{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:42:27Z","timestamp":1785494547113,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1124\/mol.106.031146","type":"journal-article","created":{"date-parts":[[2007,1,6]],"date-time":"2007-01-06T01:34:31Z","timestamp":1168047271000},"page":"1075-1088","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca2+-Activated K+ Channel Activators Selective for \u03b21 and \u03b24 but Not for \u03b22 Subunits"],"prefix":"10.1016","volume":"71","author":[{"given":"Takashi","family":"Morimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuho","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Sade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Ohya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Muraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Imaizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.106.031146_REF1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1139\/o98-082","article-title":"Differential inhibition of AE1 and AE2 anion exchangers by oxonol dyes and by novel polyaminosterol analogs of the shark antibiotic squalamine","volume":"76","author":"Alper","year":"1998","journal-title":"Biochem Cell Biol"},{"key":"10.1124\/mol.106.031146_REF2","doi-asserted-by":"crossref","first-page":"C1063","DOI":"10.1152\/ajpcell.1995.269.4.C1063","article-title":"Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye","volume":"269","author":"Arreola","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.106.031146_REF3","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.1074\/jbc.275.9.6453","article-title":"Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4","volume":"275","author":"Brenner","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.031146_REF4","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/35038011","article-title":"Vasoregulation by the beta1 subunit of the calcium-activated potassium channel","volume":"407","author":"Brenner","year":"2000","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.106.031146_REF5","doi-asserted-by":"crossref","first-page":"34594","DOI":"10.1074\/jbc.M104689200","article-title":"Tamoxifen activates smooth muscle BK channels through the regulatory \u03b21 subunit","volume":"276","author":"Dick","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.031146_REF6","doi-asserted-by":"crossref","first-page":"8415","DOI":"10.1073\/pnas.83.21.8415","article-title":"A Drosophila mutation that eliminates a calcium-dependent potassium current","volume":"83","author":"Elkins","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.031146_REF7","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1172\/JCI200420347","article-title":"Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension","volume":"113","author":"Fernandez-Fernandez","year":"2004","journal-title":"J Clin Investig"},{"key":"10.1124\/mol.106.031146_REF8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1085\/jgp.112.4.485","article-title":"Mechanism of maxi-K channel activation by dehydrosoyasaponin-I","volume":"112","author":"Giangiacomo","year":"1998","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.106.031146_REF9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1359-6446(99)01383-5","article-title":"Cell-based assays and instrumentation for screening ion-channel targets","volume":"4","author":"Gonz\u00e1lez","year":"1999","journal-title":"Drug Discov Today"},{"key":"10.1124\/mol.106.031146_REF10","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1074\/jbc.M302034200","article-title":"Two arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current in the Kv4 channel subfamily","volume":"279","author":"Hatano","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.031146_REF11","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1124\/mol.62.4.836","article-title":"Molecular basis of pimarane compounds as novel activators of large-conductance Ca2+-activated K+ channel \u03b1-subunit","volume":"62","author":"Imaizumi","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.106.031146_REF12","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1128\/AAC.41.9.2001","article-title":"Rapid assessment of antibiotic effects on Escherichia coli by bis-(1,3-dibutylbarbituric acid) trimethine oxonol and flow cytometry","volume":"41","author":"Jepras","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/mol.106.031146_REF13","doi-asserted-by":"crossref","first-page":"17274","DOI":"10.1016\/S0021-9258(17)32551-6","article-title":"Primary sequence and immunological characterization of \u03b2-subunit of high conductance Ca2+-activated K+ channel from smooth muscle","volume":"269","author":"Knaus","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.031146_REF14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0896-6273(95)90321-6","article-title":"Functional role of the beta subunit of high conductance calcium-activated potassium channels","volume":"14","author":"McManus","year":"1995","journal-title":"Neuron"},{"key":"10.1124\/mol.106.031146_REF15","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1073\/pnas.100118597","article-title":"A neuronal \u03b2 subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin","volume":"97","author":"Meera","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.031146_REF16","doi-asserted-by":"crossref","first-page":"36746","DOI":"10.1074\/jbc.M405621200","article-title":"Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel","volume":"279","author":"Meredith","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.031146_REF17","doi-asserted-by":"crossref","first-page":"C388","DOI":"10.1152\/ajpcell.00409.2005","article-title":"Two-step Ca2+ intracellular release underlies excitation-contraction coupling in mouse urinary bladder myocytes","volume":"290","author":"Morimura","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.106.031146_REF18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1055\/s-2003-45095","article-title":"Natural modulators of large-conductance calcium-activated potassium channels","volume":"69","author":"Nardi","year":"2003","journal-title":"Planta Med"},{"key":"10.1124\/mol.106.031146_REF19","first-page":"H1635","article-title":"Cardioprotective effects of estradiol include the activation of large-conductance Ca2+-activated K+ channels in cardiac mitochondria","volume":"289","author":"Ohya","year":"2005","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.106.031146_REF20","first-page":"156","article-title":"New disguises for an old channel: MaxiK channel beta-subunits","volume":"17","author":"Orio","year":"2002","journal-title":"News Physiol Sci"},{"key":"10.1124\/mol.106.031146_REF21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1469-7793.2001.00443.x","article-title":"Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle","volume":"537","author":"Petkov","year":"2001","journal-title":"J Physiol (Lond)"},{"key":"10.1124\/mol.106.031146_REF22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(01)00444-5","article-title":"Identification of a novel tetramerization domain in large conductance KCa channels","volume":"32","author":"Quirk","year":"2001","journal-title":"Neuron"},{"key":"10.1124\/mol.106.031146_REF23","doi-asserted-by":"crossref","first-page":"12922","DOI":"10.1073\/pnas.0402660101","article-title":"Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK\u03b21-subunit leads to progressive hearing loss","volume":"101","author":"R\u00fcttiger","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.031146_REF24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1124\/jpet.105.093856","article-title":"Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid","volume":"316","author":"Sakamoto","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.106.031146_REF25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/01.CIR.0000156448.74296.FE","article-title":"Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice","volume":"112","author":"Sausbier","year":"2005","journal-title":"Circulation"},{"key":"10.1124\/mol.106.031146_REF26","doi-asserted-by":"crossref","first-page":"9474","DOI":"10.1073\/pnas.0401702101","article-title":"Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency","volume":"101","author":"Sausbier","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.031146_REF27","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0006-3495(97)78168-2","article-title":"A novel calcium-sensing domain in the BK channel","volume":"73","author":"Schreiber","year":"1997","journal-title":"Biophys J"},{"key":"10.1124\/mol.106.031146_REF28","doi-asserted-by":"crossref","first-page":"23211","DOI":"10.1074\/jbc.M910187199","article-title":"Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel","volume":"275","author":"Uebele","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.031146_REF29","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.285.5435.1929","article-title":"Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit","volume":"285","author":"Valverde","year":"1999","journal-title":"Science (Wash DC)"},{"key":"10.1124\/mol.106.031146_REF30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0959-4388(98)80056-1","article-title":"Calcium-activated potassium channels","volume":"8","author":"Vergara","year":"1998","journal-title":"Curr Opin Neurobiol"},{"key":"10.1124\/mol.106.031146_REF31","doi-asserted-by":"crossref","first-page":"14922","DOI":"10.1073\/pnas.93.25.14922","article-title":"Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca2+-sensitive K+ channels: an additional transmembrane region at the N terminus","volume":"93","author":"Wallner","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.031146_REF32","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1073\/pnas.96.7.4137","article-title":"Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane \u03b2-subunit homolog","volume":"96","author":"Wallner","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.031146_REF33","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1523\/JNEUROSCI.20-10-03563.2000","article-title":"A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels","volume":"20","author":"Weiger","year":"2000","journal-title":"J Neurosci"},{"key":"10.1124\/mol.106.031146_REF34","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/108705710100600504","article-title":"Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators","volume":"6","author":"Whiteaker","year":"2001","journal-title":"J Biomol Screen"},{"key":"10.1124\/mol.106.031146_REF35","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1523\/JNEUROSCI.19-13-05255.1999","article-title":"Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells","volume":"19","author":"Xia","year":"1999","journal-title":"J Neurosci"},{"key":"10.1124\/mol.106.031146_REF36","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1523\/JNEUROSCI.20-13-04890.2000","article-title":"Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit","volume":"20","author":"Xia","year":"2000","journal-title":"J Neurosci"},{"key":"10.1124\/mol.106.031146_REF37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1126\/science.280.5362.443","article-title":"Control of alternative splicing of potassium channels by stress hormones","volume":"280","author":"Xie","year":"1998","journal-title":"Science (Wash DC)"},{"key":"10.1124\/mol.106.031146_REF38","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1254\/jjp.86.342","article-title":"Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells","volume":"86","author":"Yamada","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"10.1124\/mol.106.031146_REF39","doi-asserted-by":"crossref","first-page":"16232","DOI":"10.1074\/jbc.M008852200","article-title":"A novel MaxiK splice variant exhibits dominant-negative properties for surface expression","volume":"276","author":"Zarei","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.106.031146_REF40","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nsb932","article-title":"Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels","volume":"10","author":"Zeng","year":"2003","journal-title":"Nat Struct Biol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X2404402X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X2404402X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.106.031146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:51:05Z","timestamp":1739965865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X2404402X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0026895X2404402X"],"URL":"https:\/\/doi.org\/10.1124\/mol.106.031146","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca2+-Activated K+ Channel Activators Selective for \u03b21 and \u03b24 but Not for \u03b22 Subunits","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.106.031146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}