{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:19:04Z","timestamp":1790547544868,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1124\/mol.105.020701","type":"journal-article","created":{"date-parts":[[2005,12,31]],"date-time":"2005-12-31T01:13:48Z","timestamp":1135991628000},"page":"1328-1337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors"],"prefix":"10.1016","volume":"69","author":[{"given":"Juliane","family":"Stieber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"St\u00f6ckl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.105.020701_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pharmthera.2005.01.005","article-title":"Physiology and pharmacology of the cardiac pacemaker (\u201cfunny\u201d) current","volume":"107","author":"Baruscotti","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.1124\/mol.105.020701_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0014-2999(90)90011-T","article-title":"Use- and frequency-dependent blockade by UL-FS 49 of the If pacemaker current in sheep cardiac Purkinje fibres","volume":"187","author":"Bogaert","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.105.020701_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejphar.2003.08.083","article-title":"Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine","volume":"478","author":"Bogaert","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.105.020701_bib4","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1476-5381.1996.tb15505.x","article-title":"Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells","volume":"118","author":"Bois","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.105.020701_bib5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.CIR.0000048143.25023.87","article-title":"Antiangial and antiischemic effects of ivabradine, an If inhibitor, in stable angina","volume":"107","author":"Borer","year":"2003","journal-title":"Circulation"},{"key":"10.1124\/mol.105.020701_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1476-5381.1993.tb13815.x","article-title":"Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells","volume":"110","author":"BoSmith","year":"1993","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.105.020701_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1085\/jgp.20028593","article-title":"Current-dependent block of rabbit sino-atrial node If channels by Ivabradine","volume":"120","author":"Bucchi","year":"2002","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.105.020701_bib8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1124\/jpet.103.059717","article-title":"Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs","volume":"308","author":"Colin","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.105.020701_bib9","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2165\/00003495-200464160-00003","article-title":"Heart rate lowering by specific and selective If current inhibition with ivabradine","volume":"64","author":"DiFrancesco","year":"2004","journal-title":"Drugs"},{"key":"10.1124\/mol.105.020701_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/sj.bjp.0705696","article-title":"If channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities","volume":"142","author":"Du","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.105.020701_bib11","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1161\/01.CIR.88.5.2389","article-title":"Use-dependent block of the pacemaker current If in rabbit sinoatrial node cells by Zatebradine (UL-FS 49)","volume":"88","author":"Goethals","year":"1993","journal-title":"Circulation"},{"key":"10.1124\/mol.105.020701_bib12","series-title":"Cardiac Electrophysiology. From Cell to Bedside","first-page":"192","article-title":"Cellular mechanisms of sinoatrial activity","author":"Kodama","year":"2004"},{"key":"10.1124\/mol.105.020701_bib13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/emboj\/cdg032","article-title":"Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2","volume":"22","author":"Ludwig","year":"2003","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"10.1124\/mol.105.020701_bib14","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1093\/emboj\/18.9.2323","article-title":"Two pacemaker channels from human heart with profoundly different activation kinetics","volume":"18","author":"Ludwig","year":"1999","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"10.1124\/mol.105.020701_bib15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/31255","article-title":"A family of hyperpolarization-activated mammalian cation channels","volume":"393","author":"Ludwig","year":"1998","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.105.020701_bib16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pbiomolbio.2005.05.003","article-title":"Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes","volume":"90","author":"Mangoni","year":"2005","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1124\/mol.105.020701_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0008-6363(01)00370-4","article-title":"Properties of the hyperpolarization-activated current (If) in isolated mouse sino-atrial cells","volume":"52","author":"Mangoni","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1124\/mol.105.020701_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1113\/jphysiol.2004.074047","article-title":"Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart","volume":"562","author":"Marionneau","year":"2005","journal-title":"J Physiol (Lond)"},{"key":"10.1124\/mol.105.020701_bib19","first-page":"H747","article-title":"Measurement of heart rate and Q-T interval in the conscious mouse","volume":"274","author":"Mitchell","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.105.020701_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/01.RES.87.2.88","article-title":"Sustained inward current during pacemaker depolarization in mammalian sinoatrial node cells","volume":"87","author":"Mitsuiye","year":"2000","journal-title":"Circ Res"},{"key":"10.1124\/mol.105.020701_bib21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.ehj.2003.10.010","article-title":"Heart rate reduction during exercise-induced myocardial ischaemia and stunning","volume":"25","author":"Monnet","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1124\/mol.105.020701_bib22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/sj.bjp.0702153","article-title":"Use-dependent block of Ih in mouse dorsal root ganglion neurons by sinus node inhibitors","volume":"125","author":"Raes","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.105.020701_bib23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.physiol.65.092101.142734","article-title":"Hyperpolarization-activated cation currents: From molecules to physiological function","volume":"65","author":"Robinson","year":"2003","journal-title":"Annu Rev Physiol"},{"key":"10.1124\/mol.105.020701_bib24","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(00)81434-8","article-title":"Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain","volume":"93","author":"Santoro","year":"1998","journal-title":"Cell"},{"key":"10.1124\/mol.105.020701_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1540\/jsmr.39.175","article-title":"Sino-atrial nodal cells of mammalian hearts: Ionic currents and gene expression of pacemaker ionic channels","volume":"39","author":"Satoh","year":"2003","journal-title":"J Smooth Muscle Res"},{"key":"10.1124\/mol.105.020701_bib26","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000018627.89528.6F","article-title":"Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function","volume":"90","author":"Schram","year":"2002","journal-title":"Circ Res"},{"key":"10.1124\/mol.105.020701_bib27","doi-asserted-by":"crossref","first-page":"15235","DOI":"10.1073\/pnas.2434235100","article-title":"The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart","volume":"100","author":"Stieber","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.105.020701_bib28","doi-asserted-by":"crossref","first-page":"34635","DOI":"10.1074\/jbc.M502508200","article-title":"Functional expression of the human HCN3 channel","volume":"280","author":"Stieber","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.105.020701_bib29","doi-asserted-by":"crossref","first-page":"33672","DOI":"10.1074\/jbc.M305318200","article-title":"Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4","volume":"278","author":"Stieber","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.105.020701_bib30","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/00005344-200311000-00016","article-title":"Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs","volume":"42","author":"Vilaine","year":"2003","journal-title":"J Cardiovasc Pharmacol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24067920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24067920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.105.020701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T09:06:25Z","timestamp":1740042385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24067920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0026895X24067920"],"URL":"https:\/\/doi.org\/10.1124\/mol.105.020701","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.105.020701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}