"232","author":"Merrifield","year":"1986","journal-title":"Science (Wash DC)"},{"key":"10.1124\/mol.105.017210_bib14","doi-asserted-by":"crossref","first-page":"13698","DOI":"10.1021\/bi035209e","article-title":"Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile","volume":"42","author":"Middleton","year":"2003","journal-title":"Biochemistry"},{"key":"10.1124\/mol.105.017210_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1042\/bj20031860","article-title":"Diversity of folds in animal toxins acting on ion channels","volume":"378","author":"Mouhat","year":"2004","journal-title":"Biochem J"},{"key":"10.1124\/mol.105.017210_bib16","first-page":"1","article-title":"K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom","volume":"384","author":"Mouhat","year":"2004","journal-title":"Biochem J"},{"key":"10.1124\/mol.105.017210_bib17","series-title":"Perspectives in Drug Discovery and Design","first-page":"15","article-title":"Animal toxins and potassium channels","author":"Possani","year":"1999"},{"key":"10.1124\/mol.105.017210_bib18","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/S0026-895X(25)09623-3","article-title":"Evidence for an internal phenylalkylamine action on the voltage-gated potassium channel Kv1.3","volume":"50","author":"Rauer","year":"1996","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.105.017210_bib19","doi-asserted-by":"crossref","first-page":"55690","DOI":"10.1074\/jbc.M410055200","article-title":"Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins","volume":"279","author":"Regaya","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.105.017210_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0165-6147(03)00080-4","article-title":"Novel interactions between K+ channels and scorpion toxins","volume":"24","author":"Rodriguez de la Vega","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.105.017210_bib21","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.toxicon.2004.03.022","article-title":"Current views on scorpion toxins specific for K+-channels","volume":"43","author":"Rodriguez de la Vega","year":"2004","journal-title":"Toxicon"},{"key":"10.1124\/mol.105.017210_bib22","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1021\/bi971044w","article-title":"Purification, characterization and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels","volume":"36","author":"Romi-Lebrun","year":"1997","journal-title":"Biochemistry"},{"key":"10.1124\/mol.105.017210_bib23","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0165-6147(99)01398-X","article-title":"A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies","volume":"20","author":"Tytgat","year":"1999","journal-title":"Trends Physiol Sci"},{"key":"10.1124\/mol.105.017210_bib24","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.173.2.776","article-title":"K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity","volume":"173","author":"Wulff","year":"2004","journal-title":"J Immunol"},{"key":"10.1124\/mol.105.017210_bib25","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1124\/mol.105.011064","article-title":"Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels","volume":"67","author":"Yan","year":"2005","journal-title":"Mol Pharmacol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24050430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24050430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.105.017210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:59:25Z","timestamp":1739966365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24050430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0026895X24050430"],"URL":"https:\/\/doi.org\/10.1124\/mol.105.017210","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological Profiling of Orthochirus scrobiculosus Toxin 1 Analogs with a Trimmed N-Terminal Domain","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.105.017210","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}