{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:16:21Z","timestamp":1791033381112,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1124\/mol.106.023226","type":"journal-article","created":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T01:00:54Z","timestamp":1146790854000},"page":"493-500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Isoliquiritigenin Selectively Inhibits H2 Histamine Receptor Signaling"],"prefix":"10.1016","volume":"70","author":[{"given":"Dong-Chan","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong-Sik","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ick-Dong","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanga. Ravi Prakash","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Sup","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong-Tai","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.106.023226_REF1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1046\/j.1471-4159.1998.71020799.x","article-title":"Constitutive activity and structural instability of the wild-type human H2 receptor","volume":"71","author":"Alewijnse","year":"1998","journal-title":"J Neurochem"},{"key":"10.1124\/mol.106.023226_REF2","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0006-291X(91)90385-K","article-title":"Presence of histamine H2-receptors on human gastric carcinoma cell line MKN-45 and their increase by retinoic acid treatment","volume":"176","author":"Arima","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/mol.106.023226_REF3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1248\/bpb.25.247","article-title":"Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis","volume":"25","author":"Baba","year":"2002","journal-title":"Biol Pharm Bull"},{"key":"10.1124\/mol.106.023226_REF4","first-page":"27","article-title":"Histamine receptors: specific ligands, receptor biochemistry, and signal transduction","volume":"17","author":"Bakker","year":"2002","journal-title":"Clin Allergy Immunol"},{"key":"10.1124\/mol.106.023226_REF5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/236385a0","article-title":"Definition and antagonism of histamine H2-receptors","volume":"236","author":"Black","year":"1972","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.106.023226_REF6","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1110\/ps.9.9.1753","article-title":"Modeling of loops in protein structures","volume":"9","author":"Fiser","year":"2000","journal-title":"Protein Sci"},{"key":"10.1124\/mol.106.023226_REF7","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0024-3205(02)01864-7","article-title":"Anti-Helicobacter pylori flavonoids from licorice extract","volume":"71","author":"Fukai","year":"2002","journal-title":"Life Sci"},{"key":"10.1124\/mol.106.023226_REF8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1073\/pnas.88.2.429","article-title":"Molecular cloning of a gene encoding the histamine H2 receptor","volume":"88","author":"Gantz","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.023226_REF9","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.4049\/jimmunol.174.9.5224","article-title":"Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells","volume":"174","author":"Gutzmer","year":"2005","journal-title":"J Immunol"},{"key":"10.1124\/mol.106.023226_REF10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000085108","article-title":"Histamine in allergic inflammation and immune modulation","volume":"137","author":"Jutel","year":"2005","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1124\/mol.106.023226_REF11","first-page":"1","article-title":"Histamine in chronic allergic responses","volume":"15","author":"Jutel","year":"2005","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1124\/mol.106.023226_REF12","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/35096564","article-title":"Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors","volume":"413","author":"Jutel","year":"2001","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.106.023226_REF13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0306-3623(95)00107-7","article-title":"G-protein-coupled receptors in HL-60 human leukemia cells","volume":"27","author":"Klinker","year":"1996","journal-title":"Gen Pharmacol"},{"key":"10.1124\/mol.106.023226_REF14","first-page":"2501","article-title":"[25 years of gastric acid blockers]","volume":"143","author":"Lamers","year":"1999","journal-title":"Ned Tijdschr Geneeskd"},{"key":"10.1124\/mol.106.023226_REF15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1095-6433(00)00331-7","article-title":"Control of gastric acid secretion: the gastrin-ECL cell-parietal cell axis","volume":"128","author":"Lindstrom","year":"2001","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10.1124\/mol.106.023226_REF16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.chroma.2005.01.053","article-title":"One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography","volume":"1078","author":"Ma","year":"2005","journal-title":"J Chromatogr A"},{"key":"10.1124\/mol.106.023226_REF17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1124\/mol.64.2.512","article-title":"Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model","volume":"64","author":"Monczor","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.106.023226_REF18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000201368","article-title":"Involvement of beta-adrenergic receptor kinase-1 in homologous desensitization of histamine H2 receptors in human gastric carcinoma cell line MKN-45","volume":"57","author":"Nakata","year":"1996","journal-title":"Digestion"},{"key":"10.1124\/mol.106.023226_REF19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mce.2003.11.011","article-title":"ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells","volume":"215","author":"Reichenstein","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1124\/mol.106.023226_REF20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00001574-200411000-00003","article-title":"Gastric secretion","volume":"20","author":"Schubert","year":"2004","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1124\/mol.106.023226_REF21","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0016-5085(54)80008-4","article-title":"A quantitative method for measuring spontaneous gastric secretion in the rat","volume":"26","author":"Shay","year":"1954","journal-title":"Gastroenterology"},{"key":"10.1124\/mol.106.023226_REF22","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1124\/mol.51.6.983","article-title":"Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937","volume":"51","author":"Shayo","year":"1997","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.106.023226_REF23","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.bbrc.2003.12.166","article-title":"The time-course of cyclic AMP signaling is critical for leukemia U-937 cell differentiation","volume":"314","author":"Shayo","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/mol.106.023226_REF24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1248\/yakushi1947.118.3_88","article-title":"[Synthesis and antiulcer activity of N-2-(2-hydroxy-2-phenyl)ethyl-N\u2033-(methanesulfonyl)guanidine analogue of ranitidine. Development of a new antiulcer agent T-593]","volume":"118","author":"Shibata","year":"1998","journal-title":"Yakugaku Zasshi"},{"key":"10.1124\/mol.106.023226_REF25","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1248\/yakushi1947.120.10_849","article-title":"A drug over the millennia: pharmacognosy, chemistry and pharmacology of licorice","volume":"120","author":"Shibata","year":"2000","journal-title":"Yakugaku Zasshi"},{"key":"10.1124\/mol.106.023226_REF26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1189\/jlb.69.1.169","article-title":"Modulation of H2 histamine receptoRmediated cAMP generation and granulocytic differentiation by extracellular nucleotides via activation of protein kinase C","volume":"69","author":"Suh","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1124\/mol.106.023226_REF27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1349-7006.2004.tb03230.x","article-title":"Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis and suppresses aberrant crypt foci development","volume":"95","author":"Takahashi","year":"2004","journal-title":"Cancer Sci"},{"key":"10.1124\/mol.106.023226_REF28","doi-asserted-by":"crossref","first-page":"C2037","DOI":"10.1152\/ajpcell.1997.273.6.C2037","article-title":"Activation of the human histamine H2 receptor is linked to cell proliferation and c-fos gene transcription","volume":"273","author":"Wang","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.106.023226_REF29","first-page":"51","article-title":"Problems associated with medical treatment of peptic ulcer disease","volume":"77","author":"Zimmerman","year":"1984","journal-title":"Am J Med"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24040884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24040884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.106.023226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:29:35Z","timestamp":1739964575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24040884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0026895X24040884"],"URL":"https:\/\/doi.org\/10.1124\/mol.106.023226","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isoliquiritigenin Selectively Inhibits H2 Histamine Receptor Signaling","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.106.023226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}