{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:28:55Z","timestamp":1759937335725,"version":"3.37.3"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1124\/mol.106.033324","type":"journal-article","created":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T00:53:35Z","timestamp":1174697615000},"page":"1685-1694","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Amine-Containing Cutaneous Irritant Heptylamine Inhibits the Volume-Regulated Anion Channel and Mobilizes Intracellular Calcium in Normal Human Epidermal Keratinocytes"],"prefix":"10.1016","volume":"71","author":[{"given":"Matthieu","family":"Raoux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Colomban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Delmas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Crest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.106.033324_REF1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/excr.2000.5046","article-title":"Regulation and functions of Rho-associated kinase","volume":"261","author":"Amano","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1124\/mol.106.033324_REF2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1085\/jgp.113.3.441","article-title":"ATP dependence of the ICl,swell channel varies with rate of cell swelling. Evidence for two modes of channel activation","volume":"113","author":"Bond","year":"1999","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.106.033324_REF3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1113\/jphysiol.2004.072306","article-title":"Cell swelling-induced ATP release is tightly dependent on intracellular calcium elevations","volume":"561","author":"Boudreault","year":"2004","journal-title":"J Physiol"},{"key":"10.1124\/mol.106.033324_REF4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0005-2736(00)00243-1","article-title":"Dual role of ATP in supporting volume-regulated chloride channels in mouse fibroblasts","volume":"1468","author":"Bryan-Sisneros","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.106.033324_REF5","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1529\/biophysj.104.040634","article-title":"Cholesterol depletion increases membrane stiffness of aortic endothelial cells","volume":"87","author":"Byfield","year":"2004","journal-title":"Biophys J"},{"key":"10.1124\/mol.106.033324_REF6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1748-1716.2006.01555.x","article-title":"Evidence for the role of cell stiffness in modulation of volume-regulated anion channels","volume":"187","author":"Byfield","year":"2006","journal-title":"Acta Physiol"},{"key":"10.1124\/mol.106.033324_REF7","doi-asserted-by":"crossref","first-page":"C115","DOI":"10.1152\/ajpcell.00038.2001","article-title":"RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells","volume":"283","author":"Carton","year":"2002","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.106.033324_REF8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0887-2333(03)00019-5","article-title":"Analysis of interleukin-1alpha (IL-1alpha) and interleukin-8 (IL-8) expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and\/or sensitization","volume":"17","author":"Coquette","year":"2003","journal-title":"Toxicol In Vitro"},{"key":"10.1124\/mol.106.033324_REF9","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1152\/jn.00510.2002","article-title":"ATP released from astrocytes during swelling activates chloride channels","volume":"89","author":"Darby","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1124\/mol.106.033324_REF10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1385\/CBB:35:3:263","article-title":"Cellular function and control of volume-regulated anion channels","volume":"35","author":"Eggermont","year":"2001","journal-title":"Cell Biochem Biophys"},{"key":"10.1124\/mol.106.033324_REF11","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1469-7793.2001.0582e.x","article-title":"Osmotic swelling-induced ATP release: a new role for tyrosine and Rho-kinases?","volume":"532","author":"Grygorczyk","year":"2001","journal-title":"J Physiol"},{"key":"10.1124\/mol.106.033324_REF12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1085\/jgp.20028540","article-title":"Volume-regulated anion channels serve as an auto\/paracrine nucleotide release pathway in aortic endothelial cells","volume":"119","author":"Hisadome","year":"2002","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.106.033324_REF13","first-page":"G521","article-title":"Ammonia blockade of intestinal epithelial K+ conductance","volume":"277","author":"Hrnjez","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.106.033324_REF14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1152\/physrev.00029.2001","article-title":"Molecular structure and physiological function of chloride channels","volume":"82","author":"Jentsch","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1124\/mol.106.033324_REF15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0014-4827(87)90283-7","article-title":"Patterns of junctional communication in skin: studies on cultured keratinocytes","volume":"173","author":"Kam","year":"1987","journal-title":"Exp Cell Res"},{"key":"10.1124\/mol.106.033324_REF16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00232-004-0668-9","article-title":"Mechanisms of Na+-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: importance of transbilayer movement","volume":"198","author":"Keller","year":"2004","journal-title":"J Membr Biol"},{"key":"10.1124\/mol.106.033324_REF17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1096\/fj.00-0055com","article-title":"Expression and biological significance of Ca2+-activated ion channels in human keratinocytes","volume":"15","author":"Koegel","year":"2001","journal-title":"FASEB J"},{"key":"10.1124\/mol.106.033324_REF18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/bj20031089","article-title":"Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation","volume":"380","author":"Koizumi","year":"2004","journal-title":"Biochem J"},{"key":"10.1124\/mol.106.033324_REF19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1469-7793.2001.0759e.x","article-title":"Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells","volume":"532","author":"Koyama","year":"2001","journal-title":"J Physiol"},{"key":"10.1124\/mol.106.033324_REF20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1085\/jgp.101.6.801","article-title":"Chloride channels activated by osmotic stress in T lymphocytes","volume":"101","author":"Lewis","year":"1993","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.106.033324_REF21","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1073\/pnas.140216197","article-title":"Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis","volume":"97","author":"Maeno","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.106.033324_REF22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nm0402-358","article-title":"CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness","volume":"8","author":"Mizumoto","year":"2002","journal-title":"Nat Med"},{"key":"10.1124\/mol.106.033324_REF23","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1046\/j.1523-1747.2003.12558.x","article-title":"Keratinocyte ATP release assay for testing skin-irritating potentials of structurally diverse chemicals","volume":"121","author":"Mizumoto","year":"2003","journal-title":"J Investig Dermatol"},{"key":"10.1124\/mol.106.033324_REF24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1365-201X.2003.01060.x","article-title":"Amazing chloride channels: an overview","volume":"177","author":"Nilius","year":"2003","journal-title":"Acta Physiol Scand"},{"key":"10.1124\/mol.106.033324_REF25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0014-5793(00)01097-8","article-title":"Myosin light chain phosphorylation-dependent modulation of volume-regulated anion channels in macrovascular endothelium","volume":"466","author":"Nilius","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1124\/mol.106.033324_REF26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1469-7793.1999.067aa.x","article-title":"Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells","volume":"516","author":"Nilius","year":"1999","journal-title":"J Physiol"},{"key":"10.1124\/mol.106.033324_REF27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-7793.2001.0003g.x","article-title":"Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)","volume":"532","author":"Okada","year":"2001","journal-title":"J Physiol"},{"key":"10.1124\/mol.106.033324_REF28","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0962-8924(01)02153-5","article-title":"Rho family proteins: coordinating cell responses","volume":"11","author":"Ridley","year":"2001","journal-title":"Trends Cell Biol"},{"key":"10.1124\/mol.106.033324_REF29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1085\/jgp.200308882","article-title":"Sensitivity of volume-regulated anion current to cholesterol structural analogues","volume":"123","author":"Romanenko","year":"2004","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.106.033324_REF30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0005-2736(92)90251-G","article-title":"A volume-sensitive chloride conductance revealed in cultured human keratinocytes by 36Cl\u2013 efflux and whole-cell patch clamp recording","volume":"1112","author":"Rugolo","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.106.033324_REF31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbamem.2003.10.008","article-title":"Cell volume regulation and swelling-activated chloride channels","volume":"1618","author":"Sardini","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.106.033324_REF32","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1139\/y00-028","article-title":"External anions and volume-sensitive anion current in guinea-pig ventricular myocytes","volume":"78","author":"Shuba","year":"2000","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1124\/mol.106.033324_REF33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00018-005-5336-4","article-title":"Diversity of Cl\u2013 channels","volume":"63","author":"Suzuki","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1124\/mol.106.033324_REF34","doi-asserted-by":"crossref","first-page":"C248","DOI":"10.1152\/ajpcell.2001.281.1.C248","article-title":"Inhibition of VRAC by c-Src tyrosine kinase targeted to caveolae is mediated by the Src homology domains","volume":"281","author":"Trouet","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.106.033324_REF35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1469-7793.1999.t01-1-00113.x","article-title":"Caveolin-1 modulates the activity of the volume-regulated chloride channel","volume":"520","author":"Trouet","year":"1999","journal-title":"J Physiol"},{"key":"10.1124\/mol.106.033324_REF36","doi-asserted-by":"crossref","first-page":"C1287","DOI":"10.1152\/ajpcell.00545.2005","article-title":"Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at basolateral, but not apical, membrane of Caco-2 cells","volume":"290","author":"Ullrich","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.106.033324_REF37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1085\/jgp.110.3.313","article-title":"Modulation of voltage-dependent properties of a swelling-activated Cl\u2013 current","volume":"110","author":"Voets","year":"1997","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.106.033324_REF38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1085\/jgp.200409161","article-title":"Ca2+- and volume-sensitive chloride currents are differentially regulated by agonists and store-operated Ca2+ entry","volume":"125","author":"Zholos","year":"2005","journal-title":"J Gen Physiol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24044766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24044766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.106.033324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:52:59Z","timestamp":1739965979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24044766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0026895X24044766"],"URL":"https:\/\/doi.org\/10.1124\/mol.106.033324","relation":{},"ISSN":["0026-895X"],"issn-type":[{"type":"print","value":"0026-895X"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Amine-Containing Cutaneous Irritant Heptylamine Inhibits the Volume-Regulated Anion Channel and Mobilizes Intracellular Calcium in Normal Human Epidermal Keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.106.033324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}