{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:14:37Z","timestamp":1791918877399,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1124\/mol.106.028415","type":"journal-article","created":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T00:44:24Z","timestamp":1159490664000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis"],"prefix":"10.1016","volume":"71","author":[{"given":"Toni","family":"Ahtoniemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gundars","family":"Goldsteins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velta","family":"Keksa-Goldsteine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Malm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Kanninen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antero","family":"Salminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Koistinaho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.106.028415_REF1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1212\/WNL.57.7.1282","article-title":"Immune reactivity in a mouse model of familial ALS correlates with disease progression","volume":"57","author":"Alexianu","year":"2001","journal-title":"Neurology"},{"key":"10.1124\/mol.106.028415_REF2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1146\/annurev.neuro.27.070203.144244","article-title":"Unraveling the mechanisms involved in motor neuron degeneration in ALS","volume":"27","author":"Bruijn","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"10.1124\/mol.106.028415_REF3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.toxlet.2005.02.008","article-title":"Repeated exposure to pyrrolidine-dithiocarbamate induces peripheral nerve alterations in rats","volume":"158","author":"Calviello","year":"2005","journal-title":"Toxicol Lett"},{"key":"10.1124\/mol.106.028415_REF4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.nbd.2006.02.008","article-title":"Effects of pyrrolidine dithiocarbamate on beta-amyloid (25-35)-induced inflammatory responses and memory deficits in the rat","volume":"23","author":"Cheng","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1124\/mol.106.028415_REF5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2004.12.007","article-title":"Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome","volume":"18","author":"Cheroni","year":"2005","journal-title":"Neurobiol Dis"},{"key":"10.1124\/mol.106.028415_REF6","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/sj.bjp.0704463","article-title":"Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation","volume":"135","author":"Cuzzocrea","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.106.028415_REF7","doi-asserted-by":"crossref","first-page":"22123","DOI":"10.1074\/jbc.274.32.22123","article-title":"The proteasome, a novel protease regulated by multiple mechanisms","volume":"274","author":"DeMartino","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.028415_REF8","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/ana.10374","article-title":"Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS","volume":"52","author":"Drachman","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1124\/mol.106.028415_REF9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0169-328X(01)00242-X","article-title":"Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis","volume":"95","author":"Elliott","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1124\/mol.106.028415_REF10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1523\/JNEUROSCI.20-02-00660.2000","article-title":"Restricted expression of G86R Cu\/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration","volume":"20","author":"Gong","year":"2000","journal-title":"J Neurosci"},{"key":"10.1124\/mol.106.028415_REF11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ana.410390203","article-title":"Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis","volume":"39","author":"Gurney","year":"1996","journal-title":"Ann Neurol"},{"key":"10.1124\/mol.106.028415_REF12","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1093\/emboj\/cdg332","article-title":"Evidence that reactive oxygen species do not mediate NF-kappaB activation","volume":"22","author":"Hayakawa","year":"2003","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"issue":"Pt 2","key":"10.1124\/mol.106.028415_REF13","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1042\/bj3180603","article-title":"Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B","volume":"318","author":"Helenius","year":"1996","journal-title":"Biochem J"},{"key":"10.1124\/mol.106.028415_REF14","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.032539299","article-title":"Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)","volume":"99","author":"Howland","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.028415_REF15","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1523\/JNEUROSCI.5253-05.2006","article-title":"Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"26","author":"Kiaei","year":"2006","journal-title":"J Neurosci"},{"key":"10.1124\/mol.106.028415_REF16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.yexcr.2004.04.017","article-title":"Pyrrolidine dithiocarbamate and zinc inhibit proteasomedependent proteolysis","volume":"298","author":"Kim","year":"2004","journal-title":"Exp Cell Res"},{"key":"10.1124\/mol.106.028415_REF17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1460-9568.2005.04191.x","article-title":"Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene","volume":"22","author":"Koh","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1124\/mol.106.028415_REF18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/nbdi.2002.0487","article-title":"Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis","volume":"10","author":"Kriz","year":"2002","journal-title":"Neurobiol Dis"},{"key":"10.1124\/mol.106.028415_REF19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3171\/spi.2004.1.3.0311","article-title":"Inhibition of the nuclear factor-kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats","volume":"1","author":"La Rosa","year":"2004","journal-title":"J Neurosurg Spine"},{"key":"10.1124\/mol.106.028415_REF20","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1523\/JNEUROSCI.22-12-04825.2002","article-title":"Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease","volume":"22","author":"Lino","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/mol.106.028415_REF21","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/01.CIR.100.12.1330","article-title":"Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes","volume":"100","author":"Liu","year":"1999","journal-title":"Circulation"},{"key":"10.1124\/mol.106.028415_REF22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2131\/jts.30.103","article-title":"Inhibition of NF-kappaB activation during ischemia reduces hepatic ischemia\/reperfusion injury in rats","volume":"30","author":"Matsui","year":"2005","journal-title":"J Toxicol Sci"},{"key":"10.1124\/mol.106.028415_REF23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1172\/JCI11916","article-title":"NF-kappaB in neuronal plasticity and neurodegenerative disorders","volume":"107","author":"Mattson","year":"2001","journal-title":"J Clin Investig"},{"key":"10.1124\/mol.106.028415_REF24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.expneurol.2005.11.021","article-title":"Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice","volume":"198","author":"Messina","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1124\/mol.106.028415_REF25","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1097\/00005072-199712000-00006","article-title":"c-Jun, JNK\/SAPK kinases and transcription factor NF-kappa B are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis","volume":"56","author":"Migheli","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1124\/mol.106.028415_REF26","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1212\/WNL.36.4.511","article-title":"Familial adult motor neuron disease: amyotrophic lateral sclerosis","volume":"36","author":"Mulder","year":"1986","journal-title":"Neurology"},{"key":"10.1124\/mol.106.028415_REF27","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.1256","article-title":"Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1 beta in neurodegeneration","volume":"50","author":"Nguyen","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1124\/mol.106.028415_REF28","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.freeradbiomed.2006.01.011","article-title":"Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia","volume":"40","author":"Nurmi","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/mol.106.028415_REF29","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.STR.0000120732.45951.26","article-title":"Nuclear factor-kappaB contributes to infarction after permanent focal ischemia","volume":"35","author":"Nurmi","year":"2004","journal-title":"Stroke"},{"key":"10.1124\/mol.106.028415_REF30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1471-4159.2004.02756.x","article-title":"Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window","volume":"91","author":"Nurmi","year":"2004","journal-title":"J Neurochem"},{"key":"10.1124\/mol.106.028415_REF31","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1523\/JNEUROSCI.21-10-03369.2001","article-title":"Neuronspecific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment","volume":"21","author":"Pramatarova","year":"2001","journal-title":"J Neurosci"},{"key":"10.1124\/mol.106.028415_REF32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.expneurol.2005.08.027","article-title":"Non-neuronal induction of immunoproteasome subunits in an ALS model: possible mediation by cytokines","volume":"196","author":"Puttaparthi","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1124\/mol.106.028415_REF33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0140-6736(90)90802-C","article-title":"Inhibition of HIV progression by dithiocarb. German DTC Study Group","volume":"335","author":"Reisinger","year":"1990","journal-title":"Lancet"},{"key":"10.1124\/mol.106.028415_REF34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.106.028415_REF35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature03180","article-title":"Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression","volume":"433","author":"Rothstein","year":"2005","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.106.028415_REF36","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1084\/jem.175.5.1181","article-title":"Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells","volume":"175","author":"Schreck","year":"1992","journal-title":"J Exp Med"},{"key":"10.1124\/mol.106.028415_REF37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S1044-7431(03)00022-8","article-title":"Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression","volume":"23","author":"Tortarolo","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"10.1124\/mol.106.028415_REF38","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/00001756-200206120-00018","article-title":"Minocycline delays disease onset and mortality in a transgenic model of ALS","volume":"13","author":"Van Den Bosch","year":"2002","journal-title":"Neuroreport"},{"key":"10.1124\/mol.106.028415_REF39","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1046\/j.1471-4159.2003.01639.x","article-title":"Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis","volume":"85","author":"Wu","year":"2003","journal-title":"J Neurochem"},{"key":"10.1124\/mol.106.028415_REF40","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/417074a","article-title":"Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice","volume":"417","author":"Zhu","year":"2002","journal-title":"Nature (Lond)"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24042810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24042810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.106.028415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:40:12Z","timestamp":1739965212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24042810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0026895X24042810"],"URL":"https:\/\/doi.org\/10.1124\/mol.106.028415","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.106.028415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}