{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:37:23Z","timestamp":1790361443003,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1124\/mol.106.025981","type":"journal-article","created":{"date-parts":[[2006,8,26]],"date-time":"2006-08-26T03:00:19Z","timestamp":1156561219000},"page":"1612-1620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma"],"prefix":"10.1016","volume":"70","author":[{"given":"Kristin","family":"Gustafsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger","family":"Christensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Flygare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.106.025981_REF1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ymeth.2006.05.004","article-title":"Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry","volume":"39","author":"Bielawski","year":"2006","journal-title":"Methods"},{"key":"10.1124\/mol.106.025981_REF2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI200316116","article-title":"Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors","volume":"111","author":"Casanova","year":"2003","journal-title":"J Clin Investig"},{"key":"10.1124\/mol.106.025981_REF3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1046\/j.1471-4159.2001.00333.x","article-title":"Cannabinoids activate p38 mitogen-activated protein kinases through CB1 receptors in hippocampus","volume":"77","author":"Derkinderen","year":"2001","journal-title":"J Neurochem"},{"key":"10.1124\/mol.106.025981_REF4","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.4049\/jimmunol.173.4.2373","article-title":"Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation","volume":"173","author":"Do","year":"2004","journal-title":"J Immunol"},{"key":"10.1124\/mol.106.025981_REF5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cellsig.2004.05.011","article-title":"Cannabinoids downregulate PI3K\/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein","volume":"17","author":"Ellert-Miklaszewska","year":"2005","journal-title":"Cell Signal"},{"key":"10.1124\/mol.106.025981_REF6","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1016\/j.febslet.2005.11.020","article-title":"Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma","volume":"579","author":"Flygare","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1124\/mol.106.025981_REF7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/73171","article-title":"Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation","volume":"6","author":"Galve-Roperh","year":"2000","journal-title":"Nat Med"},{"key":"10.1124\/mol.106.025981_REF8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/bj3630183","article-title":"De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis","volume":"363","author":"Gomez del Pulgar","year":"2002","journal-title":"Biochem J"},{"key":"10.1124\/mol.106.025981_REF9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nrc1188","article-title":"Cannabinoids: potential anticancer agents","volume":"3","author":"Guzman","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/mol.106.025981_REF10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-6147(00)01586-8","article-title":"Ceramide: a new second messenger of cannabinoid action","volume":"22","author":"Guzman","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.106.025981_REF11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s001090000177","article-title":"Control of the cell survival\/death decision by cannabinoids","volume":"78","author":"Guzman","year":"2001","journal-title":"J Mol Med"},{"key":"10.1124\/mol.106.025981_REF12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0163-7258(02)00256-5","article-title":"Cannabinoids and cell fate","volume":"95","author":"Guzman","year":"2002","journal-title":"Pharmacol Ther"},{"key":"10.1124\/mol.106.025981_REF13","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1124\/mol.104.002618","article-title":"Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells","volume":"66","author":"Hinz","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.106.025981_REF14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International Union of Pharmacology. XXVII. Classification of cannabinoid receptors","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol Rev"},{"key":"10.1124\/mol.106.025981_REF15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0009-3084(00)00187-0","article-title":"Cellular signal transduction by anandamide and 2-arachidonoylglycerol","volume":"108","author":"Howlett","year":"2000","journal-title":"Chem Phys Lipids"},{"key":"10.1124\/mol.106.025981_REF16","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/sj.leu.2403057","article-title":"High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma","volume":"17","author":"Islam","year":"2003","journal-title":"Leukemia"},{"key":"10.1124\/mol.106.025981_REF17","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1046\/j.1365-2141.1998.00911.x","article-title":"Establishment and characterization of a mantle cell lymphoma cell line","volume":"102","author":"Jeon","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1124\/mol.106.025981_REF18","doi-asserted-by":"crossref","first-page":"13606","DOI":"10.1074\/jbc.M009517200","article-title":"Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria","volume":"276","author":"Kroesen","year":"2001","journal-title":"J Biol Chem"},{"issue":"Pt 3","key":"10.1124\/mol.106.025981_REF19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1042\/bj3460835","article-title":"Functional CB1 cannabinoid receptors in human vascular endothelial cells","volume":"346","author":"Liu","year":"2000","journal-title":"Biochem J"},{"key":"10.1124\/mol.106.025981_REF20","doi-asserted-by":"crossref","first-page":"31938","DOI":"10.1074\/jbc.M005722200","article-title":"Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors","volume":"275","author":"Maccarrone","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.025981_REF21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1182\/blood-2002-01-0098","article-title":"Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease","volume":"100","author":"McKallip","year":"2002","journal-title":"Blood"},{"key":"10.1124\/mol.106.025981_REF22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1124\/jpet.102.033506","article-title":"Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo","volume":"302","author":"McKallip","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.106.025981_REF23","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/ijc.2910380413","article-title":"Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement","volume":"38","author":"Melo","year":"1986","journal-title":"Int J Cancer"},{"key":"10.1124\/mol.106.025981_REF24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pros.10190","article-title":"Antiproliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production","volume":"56","author":"Mimeault","year":"2003","journal-title":"Prostate"},{"key":"10.1124\/mol.106.025981_REF25","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.174.6.3749","article-title":"B cell response to surface IgM cross-linking identifies different prognostic groups of B-chronic lymphocytic leukemia patients","volume":"174","author":"Nedellec","year":"2005","journal-title":"J Immunol"},{"key":"10.1124\/mol.106.025981_REF26","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.lfs.2004.10.025","article-title":"Inverse agonism and neutral antagonism at cannabinoid CB1 receptors","volume":"76","author":"Pertwee","year":"2005","journal-title":"Life Sci"},{"key":"10.1124\/mol.106.025981_REF27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1388-1981(02)00331-1","article-title":"Ceramide in apoptosis: an overview and current perspectives","volume":"1585","author":"Pettus","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.106.025981_REF28","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1182\/blood-2004-03-1182","article-title":"Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway","volume":"105","author":"Powles","year":"2005","journal-title":"Blood"},{"key":"10.1124\/mol.106.025981_REF29","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1124\/mol.64.5.1189","article-title":"Ceramide is involved in R(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells","volume":"64","author":"Ramer","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.106.025981_REF30","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1182\/blood.V83.12.3689.3689","article-title":"Rearrangement of CCND1 (BCL1\/PRAD1) 3\u2032 untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias","volume":"83","author":"Rimokh","year":"1994","journal-title":"Blood"},{"key":"10.1124\/mol.106.025981_REF31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2141.2004.04913.x","article-title":"B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia","volume":"125","author":"Ruchlemer","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1124\/mol.106.025981_REF32","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0026-895X(24)23114-X","article-title":"The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase","volume":"58","author":"Rueda","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.106.025981_REF33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(98)01085-0","article-title":"Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells","volume":"436","author":"Sanchez","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1124\/mol.106.025981_REF34","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1158\/0008-5472.CAN-04-3410","article-title":"Cannabinoid receptor as a novel target for the treatment of prostate cancer","volume":"65","author":"Sarfaraz","year":"2005","journal-title":"Cancer Res"},{"key":"10.1124\/mol.106.025981_REF35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.mcn.2005.02.009","article-title":"Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins","volume":"29","author":"Stoica","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"10.1124\/mol.106.025981_REF36","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1172\/JCI5457","article-title":"Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis","volume":"103","author":"Tepper","year":"1999","journal-title":"J Clin Investig"},{"key":"10.1124\/mol.106.025981_REF37","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-activated protein kinases in apoptosis regulation","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"10.1124\/mol.106.025981_REF38","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.lfs.2005.05.015","article-title":"Cannabinoids and ceramide: two lipids acting hand-by-hand","volume":"77","author":"Velasco","year":"2005","journal-title":"Life Sci"},{"key":"10.1124\/mol.106.025981_REF39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.cr.7290257","article-title":"Activation and signaling of the p38 MAP kinase pathway","volume":"15","author":"Zarubin","year":"2005","journal-title":"Cell Res"},{"key":"10.1124\/mol.106.025981_REF40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/jcp.10453","article-title":"Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells","volume":"199","author":"Zhao","year":"2004","journal-title":"J Cell Physiol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24042147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24042147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.106.025981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:34:57Z","timestamp":1739964897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24042147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0026895X24042147"],"URL":"https:\/\/doi.org\/10.1124\/mol.106.025981","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.106.025981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}